GREMLIN Database
MSMR - Uncharacterized HTH-type transcriptional regulator MsmR
UniProt: O34829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (317)
Sequences: 32396 (24426)
Seq/√Len: 1371.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_Y247_E3.4311.00
163_E208_L3.3461.00
10_K44_E3.1801.00
270_Q273_R3.0971.00
169_A278_V2.7151.00
282_G297_K2.5991.00
178_Y276_A2.5791.00
156_D314_R2.5401.00
203_I207_R2.4431.00
121_G311_L2.4101.00
167_R212_L2.3571.00
32_G36_Q2.2121.00
233_Y266_E2.2081.00
40_N44_E2.2021.00
36_Q40_N2.1791.00
94_E309_K2.1071.00
94_E97_E2.0591.00
174_F213_E2.0451.00
237_K267_A2.0431.00
306_T309_K2.0101.00
232_G259_G1.9831.00
90_G304_G1.9811.00
166_S170_I1.9781.00
264_L275_T1.9571.00
176_L336_C1.9491.00
95_C308_V1.9481.00
21_I38_V1.9341.00
167_R208_L1.9331.00
171_D175_D1.9321.00
22_L42_A1.9201.00
35_R39_I1.9201.00
165_A280_F1.9051.00
167_R209_T1.8941.00
171_D209_T1.8791.00
164_S168_Q1.8701.00
5_K15_S1.8431.00
237_K263_A1.8291.00
166_S250_F1.8271.00
25_D29_S1.8231.00
241_D267_A1.8201.00
297_K329_T1.8181.00
163_E204_E1.7731.00
313_D318_R1.7411.00
93_K301_E1.7371.00
170_I206_K1.7321.00
171_D213_E1.7161.00
11_A41_I1.6921.00
233_Y263_A1.6751.00
167_R171_D1.6411.00
292_P334_Q1.6391.00
94_E305_R1.6351.00
173_L248_A1.6331.00
236_M260_A1.6311.00
183_Y252_A1.6301.00
68_G119_L1.6301.00
269_L274_D1.6291.00
90_G301_E1.6231.00
10_K41_I1.6221.00
168_Q328_T1.6191.00
299_Y302_E1.6151.00
306_T324_V1.6031.00
270_Q274_D1.5971.00
251_I260_A1.5511.00
265_Q290_S1.5411.00
21_I42_A1.5351.00
282_G333_R1.5221.00
161_D164_S1.5061.00
146_I307_G1.5051.00
39_I43_E1.4961.00
182_G246_P1.4811.00
7_I41_I1.4751.00
107_H114_H1.4701.00
263_A267_A1.4641.00
39_I42_A1.4451.00
204_E208_L1.4401.00
165_A328_T1.4241.00
223_L238_K1.4221.00
302_E306_T1.4171.00
174_F209_T1.4121.00
236_M249_F1.4121.00
94_E98_Q1.4091.00
180_R218_Q1.4041.00
94_E308_V1.4021.00
278_V294_T1.4021.00
263_A266_E1.3941.00
180_R245_L1.3851.00
172_H336_C1.3621.00
166_S205_D1.3571.00
170_I205_D1.3521.00
172_H176_L1.3511.00
172_H332_V1.3481.00
264_L269_L1.3451.00
302_E305_R1.3431.00
98_Q312_L1.3401.00
218_Q221_H1.3301.00
26_E29_S1.3291.00
67_I95_C1.3261.00
7_I11_A1.3221.00
170_I174_F1.3201.00
178_Y248_A1.3111.00
164_S167_R1.3091.00
65_P120_D1.3061.00
201_R204_E1.3051.00
237_K266_E1.2961.00
170_I209_T1.2861.00
172_H175_D1.2851.00
226_E231_E1.2771.00
171_D212_L1.2701.00
31_A34_T1.2691.00
205_D209_T1.2651.00
32_G35_R1.2581.00
10_K45_L1.2571.00
182_G239_A1.2521.00
6_D9_L1.2521.00
20_R25_D1.2491.00
236_M264_L1.2481.00
