CHAA - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CHAA - Ca(2+)/H(+) antiporter ChaA

UniProt:	O34840	Sequences: MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYMGRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEGATLLAAYVIMAIGFFLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	351 (341)
Sequences:	2037 (1221)
Seq/√Len:	66.1

ECOLI - CHAA
BACSU - CHAA
SULSO - Q97U31 Q97YX8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_A	335_A	5.283	1.00
27_A	31_A	4.077	1.00
165_I	339_A	3.813	1.00
111_G	118_Q	3.804	1.00
292_I	296_F	3.728	1.00
16_S	33_Y	3.510	1.00
294_S	301_M	3.363	1.00
19_G	24_W	3.147	1.00
117_R	328_D	3.135	1.00
161_G	346_I	3.035	1.00
83_G	299_T	3.015	1.00
10_A	13_V	2.984	1.00
52_S	60_G	2.887	1.00
15_L	19_G	2.818	1.00
19_G	32_V	2.643	1.00
118_Q	266_N	2.638	1.00
9_V	13_V	2.576	1.00
232_A	242_I	2.563	1.00
26_S	230_S	2.548	1.00
115_Y	266_N	2.532	1.00
204_K	208_I	2.472	1.00
13_V	20_S	2.440	1.00
294_S	299_T	2.323	1.00
70_A	74_I	2.310	1.00
17_V	20_S	2.288	1.00
28_V	32_V	2.271	1.00
52_S	57_P	2.240	1.00
114_K	264_F	2.216	1.00
95_S	252_N	2.196	1.00
218_A	222_E	2.170	1.00
169_L	339_A	2.061	1.00
181_H	185_Y	2.053	1.00
208_I	212_A	2.046	1.00
109_F	172_A	2.019	1.00
8_L	13_V	1.981	1.00
255_E	278_S	1.951	1.00
111_G	266_N	1.919	1.00
61_G	65_A	1.919	1.00
326_D	333_E	1.899	1.00
109_F	338_L	1.867	1.00
72_E	255_E	1.865	1.00
109_F	113_L	1.843	1.00
262_M	270_I	1.836	1.00
81_K	297_F	1.812	1.00
258_S	262_M	1.808	1.00
110_V	264_F	1.738	1.00
176_F	180_T	1.715	1.00
282_I	286_V	1.708	0.99
49_E	52_S	1.693	0.99
41_A	44_M	1.692	0.99
181_H	184_V	1.688	0.99
16_S	220_I	1.680	0.99
12_G	15_L	1.679	0.99
20_S	24_W	1.676	0.99
37_I	41_A	1.655	0.99
164_I	168_L	1.624	0.99
95_S	103_V	1.621	0.99
176_F	331_W	1.595	0.99
11_A	18_I	1.593	0.99
203_G	207_T	1.584	0.99
92_L	287_A	1.566	0.99
17_V	219_Y	1.564	0.99
11_A	14_P	1.547	0.99
94_G	101_L	1.544	0.99
172_A	331_W	1.513	0.99
192_Q	195_E	1.509	0.99
101_L	316_A	1.509	0.99
144_E	310_L	1.508	0.99
10_A	20_S	1.504	0.99
115_Y	118_Q	1.496	0.99
55_A	59_I	1.493	0.99
75_I	91_S	1.481	0.99
18_I	22_M	1.468	0.98
106_L	338_L	1.451	0.98
13_V	22_M	1.448	0.98
24_W	132_L	1.445	0.98
168_L	335_A	1.444	0.98
19_G	22_M	1.432	0.98
17_V	21_L	1.425	0.98
130_G	246_I	1.414	0.98
10_A	14_P	1.409	0.98
86_G	89_L	1.404	0.98
84_L	239_E	1.401	0.98
104_A	320_M	1.401	0.98
15_L	32_V	1.389	0.98
118_Q	329_S	1.382	0.98
175_Y	318_L	1.369	0.98
50_S	107_S	1.345	0.97
169_L	336_T	1.338	0.97
45_G	256_H	1.336	0.97
15_L	24_W	1.320	0.97
