GREMLIN Database
FAPR - Transcription factor FapR
UniProt: O34835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (179)
Sequences: 317 (194)
Seq/√Len: 14.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_V168_S5.1211.00
93_I105_A3.6740.99
138_R144_E3.5740.99
111_F129_T2.9730.97
16_I22_I2.7100.96
9_Q31_F2.5120.93
135_R177_S2.4360.92
3_R11_L2.4250.92
80_D149_K2.3580.91
28_A35_I2.3240.90
111_F115_N2.3230.90
84_D184_R2.3050.90
93_I98_V2.1720.87
107_G128_L2.1070.85
130_A160_G2.0370.83
80_D88_I2.0340.83
26_E59_E1.9890.81
88_I149_K1.9830.81
170_V178_G1.9560.80
110_L146_V1.9320.79
105_A111_F1.9170.79
26_E103_Q1.9040.78
82_E85_D1.9000.78
2_R68_S1.8300.75
106_R129_T1.7550.72
133_D179_R1.7330.71
131_S179_R1.6810.69
43_L149_K1.6600.68
5_K9_Q1.6470.67
105_A146_V1.6410.67
84_D152_V1.6320.66
7_E10_E1.6250.66
103_Q142_Q1.6230.66
92_E145_R1.5960.65
138_R173_E1.5880.64
104_I107_G1.5800.64
115_N129_T1.5700.63
75_I136_F1.5110.60
61_T66_V1.5090.60
154_A179_R1.5060.60
10_E14_Q1.4830.59
134_I151_K1.4680.58
52_E55_K1.4620.58
79_I90_I1.4410.57
106_R115_N1.4400.56
133_D177_S1.4220.56
15_T30_K1.4140.55
109_H121_V1.4060.55
113_Q116_S1.4060.55
161_R181_D1.3760.53
66_V162_T1.3740.53
66_V118_A1.3550.52
150_A176_F1.3520.52
68_S100_S1.3370.51
10_E13_Q1.3350.51
93_I111_F1.3190.50
131_S135_R1.3150.50
43_L86_Q1.2850.48
60_K94_K1.2830.48
118_A184_R1.2680.47
144_E173_E1.2660.47
83_L99_F1.2630.47
84_D97_H1.2230.45
97_H184_R1.2140.44
78_I91_L1.2020.43
134_I180_F1.1850.42
78_I101_R1.1680.42
32_G75_I1.1440.40
107_G115_N1.1420.40
108_H119_V1.1410.40
50_L145_R1.1360.40
35_I64_D1.1220.39
91_L148_A1.1130.39
21_F58_A1.1070.38
102_N181_D1.1030.38
50_L85_D1.0970.38
81_L102_N1.0960.38
133_D165_E1.0790.37
54_I99_F1.0780.37
161_R174_I1.0730.37
83_L101_R1.0720.37
106_R111_F1.0700.36
35_I55_K1.0540.36
52_E81_L1.0370.35
36_Q150_A1.0240.34
121_V142_Q1.0210.34
86_Q151_K1.0120.34
104_I108_H1.0100.33
153_T165_E1.0050.33
31_F54_I1.0030.33
93_I115_N1.0020.33
110_L168_S0.9960.33
19_T62_L0.9560.31
91_L109_H0.9550.31
146_V183_Y0.9500.31
151_K167_N0.9420.30
46_S168_S0.9390.30
32_G147_V0.9290.30
9_Q12_L0.9270.29
93_I110_L0.9240.29
43_L88_I0.9230.29
97_H130_A0.9100.29
5_K44_E0.9080.29
18_A78_I0.9030.28
140_V147_V0.8990.28
124_D127_A0.8940.28
91_L181_D0.8930.28
61_T99_F0.8860.28
66_V77_E0.8820.27
122_I127_A0.8770.27
103_Q110_L0.8740.27
167_N174_I0.8720.27
86_Q149_K0.8710.27
67_K144_E0.8640.27
32_G91_L0.8620.27
92_E171_G0.8620.27
36_Q107_G0.8610.27
105_A115_N0.8570.26
161_R176_F0.8540.26
176_F180_F0.8500.26
124_D184_R0.8480.26
150_A166_V0.8460.26
153_T163_V0.8450.26
52_E57_V0.8400.26
44_E127_A0.8380.26
133_D138_R0.8380.26
89_S117_L0.8340.25
5_K107_G0.8320.25
89_S120_A0.8310.25
159_K163_V0.8270.25
83_L123_D0.8210.25
121_V152_V0.8180.25
147_V154_A0.8160.25
89_S113_Q0.8130.25
87_A182_M0.8100.24
12_L109_H0.8070.24
136_F146_V0.8020.24
62_L65_E0.7890.24
5_K8_R0.7870.23
36_Q111_F0.7870.23
74_V116_S0.7820.23
