GREMLIN Database
PKSC - Polyketide biosynthesis malonyl CoA-acyl carrier protein transacylase PksC
UniProt: O34825 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (273)
Sequences: 15423 (11451)
Seq/√Len: 693.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_D195_R4.0221.00
247_K250_D3.3851.00
125_A171_A3.1711.00
168_E185_P2.6001.00
6_F70_L2.5511.00
71_K74_R2.5411.00
32_D38_S2.5411.00
101_D104_T2.4751.00
118_L203_E2.4671.00
240_D244_H2.4411.00
131_N134_Q2.3731.00
249_T253_S2.3321.00
111_K114_E2.3071.00
138_A177_M2.2011.00
132_E136_A2.1941.00
198_N243_N2.1801.00
205_E236_Q2.1521.00
70_L96_A2.1141.00
62_Y105_G2.0541.00
3_T260_H2.0231.00
74_R79_K1.9511.00
161_S194_S1.9311.00
160_I170_A1.9221.00
41_R45_E1.9041.00
163_K196_Y1.8751.00
21_F29_D1.8371.00
223_N251_S1.8301.00
171_A185_P1.8141.00
55_Q117_S1.8041.00
31_A102_F1.7871.00
146_D163_K1.7761.00
28_T63_V1.7751.00
5_V276_I1.7721.00
123_G167_I1.7671.00
99_A216_P1.7551.00
25_K29_D1.7211.00
256_M280_K1.7161.00
205_E239_A1.7101.00
236_Q240_D1.7081.00
164_K185_P1.7051.00
27_L30_Q1.6981.00
82_F260_H1.6871.00
53_K117_S1.6861.00
30_Q103_E1.6771.00
147_V170_A1.6741.00
173_L177_M1.6661.00
163_K166_E1.6431.00
227_K254_Y1.6391.00
95_F105_G1.6361.00
27_L71_K1.6161.00
111_K207_F1.6111.00
171_A175_E1.5941.00
164_K168_E1.5911.00
84_A251_S1.5881.00
65_N92_N1.5821.00
3_T255_L1.5681.00
123_G164_K1.5611.00
221_I228_P1.5541.00
138_A174_F1.5541.00
221_I254_Y1.5511.00
171_A183_V1.5481.00
28_T43_C1.5431.00
108_L208_L1.5271.00
134_Q137_K1.5201.00
12_Q16_M1.4751.00
67_L95_F1.4601.00
150_A161_S1.4581.00
254_Y258_K1.4541.00
132_E247_K1.4501.00
34_I106_L1.4411.00
252_I276_I1.4381.00
125_A167_I1.4331.00
4_Y80_P1.4251.00
17_G64_V1.4211.00
208_L213_F1.4071.00
146_D166_E1.4061.00
40_K44_L1.4031.00
221_I258_K1.3921.00
141_E173_L1.3891.00
38_S41_R1.3841.00
83_V218_I1.3761.00
18_S22_D1.3691.00
110_R114_E1.3591.00
205_E209_H1.3471.00
203_E206_E1.3471.00
127_V135_V1.3171.00
28_T68_S1.3131.00
168_E172_S1.3021.00
6_F96_A1.2961.00
84_A255_L1.2911.00
132_E152_V1.2821.00
136_A140_K1.2801.00
152_V249_T1.2541.00
32_D40_K1.2521.00
130_L135_V1.2471.00
34_I103_E1.2451.00
219_P228_P1.2301.00
201_K205_E1.2221.00
134_Q177_M1.2171.00
168_E171_A1.2161.00
142_Y173_L1.2121.00
252_I279_I1.2011.00
123_G185_P1.1891.00
152_V158_I1.1851.00
221_I251_S1.1841.00
82_F255_L1.1831.00
154_A275_L1.1531.00
35_L110_R1.1481.00
206_E209_H1.1481.00
50_N53_K1.1441.00
229_Y233_F1.1431.00
263_F276_I1.1351.00
201_K243_N1.1331.00
111_K115_L1.1291.00
30_Q71_K1.1251.00
5_V84_A1.1091.00
203_E207_F1.1091.00
48_Y52_N1.1091.00
4_Y266_V1.1001.00
215_P231_Y1.0981.00
172_S175_E1.0941.00
198_N201_K1.0931.00
115_L203_E1.0801.00
173_L176_T1.0721.00
172_S176_T1.0691.00
115_L200_A1.0631.00
114_E118_L1.0621.00
207_F210_A1.0611.00
174_F181_T1.0581.00
201_K239_A1.0581.00
125_A183_V1.0561.00
86_H153_N1.0551.00
149_I152_V1.0541.00
55_Q113_G1.0531.00
50_N56_F1.0521.00
18_S44_L1.0491.00