275_A	279_T	1.316	0.97
13_V	24_W	1.312	0.97
100_L	224_L	1.310	0.97
308_P	347_G	1.307	0.97
85_T	301_M	1.306	0.97
209_V	212_A	1.298	0.97
188_N	191_A	1.293	0.96
101_L	337_L	1.292	0.96
160_I	295_I	1.290	0.96
133_I	314_V	1.286	0.96
252_N	256_H	1.285	0.96
149_G	153_A	1.282	0.96
142_I	347_G	1.270	0.96
78_F	221_S	1.269	0.96
289_V	293_C	1.269	0.96
164_I	292_I	1.258	0.96
176_F	181_H	1.247	0.96
248_A	294_S	1.245	0.96
69_N	278_S	1.239	0.95
112_G	118_Q	1.238	0.95
15_L	18_I	1.235	0.95
135_A	283_A	1.229	0.95
36_T	41_A	1.227	0.95
99_N	251_G	1.224	0.95
169_L	335_A	1.220	0.95
13_V	23_H	1.218	0.95
129_S	135_A	1.210	0.95
19_G	29_L	1.203	0.95
20_S	23_H	1.182	0.94
145_V	305_F	1.181	0.94
93_T	305_F	1.178	0.94
45_G	224_L	1.177	0.94
51_L	203_G	1.176	0.94
212_A	216_V	1.169	0.94
66_T	281_Q	1.167	0.94
177_K	273_E	1.159	0.94
51_L	55_A	1.157	0.93
98_G	252_N	1.157	0.93
84_L	229_H	1.156	0.93
17_V	22_M	1.146	0.93
12_G	16_S	1.125	0.93
13_V	21_L	1.123	0.92
9_V	20_S	1.119	0.92
89_L	302_P	1.111	0.92
109_F	335_A	1.108	0.92
247_V	280_L	1.108	0.92
17_V	223_N	1.094	0.91
117_R	121_N	1.094	0.91
54_I	221_S	1.091	0.91
103_V	252_N	1.086	0.91
244_V	344_M	1.086	0.91
201_W	205_V	1.080	0.91
114_K	266_N	1.076	0.91
248_A	308_P	1.070	0.90
249_I	253_A	1.065	0.90
11_A	15_L	1.055	0.90
258_S	274_I	1.048	0.90
164_I	218_A	1.045	0.89
297_F	300_S	1.044	0.89
180_T	185_Y	1.042	0.89
33_Y	36_T	1.039	0.89
193_T	212_A	1.038	0.89
87_I	228_F	1.036	0.89
278_S	281_Q	1.027	0.89
244_V	348_F	1.022	0.88
99_N	256_H	1.019	0.88
10_A	16_S	1.016	0.88
18_I	21_L	1.010	0.88
183_G	211_F	0.997	0.87
90_A	287_A	0.995	0.87
119_E	328_D	0.995	0.87
113_L	116_K	0.992	0.87
53_I	197_E	0.990	0.87
48_T	64_N	0.989	0.87
123_H	134_F	0.988	0.87
55_A	63_L	0.986	0.87
215_I	219_Y	0.985	0.86
95_S	256_H	0.984	0.86
63_L	211_F	0.980	0.86
38_I	228_F	0.978	0.86
14_P	18_I	0.977	0.86
25_P	231_V	0.973	0.86
25_P	28_V	0.972	0.86
278_S	282_I	0.971	0.86
317_V	321_I	0.970	0.86
68_G	99_N	0.968	0.85
228_F	231_V	0.964	0.85
21_L	24_W	0.961	0.85
49_E	60_G	0.961	0.85
217_V	243_G	0.959	0.85
8_L	11_A	0.959	0.85
141_V	313_M	0.957	0.85
120_F	329_S	0.957	0.85
306_T	309_E	0.948	0.84
28_V	292_I	0.946	0.84
192_Q	196_E	0.946	0.84
68_G	252_N	0.942	0.84
63_L	74_I	0.938	0.84
336_T	339_A	0.936	0.84
194_E	197_E	0.935	0.83
98_G	341_Y	0.935	0.83
108_F	329_S	0.935	0.83
168_L	171_V	0.928	0.83
330_N	333_E	0.928	0.83
184_V	316_A	0.927	0.83
123_H	127_H	0.926	0.83
156_L	160_I	0.925	0.83
173_A	177_K	0.911	0.82
69_N	252_N	0.910	0.82
87_I	91_S	0.910	0.82
248_A	332_F	0.909	0.82
