GREMLIN Database
YOAD - Putative 2-hydroxyacid dehydrogenase YoaD
UniProt: O34815 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (287)
Sequences: 18236 (12633)
Seq/√Len: 745.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_D236_Y4.4131.00
234_R262_F3.2151.00
256_N259_D3.1731.00
166_V182_L2.7081.00
265_K292_L2.4941.00
165_T188_K2.4801.00
224_R253_V2.4361.00
209_K239_L2.3121.00
242_E268_K2.3031.00
165_T190_K2.2791.00
167_G211_V2.2021.00
212_F236_Y2.1621.00
60_N83_S2.1311.00
207_S210_T2.1121.00
213_S239_L2.0721.00
123_I182_L2.0551.00
230_G278_Y2.0481.00
190_K214_D2.0381.00
73_D102_K2.0181.00
137_N141_K2.0051.00
171_F191_Y2.0041.00
322_K327_K1.9551.00
167_G215_S1.9181.00
130_L217_I1.8981.00
262_F266_E1.8871.00
132_H135_A1.8851.00
238_D268_K1.8731.00
177_R180_K1.8291.00
244_A269_I1.8291.00
124_G133_T1.8261.00
232_I237_F1.8121.00
246_F255_V1.8071.00
73_D77_A1.7951.00
245_I271_G1.7921.00
123_I185_F1.7611.00
84_F108_F1.7521.00
261_L292_L1.7471.00
265_K288_E1.7411.00
230_G256_N1.7231.00
292_L295_V1.6981.00
126_V217_I1.6971.00
168_M175_G1.6681.00
166_V187_C1.6601.00
58_A81_E1.6431.00
209_K236_Y1.6431.00
49_E74_S1.6191.00
216_D241_K1.6071.00
99_A102_K1.6011.00
77_A103_R1.6001.00
121_M302_A1.5951.00
234_R238_D1.5911.00
260_L272_A1.5911.00
210_T214_D1.5771.00
128_S134_S1.5701.00
212_F232_I1.5641.00
164_K307_E1.5511.00
106_P332_Q1.5461.00
129_F271_G1.5451.00
237_F263_V1.5391.00
125_N273_I1.5291.00
226_E229_L1.5201.00
257_R278_Y1.5001.00
182_L187_C1.4961.00
160_E311_H1.4961.00
235_Q239_L1.4861.00
159_N164_K1.4691.00
122_F178_I1.4411.00
168_M219_S1.4401.00
49_E72_T1.4381.00
76_F103_R1.4381.00
245_I270_S1.4361.00
48_R51_E1.4301.00
224_R229_L1.4251.00
232_I236_Y1.4241.00
178_I221_H1.4211.00
220_V254_V1.4011.00
100_A107_V1.4001.00
321_K325_G1.4001.00
240_M244_A1.3971.00
234_R259_D1.3921.00
221_H249_T1.3881.00
177_R181_L1.3821.00
222_L254_V1.3791.00
120_E181_L1.3701.00
116_Q162_T1.3661.00
188_K214_D1.3451.00
261_L265_K1.3441.00
322_K330_N1.3351.00
236_Y239_L1.3311.00
188_K204_E1.3221.00
318_K322_K1.2741.00
211_V215_S1.2711.00
314_T318_K1.2641.00
116_Q177_R1.2601.00
138_Q141_K1.2561.00
229_L253_V1.2361.00
53_I78_S1.2351.00
60_N81_E1.2341.00
203_Y206_A1.2251.00
73_D99_A1.2181.00
220_V246_F1.2121.00
190_K206_A1.2121.00
114_N303_G1.2081.00
61_A84_F1.2031.00
76_F100_A1.2021.00
138_Q142_D1.2001.00
209_K235_Q1.1981.00
250_S254_V1.1971.00
180_K186_D1.1961.00
127_I185_F1.1941.00
168_M179_A1.1921.00
178_I219_S1.1841.00
129_F245_I1.1821.00
169_I232_I1.1811.00
121_M125_N1.1801.00
169_I222_L1.1671.00
277_F297_A1.1581.00
122_F249_T1.1561.00
282_P287_Y1.1541.00
84_F323_W1.1521.00
219_S249_T1.1521.00
129_F296_L1.1501.00
72_T75_V1.1451.00
231_L254_V1.1451.00
323_W329_L1.1401.00
56_L79_V1.1391.00
237_F246_F1.1341.00
241_K244_A1.1311.00
243_S268_K1.1301.00
98_A102_K1.1291.00
171_F176_Q1.1281.00
119_A181_L1.1221.00
169_I231_L1.1211.00
95_V100_A1.1191.00
99_A103_R1.1181.00
217_I245_I1.1121.00
124_G127_I1.1081.00
87_V95_V1.1071.00
139_W144_E1.1031.00
235_Q238_D1.0921.00
129_F273_I1.0911.00
49_E53_I1.0901.00
283_E286_D1.0851.00
134_S137_N1.0771.00