127_V174_F1.0441.00
31_A63_V1.0431.00
200_A242_I1.0411.00
42_L45_E1.0411.00
26_E30_Q1.0331.00
138_A173_L1.0331.00
129_G182_M1.0331.00
135_V158_I1.0331.00
127_V160_I1.0321.00
204_F242_I1.0291.00
21_F44_L1.0281.00
152_V245_S1.0201.00
26_E29_D1.0201.00
148_D194_S1.0051.00
72_K76_E1.0021.00
115_L207_F1.0011.00
29_D40_K0.9971.00
83_V220_V0.9971.00
27_L68_S0.9961.00
5_V263_F0.9911.00
223_N241_Q0.9901.00
149_I158_I0.9881.00
228_P254_Y0.9841.00
67_L92_N0.9831.00
152_V250_D0.9781.00
121_N164_K0.9751.00
152_V247_K0.9741.00
7_P65_N0.9691.00
15_G18_S0.9671.00
137_K141_E0.9671.00
91_Y109_V0.9671.00
29_D32_D0.9671.00
4_Y78_V0.9641.00
169_K173_L0.9631.00
137_K140_K0.9591.00
73_I266_V0.9551.00
94_L238_L0.9541.00
4_Y70_L0.9481.00
169_K172_S0.9461.00
70_L74_R0.9451.00
3_T263_F0.9451.00
31_A106_L0.9431.00
156_Y278_R0.9391.00
167_I185_P0.9351.00
83_V96_A0.9341.00
27_L31_A0.9301.00
107_Q210_A0.9301.00
88_L109_V0.9261.00
142_Y169_K0.9261.00
138_A170_A0.9251.00
82_F221_I0.9131.00
202_E205_E0.9051.00
254_Y257_K0.9021.00
72_K75_D0.8961.00
19_G23_E0.8931.00
224_V244_H0.8921.00
256_M263_F0.8881.00
220_V234_M0.8821.00
104_T107_Q0.8821.00
35_L106_L0.8761.00
130_L181_T0.8721.00
202_E206_E0.8721.00
154_A278_R0.8711.00
55_Q114_E0.8681.00
147_V166_E0.8671.00
141_E177_M0.8631.00
82_F258_K0.8621.00
71_K95_F0.8601.00
125_A185_P0.8581.00
253_S257_K0.8571.00
198_N239_A0.8571.00
133_E136_A0.8521.00
52_N187_N0.8461.00
132_E158_I0.8351.00
62_Y109_V0.8341.00
29_D33_E0.8341.00
62_Y95_F0.8321.00
62_Y67_L0.8251.00
24_F27_L0.8211.00
166_E169_K0.8181.00
230_T233_F0.8151.00
135_V160_I0.8101.00
155_P279_I0.8071.00
256_M261_M0.8071.00
3_T82_F0.8011.00
209_H235_K0.8001.00
24_F68_S0.8001.00
49_S52_N0.7961.00
226_A251_S0.7931.00
37_Y56_F0.7931.00
129_G156_Y0.7901.00
130_L134_Q0.7891.00
198_N202_E0.7831.00
30_Q34_I0.7761.00
24_F64_V0.7731.00
250_D253_S0.7721.00
248_W276_I0.7701.00
3_T261_M0.7671.00
229_Y234_M0.7661.00
90_E223_N0.7661.00
22_D44_L0.7641.00
109_V113_G0.7631.00
54_T192_F0.7611.00
145_H163_K0.7521.00
226_A250_D0.7501.00
178_T181_T0.7481.00
21_F25_K0.7471.00
125_A160_I0.7441.00
188_V192_F0.7371.00
100_F213_F0.7311.00
108_L211_F0.7301.00
99_A213_F0.7291.00
17_G24_F0.7261.00
175_E183_V0.7201.00
170_A174_F0.7201.00
252_I263_F0.7191.00
253_S279_I0.7171.00
84_A248_W0.7131.00
100_F108_L0.7111.00
61_L65_N0.7111.00
11_S61_L0.7091.00
43_C64_V0.7081.00
256_M281_K0.7081.00
249_T279_I0.7071.00
46_N50_N0.7041.00
107_Q111_K0.7041.00
79_K217_S0.7031.00
135_V139_L0.7031.00
98_E217_S0.7001.00
28_T32_D0.7001.00
71_K102_F0.6971.00
55_Q59_P0.6931.00
104_T211_F0.6921.00
134_Q181_T0.6921.00
39_I63_V0.6901.00
134_Q156_Y0.6901.00
32_D39_I0.6881.00
132_E250_D0.6861.00
270_N274_G0.6851.00
221_I255_L0.6841.00
67_L71_K0.6831.00
9_Q188_V0.6821.00
220_V229_Y0.6811.00
107_Q207_F0.6801.00
28_T40_K0.6791.00
225_Y240_D0.6781.00
104_T214_S0.6781.00
25_K28_T0.6751.00
138_A142_Y0.6721.00
197_M242_I0.6721.00
