GREMLIN Database
GLMM - Phosphoglucosamine mutase
UniProt: O34824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (433)
Sequences: 10959 (6764)
Seq/√Len: 325.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_A317_K4.0681.00
227_F231_K3.9831.00
185_T243_G3.7381.00
177_A233_A3.6371.00
251_E360_S3.3761.00
175_H199_D3.1691.00
226_A230_E3.1671.00
164_K195_D2.8901.00
51_I210_L2.8391.00
28_R67_I2.8371.00
88_A158_K2.7551.00
291_Y303_Q2.7131.00
427_K431_D2.6721.00
227_F230_E2.6471.00
42_K70_E2.6371.00
191_H195_D2.6061.00
279_T300_K2.6011.00
302_V314_A2.5891.00
357_K365_E2.5861.00
32_Y130_L2.5471.00
57_E73_R2.3811.00
267_K297_E2.3731.00
157_Q161_Q2.3361.00
43_V64_L2.3121.00
239_F345_A2.2691.00
27_G60_L2.2521.00
65_L149_V2.2431.00
248_A348_L2.1601.00
20_P55_M2.1521.00
202_T205_T2.1291.00
64_L95_V2.1261.00
60_L95_V2.1221.00
46_G82_V2.1191.00
435_N439_E2.0871.00
45_I61_V2.0431.00
175_H201_S2.0401.00
404_D425_K2.0331.00
292_K295_E2.0321.00
388_E392_A2.0201.00
357_K361_E2.0111.00
426_T429_L1.9781.00
30_G93_A1.9741.00
13_V105_Q1.9581.00
31_G64_L1.9581.00
47_R57_E1.9491.00
270_K299_I1.9381.00
47_R53_G1.9371.00
54_H58_G1.9281.00
267_K271_S1.9191.00
130_L133_E1.8941.00
126_E129_R1.8881.00
44_L91_A1.8871.00
129_R133_E1.8811.00
177_A227_F1.8771.00
31_G67_I1.8691.00
391_K395_S1.8461.00
431_D435_N1.8141.00
157_Q191_H1.7991.00
291_Y295_E1.7751.00
254_N364_A1.7741.00
84_Y88_A1.7511.00
383_K386_E1.7491.00
32_Y67_I1.7441.00
358_P361_E1.7291.00
42_K72_M1.6961.00
264_I351_T1.6951.00
13_V106_D1.6831.00
160_L192_L1.6831.00
314_A318_D1.6781.00
201_S231_K1.6771.00
237_L345_A1.6761.00
30_G111_F1.6741.00
251_E358_P1.6551.00
28_R32_Y1.6501.00
432_E436_R1.5931.00
119_L127_I1.5801.00
429_L432_E1.5751.00
24_F59_A1.5741.00
430_C434_V1.5731.00
294_L299_I1.5621.00
267_K365_E1.5591.00
380_D383_K1.5581.00
161_Q195_D1.5571.00
191_H194_A1.5441.00
128_E132_D1.5381.00
422_A434_V1.5381.00
313_E317_K1.5091.00
190_T194_A1.5021.00
70_E150_N1.4981.00
348_L359_L1.4921.00
252_K360_S1.4851.00
388_E391_K1.4831.00
226_A229_K1.4811.00
180_C205_T1.4731.00
271_S355_T1.4721.00
13_V16_S1.4691.00
23_A109_I1.4431.00
279_T302_V1.4361.00
392_A396_E1.4311.00
439_E442_R1.4201.00
41_P92_E1.4141.00
64_L69_A1.4041.00
428_E432_E1.4031.00
40_R70_E1.3991.00
49_T76_V1.3881.00
190_T205_T1.3821.00
282_S301_S1.3781.00
265_C332_F1.3641.00
311_V323_G1.3621.00
209_G212_I1.3611.00
24_F62_A1.3551.00
304_T314_A1.3431.00
44_L85_L1.3331.00
33_V123_Q1.3271.00
438_V442_R1.3261.00
434_V438_V1.3251.00
176_V235_L1.3221.00
84_Y162_F1.3221.00
262_M324_G1.3221.00
42_K92_E1.3211.00
24_F66_S1.3181.00
27_G109_I1.3051.00
157_Q195_D1.3011.00
387_N391_K1.2951.00
4_Y132_D1.2861.00
51_I209_G1.2841.00
129_R132_D1.2831.00