226_H	229_H	0.907	0.82
196_E	199_P	0.903	0.81
48_T	251_G	0.902	0.81
91_S	225_V	0.900	0.81
183_G	186_Q	0.899	0.81
152_N	155_K	0.898	0.81
23_H	28_V	0.897	0.81
133_I	318_L	0.896	0.81
10_A	24_W	0.894	0.81
59_I	167_I	0.890	0.80
171_V	175_Y	0.889	0.80
13_V	16_S	0.889	0.80
64_N	274_I	0.886	0.80
107_S	228_F	0.882	0.80
111_G	259_A	0.879	0.79
41_A	49_E	0.878	0.79
15_L	164_I	0.877	0.79
110_V	260_I	0.874	0.79
98_G	103_V	0.873	0.79
252_N	281_Q	0.870	0.79
165_I	204_K	0.870	0.79
191_A	194_E	0.851	0.77
18_I	24_W	0.848	0.77
12_G	28_V	0.848	0.77
161_G	343_I	0.847	0.77
121_N	131_L	0.845	0.77
50_S	203_G	0.844	0.77
96_V	283_A	0.843	0.77
37_I	258_S	0.842	0.76
117_R	266_N	0.842	0.76
312_A	344_M	0.841	0.76
71_V	221_S	0.841	0.76
294_S	336_T	0.841	0.76
341_Y	344_M	0.840	0.76
331_W	341_Y	0.839	0.76
293_C	296_F	0.837	0.76
151_G	154_S	0.834	0.76
13_V	18_I	0.834	0.76
64_N	67_F	0.827	0.75
10_A	18_I	0.825	0.75
85_T	299_T	0.823	0.75
130_G	135_A	0.822	0.75
25_P	31_A	0.821	0.75
174_L	178_L	0.820	0.75
160_I	164_I	0.819	0.74
107_S	271_A	0.817	0.74
27_A	207_T	0.811	0.74
52_S	62_L	0.808	0.73
228_F	232_A	0.807	0.73
123_H	324_S	0.806	0.73
63_L	118_Q	0.806	0.73
97_L	313_M	0.804	0.73
47_A	67_F	0.804	0.73
15_L	26_S	0.801	0.73
14_P	36_T	0.796	0.72
171_V	216_V	0.796	0.72
294_S	298_P	0.794	0.72
222_E	274_I	0.793	0.72
246_I	344_M	0.786	0.71
246_I	298_P	0.785	0.71
214_T	218_A	0.784	0.71
288_P	334_G	0.780	0.71
250_V	254_A	0.778	0.71
111_G	115_Y	0.776	0.70
10_A	21_L	0.775	0.70
99_N	252_N	0.774	0.70
41_A	263_A	0.772	0.70
45_G	252_N	0.771	0.70
13_V	17_V	0.770	0.70
305_F	310_L	0.766	0.69
57_P	315_S	0.763	0.69
227_T	234_Q	0.763	0.69
38_I	316_A	0.763	0.69
68_G	251_G	0.759	0.69
267_K	270_I	0.757	0.69
77_L	293_C	0.757	0.69
266_N	329_S	0.757	0.69
34_C	42_S	0.756	0.68
118_Q	331_W	0.754	0.68
157_N	346_I	0.753	0.68
73_L	269_D	0.750	0.68
16_S	20_S	0.750	0.68
15_L	35_V	0.746	0.67
195_E	198_E	0.745	0.67
12_G	32_V	0.742	0.67
163_S	292_I	0.741	0.67
227_T	230_S	0.739	0.67
244_V	317_V	0.739	0.67
221_S	280_L	0.736	0.66
14_P	24_W	0.734	0.66
9_V	18_I	0.732	0.66
251_G	278_S	0.729	0.66
136_I	317_V	0.726	0.65
163_S	299_T	0.726	0.65
179_V	182_R	0.719	0.65
147_S	304_V	0.716	0.64
29_L	199_P	0.716	0.64
188_N	192_Q	0.715	0.64
338_L	349_F	0.715	0.64
205_V	208_I	0.715	0.64
202_S	205_V	0.713	0.64
296_F	343_I	0.713	0.64
32_V	202_S	0.713	0.64
65_A	214_T	0.712	0.64
88_V	222_E	0.712	0.64
193_T	196_E	0.711	0.64
78_F	81_K	0.711	0.64
58_R	273_E	0.710	0.64
29_L	32_V	0.707	0.63
159_S	291_V	0.704	0.63
