GREMLIN Database
SIRC - Precorrin-2 dehydrogenase
UniProt: O34813 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 162 (158)
Sequences: 2764 (2054)
Seq/√Len: 163.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_R67_D5.1321.00
63_I90_S4.5931.00
14_V71_A3.4281.00
23_L44_E3.0291.00
26_L47_I2.8811.00
43_V58_W2.8301.00
15_I26_L2.8021.00
12_K37_T2.4961.00
11_K72_F2.1391.00
69_L94_F2.1221.00
128_A156_Y2.0561.00
12_K35_D2.0411.00
48_K60_K2.0321.00
125_T133_T1.9841.00
37_T57_K1.9181.00
79_D84_N1.9051.00
78_T84_N1.8931.00
75_I110_M1.8371.00
61_R64_E1.8311.00
5_H122_S1.8041.00
144_I148_F1.7171.00
137_A141_D1.6921.00
102_D105_L1.6761.00
23_L46_E1.6741.00
86_E90_S1.6291.00
43_V47_I1.5431.00
51_A58_W1.5111.00
92_S107_N1.4961.00
119_V152_V1.4591.00
65_K86_E1.4541.00
48_K52_E1.4411.00
66_E90_S1.4411.00
43_V51_A1.4261.00
16_A87_I1.4151.00
39_V67_D1.4111.00
2_L110_M1.3981.00
85_K89_Q1.3851.00
35_D57_K1.3701.00
63_I87_I1.3501.00
114_V141_D1.3421.00
41_P62_T1.3051.00
121_V140_V1.3031.00
139_N143_L1.2981.00
91_A96_L1.2851.00
37_T71_A1.2831.00
76_A87_I1.2811.00
116_R141_D1.2771.00
72_F95_Q1.2771.00
76_A84_N1.2711.00
37_T59_E1.2681.00
119_V136_L1.2591.00
31_S115_K1.2481.00
99_C105_L1.2451.00
16_A63_I1.2341.00
83_V86_E1.2191.00
83_V87_I1.2181.00
18_G43_V1.1991.00
135_E139_N1.1971.00
21_I24_R1.1861.00
80_N83_V1.1841.00
96_L107_N1.1751.00
10_K35_D1.1651.00
25_R100_V1.1631.00
15_I36_I1.1631.00
121_V144_I1.1611.00
101_S106_G1.1601.00
88_A92_S1.1481.00
74_I91_A1.1411.00
85_K105_L1.1361.00
65_K90_S1.1301.00
64_E67_D1.1281.00
4_L73_F1.1161.00
12_K71_A1.1131.00
88_A106_G1.1011.00
112_K137_A1.0911.00
43_V60_K1.0911.00
51_A56_I1.0640.99
27_K46_E1.0630.99
49_Q53_E1.0610.99
118_H128_A1.0560.99
15_I29_V1.0480.99
4_L108_V1.0290.99
134_K138_E1.0210.99
88_A99_C1.0190.99
81_A102_D1.0150.99
50_M55_R1.0010.99
15_I22_A0.9850.99
2_L28_T0.9720.99
14_V39_V0.9720.99
11_K107_N0.9520.99
46_E50_M0.9480.99
106_G109_Y0.9460.99
114_V123_V0.9310.99
30_I55_R0.9260.98
18_G40_S0.9210.98
8_L13_V0.9130.98
47_I51_A0.9130.98
75_I108_V0.9100.98
102_D106_G0.9060.98
120_T126_S0.8890.98
74_I96_L0.8880.98
125_T152_V0.8790.98
13_V29_V0.8760.98
68_Y74_I0.8750.98
103_A106_G0.8700.98
138_E141_D0.8690.98
123_V136_L0.8690.98
25_R124_S0.8620.98
22_A40_S0.8490.97
118_H153_N0.8460.97
13_V34_A0.8350.97
9_E33_G0.8310.97
90_S94_F0.8220.97
135_E138_E0.8200.97
49_Q52_E0.8150.97
98_N106_G0.8140.97
89_Q93_P0.8110.96
88_A107_N0.8060.96
41_P58_W0.8020.96
123_V140_V0.8000.96
45_P48_K0.7950.96
28_T115_K0.7890.96
63_I68_Y0.7850.96
7_S109_Y0.7840.96
44_E47_I0.7840.96
101_S112_K0.7830.96