250_D360_S1.2761.00
23_A56_L1.2751.00
163_L343_L1.2751.00
47_R54_H1.2731.00
14_A52_S1.2701.00
389_K393_V1.2671.00
382_Y385_E1.2501.00
228_V236_G1.2431.00
175_H231_K1.2411.00
31_G69_A1.2381.00
360_S364_A1.2331.00
174_I234_D1.2331.00
10_V26_V1.2321.00
266_S280_V1.2301.00
431_D434_V1.2251.00
382_Y386_E1.2231.00
424_A430_C1.2231.00
61_V149_V1.2221.00
222_E225_S1.2201.00
221_P255_I1.2151.00
162_F165_Q1.2091.00
300_K318_D1.1991.00
61_V65_L1.1981.00
381_K385_E1.1971.00
33_V130_L1.1941.00
47_R73_R1.1921.00
389_K392_A1.1921.00
166_T347_M1.1891.00
235_L349_M1.1851.00
235_L352_L1.1711.00
27_G64_L1.1631.00
33_V126_E1.1631.00
267_K362_L1.1621.00
77_I81_G1.1561.00
352_L362_L1.1531.00
263_Y289_G1.1451.00
429_L433_Y1.1431.00
175_H232_N1.1321.00
289_G366_M1.1301.00
156_G188_L1.1281.00
43_V93_A1.1271.00
126_E130_L1.1241.00
45_I60_L1.1231.00
196_L346_I1.1221.00
64_L71_V1.1211.00
204_G223_A1.1201.00
154_E157_Q1.1151.00
41_P69_A1.1151.00
229_K252_K1.1131.00
163_L346_I1.1071.00
268_H272_E1.1061.00
268_H354_A1.0971.00
158_K161_Q1.0931.00
302_V318_D1.0891.00
203_M227_F1.0841.00
92_E114_G1.0781.00
57_E61_V1.0771.00
10_V111_F1.0771.00
61_V73_R1.0721.00
282_S303_Q1.0711.00
193_F345_A1.0681.00
30_G95_V1.0681.00
161_Q165_Q1.0641.00
160_L195_D1.0571.00
237_L248_A1.0571.00
20_P59_A1.0521.00
282_S286_S1.0491.00
88_A162_F1.0461.00
214_D221_P1.0461.00
272_E354_A1.0441.00
178_L193_F1.0431.00
361_E364_A1.0411.00
86_T94_G1.0391.00
59_A63_G1.0351.00
293_A297_E1.0311.00
95_V109_I1.0261.00
89_M155_G1.0251.00
60_L97_I1.0221.00
156_G191_H1.0211.00
357_K362_L1.0201.00
35_T69_A1.0191.00
292_K369_F1.0181.00
404_D429_L1.0171.00
378_V383_K1.0161.00
84_Y158_K1.0151.00
263_Y293_A1.0091.00
168_D350_N1.0091.00
160_L188_L1.0071.00
123_Q126_E1.0061.00
139_P142_V1.0051.00
60_L64_L1.0041.00
399_K402_N1.0031.00
78_S81_G1.0021.00
397_V433_Y1.0011.00
250_D254_N1.0011.00
28_R66_S1.0011.00
82_V96_M0.9991.00
270_K278_D0.9981.00
387_N390_V0.9981.00
264_I363_A0.9961.00
374_V435_N0.9941.00
82_V94_G0.9941.00
362_L365_E0.9931.00
204_G216_V0.9921.00
141_P144_A0.9881.00
372_L431_D0.9881.00
270_K297_E0.9861.00
185_T239_F0.9801.00
201_S233_A0.9801.00
186_S190_T0.9781.00
125_A128_E0.9681.00
46_G96_M0.9661.00
286_S290_F0.9661.00
177_A201_S0.9661.00
425_K429_L0.9611.00
393_V396_E0.9591.00
310_Y313_E0.9561.00
74_L77_I0.9551.00
58_G62_A0.9541.00
291_Y301_S0.9531.00
49_T207_P0.9521.00
224_L249_V0.9511.00
162_F166_T0.9511.00
186_S205_T0.9491.00
52_S55_M0.9441.00
29_F130_L0.9431.00
381_K384_V0.9421.00
262_M290_F0.9421.00
62_A66_S0.9411.00
224_L238_A0.9401.00
194_A202_T0.9351.00
57_E97_I0.9341.00
22_L26_V0.9341.00
350_N354_A0.9341.00
193_F349_M0.9321.00
178_L239_F0.9311.00
294_L301_S0.9281.00
214_D217_G0.9281.00
