YFMJ - BACSU - GREMLIN Contacts

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YFMJ - Putative NADP-dependent oxidoreductase YfmJ

UniProt:	O34812	Sequences: MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLYVSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFSAVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGSTVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDVYFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQGFIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIKVSDPS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	339 (300)
Sequences:	52788 (36800)
Seq/√Len:	2124.6

ECOLI - CURA QOR1 YGGP YBDR YPHC ACUI YDJL ADHP GATD YAHK AHR YCJQ RSPB YJJN FRMA YDJJ TDH IDND
BACSU - YFMJ YOGA YHFP YYCR DHSO BDHA ADHB YJMD ADHA TDH
HALSA - Q9HR85 Q9HP38 Q9HMB6 Q9HQS8 GLCDH
SULSO - ADH Q97ZV3 Q97YT7 Q7LXK1 Q97XR4 Q97WA1 Q97VV5 Q97VW0 Q97V32 Q97YM2 GLCD2 Q97TZ4 GLCD3 GLCD1 Q97VB8 Q97W06 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
314_N	317_D	3.001	1.00
43_L	118_P	2.864	1.00
41_K	77_A	2.814	1.00
43_L	75_V	2.732	1.00
39_L	77_A	2.666	1.00
167_K	193_D	2.610	1.00
38_V	109_L	2.608	1.00
148_T	172_R	2.532	1.00
310_E	321_G	2.407	1.00
117_A	120_S	2.402	1.00
90_D	111_K	2.400	1.00
91_I	112_I	2.385	1.00
87_K	90_D	2.329	1.00
207_A	210_N	2.329	1.00
172_R	194_E	2.316	1.00
41_K	75_V	2.232	1.00
30_V	101_F	2.184	1.00
41_K	101_F	2.167	1.00
71_L	97_S	2.110	1.00
295_E	299_A	2.088	1.00
183_I	187_K	2.088	1.00
119_A	309_T	2.073	1.00
149_V	166_A	2.068	1.00
144_K	147_E	2.055	1.00
85_H	106_E	2.054	1.00
311_G	314_N	2.042	1.00
138_L	169_K	2.017	1.00
163_G	192_F	1.989	1.00
34_K	37_E	1.987	1.00
35_Q	81_S	1.987	1.00
36_G	82_D	1.981	1.00
308_I	321_G	1.975	1.00
184_D	189_E	1.955	1.00
309_T	334_K	1.942	1.00
35_Q	82_D	1.914	1.00
32_E	78_E	1.882	1.00
320_L	324_K	1.867	1.00
115_S	298_K	1.862	1.00
93_I	96_L	1.849	1.00
91_I	118_P	1.843	1.00
147_E	240_R	1.834	1.00
201_A	207_A	1.804	1.00
130_G	161_T	1.798	1.00
150_V	176_I	1.787	1.00
39_L	103_A	1.770	1.00
150_V	216_V	1.764	1.00
180_D	184_D	1.760	1.00
77_A	101_F	1.758	1.00
56_Q	323_F	1.757	1.00
138_L	292_Q	1.757	1.00
317_D	320_L	1.754	1.00
15_Q	26_E	1.724	1.00
310_E	318_A	1.720	1.00
184_D	187_K	1.710	1.00
217_D	236_N	1.708	1.00
174_V	216_V	1.705	1.00
183_I	195_A	1.700	1.00
80_V	83_G	1.657	1.00
112_I	118_P	1.651	1.00
177_A	183_I	1.642	1.00
317_D	321_G	1.634	1.00
321_G	326_E	1.633	1.00
235_L	241_I	1.624	1.00
168_I	301_K	1.622	1.00
72_S	118_P	1.597	1.00
240_R	273_L	1.597	1.00
194_E	211_A	1.592	1.00
