GREMLIN Database
YFME - Fe(3+)-citrate import system permease protein YfmE
UniProt: O34832 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (318)
Sequences: 13883 (9948)
Seq/√Len: 557.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
217_D276_K4.6991.00
73_A285_A3.7851.00
109_V124_S3.6151.00
25_L294_I3.5731.00
81_I209_V3.5421.00
26_S65_I3.3991.00
232_N235_R3.2551.00
74_G202_L3.1651.00
81_I240_L3.0571.00
69_I289_A3.0451.00
68_A187_L2.9381.00
269_A287_I2.8141.00
67_L190_R2.6731.00
41_A53_F2.6461.00
74_G247_L2.5821.00
74_G251_C2.5481.00
77_A285_A2.4931.00
26_S69_I2.4681.00
41_A44_T2.4471.00
104_L164_G2.3901.00
223_D237_R2.3771.00
22_L290_I2.3651.00
71_A251_C2.2551.00
77_A206_F2.2461.00
21_I290_I2.2421.00
80_A284_S2.2161.00
273_T283_A2.1511.00
104_L161_C2.1151.00
31_G39_P2.1081.00
71_A255_V2.0621.00
22_L69_I2.0381.00
69_I293_L2.0371.00
201_W250_S1.9941.00
64_R296_D1.9931.00
29_S65_I1.9911.00
217_D277_A1.9771.00
215_K236_L1.9751.00
50_D53_F1.9471.00
38_S41_A1.9441.00
70_L199_A1.9441.00
84_G277_A1.9051.00
108_A112_I1.8651.00
82_L244_A1.8491.00
25_L290_I1.8281.00
107_M165_M1.8191.00
218_L231_E1.8051.00
212_L215_K1.8001.00
15_I283_A1.7911.00
208_I243_T1.7461.00
190_R194_E1.7421.00
40_D44_T1.7151.00
51_H54_E1.6671.00
205_L247_L1.6451.00
54_E58_Q1.6381.00
212_L239_I1.6011.00
235_R239_I1.5761.00
129_A249_G1.5751.00
298_L302_I1.5611.00
261_I292_L1.5591.00
66_I195_V1.5341.00
22_L286_L1.5231.00
106_A125_A1.5181.00
299_G310_A1.5141.00
80_A280_L1.5061.00
28_I31_G1.5031.00
205_L246_A1.4931.00
196_K200_P1.4921.00
18_L286_L1.4761.00
45_N58_Q1.4721.00
212_L236_L1.4651.00
191_N194_E1.4631.00
25_L293_L1.4561.00
187_L292_L1.4251.00
28_I32_I1.4161.00
14_A283_A1.4091.00
279_Y282_P1.4071.00
298_L313_L1.4041.00
105_A124_S1.4031.00
43_V47_L1.4001.00
78_A247_L1.3841.00
205_L243_T1.3711.00
18_L283_A1.3701.00
133_A245_V1.3671.00
103_G165_M1.3441.00
29_S297_T1.3391.00
269_A283_A1.3211.00
67_L254_V1.3201.00
269_A280_L1.3131.00
160_V319_A1.3061.00
76_A265_A1.2901.00
196_K199_A1.2861.00
200_P204_I1.2831.00
132_I161_C1.2661.00
265_A291_I1.2561.00
208_I212_L1.2531.00
18_L287_I1.2521.00
99_S248_A1.2491.00
212_L240_L1.2391.00
105_A128_G1.2361.00
70_L195_V1.2151.00
22_L289_A1.2091.00
15_I279_Y1.2061.00
227_Q234_N1.2021.00
85_V240_L1.1961.00
265_A287_I1.1941.00
124_S128_G1.1901.00
235_R238_F1.1811.00
55_F59_Q1.1811.00
236_L239_I1.1711.00
107_M179_A1.1681.00
49_L54_E1.1671.00
80_A277_A1.1561.00
225_L228_G1.1501.00
103_G183_L1.1471.00
198_L254_V1.1451.00
300_R307_E1.1451.00
255_V258_I1.1391.00
