GREMLIN Database
YCEH - Uncharacterized protein YceH
UniProt: O34833 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (337)
Sequences: 935 (578)
Seq/√Len: 31.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
294_E319_S5.7511.00
293_A323_T5.6591.00
297_S326_S5.2021.00
318_E348_R4.9791.00
178_E182_S4.8171.00
302_E305_R4.4431.00
333_Q337_E4.3551.00
43_D46_N3.7571.00
272_K276_D3.7461.00
340_R344_D3.6861.00
319_S323_T3.4801.00
294_E323_T3.4001.00
290_K319_S3.3871.00
190_K198_A3.3111.00
174_Q220_D3.2261.00
322_N326_S3.0951.00
173_G216_V2.9981.00
33_P37_R2.8621.00
225_V312_I2.8521.00
184_L209_I2.6611.00
149_N240_N2.5941.00
183_I186_S2.5201.00
27_L35_V2.5111.00
180_M205_L2.4150.99
344_D347_R2.4000.99
59_V63_K2.3770.99
297_S323_T2.2700.99
283_R287_E2.2670.99
309_R313_D2.2450.99
297_S301_V2.1680.99
193_S198_A2.1270.98
351_Q355_N2.1150.98
37_R40_Q2.0400.98
239_G254_T2.0020.97
87_L250_A1.9860.97
202_L206_R1.9780.97
186_S190_K1.9530.97
37_R41_Q1.9370.97
173_G293_A1.9360.97
287_E290_K1.9110.97
152_L233_I1.9100.97
186_S189_E1.8630.96
217_Y221_M1.7780.95
315_E318_E1.7530.95
84_L243_L1.7520.95
221_M310_P1.7520.95
286_N316_T1.7370.94
301_V333_Q1.7260.94
229_T299_Q1.7160.94
355_N358_K1.7110.94
187_Y205_L1.6630.93
284_R295_N1.6540.93
104_G110_F1.6350.92
215_R224_M1.6320.92
279_S283_R1.6190.92
105_L109_I1.6090.92
32_E36_K1.5900.91
298_S302_E1.5690.90
110_F113_G1.5620.90
125_Q129_G1.5460.90
337_E341_L1.5400.90
351_Q354_D1.5390.90
297_S330_E1.5090.89
33_P36_K1.5030.88
283_R309_R1.4980.88
33_P343_E1.4660.87
126_T129_G1.4500.87
232_Q255_I1.4480.86
188_E206_R1.4410.86
177_L213_E1.4280.86
181_Q209_I1.4270.86
341_L344_D1.4270.86
330_E333_Q1.4260.86
214_E307_A1.4050.85
28_Q31_Q1.4000.85
175_M305_R1.3920.84
87_L244_I1.3920.84
152_L240_N1.3880.84
340_R343_E1.3590.83
290_K323_T1.3490.82
80_S247_I1.3440.82
158_N161_K1.3340.82
268_V271_Q1.3310.81
34_E37_R1.3290.81
279_S306_M1.3280.81
290_K316_T1.3250.81
333_Q336_E1.3240.81
211_A245_G1.3210.81
111_K114_G1.3140.81
29_L38_L1.3120.80
60_E79_D1.3040.80
184_L202_L1.3010.80
268_V284_R1.2980.80
157_E161_K1.2940.79
159_N230_A1.2780.79
203_D229_T1.2750.78
31_Q34_E1.2750.78
94_F252_I1.2730.78
312_I315_E1.2670.78
122_K125_Q1.2540.77
104_G107_A1.2520.77
294_E298_S1.2310.76
329_Q359_A1.2270.76
132_E268_V1.2240.76
29_L32_E1.2220.75
247_I274_V1.2160.75
179_E183_I1.2150.75
317_I327_G1.2000.74
38_L42_I1.1830.73
336_E340_R1.1810.73
226_A229_T1.1780.73
268_V299_Q1.1710.72
300_S304_A1.1560.71
267_T321_W1.1530.71
84_L254_T1.1500.71
34_E38_L1.1480.71
195_N198_A1.1380.70
271_Q284_R1.1310.70
113_G131_I1.1290.69
198_A201_Q1.1190.69
291_R294_E1.1180.69
42_I172_A1.1150.68
218_D334_I1.1140.68
228_Q285_T1.1120.68