207_R211_F1.2451.00
5_K9_L1.2311.00
41_I45_L1.2311.00
309_K313_D1.2261.00
261_L277_I1.2221.00
65_P100_I1.2141.00
237_K241_D1.2121.00
209_T212_L1.2111.00
91_I123_I1.2021.00
276_A336_C1.2011.00
69_V91_I1.2011.00
180_R247_E1.1931.00
7_I45_L1.1921.00
37_R41_I1.1911.00
233_Y237_K1.1851.00
41_I44_E1.1671.00
233_Y262_K1.1621.00
111_F114_H1.1581.00
4_I15_S1.1541.00
163_E201_R1.1531.00
184_I260_A1.1501.00
181_L210_A1.1411.00
91_I308_V1.1391.00
134_K138_G1.1341.00
95_C102_I1.1331.00
243_G246_P1.1311.00
34_T37_R1.1201.00
168_Q171_D1.1181.00
21_I30_V1.1161.00
259_G263_A1.1121.00
238_K242_Q1.1081.00
210_A215_A1.1041.00
254_D295_T1.1011.00
175_D213_E1.0991.00
123_I307_G1.0971.00
249_F260_A1.0911.00
4_I18_V1.0881.00
50_V53_R1.0871.00
254_D279_S1.0831.00
179_K247_E1.0821.00
163_E167_R1.0791.00
69_V102_I1.0761.00
312_L316_N1.0761.00
301_E305_R1.0721.00
230_R234_R1.0691.00
304_G308_V1.0671.00
40_N43_E1.0651.00
310_L324_V1.0611.00
36_Q39_I1.0591.00
206_K210_A1.0571.00
208_L212_L1.0551.00
169_A250_F1.0531.00
306_T310_L1.0491.00
232_G236_M1.0491.00
176_L332_V1.0481.00
180_R244_H1.0391.00
98_Q309_K1.0331.00
183_Y203_I1.0241.00
163_E205_D1.0231.00
98_Q316_N1.0111.00
42_A45_L1.0061.00
261_L271_V1.0011.00
174_F215_A1.0001.00
50_V56_S1.0001.00
24_E35_R0.9991.00
209_T213_E0.9921.00
299_Y326_L0.9911.00
251_I257_A0.9911.00
188_E224_I0.9881.00
176_L276_A0.9881.00
235_L238_K0.9801.00
306_T326_L0.9631.00
52_K55_K0.9561.00
311_L315_L0.9541.00
261_L289_A0.9491.00
69_V88_R0.9471.00
169_A296_V0.9391.00
53_R56_S0.9391.00
66_L103_T0.9381.00
234_R238_K0.9381.00
181_L248_A0.9381.00
297_K331_I0.9381.00
11_A18_V0.9331.00
228_S231_E0.9321.00
204_E207_R0.9241.00
236_M240_I0.9231.00
160_I299_Y0.9231.00
92_E96_F0.9231.00
305_R309_K0.9221.00
93_K305_R0.9201.00
164_S327_P0.9151.00
207_R217_P0.9021.00
279_S295_T0.9011.00
180_R221_H0.9001.00
170_I210_A0.8981.00
161_D325_T0.8971.00
49_T54_R0.8911.00
186_G227_Y0.8911.00
251_I256_M0.8881.00
174_F179_K0.8851.00
100_I312_L0.8801.00
206_K250_F0.8791.00
157_S323_H0.8791.00
329_T332_V0.8761.00
111_F115_I0.8741.00
158_I310_L0.8721.00
67_I123_I0.8721.00
156_D322_Q0.8711.00
64_Q120_D0.8691.00
332_V336_C0.8641.00
91_I304_G0.8611.00
231_E234_R0.8601.00
254_D257_A0.8601.00
123_I311_L0.8581.00
225_G256_M0.8581.00
179_K215_A0.8571.00
223_L235_L0.8531.00
24_E39_I0.8511.00
172_H294_T0.8491.00
164_S328_T0.8461.00
160_I328_T0.8451.00
97_E305_R0.8441.00
254_D282_G0.8441.00
66_L101_F0.8411.00
21_I39_I0.8371.00
156_D310_L0.8361.00
159_G325_T0.8351.00
229_M262_K0.8321.00
221_H242_Q0.8281.00