80_A281_L1.1381.00
36_Y39_P1.1321.00
277_A280_L1.1311.00
35_L56_I1.1311.00
134_V138_M1.1201.00
52_S55_F1.1171.00
218_L229_L1.1171.00
18_L290_I1.1161.00
67_L195_V1.1001.00
222_G226_A1.0991.00
73_A76_A1.0991.00
45_N54_E1.0961.00
234_N237_R1.0901.00
101_G132_I1.0891.00
208_I239_I1.0871.00
101_G128_G1.0821.00
104_L108_A1.0771.00
70_L198_L1.0751.00
136_L157_L1.0671.00
66_I192_W1.0661.00
141_R234_N1.0661.00
73_A289_A1.0641.00
111_L168_M1.0601.00
209_V243_T1.0601.00
207_P211_I1.0591.00
68_A292_L1.0591.00
296_D300_R1.0521.00
68_A293_L1.0511.00
13_L16_L1.0421.00
198_L202_L1.0331.00
126_F246_A1.0271.00
282_P285_A1.0231.00
58_Q62_L1.0231.00
298_L301_G1.0171.00
44_T49_L1.0171.00
131_I135_L1.0141.00
158_G162_H1.0111.00
258_I292_L1.0091.00
234_N238_F1.0081.00
100_K161_C0.9981.00
45_N49_L0.9961.00
290_I294_I0.9911.00
205_L250_S0.9901.00
26_S293_L0.9861.00
315_A320_P0.9851.00
123_F127_A0.9811.00
30_I65_I0.9771.00
299_G313_L0.9731.00
273_T279_Y0.9691.00
204_I207_P0.9671.00
108_A168_M0.9671.00
32_I301_G0.9671.00
31_G42_V0.9651.00
265_A269_A0.9641.00
200_P203_L0.9611.00
45_N57_I0.9581.00
197_L200_P0.9561.00
19_A23_I0.9551.00
65_I297_T0.9501.00
20_V24_V0.9481.00
25_L297_T0.9471.00
216_L240_L0.9431.00
44_T47_L0.9401.00
117_P120_V0.9401.00
99_S257_S0.9371.00
27_V31_G0.9341.00
236_L240_L0.9341.00
33_G61_R0.9281.00
192_W195_V0.9241.00
303_M306_V0.9211.00
251_C255_V0.9151.00
104_L165_M0.9141.00
224_E227_Q0.9111.00
279_Y283_A0.9071.00
280_L284_S0.9001.00
320_P324_Y0.8991.00
167_Y171_K0.8951.00
231_E236_L0.8931.00
54_E59_Q0.8881.00
272_L287_I0.8871.00
70_L202_L0.8831.00
276_K279_Y0.8831.00
42_V57_I0.8831.00
14_A17_I0.8811.00
79_G266_P0.8801.00
13_L17_I0.8791.00
104_L168_M0.8751.00
27_V39_P0.8741.00
321_Y324_Y0.8711.00
111_L172_F0.8701.00
44_T48_G0.8681.00
294_I298_L0.8671.00
45_N53_F0.8631.00
217_D278_K0.8521.00
299_G309_P0.8501.00
98_I129_A0.8481.00
94_D99_S0.8461.00
179_A183_L0.8451.00
277_A282_P0.8441.00
37_I57_I0.8431.00
73_A206_F0.8421.00
126_F130_A0.8421.00
78_A244_A0.8411.00
23_I27_V0.8371.00
223_D227_Q0.8351.00
14_A18_L0.8331.00
213_I278_K0.8301.00
65_I293_L0.8251.00
74_G78_A0.8251.00
110_I121_L0.8201.00
19_A286_L0.8181.00
106_A121_L0.8111.00
121_L124_S0.8081.00
137_L234_N0.8051.00
302_I305_P0.8041.00
238_F242_F0.8021.00
270_R280_L0.7981.00
22_L26_S0.7971.00
233_A237_R0.7961.00
209_V240_L0.7961.00
212_L243_T0.7941.00
29_S300_R0.7941.00
64_R307_E0.7911.00
177_N180_L0.7911.00
141_R144_S0.7891.00
201_W205_L0.7891.00
301_G304_P0.7881.00
137_L238_F0.7881.00