218_V240_M1.0681.00
169_I218_V1.0661.00
190_K215_S1.0581.00
165_T214_D1.0551.00
258_E288_E1.0531.00
121_M298_T1.0511.00
265_K291_S1.0471.00
143_G291_S1.0471.00
315_I331_I1.0461.00
264_L295_V1.0441.00
233_D259_D1.0421.00
77_A99_A1.0401.00
86_G319_A1.0341.00
51_E54_Q1.0341.00
257_R279_H1.0321.00
126_V166_V1.0281.00
206_A210_T1.0201.00
116_Q181_L1.0151.00
98_A101_S1.0151.00
318_K330_N1.0091.00
193_D197_Q1.0011.00
194_P227_E0.9991.00
208_L236_Y0.9901.00
204_E214_D0.9881.00
169_I208_L0.9861.00
208_L212_F0.9851.00
76_F85_V0.9791.00
106_P329_L0.9771.00
125_N296_L0.9701.00
31_L321_K0.9641.00
126_V182_L0.9641.00
257_R287_Y0.9561.00
279_H283_E0.9541.00
97_V101_S0.9491.00
121_M273_I0.9471.00
206_A211_V0.9461.00
310_D314_T0.9431.00
223_P228_T0.9391.00
263_V268_K0.9381.00
87_V94_N0.9291.00
237_F268_K0.9271.00
233_D256_N0.9261.00
180_K183_T0.9201.00
261_L288_E0.9191.00
86_G108_F0.9181.00
123_I181_L0.9181.00
222_L231_L0.9121.00
176_Q197_Q0.9101.00
54_Q57_K0.9081.00
96_D99_A0.9061.00
199_D202_L0.8931.00
169_I220_V0.8901.00
117_A160_E0.8871.00
215_S218_V0.8871.00
138_Q293_P0.8851.00
232_I246_F0.8831.00
130_L159_N0.8831.00
86_G316_L0.8821.00
237_F240_M0.8751.00
263_V269_I0.8721.00
128_S133_T0.8591.00
168_M178_I0.8561.00
128_S296_L0.8521.00
160_E305_T0.8511.00
178_I182_L0.8501.00
166_V219_S0.8491.00
198_D202_L0.8481.00
118_V302_A0.8461.00
161_L187_C0.8431.00
196_I201_P0.8411.00
27_E314_T0.8401.00
162_T186_D0.8401.00
220_V232_I0.8341.00
53_I75_V0.8331.00
176_Q200_H0.8321.00
130_L245_I0.8321.00
123_I178_I0.8291.00
57_K78_S0.8281.00
61_A320_L0.8271.00
243_S270_S0.8251.00
218_V244_A0.8231.00
187_C217_I0.8191.00
212_F218_V0.8191.00
89_R94_N0.8181.00
84_F320_L0.8181.00
130_L164_K0.8181.00
198_D201_P0.8161.00
95_V107_V0.8141.00
260_L269_I0.8111.00
319_A322_K0.8071.00
116_Q160_E0.8051.00
115_A177_R0.8051.00
264_L294_N0.8021.00
258_E262_F0.7981.00
262_F265_K0.7981.00
257_R289_L0.7921.00
255_V260_L0.7921.00
123_I126_V0.7901.00
51_E55_L0.7861.00
171_F179_A0.7851.00
134_S138_Q0.7841.00
74_S77_A0.7821.00
85_V100_A0.7781.00
27_E321_K0.7771.00
224_R228_T0.7711.00
238_D266_E0.7611.00
122_F221_H0.7591.00
271_G296_L0.7561.00
179_A189_I0.7551.00
61_A324_K0.7541.00
272_A295_V0.7531.00
258_E278_Y0.7501.00
165_T215_S0.7481.00
27_E31_L0.7431.00
62_T71_V0.7431.00
116_Q120_E0.7421.00
181_L185_F0.7381.00
159_N307_E0.7341.00
192_Y208_L0.7331.00
279_H282_P0.7331.00
191_Y205_K0.7311.00
136_S301_L0.7311.00
124_G128_S0.7301.00
73_D103_R0.7291.00
282_P290_I0.7291.00
122_F219_S0.7221.00
120_E131_R0.7211.00
73_D96_D0.7201.00
28_L32_F0.7201.00
274_L295_V0.7191.00
260_L274_L0.7191.00
115_A173_A0.7181.00
140_L290_I0.7181.00
197_Q200_H0.7171.00
130_L134_S0.7171.00
159_N243_S0.7161.00
50_D54_Q0.7131.00
243_S269_I0.7121.00
112_G173_A0.7111.00
159_N306_F0.7071.00
212_F239_L0.7011.00
277_F282_P0.6971.00
234_R268_K0.6931.00
117_A308_V0.6921.00
126_V178_I0.6911.00
126_V161_L0.6891.00
210_T213_S0.6891.00
209_K213_S0.6871.00
27_E30_N0.6861.00
193_D196_I0.6821.00
48_R52_L0.6771.00
208_L231_L0.6771.00
110_T315_I0.6741.00
229_L278_Y0.6711.00
110_T312_H0.6701.00