152_S	231_V	1.574	1.00
185_Y	189_E	1.572	1.00
86_L	111_K	1.561	1.00
180_D	197_N	1.558	1.00
112_I	121_A	1.526	1.00
197_N	200_T	1.524	1.00
33_P	103_A	1.523	1.00
79_V	88_K	1.515	1.00
141_G	218_V	1.509	1.00
37_E	105_S	1.501	1.00
203_D	206_K	1.495	1.00
119_A	334_K	1.495	1.00
235_L	272_S	1.479	1.00
163_G	175_G	1.479	1.00
240_R	275_Q	1.475	1.00
98_W	319_F	1.471	1.00
78_E	88_K	1.470	1.00
39_L	101_F	1.465	1.00
180_D	200_T	1.452	1.00
42_T	71_L	1.447	1.00
235_L	239_A	1.431	1.00
178_G	198_Y	1.429	1.00
71_L	94_G	1.423	1.00
91_I	114_T	1.416	1.00
307_T	321_G	1.404	1.00
33_P	39_L	1.402	1.00
36_G	105_S	1.394	1.00
75_V	91_I	1.383	1.00
37_E	103_A	1.374	1.00
86_L	90_D	1.364	1.00
219_Y	231_V	1.358	1.00
316_P	320_L	1.340	1.00
76_I	86_L	1.321	1.00
219_Y	235_L	1.314	1.00
155_A	175_G	1.304	1.00
172_R	193_D	1.301	1.00
206_K	210_N	1.295	1.00
39_L	78_E	1.285	1.00
44_Y	334_K	1.279	1.00
38_V	86_L	1.278	1.00
148_T	174_V	1.263	1.00
75_V	118_P	1.263	1.00
55_M	319_F	1.261	1.00
44_Y	119_A	1.247	1.00
18_P	22_D	1.234	1.00
162_V	220_F	1.233	1.00
295_E	298_K	1.227	1.00
152_S	176_I	1.224	1.00
134_Y	138_L	1.213	1.00
168_I	296_W	1.207	1.00
143_P	171_A	1.192	1.00
86_L	109_L	1.183	1.00
33_P	37_E	1.162	1.00
30_V	39_L	1.152	1.00
18_P	24_R	1.150	1.00
155_A	177_A	1.146	1.00
148_T	217_D	1.138	1.00
43_L	91_I	1.135	1.00
183_I	197_N	1.130	1.00
187_K	195_A	1.128	1.00
187_K	194_E	1.103	1.00
141_G	242_P	1.100	1.00
164_Q	303_H	1.097	1.00
175_G	192_F	1.095	1.00
42_T	102_S	1.094	1.00
36_G	106_E	1.093	1.00
77_A	88_K	1.090	1.00
315_I	333_I	1.086	1.00
292_Q	295_E	1.078	1.00
207_A	211_A	1.064	1.00
15_Q	24_R	1.061	1.00
47_V	318_A	1.055	1.00
147_E	217_D	1.055	1.00
104_V	109_L	1.051	1.00
120_S	303_H	1.049	1.00
180_D	183_I	1.042	1.00
25_F	313_E	1.041	1.00
40_V	74_G	1.040	1.00
178_G	199_K	1.040	1.00
296_W	301_K	1.029	1.00
19_V	22_D	1.029	1.00
179_S	197_N	1.026	1.00
140_I	273_L	1.025	1.00
133_A	165_I	1.023	1.00
55_M	323_F	1.020	1.00
138_L	289_G	1.018	1.00
200_T	207_A	1.009	1.00
311_G	334_K	1.008	1.00
135_F	289_G	1.004	1.00
40_V	92_V	1.002	1.00
185_Y	328_K	0.995	1.00
291_K	295_E	0.994	1.00
233_N	266_K	0.994	1.00
212_C	215_G	0.992	1.00
143_P	147_E	0.990	1.00
44_Y	118_P	0.985	1.00
98_W	315_I	0.977	1.00
133_A	162_V	0.973	1.00
48_D	70_A	0.970	1.00
267_L	274_M	0.965	1.00
223_V	227_I	0.954	1.00
136_G	244_C	0.953	1.00
321_G	331_Q	0.952	1.00
205_Q	233_N	0.951	1.00
221_D	224_G	0.951	1.00
45_V	98_W	0.946	1.00
44_Y	332_L	0.946	1.00
203_D	207_A	0.945	1.00
48_D	69_K	0.944	1.00
174_V	194_E	0.937	1.00
30_V	78_E	0.937	1.00
166_A	171_A	0.934	1.00
