GREMLIN Database
YRZB - UPF0473 protein YrzB
UniProt: O34828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (88)
Sequences: 295 (162)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_Y54_S3.7721.00
37_L53_A3.5401.00
6_K22_V2.9780.99
12_D16_N2.8260.98
69_P81_E2.7310.98
21_E42_E2.5430.96
27_E34_S2.3840.94
33_K55_S2.3320.94
70_I79_I2.3120.93
26_F85_T2.2830.93
31_F72_T2.0550.89
19_L42_E1.8320.82
37_L83_L1.6750.76
20_C41_I1.5490.70
24_F34_S1.5490.70
54_S68_F1.5330.69
24_F85_T1.5320.69
32_G66_E1.4570.65
36_V65_G1.3920.61
10_I38_Y1.3560.59
10_I54_S1.3560.59
33_K88_A1.3480.58
12_D70_I1.3390.58
78_M82_T1.3060.56
13_D59_N1.3000.56
13_D42_E1.2310.51
24_F86_F1.2000.50
11_V16_N1.1980.49
83_L87_L1.1960.49
27_E32_G1.1570.47
77_D80_E1.1550.47
18_Q72_T1.1490.47
23_L39_Y1.1240.45
31_F65_G1.1200.45
55_S68_F1.1080.44
20_C38_Y1.0780.42
29_E32_G1.0490.41
36_V55_S1.0420.40
71_E74_E1.0420.40
76_W86_F1.0330.40
53_A76_W1.0280.39
9_T87_L1.0270.39
16_N19_L1.0270.39
73_D86_F1.0220.39
10_I89_D1.0170.39
36_V57_T1.0110.38
8_I40_P0.9720.36
44_K72_T0.9690.36
86_F90_E0.9520.35
20_C54_S0.9490.35
23_L83_L0.9480.35
28_N31_F0.9460.35
40_P86_F0.9420.35
61_D84_N0.9390.34
51_I58_P0.9290.34
9_T19_L0.9120.33
40_P81_E0.9010.32
35_Y75_E0.9010.32
45_D73_D0.8850.32
43_S69_P0.8480.30
61_D68_F0.8460.30
30_E41_I0.8430.29
32_G69_P0.8250.28
28_N67_L0.8150.28
8_I70_I0.8030.27
18_Q54_S0.8030.27
46_D88_A0.8020.27
82_T85_T0.7940.27
6_K48_E0.7780.26
8_I22_V0.7720.26
4_G30_E0.7670.26
25_T73_D0.7660.26
45_D84_N0.7660.26
32_G79_I0.7620.26
18_Q66_E0.7550.25
65_G69_P0.7550.25
3_H56_F0.7460.25
5_E51_I0.7440.25
85_T89_D0.7330.24
65_G81_E0.7190.24
17_E23_L0.6840.22
24_F28_N0.6650.21
37_L88_A0.6630.21
26_F83_L0.6510.21
3_H79_I0.6490.21
22_V25_T0.6460.21
49_V55_S0.6460.21
52_L82_T0.6450.21
33_K58_P0.6430.20
22_V36_V0.6400.20
39_Y45_D0.6380.20
24_F30_E0.6320.20
25_T70_I0.6310.20
63_E79_I0.6230.20
11_V55_S0.6220.20
19_L49_V0.6210.20
6_K54_S0.6150.19
27_E61_D0.6090.19
22_V63_E0.5990.19
5_E58_P0.5950.19
38_Y80_E0.5940.19
81_E85_T0.5900.18
57_T66_E0.5880.18
23_L34_S0.5860.18
47_E80_E0.5820.18
45_D48_E0.5820.18
20_C52_L0.5730.18
40_P90_E0.5720.18
21_E62_G0.5710.18
66_E73_D0.5660.18
62_G89_D0.5640.18
13_D57_T0.5630.17
61_D88_A0.5560.17
6_K51_I0.5510.17
55_S65_G0.5510.17
5_E90_E0.5500.17
23_L41_I0.5400.17
56_F61_D0.5310.16
47_E59_N0.5300.16
18_Q39_Y0.5280.16
40_P83_L0.5230.16
21_E25_T0.5200.16
41_I83_L0.5180.16
38_Y58_P0.5170.16
54_S79_I0.5150.16
53_A83_L0.5140.16
73_D87_L0.5130.16
21_E40_P0.5070.16
22_V86_F0.5060.16
27_E30_E0.5030.16
11_V39_Y0.5010.15
51_I65_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ovrB 1 0.3226 2.5 0.947 Contact Map
1ufgA 1 0.3333 2.3 0.948 Contact Map
3kh5A 1 0.3333 2.2 0.949 Contact Map
1pqsA 1 0.5806 2.2 0.949 Contact Map
2ra1A 1 0.6237 1.8 0.951 Contact Map
1t4wA 1 0.5054 1.7 0.952 Contact Map
4qjiA 2 0.3978 1.7 0.952 Contact Map
4u3qA 1 0.2796 1.4 0.954 Contact Map
3u6xS 3 0.3548 1.4 0.954 Contact Map
2bu3A 1 0.4301 1.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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