GREMLIN Database
CHAA - Ca(2+)/H(+) antiporter ChaA
UniProt: O34840 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (341)
Sequences: 2037 (1221)
Seq/√Len: 66.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_A335_A5.2831.00
27_A31_A4.0771.00
165_I339_A3.8131.00
111_G118_Q3.8041.00
292_I296_F3.7281.00
16_S33_Y3.5101.00
294_S301_M3.3631.00
19_G24_W3.1471.00
117_R328_D3.1351.00
161_G346_I3.0351.00
83_G299_T3.0151.00
10_A13_V2.9841.00
52_S60_G2.8871.00
15_L19_G2.8181.00
19_G32_V2.6431.00
118_Q266_N2.6381.00
9_V13_V2.5761.00
232_A242_I2.5631.00
26_S230_S2.5481.00
115_Y266_N2.5321.00
204_K208_I2.4721.00
13_V20_S2.4401.00
294_S299_T2.3231.00
70_A74_I2.3101.00
17_V20_S2.2881.00
28_V32_V2.2711.00
52_S57_P2.2401.00
114_K264_F2.2161.00
95_S252_N2.1961.00
218_A222_E2.1701.00
169_L339_A2.0611.00
181_H185_Y2.0531.00
208_I212_A2.0461.00
109_F172_A2.0191.00
8_L13_V1.9811.00
255_E278_S1.9511.00
111_G266_N1.9191.00
61_G65_A1.9191.00
326_D333_E1.8991.00
109_F338_L1.8671.00
72_E255_E1.8651.00
109_F113_L1.8431.00
262_M270_I1.8361.00
81_K297_F1.8121.00
258_S262_M1.8081.00
110_V264_F1.7381.00
176_F180_T1.7151.00
282_I286_V1.7080.99
49_E52_S1.6930.99
41_A44_M1.6920.99
181_H184_V1.6880.99
16_S220_I1.6800.99
12_G15_L1.6790.99
20_S24_W1.6760.99
37_I41_A1.6550.99
164_I168_L1.6240.99
95_S103_V1.6210.99
176_F331_W1.5950.99
11_A18_I1.5930.99
203_G207_T1.5840.99
92_L287_A1.5660.99
17_V219_Y1.5640.99
11_A14_P1.5470.99
94_G101_L1.5440.99
172_A331_W1.5130.99
192_Q195_E1.5090.99
101_L316_A1.5090.99
144_E310_L1.5080.99
10_A20_S1.5040.99
115_Y118_Q1.4960.99
55_A59_I1.4930.99
75_I91_S1.4810.99
18_I22_M1.4680.98
106_L338_L1.4510.98
13_V22_M1.4480.98
24_W132_L1.4450.98
168_L335_A1.4440.98
19_G22_M1.4320.98
17_V21_L1.4250.98
130_G246_I1.4140.98
10_A14_P1.4090.98
86_G89_L1.4040.98
84_L239_E1.4010.98
104_A320_M1.4010.98
15_L32_V1.3890.98
118_Q329_S1.3820.98
175_Y318_L1.3690.98
50_S107_S1.3450.97
169_L336_T1.3380.97
45_G256_H1.3360.97
15_L24_W1.3200.97
275_A279_T1.3160.97
13_V24_W1.3120.97
100_L224_L1.3100.97
308_P347_G1.3070.97
85_T301_M1.3060.97
209_V212_A1.2980.97
188_N191_A1.2930.96
101_L337_L1.2920.96
160_I295_I1.2900.96
133_I314_V1.2860.96
252_N256_H1.2850.96
149_G153_A1.2820.96
142_I347_G1.2700.96
78_F221_S1.2690.96
289_V293_C1.2690.96
164_I292_I1.2580.96
176_F181_H1.2470.96
248_A294_S1.2450.96
69_N278_S1.2390.95
112_G118_Q1.2380.95
15_L18_I1.2350.95
135_A283_A1.2290.95
36_T41_A1.2270.95
99_N251_G1.2240.95
169_L335_A1.2200.95
13_V23_H1.2180.95
129_S135_A1.2100.95
19_G29_L1.2030.95
20_S23_H1.1820.94
145_V305_F1.1810.94
93_T305_F1.1780.94
45_G224_L1.1770.94
51_L203_G1.1760.94
212_A216_V1.1690.94
66_T281_Q1.1670.94
177_K273_E1.1590.94