288_P	303_L	0.704	0.63
190_A	196_E	0.702	0.63
68_G	337_L	0.699	0.62
176_F	341_Y	0.695	0.62
9_V	12_G	0.694	0.62
119_E	125_A	0.694	0.62
187_P	269_D	0.694	0.62
103_V	256_H	0.693	0.62
41_A	45_G	0.691	0.61
252_N	282_I	0.690	0.61
231_V	238_S	0.690	0.61
184_V	331_W	0.690	0.61
160_I	248_A	0.689	0.61
125_A	323_I	0.689	0.61
107_S	325_N	0.688	0.61
62_L	277_G	0.687	0.61
240_L	306_T	0.684	0.61
9_V	223_N	0.679	0.60
8_L	31_A	0.678	0.60
41_A	241_F	0.675	0.60
259_A	275_A	0.673	0.59
49_E	277_G	0.673	0.59
96_V	301_M	0.671	0.59
11_A	20_S	0.670	0.59
107_S	262_M	0.670	0.59
91_S	251_G	0.669	0.59
136_I	147_S	0.666	0.59
186_Q	204_K	0.665	0.59
66_T	69_N	0.663	0.58
208_I	292_I	0.663	0.58
319_L	340_A	0.662	0.58
129_S	134_F	0.659	0.58
231_V	235_F	0.658	0.58
271_A	278_S	0.658	0.58
25_P	149_G	0.658	0.58
157_N	289_V	0.656	0.57
189_N	193_T	0.656	0.57
133_I	144_E	0.654	0.57
224_L	232_A	0.653	0.57
65_A	72_E	0.652	0.57
245_I	344_M	0.652	0.57
253_A	256_H	0.651	0.57
50_S	332_F	0.649	0.57
323_I	337_L	0.649	0.57
8_L	12_G	0.648	0.57
71_V	231_V	0.647	0.56
246_I	325_N	0.647	0.56
227_T	242_I	0.647	0.56
56_G	243_G	0.645	0.56
91_S	222_E	0.645	0.56
175_Y	179_V	0.642	0.56
107_S	274_I	0.637	0.55
17_V	25_P	0.637	0.55
10_A	23_H	0.631	0.55
69_N	72_E	0.631	0.55
26_S	307_L	0.631	0.55
133_I	322_A	0.628	0.54
161_G	231_V	0.626	0.54
169_L	304_V	0.624	0.54
48_T	278_S	0.624	0.54
291_V	294_S	0.622	0.54
168_L	200_E	0.622	0.54
326_D	332_F	0.621	0.53
176_F	184_V	0.621	0.53
28_V	223_N	0.619	0.53
11_A	197_E	0.618	0.53
16_S	29_L	0.618	0.53
168_L	212_A	0.616	0.53
67_F	70_A	0.615	0.53
167_I	287_A	0.614	0.53
138_V	340_A	0.613	0.52
164_I	230_S	0.612	0.52
66_T	134_F	0.611	0.52
173_A	185_Y	0.610	0.52
63_L	195_E	0.609	0.52
94_G	344_M	0.609	0.52
138_V	307_L	0.608	0.52
214_T	252_N	0.608	0.52
61_G	120_F	0.607	0.52
63_L	100_L	0.607	0.52
14_P	39_A	0.606	0.52
43_Y	209_V	0.605	0.52
132_L	173_A	0.605	0.52
334_G	337_L	0.603	0.51
254_A	259_A	0.602	0.51
178_L	181_H	0.601	0.51
231_V	307_L	0.601	0.51
307_L	310_L	0.600	0.51
188_N	193_T	0.600	0.51
166_M	284_M	0.600	0.51
120_F	263_A	0.597	0.51
33_Y	220_I	0.597	0.51
251_G	256_H	0.593	0.50
11_A	17_V	0.593	0.50
222_E	226_H	0.593	0.50
112_G	329_S	0.588	0.50
93_T	310_L	0.587	0.49
168_L	202_S	0.587	0.49
73_L	77_L	0.586	0.49
100_L	316_A	0.584	0.49
16_S	21_L	0.581	0.49
324_S	332_F	0.581	0.49
190_A	194_E	0.580	0.49
42_S	45_G	0.579	0.48
60_G	277_G	0.578	0.48
221_S	285_F	0.577	0.48
246_I	249_I	0.577	0.48
30_F	40_L	0.576	0.48
197_E	208_I	0.576	0.48
83_G	297_F	0.576	0.48