130_G	293_L	0.925	1.00
45_V	97_S	0.925	1.00
178_G	183_I	0.920	1.00
163_G	173_V	0.917	1.00
79_V	83_G	0.909	1.00
151_V	162_V	0.909	1.00
176_I	198_Y	0.905	1.00
320_L	323_F	0.897	1.00
84_N	106_E	0.890	1.00
177_A	195_A	0.889	1.00
229_D	233_N	0.887	1.00
83_G	106_E	0.886	1.00
151_V	166_A	0.883	1.00
52_R	322_L	0.882	1.00
41_K	100_E	0.881	1.00
98_W	333_I	0.881	1.00
152_S	219_Y	0.881	1.00
32_E	39_L	0.879	1.00
46_S	70_A	0.878	1.00
205_Q	230_A	0.877	1.00
165_I	293_L	0.875	1.00
134_Y	292_Q	0.872	1.00
87_K	111_K	0.866	1.00
230_A	233_N	0.866	1.00
150_V	234_L	0.864	1.00
208_L	216_V	0.864	1.00
189_E	303_H	0.859	1.00
18_P	26_E	0.857	1.00
160_S	185_Y	0.851	1.00
126_L	297_L	0.851	1.00
181_E	184_D	0.848	1.00
174_V	196_I	0.842	1.00
36_G	80_V	0.842	1.00
30_V	77_A	0.839	1.00
71_L	102_S	0.835	1.00
175_G	186_L	0.835	1.00
322_L	331_Q	0.832	1.00
205_Q	209_Q	0.830	1.00
148_T	216_V	0.826	1.00
25_F	312_F	0.815	1.00
136_G	220_F	0.815	1.00
147_E	218_V	0.812	1.00
43_L	72_S	0.810	1.00
288_E	292_Q	0.810	1.00
186_L	192_F	0.809	1.00
238_F	271_K	0.807	1.00
47_V	322_L	0.804	1.00
114_T	298_K	0.801	1.00
182_K	328_K	0.796	1.00
36_G	81_S	0.796	1.00
48_D	51_M	0.793	1.00
133_A	158_V	0.792	1.00
292_Q	296_W	0.790	1.00
266_K	270_T	0.787	1.00
165_I	296_W	0.785	1.00
131_L	289_G	0.783	1.00
136_G	162_V	0.781	1.00
137_L	166_A	0.778	1.00
28_I	66_A	0.777	1.00
155_A	186_L	0.770	1.00
179_S	182_K	0.769	1.00
34_K	103_A	0.769	1.00
33_P	80_V	0.766	1.00
133_A	161_T	0.765	1.00
174_V	208_L	0.763	1.00
143_P	218_V	0.761	1.00
174_V	211_A	0.758	1.00
206_K	209_Q	0.757	1.00
120_S	305_E	0.756	1.00
116_L	121_A	0.755	1.00
113_D	298_K	0.750	1.00
267_L	272_S	0.750	1.00
205_Q	234_L	0.748	1.00
47_V	98_W	0.746	1.00
38_V	106_E	0.746	1.00
310_E	314_N	0.744	1.00
140_I	275_Q	0.744	1.00
138_L	165_I	0.743	1.00
296_W	300_G	0.742	1.00
169_K	292_Q	0.739	1.00
33_P	78_E	0.737	1.00
204_I	230_A	0.737	1.00
166_A	173_V	0.733	1.00
327_N	331_Q	0.733	1.00
135_F	271_K	0.733	1.00
14_P	22_D	0.733	1.00
231_V	241_I	0.731	1.00
308_I	317_D	0.731	1.00
173_V	193_D	0.730	1.00
296_W	299_A	0.729	1.00
79_V	87_K	0.727	1.00
200_T	203_D	0.726	1.00
203_D	230_A	0.725	1.00
93_I	294_A	0.725	1.00
149_V	171_A	0.724	1.00
288_E	291_K	0.722	1.00
219_Y	241_I	0.722	1.00
92_V	109_L	0.721	1.00
267_L	276_G	0.721	1.00
116_L	297_L	0.718	1.00
310_E	333_I	0.717	1.00
70_A	128_M	0.716	1.00
226_P	230_A	0.715	1.00
321_G	324_K	0.714	1.00
50_Y	69_K	0.712	1.00
148_T	214_D	0.712	1.00
222_N	244_C	0.710	1.00
306_E	309_T	0.709	1.00
48_D	128_M	0.708	1.00
110_R	291_K	0.704	1.00