51_L55_A1.1570.93
98_G252_N1.1570.93
84_L229_H1.1560.93
17_V22_M1.1460.93
12_G16_S1.1250.93
13_V21_L1.1230.92
9_V20_S1.1190.92
89_L302_P1.1110.92
109_F335_A1.1080.92
247_V280_L1.1080.92
17_V223_N1.0940.91
117_R121_N1.0940.91
54_I221_S1.0910.91
103_V252_N1.0860.91
244_V344_M1.0860.91
201_W205_V1.0800.91
114_K266_N1.0760.91
248_A308_P1.0700.90
249_I253_A1.0650.90
11_A15_L1.0550.90
258_S274_I1.0480.90
164_I218_A1.0450.89
297_F300_S1.0440.89
180_T185_Y1.0420.89
33_Y36_T1.0390.89
193_T212_A1.0380.89
87_I228_F1.0360.89
278_S281_Q1.0270.89
244_V348_F1.0220.88
99_N256_H1.0190.88
10_A16_S1.0160.88
18_I21_L1.0100.88
183_G211_F0.9970.87
90_A287_A0.9950.87
119_E328_D0.9950.87
113_L116_K0.9920.87
53_I197_E0.9900.87
48_T64_N0.9890.87
123_H134_F0.9880.87
55_A63_L0.9860.87
215_I219_Y0.9850.86
95_S256_H0.9840.86
63_L211_F0.9800.86
38_I228_F0.9780.86
14_P18_I0.9770.86
25_P231_V0.9730.86
25_P28_V0.9720.86
278_S282_I0.9710.86
317_V321_I0.9700.86
68_G99_N0.9680.85
228_F231_V0.9640.85
21_L24_W0.9610.85
49_E60_G0.9610.85
217_V243_G0.9590.85
8_L11_A0.9590.85
141_V313_M0.9570.85
120_F329_S0.9570.85
306_T309_E0.9480.84
28_V292_I0.9460.84
192_Q196_E0.9460.84
68_G252_N0.9420.84
63_L74_I0.9380.84
336_T339_A0.9360.84
194_E197_E0.9350.83
98_G341_Y0.9350.83
108_F329_S0.9350.83
168_L171_V0.9280.83
330_N333_E0.9280.83
184_V316_A0.9270.83
123_H127_H0.9260.83
156_L160_I0.9250.83
173_A177_K0.9110.82
69_N252_N0.9100.82
87_I91_S0.9100.82
248_A332_F0.9090.82
226_H229_H0.9070.82
196_E199_P0.9030.81
48_T251_G0.9020.81
91_S225_V0.9000.81
183_G186_Q0.8990.81
152_N155_K0.8980.81
23_H28_V0.8970.81
133_I318_L0.8960.81
10_A24_W0.8940.81
59_I167_I0.8900.80
171_V175_Y0.8890.80
13_V16_S0.8890.80
64_N274_I0.8860.80
107_S228_F0.8820.80
111_G259_A0.8790.79
41_A49_E0.8780.79
15_L164_I0.8770.79
110_V260_I0.8740.79
98_G103_V0.8730.79
252_N281_Q0.8700.79
165_I204_K0.8700.79
191_A194_E0.8510.77
18_I24_W0.8480.77
12_G28_V0.8480.77
161_G343_I0.8470.77
121_N131_L0.8450.77
50_S203_G0.8440.77
96_V283_A0.8430.77
37_I258_S0.8420.76
117_R266_N0.8420.76
312_A344_M0.8410.76
71_V221_S0.8410.76
294_S336_T0.8410.76
341_Y344_M0.8400.76
331_W341_Y0.8390.76
293_C296_F0.8370.76
151_G154_S0.8340.76
13_V18_I0.8340.76
64_N67_F0.8270.75
10_A18_I0.8250.75
85_T299_T0.8230.75
130_G135_A0.8220.75
25_P31_A0.8210.75
174_L178_L0.8200.75
160_I164_I0.8190.74
107_S271_A0.8170.74
27_A207_T0.8110.74
52_S62_L0.8080.73
228_F232_A0.8070.73
123_H324_S0.8060.73
63_L118_Q0.8060.73
97_L313_M0.8040.73
47_A67_F0.8040.73
15_L26_S0.8010.73
14_P36_T0.7960.72
171_V216_V0.7960.72
294_S298_P0.7940.72
222_E274_I0.7930.72
246_I344_M0.7860.71
246_I298_P0.7850.71
214_T218_A0.7840.71
288_P334_G0.7800.71