72_M150_N0.9251.00
35_T41_P0.9221.00
120_S123_Q0.9211.00
381_K386_E0.9201.00
273_G277_D0.9201.00
38_K92_E0.9181.00
315_M320_Y0.9171.00
332_F347_M0.9151.00
174_I352_L0.9131.00
292_K296_K0.9131.00
125_A129_R0.9031.00
178_L185_T0.9031.00
435_N442_R0.9031.00
29_F131_M0.9021.00
164_K196_L0.8941.00
374_V438_V0.8941.00
70_E147_G0.8921.00
214_D223_A0.8911.00
182_N204_G0.8901.00
140_R143_G0.8901.00
260_Q368_K0.8891.00
25_K134_P0.8881.00
261_I348_L0.8871.00
121_D310_Y0.8851.00
280_V290_F0.8841.00
113_G123_Q0.8821.00
122_E126_E0.8791.00
215_G220_H0.8731.00
322_V330_L0.8731.00
280_V294_L0.8711.00
351_T355_T0.8701.00
261_I330_L0.8651.00
189_A239_F0.8611.00
201_S227_F0.8571.00
175_H234_D0.8561.00
161_Q164_K0.8541.00
248_A261_I0.8501.00
435_N438_V0.8461.00
177_A231_K0.8441.00
44_L74_L0.8441.00
26_V131_M0.8431.00
217_G220_H0.8431.00
229_K232_N0.8411.00
47_R76_V0.8391.00
228_V249_V0.8361.00
128_E131_M0.8351.00
217_G223_A0.8341.00
75_G187_S0.8341.00
34_L93_A0.8331.00
221_P247_I0.8321.00
215_G223_A0.8311.00
279_T320_Y0.8311.00
378_V386_E0.8291.00
260_Q363_A0.8291.00
20_P24_F0.8291.00
347_M350_N0.8291.00
271_S297_E0.8261.00
53_G107_N0.8241.00
188_L342_L0.8241.00
214_D220_H0.8221.00
433_Y436_R0.8141.00
380_D384_V0.8121.00
27_G63_G0.8111.00
156_G187_S0.8091.00
76_V184_A0.8071.00
319_G333_L0.8061.00
237_L246_L0.8041.00
433_Y437_I0.8011.00
140_R144_A0.8011.00
273_G278_D0.8011.00
46_G77_I0.7981.00
155_G158_K0.7971.00
264_I362_L0.7971.00
269_L347_M0.7961.00
400_E436_R0.7951.00
176_V198_A0.7951.00
174_I353_K0.7941.00
293_A296_K0.7931.00
86_T93_A0.7901.00
428_E431_D0.7901.00
77_I96_M0.7901.00
221_P225_S0.7901.00
420_V438_V0.7891.00
268_H351_T0.7881.00
378_V384_V0.7861.00
279_T318_D0.7851.00
399_K405_G0.7851.00
394_I409_V0.7851.00
85_L155_G0.7851.00
176_V349_M0.7851.00
305_A310_Y0.7841.00
254_N360_S0.7831.00
142_V145_D0.7811.00
246_L344_S0.7801.00
72_M91_A0.7791.00
199_D231_K0.7771.00
287_N324_G0.7761.00
147_G150_N0.7741.00
330_L344_S0.7731.00
171_F354_A0.7731.00
119_L123_Q0.7711.00
430_C433_Y0.7711.00
46_G74_L0.7701.00
193_F198_A0.7701.00
422_A430_C0.7701.00
254_N363_A0.7681.00
189_A342_L0.7671.00
88_A155_G0.7641.00
81_G156_G0.7631.00
267_K366_M0.7611.00
261_I265_C0.7600.99
352_L359_L0.7580.99
281_V323_G0.7570.99
424_A429_L0.7540.99
21_E25_K0.7530.99
267_K293_A0.7530.99
160_L191_H0.7520.99
154_E158_K0.7440.99
390_V394_I0.7440.99
27_G31_G0.7410.99
262_M280_V0.7400.99
278_D321_N0.7400.99
35_T39_Q0.7400.99
225_S229_K0.7400.99
239_F341_G0.7380.99
282_S291_Y0.7380.99
249_V255_I0.7360.99
35_T67_I0.7360.99
146_L149_V0.7350.99
407_I437_I0.7340.99
281_V314_A0.7340.99
251_E361_E0.7330.99
221_P224_L0.7300.99
174_I235_L0.7300.99
173_G353_K0.7290.99
49_T184_A0.7280.99
329_H339_G0.7270.99
