GREMLIN Database
YBCF - Putative carbonic anhydrase-like protein YbcF
UniProt: O34823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (151)
Sequences: 4974 (3088)
Seq/√Len: 251.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_I145_G4.1261.00
8_K65_E3.9251.00
10_L55_V3.0261.00
128_V143_V2.7211.00
128_V145_G2.7091.00
121_S156_S2.6751.00
66_E144_R2.5151.00
77_T81_N2.4661.00
40_Y54_S2.3751.00
73_K147_F2.3461.00
78_S81_N2.2971.00
120_S147_F2.2561.00
77_T80_G2.1741.00
77_T82_G1.9631.00
74_D151_K1.9561.00
149_N156_S1.9541.00
66_E142_K1.8801.00
146_L155_P1.8551.00
42_A123_T1.8181.00
56_I60_Y1.7041.00
15_I35_L1.6971.00
29_T34_M1.6671.00
69_V131_I1.6551.00
112_V116_L1.6411.00
10_L64_V1.6091.00
122_D126_K1.6081.00
149_N152_G1.6071.00
52_M134_H1.5471.00
121_S147_F1.5301.00
5_Q17_N1.4841.00
37_I54_S1.4831.00
135_P138_P1.4661.00
27_T34_M1.4571.00
122_D125_E1.4481.00
78_S82_G1.4381.00
112_V115_W1.3891.00
73_K149_N1.3631.00
11_F70_V1.3591.00
44_I51_I1.3501.00
82_G86_L1.3281.00
9_V68_F1.3251.00
57_F61_Q1.2731.00
68_F146_L1.2581.00
10_L67_I1.2521.00
146_L157_I1.2331.00
70_V146_L1.2281.00
10_L54_S1.2261.00
88_T92_K1.2241.00
79_A82_G1.2211.00
55_V131_I1.1981.00
41_G77_T1.1751.00
42_A71_G1.1601.00
89_M92_K1.1571.00
130_M133_H1.1551.00
45_S50_E1.1531.00
27_T70_V1.1521.00
132_R143_V1.1501.00
88_T93_I1.1441.00
4_N74_D1.1341.00
124_I128_V1.1281.00
92_K95_T1.1221.00
137_V141_V1.1101.00
13_T19_L1.1021.00
103_C106_E1.0941.00
123_T127_S1.0881.00
111_T114_E1.0681.00
87_E90_K1.0661.00
95_T98_Y1.0611.00
125_E158_A1.0581.00
73_K150_H1.0491.00
104_K108_L1.0381.00
90_K96_L1.0271.00
126_K129_D1.0191.00
39_S42_A1.0161.00
11_F34_M1.0061.00
129_D132_R1.0021.00
136_L139_S1.0001.00
11_F27_T0.9981.00
104_K107_F0.9951.00
59_I141_V0.9951.00
52_M131_I0.9941.00
58_A64_V0.9861.00
59_I67_I0.9711.00
87_E92_K0.9501.00
87_E91_D0.9491.00
59_I64_V0.9421.00
71_G124_I0.9411.00
144_R157_I0.9401.00
5_Q76_K0.9331.00
88_T91_D0.9311.00
59_I137_V0.9201.00
124_I147_F0.9141.00
12_L55_V0.9101.00
21_P25_E0.9091.00
12_L44_I0.9071.00
94_Q97_D0.9071.00
121_S125_E0.9031.00
134_H138_P0.9031.00
97_D101_Q0.9031.00
106_E118_E0.8951.00
129_D133_H0.8911.00
37_I51_I0.8841.00
43_S127_S0.8811.00
63_D140_Y0.8791.00
131_I143_V0.8781.00
35_L58_A0.8701.00
92_K96_L0.8670.99
89_M93_I0.8660.99
44_I127_S0.8630.99
79_A83_L0.8490.99
15_I62_E0.8310.99
93_I98_Y0.8310.99
20_E36_T0.8310.99
135_P140_Y0.8300.99
60_Y140_Y0.8280.99
94_Q98_Y0.8160.99
110_G113_D0.8150.99
15_I37_I0.8120.99
107_F111_T0.7990.99
51_I55_V0.7990.99