118_L200_A0.6701.00
274_G277_H0.6701.00
222_S237_T0.6661.00
129_G181_T0.6631.00
69_Y266_V0.6611.00
62_Y106_L0.6581.00
206_E210_A0.6561.00
225_Y237_T0.6551.00
101_D214_S0.6521.00
127_V130_L0.6491.00
127_V183_V0.6491.00
253_S256_M0.6441.00
57_T61_L0.6441.00
45_E49_S0.6411.00
95_F102_F0.6391.00
192_F242_I0.6361.00
131_N135_V0.6351.00
116_M197_M0.6351.00
42_L56_F0.6331.00
91_Y208_L0.6291.00
133_E137_K0.6281.00
63_V106_L0.6271.00
52_N57_T0.6241.00
147_V160_I0.6161.00
35_L59_P0.6151.00
91_Y211_F0.6151.00
41_R50_N0.6141.00
68_S72_K0.6141.00
131_N156_Y0.6101.00
102_F106_L0.6071.00
88_L192_F0.6031.00
119_I197_M0.6011.00
225_Y229_Y0.6011.00
200_A204_F0.5971.00
196_Y199_K0.5941.00
137_K177_M0.5941.00
21_F28_T0.5931.00
165_D168_E0.5931.00
7_P267_G0.5931.00
34_I107_Q0.5931.00
124_M188_V0.5931.00
255_L260_H0.5921.00
67_L96_A0.5891.00
215_P232_E0.5881.00
95_F100_F0.5881.00
65_N266_V0.5861.00
9_Q116_M0.5831.00
70_L73_I0.5821.00
27_L102_F0.5801.00
142_Y146_D0.5801.00
146_D195_R0.5791.00
139_L149_I0.5781.00
136_A152_V0.5751.00
213_F235_K0.5721.00
58_Q112_R0.5711.00
155_P249_T0.5701.00
90_E222_S0.5661.00
184_L187_N0.5651.00
30_Q33_E0.5621.00
195_R198_N0.5611.00
82_F228_P0.5611.00
30_Q102_F0.5611.00
121_N163_K0.5591.00
86_H246_V0.5581.00
199_K202_E0.5581.00
146_D169_K0.5561.00
115_L118_L0.5551.00
74_R217_S0.5541.00
56_F59_P0.5521.00
239_A243_N0.5521.00
67_L102_F0.5501.00
108_L204_F0.5491.00
135_V174_F0.5471.00
9_Q58_Q0.5461.00
100_F105_G0.5451.00
119_I200_A0.5441.00
222_S229_Y0.5431.00
222_S225_Y0.5431.00
116_M190_G0.5431.00
134_Q138_A0.5401.00
251_S254_Y0.5381.00
191_A196_Y0.5381.00
62_Y92_N0.5381.00
116_M119_I0.5371.00
31_A34_I0.5371.00
42_L50_N0.5371.00
141_E145_H0.5351.00
265_E272_L0.5311.00
94_L99_A0.5301.00
80_P83_V0.5291.00
92_N95_F0.5291.00
7_P269_G0.5291.00
124_M161_S0.5261.00
142_Y145_H0.5261.00
224_V240_D0.5261.00
160_I167_I0.5251.00
59_P113_G0.5251.00
4_Y264_E0.5241.00
100_F104_T0.5231.00
215_P230_T0.5231.00
191_A197_M0.5231.00
21_F40_K0.5201.00
27_L67_L0.5181.00
132_E149_I0.5170.99
54_T58_Q0.5160.99
228_P258_K0.5160.99
227_K250_D0.5140.99
39_I60_A0.5120.99
151_N159_V0.5110.99
24_F72_K0.5100.99
97_A220_V0.5090.99
62_Y102_F0.5090.99
67_L106_L0.5060.99
142_Y170_A0.5060.99
192_F197_M0.5050.99
200_A203_E0.5040.99
126_A157_Q0.5030.99
80_P218_I0.5020.99
28_T31_A0.5020.99
122_G191_A0.5020.99
123_G168_E0.5010.99
7_P266_V0.5000.99
101_D212_Y0.5000.99
207_F211_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g87A 1 0.9826 100 0.042 Contact Map
3sbmA 1 0.9757 100 0.061 Contact Map
3ptwA 1 0.9896 100 0.072 Contact Map
2cuyA 2 0.9792 100 0.075 Contact Map
3qatA 2 0.9896 100 0.081 Contact Map
4rr5A 1 0.9688 100 0.081 Contact Map
3im8A 1 0.9861 100 0.081 Contact Map
3k89A 1 0.9896 100 0.082 Contact Map
3tqeA 1 0.9896 100 0.086 Contact Map
3ezoA 1 0.9896 100 0.087 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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