111_P122_S0.7790.96
30_I56_I0.7760.95
117_G120_T0.7740.95
91_A97_V0.7730.95
149_V152_V0.7700.95
23_L50_M0.7700.95
2_L32_E0.7670.95
77_A100_V0.7650.95
39_V71_A0.7640.95
41_P83_V0.7580.95
36_I56_I0.7570.95
68_Y96_L0.7570.95
81_A104_E0.7490.94
32_E36_I0.7420.94
65_K93_P0.7410.94
28_T113_I0.7410.94
132_H152_V0.7360.94
25_R131_K0.7320.94
98_N108_V0.7300.94
125_T130_P0.7160.93
47_I50_M0.7100.93
23_L27_K0.7010.92
6_I108_V0.6860.91
119_V125_T0.6850.91
26_L30_I0.6770.91
65_K94_F0.6760.91
118_H156_Y0.6730.91
18_G22_A0.6700.90
40_S43_V0.6640.90
116_R149_V0.6630.90
131_K134_K0.6560.90
99_C106_G0.6540.89
26_L56_I0.6520.89
147_D150_A0.6490.89
48_K58_W0.6470.89
51_A54_R0.6440.89
88_A105_L0.6440.89
100_V110_M0.6420.89
76_A99_C0.6390.88
13_V36_I0.6390.88
38_L56_I0.6380.88
117_G149_V0.6340.88
5_H120_T0.6290.88
83_V152_V0.6250.87
75_I107_N0.6210.87
119_V144_I0.6140.86
23_L47_I0.6130.86
13_V73_F0.6120.86
21_I84_N0.6090.86
22_A110_M0.6070.86
136_L140_V0.6030.85
88_A97_V0.6010.85
150_A153_N0.5990.85
153_N157_Q0.5970.85
21_I99_C0.5920.84
84_N102_D0.5890.84
136_L144_I0.5880.84
41_P61_R0.5870.84
59_E67_D0.5870.84
43_V48_K0.5870.84
75_I100_V0.5840.83
144_I151_E0.5830.83
25_R137_A0.5820.83
21_I79_D0.5810.83
21_I100_V0.5800.83
54_R57_K0.5800.83
78_T83_V0.5790.83
139_N144_I0.5780.83
63_I66_E0.5720.82
45_P49_Q0.5710.82
85_K104_E0.5710.82
67_D70_N0.5660.81
26_L36_I0.5620.81
6_I107_N0.5620.81
151_E154_R0.5620.81
154_R157_Q0.5610.81
19_G78_T0.5590.81
2_L5_H0.5580.81
21_I78_T0.5570.80
68_Y94_F0.5550.80
123_V137_A0.5520.80
21_I77_A0.5470.79
130_P159_R0.5450.79
29_V36_I0.5430.79
27_K49_Q0.5410.78
118_H152_V0.5410.78
112_K138_E0.5400.78
118_H149_V0.5390.78
50_M54_R0.5380.78
27_K31_S0.5370.78
74_I87_I0.5360.78
66_E69_L0.5300.77
39_V66_E0.5290.77
4_L110_M0.5290.77
128_A153_N0.5280.77
113_I120_T0.5280.77
101_S137_A0.5270.77
8_L11_K0.5190.76
28_T75_I0.5190.76
32_E120_T0.5180.75
41_P60_K0.5150.75
119_V132_H0.5140.75
148_F151_E0.5110.74
111_P126_S0.5100.74
16_A83_V0.5100.74
25_R130_P0.5090.74
31_S113_I0.5080.74
154_R158_M0.5060.74
129_S134_K0.5040.73
122_S130_P0.5030.73
124_S130_P0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 1 100 0.19 Contact Map
1kyqA 2 1 100 0.211 Contact Map
3dfzA 2 0.9938 100 0.259 Contact Map
4d79A 2 0.9383 98.6 0.791 Contact Map
2g1uA 2 0.784 98.3 0.812 Contact Map
3c85A 2 0.858 97.9 0.828 Contact Map
3d4oA 4 0.858 97.8 0.83 Contact Map
2rirA 4 0.9012 97.8 0.83 Contact Map
1id1A 2 0.8642 97.8 0.832 Contact Map
1lssA 3 0.7593 97.8 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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