100_K103_G0.7871.00
64_R300_R0.7861.00
208_I211_I0.7851.00
223_D233_A0.7811.00
316_V320_P0.7731.00
109_V121_L0.7721.00
226_A233_A0.7721.00
23_I26_S0.7701.00
76_A80_A0.7691.00
82_L96_V0.7671.00
42_V45_N0.7661.00
203_L207_P0.7651.00
174_G178_A0.7601.00
241_I245_V0.7581.00
62_L192_W0.7561.00
48_G54_E0.7561.00
292_L314_T0.7551.00
136_L140_A0.7531.00
269_A273_T0.7521.00
303_M308_I0.7511.00
193_E196_K0.7471.00
73_A202_L0.7471.00
102_S129_A0.7461.00
92_S95_V0.7461.00
286_L290_I0.7461.00
129_A245_V0.7451.00
37_I53_F0.7421.00
31_G36_Y0.7351.00
77_A209_V0.7351.00
198_L250_S0.7341.00
172_F175_D0.7331.00
269_A272_L0.7301.00
132_I136_L0.7281.00
50_D54_E0.7271.00
120_V123_F0.7271.00
24_V27_V0.7231.00
128_G132_I0.7231.00
194_E254_V0.7221.00
261_I314_T0.7211.00
202_L251_C0.7201.00
101_G161_C0.7161.00
211_I215_K0.7141.00
86_I151_A0.7101.00
210_C213_I0.7091.00
32_I36_Y0.7061.00
108_A164_G0.7021.00
107_M169_M0.7011.00
324_Y328_F0.7001.00
76_A285_A0.6951.00
51_H55_F0.6921.00
67_L198_L0.6911.00
268_I287_I0.6901.00
119_Y123_F0.6901.00
66_I70_L0.6891.00
98_I133_A0.6891.00
35_L38_S0.6891.00
30_I57_I0.6871.00
103_G257_S0.6861.00
22_L293_L0.6861.00
172_F176_V0.6861.00
55_F60_Y0.6851.00
77_A281_L0.6841.00
250_S254_V0.6821.00
130_A249_G0.6811.00
215_K231_E0.6811.00
75_L261_I0.6811.00
35_L39_P0.6801.00
217_D282_P0.6801.00
291_I295_A0.6801.00
133_A241_I0.6801.00
143_K149_S0.6791.00
121_L125_A0.6741.00
84_G220_S0.6731.00
199_A203_L0.6711.00
110_I178_A0.6681.00
227_Q233_A0.6681.00
55_F58_Q0.6661.00
141_R145_I0.6661.00
71_A187_L0.6631.00
180_L183_L0.6631.00
266_P284_S0.6621.00
271_R325_L0.6621.00
30_I62_L0.6591.00
14_A272_L0.6591.00
140_A153_S0.6571.00
250_S253_A0.6561.00
219_M233_A0.6551.00
206_F210_C0.6541.00
92_S262_G0.6531.00
78_A248_A0.6521.00
138_M141_R0.6491.00
198_L201_W0.6481.00
289_A293_L0.6471.00
258_I310_A0.6461.00
201_W246_A0.6421.00
296_D307_E0.6411.00
110_I179_A0.6361.00
285_A289_A0.6341.00
39_P43_V0.6341.00
169_M180_L0.6321.00
264_L322_F0.6311.00
268_I271_R0.6311.00
40_D43_V0.6311.00
278_K282_P0.6311.00
268_I291_I0.6281.00
42_V46_L0.6271.00
62_L66_I0.6261.00
292_L310_A0.6251.00
99_S102_S0.6241.00
24_V28_I0.6231.00
295_A313_L0.6231.00
37_I45_N0.6211.00
127_A131_I0.6201.00
81_I243_T0.6191.00
38_S53_F0.6181.00
187_L310_A0.6161.00
68_A310_A0.6141.00
166_Q182_W0.6121.00
148_S151_A0.6101.00
86_I89_P0.6101.00
205_L209_V0.6091.00
26_S30_I0.6091.00
17_I21_I0.6091.00
105_A109_V0.6081.00
18_L22_L0.6071.00
263_L325_L0.6031.00
175_D178_A0.6031.00
132_I157_L0.6021.00
139_I153_S0.6001.00
