GREMLIN Database
MHQD - Putative hydrolase MhqD
UniProt: O34842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (189)
Sequences: 3812 (2874)
Seq/√Len: 209.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_L120_A3.3941.00
103_A125_P3.3641.00
177_Q190_Q3.1101.00
155_K176_W2.9661.00
123_H191_A2.9241.00
56_F126_M2.8921.00
24_E44_R2.8341.00
103_A122_L2.7641.00
22_G26_D2.5451.00
121_I191_A2.5151.00
95_I195_Y2.5091.00
14_L40_L2.3851.00
173_S197_E2.3851.00
159_E176_W2.3681.00
95_I119_G2.3661.00
12_N38_A2.3181.00
148_K178_D2.2731.00
162_Y166_R2.2611.00
17_L76_L2.1261.00
145_G187_E2.0581.00
81_D85_E2.0571.00
97_V121_I1.9701.00
175_Y190_Q1.9311.00
106_A120_A1.9011.00
13_V83_A1.8511.00
77_K109_L1.8081.00
12_N93_R1.7581.00
66_E70_V1.7511.00
10_S13_V1.7491.00
151_P180_G1.7291.00
148_K176_W1.7211.00
163_R166_R1.7071.00
158_S174_V1.6641.00
77_K113_Y1.6361.00
41_L83_A1.6071.00
83_A86_T1.5781.00
192_R196_K1.5601.00
44_R53_P1.5441.00
73_T108_S1.5231.00
122_L144_I1.5131.00
110_L140_L1.4901.00
47_V51_G1.4721.00
48_L71_V1.4451.00
155_K159_E1.4371.00
105_I125_P1.4291.00
107_A144_I1.4111.00
122_L125_P1.3821.00
74_R78_D1.3771.00
107_A122_L1.3691.00
124_H187_E1.3631.00
84_A94_V1.3481.00
19_G100_S1.3391.00
144_I162_Y1.3171.00
15_L80_I1.2961.00
142_V170_A1.2871.00
84_A91_R1.2831.00
163_R167_D1.2761.00
185_Q189_E1.2681.00
146_A158_S1.2561.00
11_D37_D1.2561.00
27_L183_L1.2541.00
48_L54_R1.2471.00
143_F190_Q1.2281.00
78_D82_E1.2271.00
23_N26_D1.2081.00
77_K81_D1.2081.00
156_E160_E1.1961.00
82_E86_T1.1651.00
90_N93_R1.1611.00
144_I172_A1.1431.00
104_N126_M1.1411.00
108_S112_H1.1391.00
11_D93_R1.1371.00
119_G141_P1.1311.00
156_E159_E1.1021.00
100_S181_H1.0821.00
124_H146_A1.0561.00
48_L53_P1.0531.00
73_T109_L1.0461.00
162_Y172_A1.0441.00
148_K155_K1.0341.00
162_Y174_V1.0301.00
43_V76_L1.0261.00
143_F175_Y1.0211.00
39_H83_A1.0191.00
81_D113_Y1.0181.00
59_L63_V1.0181.00
65_D68_D1.0041.00
29_S32_R1.0041.00
141_P171_S1.0001.00
145_G177_Q0.9971.00
76_L105_I0.9921.00
82_E85_E0.9861.00
14_L38_A0.9831.00
74_R77_K0.9821.00
13_V39_H0.9801.00
135_P138_A0.9741.00
107_A161_L0.9691.00
143_F177_Q0.9691.00
16_L97_V0.9611.00
43_V79_F0.9601.00
164_Y168_S0.9450.99
184_T187_E0.9350.99
159_E162_Y0.9330.99
16_L31_G0.9320.99
75_E78_D0.9320.99
81_D84_A0.9300.99
159_E174_V0.9280.99
22_G183_L0.9200.99
15_L96_A0.9160.99
33_F188_A0.9040.99
99_Y124_H0.9020.99
25_H28_L0.8840.99
154_T157_E0.8830.99
20_T58_R0.8830.99
16_L27_L0.8820.99
100_S150_D0.8810.99
28_L42_G0.8800.99
160_E163_R0.8790.99
143_F187_E0.8650.99
76_L109_L0.8600.99
46_S75_E0.8550.99
149_Y179_G0.8550.99
69_L108_S0.8550.99
106_A125_P0.8520.99
93_R118_K0.8500.99
164_Y167_D0.8460.99
159_E163_R0.8450.99
31_G40_L0.8440.99
70_V108_S0.8420.99
89_F94_V0.8400.99
96_A106_A0.8380.99
179_G184_T0.8380.99
92_G116_V0.8370.99
155_K174_V0.8340.99
54_R58_R0.8330.99
81_D115_D0.8310.99
177_Q184_T0.8250.99
148_K179_G0.8250.99
193_E197_E0.8180.98
160_E164_Y0.8110.98
80_I94_V0.8110.98
25_H44_R0.8040.98
29_S33_F0.7960.98
165_L170_A0.7950.98
70_V73_T0.7860.98
33_F185_Q0.7850.98
120_A142_V0.7830.98
189_E192_R0.7830.98