301_V330_E1.1120.68
36_K175_M1.1090.68
127_L222_A1.1090.68
87_L243_L1.1070.68
177_L209_I1.1050.68
333_Q351_Q1.1030.68
171_V175_M1.1010.67
21_K24_D1.1000.67
276_D280_E1.0990.67
275_A299_Q1.0870.66
72_M81_G1.0800.66
347_R351_Q1.0610.64
55_K59_V1.0590.64
204_T234_R1.0570.64
31_Q42_I1.0500.64
22_A25_I1.0490.64
236_L280_E1.0340.62
294_E355_N1.0310.62
180_M343_E1.0250.62
264_Q295_N1.0190.61
275_A293_A1.0150.61
91_M243_L1.0140.61
148_T270_R1.0130.61
84_L328_M1.0070.60
47_Q153_D1.0000.60
84_L88_G0.9950.59
225_V254_T0.9850.59
286_N313_D0.9820.58
296_I327_G0.9800.58
54_G69_L0.9750.58
154_E173_G0.9740.58
50_L133_K0.9740.58
29_L42_I0.9730.58
355_N359_A0.9630.57
250_A299_Q0.9550.56
354_D358_K0.9550.56
215_R228_Q0.9550.56
118_E122_K0.9520.56
239_G303_I0.9490.56
156_Y234_R0.9490.56
71_M239_G0.9480.56
53_Y286_N0.9460.56
234_R237_Q0.9430.55
272_K275_A0.9330.54
109_I160_I0.9300.54
34_E42_I0.9210.54
218_D246_K0.9210.54
338_N345_G0.9200.53
91_M250_A0.9200.53
124_Y134_I0.9180.53
301_V350_A0.9140.53
253_I271_Q0.9120.53
156_Y160_I0.9100.53
225_V289_L0.9090.53
235_L300_S0.9090.53
24_D216_V0.9080.52
142_K145_M0.8970.52
250_A274_V0.8970.52
131_I318_E0.8950.51
349_I354_D0.8950.51
337_E340_R0.8940.51
101_E287_E0.8910.51
222_A271_Q0.8910.51
25_I28_Q0.8900.51
167_E223_R0.8880.51
35_V39_A0.8880.51
271_Q299_Q0.8810.50
103_K350_A0.8720.50
160_I227_L0.8720.50
169_Y219_L0.8710.49
23_D29_L0.8690.49
154_E157_E0.8640.49
258_F261_G0.8610.49
32_E179_E0.8590.48
326_S330_E0.8580.48
31_Q38_L0.8540.48
231_P256_P0.8530.48
65_S285_T0.8520.48
185_P188_E0.8480.48
184_L188_E0.8430.47
216_V220_D0.8390.47
233_I236_L0.8330.46
175_M179_E0.8320.46
221_M288_M0.8320.46
231_P246_K0.8260.46
317_I359_A0.8240.46
137_E328_M0.8180.45
213_E343_E0.8170.45
102_P333_Q0.8140.45
105_L108_K0.8100.45
222_A299_Q0.8080.44
305_R337_E0.8070.44
245_G281_L0.8050.44
308_G338_N0.8010.44
65_S169_Y0.8010.44
61_I229_T0.7980.44
60_E201_Q0.7980.44
178_E188_E0.7970.43
45_K201_Q0.7950.43
33_P52_E0.7830.42
240_N268_V0.7810.42
235_L239_G0.7770.42
258_F342_R0.7760.42
109_I358_K0.7760.42
87_L275_A0.7740.42
98_D123_K0.7720.41
175_M215_R0.7710.41
52_E56_E0.7710.41
232_Q278_M0.7700.41
60_E63_K0.7700.41
243_L271_Q0.7680.41
133_K318_E0.7660.41
307_A338_N0.7650.41
204_T261_G0.7630.41
82_T86_Q0.7620.41
66_D259_K0.7610.41
84_L303_I0.7580.40
236_L340_R0.7560.40
42_I157_E0.7500.40
272_K302_E0.7480.40
43_D48_M0.7470.40
348_R351_Q0.7460.39
61_I230_A0.7460.39
24_D175_M0.7440.39
116_M215_R0.7420.39
213_E246_K0.7410.39
214_E345_G0.7410.39
25_I29_L0.7350.39
58_A251_F0.7330.38
193_S216_V0.7330.38
246_K334_I0.7330.38
223_R353_Q0.7280.38
83_M137_E0.7260.38
176_K179_E0.7250.38
177_L216_V0.7240.38
143_D147_K0.7220.38