19_G	132_L	0.576	0.48
118_Q	132_L	0.573	0.48
232_A	261_I	0.573	0.48
10_A	22_M	0.571	0.48
113_L	119_E	0.570	0.47
11_A	195_E	0.570	0.47
161_G	165_I	0.569	0.47
262_M	274_I	0.568	0.47
41_A	48_T	0.566	0.47
156_L	295_I	0.566	0.47
243_G	310_L	0.565	0.47
67_F	270_I	0.565	0.47
44_M	206_A	0.565	0.47
52_S	72_E	0.560	0.46
98_G	316_A	0.560	0.46
192_Q	215_I	0.560	0.46
132_L	281_Q	0.557	0.46
68_G	74_I	0.557	0.46
33_Y	40_L	0.557	0.46
56_G	69_N	0.557	0.46
212_A	239_E	0.556	0.46
268_M	339_A	0.556	0.46
163_S	239_E	0.555	0.46
220_I	223_N	0.555	0.46
278_S	286_V	0.555	0.46
146_F	304_V	0.554	0.46
94_G	341_Y	0.554	0.46
76_S	247_V	0.553	0.45
69_N	99_N	0.551	0.45
200_E	203_G	0.550	0.45
108_F	330_N	0.549	0.45
297_F	346_I	0.548	0.45
83_G	290_L	0.548	0.45
110_V	300_S	0.548	0.45
112_G	132_L	0.547	0.45
189_N	196_E	0.544	0.44
122_I	125_A	0.542	0.44
44_M	217_V	0.542	0.44
269_D	273_E	0.541	0.44
91_S	256_H	0.541	0.44
94_G	248_A	0.540	0.44
56_G	73_L	0.539	0.44
120_F	210_L	0.538	0.44
85_T	248_A	0.537	0.44
195_E	211_F	0.535	0.43
132_L	322_A	0.535	0.43
112_G	334_G	0.535	0.43
126_R	321_I	0.533	0.43
37_I	313_M	0.531	0.43
49_E	70_A	0.530	0.43
125_A	324_S	0.529	0.43
9_V	24_W	0.529	0.43
157_N	212_A	0.527	0.42
190_A	292_I	0.526	0.42
39_A	42_S	0.526	0.42
129_S	336_T	0.526	0.42
68_G	281_Q	0.525	0.42
76_S	269_D	0.525	0.42
280_L	335_A	0.524	0.42
225_V	254_A	0.524	0.42
93_T	244_V	0.524	0.42
277_G	283_A	0.522	0.42
198_E	219_Y	0.522	0.42
16_S	19_G	0.522	0.42
206_A	252_N	0.520	0.42
119_E	168_L	0.518	0.41
99_N	254_A	0.518	0.41
164_I	167_I	0.518	0.41
79_A	225_V	0.515	0.41
17_V	29_L	0.514	0.41
177_K	185_Y	0.514	0.41
41_A	255_E	0.514	0.41
126_R	313_M	0.513	0.41
30_F	34_C	0.512	0.41
8_L	16_S	0.512	0.41
177_K	255_E	0.511	0.41
141_V	158_L	0.511	0.41
86_G	152_N	0.511	0.41
206_A	221_S	0.510	0.40
177_K	332_F	0.510	0.40
106_L	109_F	0.510	0.40
246_I	327_G	0.509	0.40
162_I	343_I	0.506	0.40
128_N	220_I	0.506	0.40
81_K	206_A	0.506	0.40
189_N	192_Q	0.505	0.40
9_V	21_L	0.503	0.40
248_A	304_V	0.502	0.40
35_V	272_V	0.501	0.39
203_G	206_A	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k1cA	4	0.9943	100	0.284	Contact Map
4kjrA	3	0.9259	100	0.358	Contact Map
4kppA	1	0.9601	100	0.539	Contact Map
3v5uA	1	0.8319	100	0.568	Contact Map
4j05A	3	0.5157	27.5	0.965	Contact Map
4mndA	2	0.4444	27.5	0.965	Contact Map
4ikvA	1	0.5043	25.1	0.966	Contact Map
3giaA	1	0.4872	24.5	0.966	Contact Map
4w6vA	1	0.49	18.7	0.968	Contact Map
4djkA	2	0.5242	16.7	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.