295_E301_S0.7270.99
391_K394_I0.7270.99
70_E148_L0.7260.99
162_F335_Y0.7260.99
353_K356_G0.7250.99
395_S399_K0.7240.99
174_I349_M0.7240.99
254_N260_Q0.7240.99
187_S191_H0.7240.99
59_A62_A0.7200.99
217_G224_L0.7200.99
203_M226_A0.7200.99
72_M153_F0.7180.99
278_D299_I0.7180.99
284_V408_L0.7160.99
204_G213_N0.7150.99
42_K91_A0.7150.99
349_M352_L0.7140.99
167_A346_I0.7120.99
237_L349_M0.7120.99
312_V331_I0.7070.99
182_N216_V0.7060.99
288_L423_E0.7030.99
263_Y287_N0.7030.99
8_D283_T0.7030.99
387_N395_S0.7020.99
168_D171_F0.7020.99
38_K41_P0.7010.99
390_V395_S0.7000.99
376_V438_V0.6990.99
142_V146_L0.6980.99
321_N334_D0.6970.99
436_R439_E0.6950.99
405_G424_A0.6940.99
247_I255_I0.6940.99
290_F324_G0.6930.99
214_D218_S0.6930.99
295_E300_K0.6920.99
104_V210_L0.6910.99
178_L189_A0.6890.99
15_N55_M0.6870.99
85_L89_M0.6860.99
69_A92_E0.6860.99
392_A395_S0.6840.99
265_C347_M0.6840.99
378_V381_K0.6820.99
6_G9_G0.6820.99
220_H223_A0.6820.99
25_K131_M0.6810.99
32_Y134_P0.6810.99
236_G249_V0.6790.99
218_S221_P0.6790.99
246_L341_G0.6770.99
182_N213_N0.6750.99
256_V359_L0.6740.99
111_F127_I0.6730.99
32_Y35_T0.6730.99
278_D319_G0.6730.99
44_L89_M0.6730.99
246_L345_A0.6720.99
101_H110_K0.6720.99
369_F372_L0.6720.99
173_G199_D0.6710.99
177_A236_G0.6680.99
7_T413_G0.6670.99
296_K369_F0.6670.99
217_G221_P0.6660.99
265_C351_T0.6640.99
160_L164_K0.6640.99
384_V411_P0.6640.99
157_Q160_L0.6630.99
32_Y133_E0.6620.99
117_F316_K0.6620.99
190_T202_T0.6620.99
375_N378_V0.6610.99
153_F157_Q0.6610.99
162_F336_N0.6590.99
61_V71_V0.6550.99
140_R149_V0.6550.99
228_V233_A0.6540.98
74_L81_G0.6490.98
400_E432_E0.6490.98
225_S255_I0.6490.98
89_M158_K0.6480.98
131_M134_P0.6470.98
363_A367_Q0.6470.98
277_D299_I0.6430.98
379_T386_E0.6420.98
214_D222_E0.6410.98
27_G95_V0.6400.98
436_R440_V0.6390.98
215_G221_P0.6390.98
235_L248_A0.6370.98
359_L363_A0.6340.98
376_V442_R0.6340.98
177_A203_M0.6320.98
262_M322_V0.6310.98
16_S105_Q0.6300.98
364_A367_Q0.6230.98
53_G57_E0.6220.98
150_N153_F0.6210.98
266_S290_F0.6210.98
159_Y163_L0.6210.98
224_L236_G0.6190.98
132_D135_E0.6180.98
189_A345_A0.6160.98
23_A59_A0.6160.98
376_V381_K0.6130.98
208_N214_D0.6120.98
182_N214_D0.6110.98
193_F197_D0.6100.98
266_S322_V0.6090.98
355_T362_L0.6080.98
252_K364_A0.6080.98
265_C344_S0.6070.98
220_H225_S0.6060.98
355_T358_P0.6040.97
99_A102_N0.6030.97
115_D316_K0.6010.97
13_V17_E0.6000.97
143_G148_L0.5980.97
270_K294_L0.5970.97
119_L124_E0.5970.97
432_E435_N0.5960.97
51_I104_V0.5940.97
168_D354_A0.5930.97
77_I156_G0.5920.97
130_L134_P0.5910.97
74_L82_V0.5890.97
55_M59_A0.5890.97
382_Y411_P0.5890.97
273_G276_K0.5870.97
30_G34_L0.5870.97
24_F63_G0.5860.97
390_V393_V0.5860.97
218_S223_A0.5840.97