126_V247_V0.6681.00
167_G192_Y0.6681.00
311_H314_T0.6681.00
245_I273_I0.6671.00
196_I205_K0.6661.00
165_T241_K0.6651.00
255_V272_A0.6641.00
117_A305_T0.6611.00
197_Q202_L0.6601.00
122_F125_N0.6601.00
27_E318_K0.6571.00
113_R303_G0.6551.00
318_K321_K0.6541.00
112_G315_I0.6531.00
86_G320_L0.6531.00
283_E287_Y0.6501.00
32_F321_K0.6491.00
220_V250_S0.6481.00
306_F310_D0.6471.00
222_L250_S0.6441.00
290_I297_A0.6421.00
164_K217_I0.6421.00
87_V92_P0.6411.00
56_L62_T0.6411.00
53_I74_S0.6401.00
162_T311_H0.6381.00
273_I296_L0.6361.00
230_G233_D0.6331.00
79_V82_L0.6321.00
92_P97_V0.6321.00
117_A120_E0.6291.00
29_E32_F0.6251.00
137_N297_A0.6241.00
262_F268_K0.6241.00
329_L332_Q0.6241.00
161_L185_F0.6231.00
190_K211_V0.6221.00
183_T189_I0.6201.00
218_V241_K0.6171.00
76_F105_I0.6161.00
212_F240_M0.6151.00
176_Q180_K0.6141.00
121_M124_G0.6121.00
322_K329_L0.6111.00
206_A214_D0.6111.00
287_Y291_S0.6111.00
191_Y203_Y0.6111.00
53_I79_V0.6091.00
137_N140_L0.6081.00
130_L187_C0.6081.00
166_V178_I0.6071.00
119_A177_R0.6051.00
322_K328_T0.6051.00
243_S266_E0.6011.00
225_T228_T0.5961.00
93_S224_R0.5961.00
80_P103_R0.5931.00
317_N321_K0.5921.00
121_M131_R0.5911.00
304_A309_E0.5881.00
74_S78_S0.5881.00
83_S323_W0.5871.00
125_N128_S0.5861.00
61_A86_G0.5851.00
265_K293_P0.5851.00
113_R312_H0.5811.00
234_R266_E0.5811.00
136_S299_P0.5801.00
58_A80_P0.5791.00
140_L277_F0.5781.00
92_P109_Y0.5751.00
165_T216_D0.5731.00
139_W142_D0.5721.00
230_G253_V0.5721.00
190_K205_K0.5721.00
181_L184_A0.5721.00
55_L59_T0.5711.00
125_N129_F0.5701.00
57_K80_P0.5691.00
164_K187_C0.5691.00
50_D74_S0.5681.00
218_V246_F0.5671.00
118_V122_F0.5641.00
88_C312_H0.5611.00
328_T332_Q0.5581.00
71_V76_F0.5581.00
253_V278_Y0.5581.00
116_Q186_D0.5581.00
112_G115_A0.5571.00
27_E317_N0.5531.00
86_G110_T0.5521.00
263_V266_E0.5511.00
261_L295_V0.5501.00
184_A187_C0.5491.00
171_F175_G0.5481.00
218_V232_I0.5481.00
197_Q201_P0.5471.00
265_K294_N0.5471.00
134_S296_L0.5461.00
31_L325_G0.5451.00
114_N117_A0.5431.00
28_L31_L0.5401.00
126_V219_S0.5351.00
140_L297_A0.5331.00
258_E287_Y0.5321.00
264_L292_L0.5321.00
234_R263_V0.5281.00
244_A268_K0.5261.00
208_L232_I0.5261.00
279_H287_Y0.5251.00
188_K203_Y0.5251.00
257_R261_L0.5251.00
314_T317_N0.5241.00
180_K184_A0.5241.00
123_I166_V0.5211.00
212_F231_L0.5211.00
194_P197_Q0.5211.00
160_E307_E0.5181.00
171_F193_D0.5161.00
108_F319_A0.5161.00
113_R315_I0.5121.00
222_L228_T0.5121.00
316_L319_A0.5121.00
135_A139_W0.5091.00
251_R300_H0.5091.00
287_Y290_I0.5081.00
141_K291_S0.5061.00
84_F106_P0.5061.00
103_R106_P0.5001.00
169_I211_V0.5001.00
53_I57_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sc6A 4 0.907 100 0.236 Contact Map
3k5pA 3 0.9273 100 0.237 Contact Map
3ba1A 2 0.907 100 0.248 Contact Map
2g76A 2 0.8692 100 0.252 Contact Map
4g2nA 3 0.9157 100 0.252 Contact Map
4lswA 2 0.9157 100 0.254 Contact Map
1ygyA 4 0.9273 100 0.254 Contact Map
2d0iA 2 0.939 100 0.257 Contact Map
2w2kA 2 0.936 100 0.262 Contact Map
2gcgA 2 0.9273 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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