250_V254_A0.7780.71
111_G115_Y0.7760.70
10_A21_L0.7750.70
99_N252_N0.7740.70
41_A263_A0.7720.70
45_G252_N0.7710.70
13_V17_V0.7700.70
305_F310_L0.7660.69
57_P315_S0.7630.69
227_T234_Q0.7630.69
38_I316_A0.7630.69
68_G251_G0.7590.69
267_K270_I0.7570.69
77_L293_C0.7570.69
266_N329_S0.7570.69
34_C42_S0.7560.68
118_Q331_W0.7540.68
157_N346_I0.7530.68
73_L269_D0.7500.68
16_S20_S0.7500.68
15_L35_V0.7460.67
195_E198_E0.7450.67
12_G32_V0.7420.67
163_S292_I0.7410.67
227_T230_S0.7390.67
244_V317_V0.7390.67
221_S280_L0.7360.66
14_P24_W0.7340.66
9_V18_I0.7320.66
251_G278_S0.7290.66
136_I317_V0.7260.65
163_S299_T0.7260.65
179_V182_R0.7190.65
147_S304_V0.7160.64
29_L199_P0.7160.64
188_N192_Q0.7150.64
338_L349_F0.7150.64
205_V208_I0.7150.64
202_S205_V0.7130.64
296_F343_I0.7130.64
32_V202_S0.7130.64
65_A214_T0.7120.64
88_V222_E0.7120.64
193_T196_E0.7110.64
78_F81_K0.7110.64
58_R273_E0.7100.64
29_L32_V0.7070.63
159_S291_V0.7040.63
288_P303_L0.7040.63
190_A196_E0.7020.63
68_G337_L0.6990.62
176_F341_Y0.6950.62
9_V12_G0.6940.62
119_E125_A0.6940.62
187_P269_D0.6940.62
103_V256_H0.6930.62
41_A45_G0.6910.61
252_N282_I0.6900.61
231_V238_S0.6900.61
184_V331_W0.6900.61
160_I248_A0.6890.61
125_A323_I0.6890.61
107_S325_N0.6880.61
62_L277_G0.6870.61
240_L306_T0.6840.61
9_V223_N0.6790.60
8_L31_A0.6780.60
41_A241_F0.6750.60
259_A275_A0.6730.59
49_E277_G0.6730.59
96_V301_M0.6710.59
11_A20_S0.6700.59
107_S262_M0.6700.59
91_S251_G0.6690.59
136_I147_S0.6660.59
186_Q204_K0.6650.59
66_T69_N0.6630.58
208_I292_I0.6630.58
319_L340_A0.6620.58
129_S134_F0.6590.58
231_V235_F0.6580.58
271_A278_S0.6580.58
25_P149_G0.6580.58
157_N289_V0.6560.57
189_N193_T0.6560.57
133_I144_E0.6540.57
224_L232_A0.6530.57
65_A72_E0.6520.57
245_I344_M0.6520.57
253_A256_H0.6510.57
50_S332_F0.6490.57
323_I337_L0.6490.57
8_L12_G0.6480.57
71_V231_V0.6470.56
246_I325_N0.6470.56
227_T242_I0.6470.56
56_G243_G0.6450.56
91_S222_E0.6450.56
175_Y179_V0.6420.56
107_S274_I0.6370.55
17_V25_P0.6370.55
10_A23_H0.6310.55
69_N72_E0.6310.55
26_S307_L0.6310.55
133_I322_A0.6280.54
161_G231_V0.6260.54
169_L304_V0.6240.54
48_T278_S0.6240.54
291_V294_S0.6220.54
168_L200_E0.6220.54
326_D332_F0.6210.53
176_F184_V0.6210.53
28_V223_N0.6190.53
11_A197_E0.6180.53
16_S29_L0.6180.53
168_L212_A0.6160.53
67_F70_A0.6150.53
167_I287_A0.6140.53
138_V340_A0.6130.52
164_I230_S0.6120.52
66_T134_F0.6110.52
173_A185_Y0.6100.52
63_L195_E0.6090.52
94_G344_M0.6090.52
138_V307_L0.6080.52
214_T252_N0.6080.52
61_G120_F0.6070.52
63_L100_L0.6070.52
14_P39_A0.6060.52
43_Y209_V0.6050.52
132_L173_A0.6050.52
334_G337_L0.6030.51
254_A259_A0.6020.51
178_L181_H0.6010.51
231_V307_L0.6010.51
307_L310_L0.6000.51
188_N193_T0.6000.51