45_G55_F0.7810.98
10_S39_H0.7690.98
42_G97_V0.7660.98
57_K68_D0.7640.98
89_F93_R0.7630.98
13_V41_L0.7630.98
28_L32_R0.7610.98
23_N53_P0.7580.97
111_F170_A0.7560.97
35_D192_R0.7550.97
58_R101_N0.7470.97
13_V89_F0.7470.97
80_I117_L0.7460.97
77_K117_L0.7440.97
15_L83_A0.7370.97
123_H187_E0.7350.97
8_G37_D0.7310.97
80_I83_A0.7300.97
177_Q187_E0.7280.97
23_N44_R0.7240.97
20_T104_N0.7200.97
104_N153_C0.7180.97
148_K159_E0.7160.96
104_N128_P0.7140.96
17_L105_I0.7120.96
69_L105_I0.7100.96
73_T105_I0.7090.96
58_R68_D0.7060.96
47_V53_P0.7040.96
72_R101_N0.7010.96
113_Y117_L0.7000.96
190_Q193_E0.6980.96
153_C157_E0.6930.96
30_L188_A0.6910.96
149_Y180_G0.6880.96
97_V123_H0.6880.96
137_M170_A0.6860.95
35_D38_A0.6850.95
22_G53_P0.6840.95
91_R115_D0.6840.95
30_L35_D0.6830.95
107_A120_A0.6820.95
146_A153_C0.6820.95
79_F83_A0.6810.95
13_V94_V0.6770.95
107_A127_V0.6750.95
17_L106_A0.6680.95
189_E197_E0.6630.95
134_L167_D0.6620.95
177_Q186_H0.6610.95
15_L94_V0.6590.94
142_V165_L0.6550.94
28_L40_L0.6510.94
24_E42_G0.6490.94
64_F108_S0.6480.94
144_I161_L0.6470.94
22_G152_L0.6470.94
49_E52_M0.6450.94
80_I109_L0.6440.94
22_G29_S0.6440.94
24_E43_V0.6420.94
85_E115_D0.6410.94
146_A155_K0.6390.93
54_R101_N0.6380.93
67_K71_V0.6370.93
73_T112_H0.6320.93
20_T54_R0.6300.93
147_G181_H0.6300.93
193_E196_K0.6270.93
150_D181_H0.6270.93
49_E57_K0.6260.93
123_H143_F0.6250.93
143_F194_W0.6180.92
77_K114_K0.6170.92
26_D29_S0.6150.92
127_V144_I0.6150.92
133_E138_A0.6140.92
20_T101_N0.6120.92
34_I192_R0.6100.92
81_D116_V0.6060.92
31_G35_D0.6050.91
77_K115_D0.6040.91
96_A117_L0.6020.91
145_G190_Q0.5970.91
96_A110_L0.5960.91
31_G34_I0.5940.91
108_S128_P0.5940.91
123_H145_G0.5930.91
71_V74_R0.5920.91
99_Y183_L0.5900.90
66_E129_I0.5840.90
78_D81_D0.5840.90
149_Y178_D0.5770.89
121_I143_F0.5770.89
110_L142_V0.5760.89
64_F130_R0.5730.89
175_Y186_H0.5690.89
72_R75_E0.5690.89
149_Y182_Q0.5620.88
30_L33_F0.5610.88
91_R113_Y0.5590.88
68_D72_R0.5590.88
48_L52_M0.5560.88
166_R171_S0.5530.87
123_H183_L0.5520.87
72_R105_I0.5480.87
118_K141_P0.5460.87
86_T171_S0.5410.86
111_F168_S0.5370.86
70_V74_R0.5360.86
27_L31_G0.5360.86
97_V191_A0.5330.85
182_Q185_Q0.5320.85
15_L41_L0.5300.85
22_G27_L0.5290.85
130_R164_Y0.5280.85
127_V161_L0.5260.85
101_N126_M0.5260.85
157_E161_L0.5250.85
115_D137_M0.5240.85
175_Y193_E0.5210.84
84_A90_N0.5200.84
171_S193_E0.5200.84
130_R134_L0.5190.84
57_K65_D0.5180.84
95_I121_I0.5160.84
77_K116_V0.5150.83
81_D139_G0.5130.83
26_D152_L0.5130.83
134_L138_A0.5120.83
26_D183_L0.5120.83
25_H30_L0.5080.83
40_L44_R0.5020.82
58_R72_R0.5020.82
12_N95_I0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5eA 2 0.985 100 0.387 Contact Map
3og9A 1 0.99 100 0.41 Contact Map
2r8bA 1 0.985 100 0.411 Contact Map
2h1iA 3 0.995 100 0.42 Contact Map
1fj2A 2 0.995 100 0.444 Contact Map
1auoA 2 0.995 100 0.45 Contact Map
3cn9A 1 0.99 100 0.457 Contact Map
3u0vA 1 0.995 100 0.458 Contact Map
1ycdA 1 0.915 100 0.459 Contact Map
4f21A 1 0.995 99.9 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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