107_H111_F0.8261.00
210_A217_P0.8251.00
269_L275_T0.8201.00
249_F275_T0.8171.00
282_G331_I0.8131.00
182_G249_F0.8111.00
240_I263_A0.8091.00
217_P220_E0.8071.00
310_L313_D0.8061.00
245_L269_L0.8051.00
162_F202_T0.8051.00
308_V312_L0.8041.00
17_T20_R0.8021.00
282_G286_A0.7991.00
299_Y329_T0.7991.00
107_H110_S0.7991.00
172_H330_L0.7991.00
281_N298_V0.7951.00
160_I298_V0.7931.00
110_S114_H0.7931.00
161_D327_P0.7921.00
112_Q116_F0.7911.00
89_K93_K0.7881.00
294_T336_C0.7841.00
33_E36_Q0.7841.00
173_L278_V0.7831.00
264_L277_I0.7831.00
86_S301_E0.7811.00
51_A54_R0.7781.00
33_E37_R0.7761.00
247_E276_A0.7751.00
63_A120_D0.7741.00
83_Y300_T0.7711.00
13_V38_V0.7701.00
121_G315_L0.7701.00
111_F116_F0.7691.00
250_F278_V0.7671.00
20_R26_E0.7631.00
258_I289_A0.7631.00
3_R6_D0.7631.00
87_I146_I0.7581.00
203_I222_V0.7561.00
234_R237_K0.7521.00
183_Y250_F0.7481.00
20_R29_S0.7471.00
159_G323_H0.7461.00
185_G203_I0.7451.00
68_G122_V0.7441.00
168_Q296_V0.7421.00
231_E235_L0.7381.00
92_E102_I0.7371.00
66_L117_R0.7351.00
201_R205_D0.7341.00
236_M239_A0.7341.00
16_A20_R0.7341.00
208_L211_F0.7331.00
67_I308_V0.7321.00
236_M263_A0.7271.00
242_Q246_P0.7251.00
91_I102_I0.7251.00
184_I251_I0.7241.00
90_G94_E0.7241.00
189_K194_K0.7221.00
240_I267_A0.7111.00
90_G305_R0.7111.00
63_A316_N0.7091.00
174_F210_A0.7071.00
225_G231_E0.7021.00
294_T330_L0.7011.00
145_F150_P0.6981.00
289_A292_P0.6971.00
232_G235_L0.6941.00
236_M259_G0.6931.00
135_H138_G0.6881.00
223_L239_A0.6841.00
181_L247_E0.6841.00
313_D317_G0.6831.00
264_L271_V0.6801.00
242_Q245_L0.6801.00
181_L206_K0.6771.00
113_E116_F0.6761.00
136_I143_A0.6751.00
137_S143_A0.6741.00
36_Q43_E0.6741.00
262_K292_P0.6731.00
292_P333_R0.6721.00
149_S323_H0.6711.00
121_G144_V0.6681.00
301_E304_G0.6601.00
262_K265_Q0.6601.00
109_G114_H0.6551.00
167_R205_D0.6531.00
81_D255_S0.6521.00
264_L267_A0.6521.00
223_L242_Q0.6501.00
176_L247_E0.6501.00
18_V21_I0.6501.00
313_D322_Q0.6491.00
21_I35_R0.6471.00
5_K57_R0.6461.00
134_K137_S0.6431.00
145_F155_Y0.6391.00
253_S281_N0.6391.00
137_S155_Y0.6381.00
123_I146_I0.6361.00
93_K97_E0.6351.00
137_S154_A0.6331.00
87_I300_T0.6281.00
278_V336_C0.6281.00
89_K301_E0.6271.00
258_I283_I0.6271.00
83_Y87_I0.6251.00
20_R30_V0.6241.00
183_Y206_K0.6221.00
238_K241_D0.6211.00
173_L250_F0.6201.00
191_H201_R0.6201.00
262_K266_E0.6191.00
7_I18_V0.6181.00
18_V42_A0.6171.00
147_N162_F0.6141.00
143_A155_Y0.6121.00
86_S300_T0.6121.00
43_E46_G0.6111.00
37_R40_N0.6111.00
89_K92_E0.6111.00
280_F298_V0.6101.00
121_G307_G0.6071.00