166_M284_M0.6000.51
120_F263_A0.5970.51
33_Y220_I0.5970.51
251_G256_H0.5930.50
11_A17_V0.5930.50
222_E226_H0.5930.50
112_G329_S0.5880.50
93_T310_L0.5870.49
168_L202_S0.5870.49
73_L77_L0.5860.49
100_L316_A0.5840.49
16_S21_L0.5810.49
324_S332_F0.5810.49
190_A194_E0.5800.49
42_S45_G0.5790.48
60_G277_G0.5780.48
221_S285_F0.5770.48
246_I249_I0.5770.48
30_F40_L0.5760.48
197_E208_I0.5760.48
83_G297_F0.5760.48
19_G132_L0.5760.48
118_Q132_L0.5730.48
232_A261_I0.5730.48
10_A22_M0.5710.48
113_L119_E0.5700.47
11_A195_E0.5700.47
161_G165_I0.5690.47
262_M274_I0.5680.47
41_A48_T0.5660.47
156_L295_I0.5660.47
243_G310_L0.5650.47
67_F270_I0.5650.47
44_M206_A0.5650.47
52_S72_E0.5600.46
98_G316_A0.5600.46
192_Q215_I0.5600.46
132_L281_Q0.5570.46
68_G74_I0.5570.46
33_Y40_L0.5570.46
56_G69_N0.5570.46
212_A239_E0.5560.46
268_M339_A0.5560.46
163_S239_E0.5550.46
220_I223_N0.5550.46
278_S286_V0.5550.46
146_F304_V0.5540.46
94_G341_Y0.5540.46
76_S247_V0.5530.45
69_N99_N0.5510.45
200_E203_G0.5500.45
108_F330_N0.5490.45
297_F346_I0.5480.45
83_G290_L0.5480.45
110_V300_S0.5480.45
112_G132_L0.5470.45
189_N196_E0.5440.44
122_I125_A0.5420.44
44_M217_V0.5420.44
269_D273_E0.5410.44
91_S256_H0.5410.44
94_G248_A0.5400.44
56_G73_L0.5390.44
120_F210_L0.5380.44
85_T248_A0.5370.44
195_E211_F0.5350.43
132_L322_A0.5350.43
112_G334_G0.5350.43
126_R321_I0.5330.43
37_I313_M0.5310.43
49_E70_A0.5300.43
125_A324_S0.5290.43
9_V24_W0.5290.43
157_N212_A0.5270.42
190_A292_I0.5260.42
39_A42_S0.5260.42
129_S336_T0.5260.42
68_G281_Q0.5250.42
76_S269_D0.5250.42
280_L335_A0.5240.42
225_V254_A0.5240.42
93_T244_V0.5240.42
277_G283_A0.5220.42
198_E219_Y0.5220.42
16_S19_G0.5220.42
206_A252_N0.5200.42
119_E168_L0.5180.41
99_N254_A0.5180.41
164_I167_I0.5180.41
79_A225_V0.5150.41
17_V29_L0.5140.41
177_K185_Y0.5140.41
41_A255_E0.5140.41
126_R313_M0.5130.41
30_F34_C0.5120.41
8_L16_S0.5120.41
177_K255_E0.5110.41
141_V158_L0.5110.41
86_G152_N0.5110.41
206_A221_S0.5100.40
177_K332_F0.5100.40
106_L109_F0.5100.40
246_I327_G0.5090.40
162_I343_I0.5060.40
128_N220_I0.5060.40
81_K206_A0.5060.40
189_N192_Q0.5050.40
9_V21_L0.5030.40
248_A304_V0.5020.40
35_V272_V0.5010.39
203_G206_A0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k1cA 4 0.9943 100 0.284 Contact Map
4kjrA 3 0.9259 100 0.358 Contact Map
4kppA 1 0.9601 100 0.539 Contact Map
3v5uA 1 0.8319 100 0.568 Contact Map
4j05A 3 0.5157 27.5 0.965 Contact Map
4mndA 2 0.4444 27.5 0.965 Contact Map
4ikvA 1 0.5043 25.1 0.966 Contact Map
3giaA 1 0.4872 24.5 0.966 Contact Map
4w6vA 1 0.49 18.7 0.968 Contact Map
4djkA 2 0.5242 16.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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