27_T146_L0.7930.99
152_G156_S0.7930.99
125_E145_G0.7920.99
126_K130_M0.7910.99
99_L126_K0.7890.99
95_T102_N0.7780.99
59_I140_Y0.7660.99
29_T33_N0.7660.99
71_G123_T0.7600.99
17_N35_L0.7600.99
22_I25_E0.7590.99
9_V34_M0.7440.98
90_K93_I0.7430.98
13_T70_V0.7360.98
57_F76_K0.7290.98
107_F112_V0.7200.98
45_S51_I0.7190.98
92_K98_Y0.7160.98
11_F21_P0.7150.98
12_L39_S0.7130.98
9_V66_E0.7050.98
18_G32_E0.7050.98
105_P108_L0.7020.98
68_F144_R0.6980.98
39_S50_E0.6960.98
6_N63_D0.6940.98
60_Y136_L0.6870.97
25_E31_A0.6840.97
102_N105_P0.6820.97
20_E26_A0.6810.97
50_E64_V0.6800.97
9_V65_E0.6770.97
110_G116_L0.6740.97
95_T99_L0.6730.97
118_E122_D0.6720.97
35_L57_F0.6710.97
134_H140_Y0.6640.97
73_K151_K0.6630.97
13_T20_E0.6630.97
19_L26_A0.6610.97
26_A155_P0.6540.97
39_S51_I0.6520.96
89_M99_L0.6490.96
60_Y139_S0.6490.96
22_I34_M0.6470.96
89_M98_Y0.6430.96
15_I40_Y0.6420.96
91_D94_Q0.6420.96
109_G112_V0.6420.96
50_E53_R0.6300.96
108_L111_T0.6290.96
30_S33_N0.6280.96
147_F156_S0.6230.95
93_I96_L0.6170.95
101_Q106_E0.6160.95
21_P36_T0.6150.95
81_N85_Q0.6150.95
81_N84_T0.6120.95
83_L86_L0.6120.95
93_I99_L0.6120.95
42_A127_S0.6110.95
84_T87_E0.6100.95
78_S85_Q0.6060.95
43_S123_T0.6060.95
4_N17_N0.6050.95
107_F110_G0.6030.95
111_T115_W0.6020.95
91_D95_T0.5940.94
105_P109_G0.5910.94
103_C110_G0.5910.94
105_P110_G0.5810.93
87_E93_I0.5770.93
135_P139_S0.5720.93
14_D75_K0.5650.92
102_N126_K0.5650.92
137_V140_Y0.5640.92
92_K99_L0.5640.92
13_T21_P0.5630.92
10_L58_A0.5600.92
107_F116_L0.5590.92
113_D117_N0.5580.92
15_I57_F0.5560.92
57_F62_E0.5550.92
106_E109_G0.5510.92
110_G115_W0.5500.91
110_G114_E0.5470.91
86_L89_M0.5470.91
128_V132_R0.5420.91
98_Y101_Q0.5360.90
22_I29_T0.5350.90
91_D97_D0.5330.90
103_C107_F0.5320.90
5_Q35_L0.5260.90
20_E25_E0.5240.89
58_A62_E0.5220.89
49_G134_H0.5200.89
82_G85_Q0.5180.89
127_S130_M0.5170.89
10_L37_I0.5120.88
114_E117_N0.5100.88
7_K35_L0.5090.88
132_R138_P0.5070.88
71_G127_S0.5060.88
11_F127_S0.5010.87
113_D116_L0.5010.87
89_M96_L0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ddzA 2 0.9886 100 0.123 Contact Map
3e3iA 6 0.9886 100 0.123 Contact Map
3qy1A 4 0.9886 100 0.128 Contact Map
4rxyA 4 0.9886 100 0.129 Contact Map
3ucjA 4 0.9886 100 0.145 Contact Map
2w3qA 2 0.8971 100 0.155 Contact Map
4o1jA 4 0.92 100 0.156 Contact Map
4o1kA 4 0.9886 100 0.163 Contact Map
1ekjA 5 0.96 100 0.166 Contact Map
3eyxA 2 0.9086 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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