26_E31_F0.7720.23
134_I174_I0.7710.23
20_P24_D0.7690.23
77_E88_I0.7650.23
7_E54_I0.7620.22
105_A119_V0.7560.22
99_F166_V0.7520.22
93_I129_T0.7520.22
66_V99_F0.7470.22
75_I179_R0.7470.22
96_E104_I0.7460.22
110_L178_G0.7440.22
83_L104_I0.7300.21
97_H162_T0.7280.21
114_A150_A0.7270.21
125_E167_N0.7230.21
12_L25_E0.7220.21
84_D124_D0.7180.21
30_K45_L0.7070.20
114_A180_F0.7060.20
86_Q90_I0.7000.20
150_A180_F0.7000.20
29_G60_K0.6930.20
165_E174_I0.6920.20
144_E168_S0.6870.20
118_A164_V0.6840.20
112_A115_N0.6820.20
80_D180_F0.6800.19
134_I149_K0.6790.19
49_E117_L0.6760.19
2_R52_E0.6760.19
25_E52_E0.6730.19
28_A118_A0.6700.19
64_D162_T0.6680.19
69_L99_F0.6670.19
19_T172_E0.6630.19
18_A155_V0.6620.19
151_K163_V0.6620.19
146_V169_Y0.6610.19
43_L90_I0.6600.19
24_D27_L0.6570.19
181_D184_R0.6570.19
122_I176_F0.6560.19
19_T142_Q0.6510.18
95_Q155_V0.6510.18
73_E126_L0.6500.18
75_I78_I0.6460.18
21_F54_I0.6450.18
61_T81_L0.6380.18
50_L120_A0.6370.18
44_E119_V0.6340.18
29_G174_I0.6310.18
78_I81_L0.6300.18
6_R145_R0.6270.18
177_S181_D0.6240.18
102_N159_K0.6230.18
16_I19_T0.6210.18
99_F182_M0.6170.17
85_D95_Q0.6160.17
114_A164_V0.6150.17
74_V87_A0.6120.17
103_Q141_K0.6120.17
73_E92_E0.6090.17
69_L119_V0.6090.17
61_T65_E0.6080.17
12_L88_I0.6070.17
18_A81_L0.6050.17
25_E91_L0.6040.17
83_L97_H0.6030.17
30_K155_V0.6030.17
105_A129_T0.5980.17
71_L91_L0.5970.17
8_R24_D0.5910.17
101_R175_V0.5900.17
126_L139_Q0.5890.17
26_E46_S0.5890.17
69_L164_V0.5850.16
111_F128_L0.5840.16
14_Q121_V0.5840.16
11_L35_I0.5820.16
36_Q119_V0.5770.16
78_I159_K0.5750.16
60_K141_K0.5730.16
174_I177_S0.5720.16
43_L172_E0.5720.16
16_I70_S0.5720.16
83_L127_A0.5710.16
9_Q36_Q0.5700.16
32_G103_Q0.5680.16
7_E94_K0.5670.16
75_I152_V0.5670.16
64_D121_V0.5660.16
18_A126_L0.5660.16
96_E141_K0.5660.16
151_K165_E0.5630.16
107_G129_T0.5620.16
36_Q129_T0.5600.16
61_T171_G0.5580.16
151_K179_R0.5550.16
119_V182_M0.5540.15
59_E79_I0.5540.15
93_I146_V0.5490.15
8_R12_L0.5440.15
107_G175_V0.5410.15
137_T174_I0.5380.15
19_T32_G0.5380.15
16_I23_T0.5380.15
36_Q105_A0.5370.15
45_L147_V0.5340.15
14_Q18_A0.5300.15
60_K152_V0.5260.15
108_H111_F0.5210.15
99_F173_E0.5200.15
18_A133_D0.5200.15
29_G154_A0.5180.14
21_F88_I0.5170.14
54_I66_V0.5150.14
56_N64_D0.5140.14
146_V181_D0.5130.14
134_I177_S0.5120.14
135_R182_M0.5100.14
34_S37_T0.5090.14
34_S39_R0.5090.14
138_R183_Y0.5050.14
90_I95_Q0.5030.14
19_T91_L0.5000.14
23_T81_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a0zA 2 0.9681 100 0.647 Contact Map
2f3xA 2 0.75 99.9 0.727 Contact Map
2f41A 2 0.5691 99.6 0.802 Contact Map
3bnvA 2 0.7447 99.6 0.809 Contact Map
2gllA 3 0.6862 99.2 0.844 Contact Map
1q4tA 3 0.6755 99.1 0.851 Contact Map
1u1zA 3 0.6649 99.1 0.853 Contact Map
3d6xA 3 0.6596 99 0.857 Contact Map
1ixlA 2 0.6755 99 0.857 Contact Map
1z6bA 3 0.7074 99 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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