248_A252_V0.6001.00
133_A137_L0.5981.00
192_W196_K0.5981.00
108_A113_F0.5961.00
42_V47_L0.5951.00
294_I297_T0.5941.00
215_K218_L0.5931.00
130_A245_V0.5921.00
57_I62_L0.5911.00
217_D220_S0.5901.00
261_I291_I0.5901.00
153_S156_A0.5891.00
162_H183_L0.5891.00
291_I317_I0.5871.00
146_Q149_S0.5861.00
162_H166_Q0.5851.00
39_P42_V0.5841.00
127_A130_A0.5821.00
100_K158_G0.5821.00
73_A77_A0.5811.00
82_L91_A0.5811.00
202_L206_F0.5801.00
109_V113_F0.5781.00
240_L244_A0.5770.99
264_L321_Y0.5770.99
100_K162_H0.5750.99
82_L98_I0.5740.99
211_I214_P0.5720.99
264_L268_I0.5700.99
32_I297_T0.5690.99
249_G253_A0.5690.99
135_L138_M0.5670.99
187_L255_V0.5650.99
268_I321_Y0.5630.99
27_V43_V0.5630.99
299_G307_E0.5590.99
239_I243_T0.5580.99
14_A273_T0.5570.99
109_V120_V0.5570.99
299_G302_I0.5540.99
41_A49_L0.5530.99
216_L277_A0.5520.99
17_I20_V0.5520.99
232_N239_I0.5510.99
297_T301_G0.5500.99
140_A150_L0.5420.99
327_K330_A0.5400.99
67_L71_A0.5390.99
116_S120_V0.5380.99
293_L297_T0.5380.99
244_A249_G0.5360.99
202_L207_P0.5360.99
169_M176_V0.5350.99
269_A284_S0.5340.99
197_L201_W0.5320.99
176_V179_A0.5320.99
204_I208_I0.5310.99
29_S293_L0.5310.99
245_V249_G0.5310.99
263_L266_P0.5290.99
239_I242_F0.5290.99
140_A145_I0.5280.99
169_M183_L0.5250.99
15_I19_A0.5240.99
92_S257_S0.5240.99
25_L28_I0.5230.99
153_S157_L0.5200.99
232_N238_F0.5190.99
217_D280_L0.5180.99
106_A124_S0.5170.99
34_A305_P0.5160.99
214_P217_D0.5160.99
274_G282_P0.5160.99
197_L250_S0.5150.99
22_L65_I0.5140.99
31_G43_V0.5140.99
193_E197_L0.5130.99
282_P286_L0.5130.99
195_V198_L0.5120.99
163_A264_L0.5120.99
91_A98_I0.5110.99
98_I136_L0.5110.99
67_L255_V0.5090.99
98_I186_S0.5090.99
177_N183_L0.5090.99
169_M179_A0.5080.99
195_V199_A0.5080.99
66_I199_A0.5060.99
87_R222_G0.5060.99
131_I134_V0.5060.99
258_I314_T0.5050.99
87_R223_D0.5040.99
102_S125_A0.5030.99
76_A288_G0.5030.99
80_A269_A0.5030.99
267_H270_R0.5020.99
46_L57_I0.5020.99
135_L157_L0.5020.99
89_P267_H0.5020.99
94_D98_I0.5010.99
41_A48_G0.5010.99
37_I56_I0.5000.99
265_A295_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9219 100 0.199 Contact Map
4g1uA 2 0.8889 100 0.199 Contact Map
2qi9A 2 0.958 100 0.207 Contact Map
2m8rA 1 0.1111 34.5 0.959 Contact Map
4z7fA 2 0.4895 29.8 0.961 Contact Map
3rceA 1 0.7598 29 0.961 Contact Map
3rlbA 1 0.5075 28.5 0.961 Contact Map
3wajA 1 0.7778 28 0.961 Contact Map
4huqS 1 0.4625 22.3 0.963 Contact Map
4pypA 1 0.9129 19.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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