165_E168_K0.7210.38
252_I359_A0.7210.38
59_V305_R0.7210.38
91_M215_R0.7190.37
239_G242_K0.7180.37
39_A180_M0.7170.37
29_L73_K0.7160.37
195_N243_L0.7140.37
43_D70_G0.7140.37
298_S305_R0.7120.37
125_Q165_E0.7110.37
177_L249_S0.7080.37
130_E329_Q0.7060.36
239_G296_I0.7060.36
29_L190_K0.7050.36
71_M206_R0.7040.36
38_L128_G0.7030.36
219_L233_I0.6960.36
50_L94_F0.6920.35
32_E41_Q0.6920.35
54_G170_V0.6920.35
94_F222_A0.6910.35
86_Q182_S0.6910.35
81_G153_D0.6910.35
250_A281_L0.6900.35
175_M178_E0.6890.35
106_M193_S0.6890.35
29_L198_A0.6890.35
334_I342_R0.6880.35
56_E343_E0.6880.35
104_G108_K0.6870.35
200_M204_T0.6870.35
132_E154_E0.6860.35
55_K91_M0.6850.35
44_V50_L0.6850.35
240_N299_Q0.6840.35
68_I154_E0.6840.35
156_Y230_A0.6840.35
335_E338_N0.6830.35
30_R36_K0.6830.35
73_K295_N0.6780.34
43_D190_K0.6770.34
215_R254_T0.6770.34
182_S185_P0.6760.34
101_E110_F0.6760.34
37_R178_E0.6740.34
331_T335_E0.6730.34
42_I122_K0.6730.34
97_N140_K0.6720.34
71_M152_L0.6710.34
163_Y227_L0.6710.34
258_F321_W0.6710.34
148_T296_I0.6680.34
278_M282_D0.6680.34
301_V305_R0.6680.34
266_V323_T0.6650.33
97_N107_A0.6640.33
92_D326_S0.6620.33
118_E349_I0.6620.33
70_G189_E0.6610.33
256_P342_R0.6600.33
260_N282_D0.6590.33
152_L237_Q0.6580.33
64_F230_A0.6580.33
237_Q256_P0.6580.33
145_M148_T0.6570.33
318_E322_N0.6570.33
145_M247_I0.6570.33
242_K275_A0.6560.33
310_P315_E0.6540.33
33_P106_M0.6540.33
61_I159_N0.6520.32
145_M274_V0.6500.32
214_E335_E0.6500.32
199_Q356_I0.6470.32
268_V285_T0.6470.32
94_F249_S0.6470.32
287_E291_R0.6460.32
29_L161_K0.6450.32
159_N226_A0.6440.32
81_G237_Q0.6420.32
219_L237_Q0.6410.32
247_I250_A0.6400.32
48_M73_K0.6390.32
35_V149_N0.6380.31
341_L346_A0.6360.31
138_I228_Q0.6340.31
268_V295_N0.6330.31
276_D326_S0.6330.31
30_R38_L0.6290.31
228_Q243_L0.6290.31
90_I94_F0.6280.31
87_L299_Q0.6280.31
67_R129_G0.6270.31
185_P189_E0.6240.30
234_R338_N0.6180.30
144_E216_V0.6180.30
109_I117_I0.6170.30
223_R227_L0.6170.30
336_E343_E0.6160.30
180_M209_I0.6150.30
240_N284_R0.6130.30
256_P334_I0.6100.30
275_A323_T0.6080.29
268_V296_I0.6080.29
68_I263_I0.6050.29
97_N100_D0.6050.29
76_S168_K0.6050.29
149_N300_S0.6050.29
25_I35_V0.6040.29
116_M119_K0.6030.29
30_R40_Q0.6030.29
222_A229_T0.6030.29
213_E342_R0.6020.29
276_D344_D0.6000.29
239_G300_S0.6000.29
95_D236_L0.6000.29
40_Q287_E0.5990.29
223_R237_Q0.5980.29
250_A295_N0.5970.29
282_D306_M0.5960.29
243_L250_A0.5960.29
259_K346_A0.5950.29
240_N271_Q0.5950.29
31_Q168_K0.5940.28
102_P107_A0.5930.28
287_E315_E0.5930.28
120_I323_T0.5920.28
224_M352_L0.5920.28
85_T89_K0.5920.28
148_T225_V0.5910.28
82_T89_K0.5890.28
230_A352_L0.5890.28
21_K351_Q0.5870.28
206_R336_E0.5860.28