13_V34_T0.6061.00
95_C312_L0.6041.00
162_F201_R0.6041.00
167_R170_I0.6031.00
227_Y252_A0.6031.00
144_V158_I0.6031.00
262_K290_S0.5981.00
182_G221_H0.5971.00
29_S34_T0.5961.00
206_K217_P0.5951.00
314_R317_G0.5951.00
110_S113_E0.5931.00
217_P222_V0.5931.00
194_K204_E0.5911.00
168_Q172_H0.5911.00
107_H115_I0.5901.00
103_T119_L0.5901.00
203_I224_I0.5901.00
246_P269_L0.5891.00
294_T332_V0.5891.00
257_A279_S0.5871.00
90_G300_T0.5861.00
58_G63_A0.5811.00
144_V311_L0.5811.00
92_E106_I0.5801.00
240_I264_L0.5801.00
18_V38_V0.5781.00
229_M259_G0.5781.00
258_I285_E0.5761.00
251_I279_S0.5751.00
169_A248_A0.5741.00
25_D30_V0.5741.00
303_M326_L0.5731.00
48_Q52_K0.5731.00
81_D84_F0.5711.00
108_L114_H0.5711.00
67_I315_L0.5701.00
253_S256_M0.5691.00
88_R92_E0.5651.00
296_V328_T0.5631.00
55_K58_G0.5621.00
78_E89_K0.5601.00
233_Y259_G0.5561.00
286_A293_L0.5541.00
158_I306_T0.5531.00
144_V310_L0.5521.00
207_R219_P0.5511.00
287_E292_P0.5511.00
260_A264_L0.5511.00
291_T335_S0.5511.00
119_L122_V0.5501.00
261_L265_Q0.5491.00
185_G224_I0.5491.00
250_F280_F0.5481.00
13_V18_V0.5471.00
310_L314_R0.5461.00
229_M285_E0.5441.00
11_A21_I0.5431.00
231_E256_M0.5401.00
16_A25_D0.5391.00
67_I121_G0.5391.00
144_V307_G0.5361.00
180_R246_P0.5341.00
100_I120_D0.5331.00
122_V141_E0.5331.00
160_I165_A0.5321.00
266_E290_S0.5281.00
109_G113_E0.5271.00
160_I280_F0.5271.00
54_R58_G0.5271.00
100_I315_L0.5261.00
82_P255_S0.5241.00
262_K287_E0.5241.00
144_V314_R0.5231.00
180_R216_A0.5221.00
131_E134_K0.5211.00
66_L120_D0.5191.00
11_A38_V0.5161.00
265_Q270_Q0.5161.00
172_H278_V0.5151.00
245_L274_D0.5151.00
163_E166_S0.5131.00
306_T313_D0.5131.00
299_Y303_M0.5111.00
30_V35_R0.5091.00
260_A277_I0.5091.00
286_A295_T0.5091.00
64_Q100_I0.5071.00
283_I295_T0.5071.00
149_S157_S0.5061.00
190_E193_L0.5061.00
220_E242_Q0.5061.00
94_E312_L0.5061.00
193_L227_Y0.5051.00
15_S57_R0.5051.00
124_V145_F0.5041.00
227_Y256_M0.5031.00
269_L272_P0.5031.00
159_G162_F0.5021.00
233_Y236_M0.5011.00
246_P249_F0.5011.00
286_A289_A0.5011.00
91_I95_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.7791 100 0.1 Contact Map
4o5aA 2 0.7558 100 0.113 Contact Map
2hsgA 1 0.9244 100 0.115 Contact Map
1qpzA 2 0.9506 100 0.119 Contact Map
2o20A 2 0.7733 100 0.122 Contact Map
3bilA 2 0.7209 100 0.126 Contact Map
3ctpA 2 0.7471 100 0.126 Contact Map
3kjxA 2 0.936 100 0.128 Contact Map
1jyeA 2 0.7587 100 0.128 Contact Map
3e3mA 2 0.7558 100 0.131 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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