378_V382_Y0.5840.97
26_V111_F0.5820.97
43_V69_A0.5810.97
379_T382_Y0.5810.97
285_M306_V0.5780.97
54_H75_G0.5780.97
186_S207_P0.5780.97
8_D118_K0.5760.97
15_N19_T0.5750.97
234_D353_K0.5740.97
189_A193_F0.5730.97
124_E127_I0.5720.97
427_K430_C0.5720.97
214_D219_T0.5720.97
380_D385_E0.5710.96
102_N414_T0.5710.96
175_H233_A0.5710.96
434_V437_I0.5710.96
215_G218_S0.5700.96
278_D300_K0.5700.96
256_V264_I0.5700.96
122_E125_A0.5690.96
66_S146_L0.5680.96
374_V434_V0.5680.96
217_G222_E0.5680.96
25_K135_E0.5680.96
290_F301_S0.5670.96
373_L378_V0.5670.96
166_T343_L0.5670.96
100_S110_K0.5650.96
19_T22_L0.5650.96
282_S290_F0.5630.96
215_G222_E0.5630.96
62_A65_L0.5620.96
402_N405_G0.5610.96
282_S288_L0.5610.96
256_V363_A0.5610.96
363_A366_M0.5600.96
200_V205_T0.5600.96
180_C203_M0.5600.96
409_V441_V0.5580.96
23_A27_G0.5560.96
429_L436_R0.5550.96
374_V442_R0.5540.96
102_N106_D0.5530.96
81_G188_L0.5520.96
143_G146_L0.5510.96
172_T234_D0.5500.96
273_G321_N0.5490.96
167_A171_F0.5470.96
355_T365_E0.5460.95
39_Q92_E0.5450.95
179_D238_A0.5450.95
277_D300_K0.5440.95
387_N394_I0.5430.95
33_V127_I0.5430.95
42_K150_N0.5420.95
6_G413_G0.5420.95
379_T383_K0.5410.95
189_A200_V0.5400.95
302_V320_Y0.5390.95
22_L131_M0.5390.95
121_D124_E0.5390.95
216_V223_A0.5380.95
426_T430_C0.5370.95
141_P145_D0.5360.95
261_I328_G0.5360.95
25_K28_R0.5360.95
178_L200_V0.5350.95
12_G17_E0.5350.95
238_A249_V0.5330.95
72_M152_Y0.5310.95
73_R152_Y0.5290.95
379_T384_V0.5290.95
263_Y366_M0.5280.95
380_D386_E0.5280.95
65_L71_V0.5270.95
219_T222_E0.5250.94
30_G43_V0.5250.94
156_G160_L0.5230.94
8_D373_L0.5230.94
265_C348_L0.5230.94
20_P62_A0.5190.94
375_N417_L0.5190.94
399_K403_G0.5170.94
288_L292_K0.5170.94
406_R423_E0.5160.94
24_F28_R0.5160.94
437_I440_V0.5140.94
60_L109_I0.5140.94
263_Y267_K0.5140.94
377_R380_D0.5130.94
23_A60_L0.5130.94
405_G433_Y0.5120.94
432_E439_E0.5110.94
246_L348_L0.5110.94
4_Y22_L0.5100.94
352_L355_T0.5090.93
384_V387_N0.5090.93
173_G198_A0.5080.93
28_R134_P0.5080.93
11_R101_H0.5070.93
139_P143_G0.5060.93
322_V332_F0.5060.93
83_S337_T0.5050.93
102_N110_K0.5040.93
400_E433_Y0.5040.93
409_V420_V0.5030.93
73_R149_V0.5020.93
281_V311_V0.5010.93
192_L342_L0.5000.93
101_H244_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pdkA 2 0.9933 100 0.063 Contact Map
2f7lA 4 0.9777 100 0.073 Contact Map
1wqaA 3 0.9799 100 0.074 Contact Map
3i3wA 2 0.9754 100 0.086 Contact Map
1tuoA 1 0.9129 100 0.115 Contact Map
3uw2A 1 0.9554 100 0.124 Contact Map
1p5dX 1 0.971 100 0.13 Contact Map
3na5A 2 0.9911 100 0.148 Contact Map
2z0fA 2 0.942 100 0.15 Contact Map
4hjhA 2 0.9598 100 0.17 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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