349_I352_L0.5850.28
29_L33_P0.5840.28
51_L134_I0.5840.28
141_Y320_S0.5830.28
149_N268_V0.5830.28
137_E173_G0.5820.28
135_H251_F0.5820.28
218_D228_Q0.5820.28
35_V76_S0.5810.28
292_N296_I0.5800.28
60_E70_G0.5790.27
124_Y131_I0.5760.27
73_K154_E0.5750.27
27_L32_E0.5740.27
189_E351_Q0.5730.27
86_Q140_K0.5720.27
26_R102_P0.5700.27
37_R355_N0.5700.27
246_K289_L0.5690.27
83_M131_I0.5680.27
29_L35_V0.5660.27
139_S142_K0.5660.27
289_L292_N0.5660.27
33_P40_Q0.5640.26
120_I262_I0.5620.26
123_K240_N0.5610.26
84_L228_Q0.5600.26
236_L330_E0.5580.26
112_R119_K0.5580.26
58_A148_T0.5570.26
45_K105_L0.5560.26
334_I353_Q0.5560.26
178_E186_S0.5550.26
107_A110_F0.5540.26
342_R345_G0.5510.26
182_S186_S0.5510.26
73_K337_E0.5500.26
138_I243_L0.5490.26
161_K165_E0.5490.26
90_I281_L0.5480.25
38_L271_Q0.5470.25
275_A283_R0.5470.25
220_D232_Q0.5470.25
344_D348_R0.5460.25
128_G271_Q0.5420.25
250_A280_E0.5420.25
21_K25_I0.5420.25
92_D283_R0.5410.25
167_E171_V0.5400.25
85_T88_G0.5390.25
57_P174_Q0.5390.25
78_T211_A0.5390.25
26_R40_Q0.5360.25
278_M281_L0.5360.25
261_G292_N0.5350.25
78_T81_G0.5350.25
222_A247_I0.5340.25
293_A298_S0.5340.25
261_G296_I0.5330.25
110_F114_G0.5330.25
145_M240_N0.5320.25
237_Q334_I0.5310.24
33_P354_D0.5310.24
50_L210_Q0.5300.24
109_I357_K0.5300.24
224_M227_L0.5290.24
159_N219_L0.5290.24
26_R140_K0.5290.24
215_R240_N0.5280.24
106_M205_L0.5270.24
24_D37_R0.5260.24
97_N318_E0.5260.24
217_Y247_I0.5260.24
296_I308_G0.5240.24
253_I321_W0.5230.24
35_V300_S0.5220.24
246_K256_P0.5210.24
150_Y194_G0.5200.24
40_Q82_T0.5190.24
213_E258_F0.5180.24
169_Y172_A0.5170.24
42_I110_F0.5170.24
21_K354_D0.5150.24
218_D285_T0.5150.24
300_S316_T0.5150.24
96_K224_M0.5140.23
129_G133_K0.5130.23
35_V41_Q0.5130.23
326_S333_Q0.5110.23
239_G271_Q0.5110.23
33_P178_E0.5110.23
258_F338_N0.5100.23
40_Q326_S0.5090.23
154_E303_I0.5090.23
57_P203_D0.5090.23
205_L322_N0.5080.23
33_P161_K0.5080.23
78_T134_I0.5080.23
37_R201_Q0.5070.23
32_E39_A0.5070.23
45_K350_A0.5070.23
228_Q296_I0.5050.23
87_L284_R0.5050.23
94_F262_I0.5050.23
254_T262_I0.5040.23
234_R353_Q0.5040.23
50_L106_M0.5020.23
44_V343_E0.5020.23
264_Q268_V0.5010.23
205_L239_G0.5010.23
322_N355_N0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tulA 4 0.3719 59.1 0.955 Contact Map
2a01A 1 0.6253 40.9 0.96 Contact Map
4uxvA 1 0.8871 39.8 0.96 Contact Map
3vkgA 2 0.7631 38 0.961 Contact Map
4uy3A 1 0.5262 34.2 0.962 Contact Map
1ykhB 1 0.281 28.9 0.963 Contact Map
1c1gA 2 0.7218 28.8 0.963 Contact Map
3wuqA 1 0.4821 22 0.965 Contact Map
4cqiA 1 0.2837 18.4 0.966 Contact Map
1uixA 2 0.1901 17.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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