18_P	21_E	0.701	1.00
151_V	175_G	0.696	1.00
142_R	240_R	0.694	1.00
218_V	242_P	0.691	1.00
214_D	236_N	0.690	1.00
216_V	219_Y	0.687	1.00
133_A	137_L	0.687	1.00
91_I	115_S	0.687	1.00
21_E	320_L	0.679	1.00
310_E	331_Q	0.676	1.00
97_S	102_S	0.674	1.00
243_V	274_M	0.668	1.00
49_P	53_G	0.665	1.00
152_S	227_I	0.659	1.00
110_R	290_A	0.658	1.00
110_R	294_A	0.657	1.00
31_P	103_A	0.657	1.00
228_S	241_I	0.655	1.00
69_K	128_M	0.655	1.00
177_A	186_L	0.653	1.00
171_A	218_V	0.653	1.00
208_L	234_L	0.652	1.00
308_I	331_Q	0.651	1.00
132_T	158_V	0.651	1.00
85_H	111_K	0.649	1.00
237_E	270_T	0.648	1.00
38_V	76_I	0.648	1.00
134_Y	296_W	0.647	1.00
183_I	186_L	0.644	1.00
128_M	132_T	0.643	1.00
17_I	63_E	0.641	1.00
194_E	207_A	0.640	1.00
36_G	107_S	0.639	1.00
129_T	157_A	0.638	1.00
16_G	24_R	0.637	1.00
44_Y	309_T	0.635	1.00
142_R	275_Q	0.635	1.00
209_Q	212_C	0.634	1.00
134_Y	293_L	0.633	1.00
85_H	88_K	0.633	1.00
50_Y	54_R	0.632	1.00
48_D	129_T	0.631	1.00
163_G	190_L	0.628	1.00
142_R	273_L	0.628	1.00
183_I	198_Y	0.628	1.00
167_K	173_V	0.627	1.00
177_A	198_Y	0.618	1.00
176_I	196_I	0.615	1.00
185_Y	190_L	0.615	1.00
43_L	334_K	0.614	1.00
61_Y	65_F	0.614	1.00
14_P	18_P	0.614	1.00
165_I	169_K	0.614	1.00
141_G	240_R	0.613	1.00
125_I	332_L	0.612	1.00
216_V	234_L	0.611	1.00
196_I	201_A	0.609	1.00
90_D	114_T	0.608	1.00
163_G	186_L	0.607	1.00
319_F	323_F	0.604	1.00
294_A	298_K	0.604	1.00
185_Y	305_E	0.603	1.00
221_D	241_I	0.602	1.00
25_F	315_I	0.601	1.00
42_T	45_V	0.600	1.00
160_S	305_E	0.600	1.00
155_A	163_G	0.596	1.00
218_V	240_R	0.593	1.00
164_Q	190_L	0.592	1.00
136_G	277_F	0.590	1.00
53_G	58_T	0.589	1.00
162_V	244_C	0.587	1.00
219_Y	234_L	0.587	1.00
134_Y	289_G	0.586	1.00
33_P	82_D	0.586	1.00
132_T	244_C	0.586	1.00
31_P	39_L	0.583	1.00
48_D	330_K	0.583	1.00
117_A	121_A	0.583	1.00
149_V	218_V	0.582	1.00
177_A	197_N	0.582	1.00
221_D	245_G	0.581	1.00
209_Q	215_G	0.581	1.00
93_I	112_I	0.580	1.00
189_E	305_E	0.576	1.00
79_V	90_D	0.576	1.00
52_R	323_F	0.575	1.00
266_K	272_S	0.575	1.00
31_P	101_F	0.574	1.00
196_I	211_A	0.574	1.00
186_L	195_A	0.573	1.00
227_I	231_V	0.573	1.00
14_P	17_I	0.570	1.00
129_T	161_T	0.570	1.00
16_G	22_D	0.569	1.00
266_K	269_K	0.568	1.00
84_N	87_K	0.566	1.00
297_L	304_Y	0.561	1.00
30_V	103_A	0.556	1.00
137_L	165_I	0.555	1.00
167_K	192_F	0.555	1.00
50_Y	53_G	0.554	1.00
174_V	212_C	0.553	1.00
49_P	156_G	0.553	1.00
201_A	204_I	0.552	1.00
20_H	320_L	0.550	1.00
40_V	109_L	0.548	1.00
297_L	302_L	0.548	1.00
321_G	327_N	0.548	1.00
161_T	165_I	0.547	1.00
150_V	219_Y	0.547	1.00
148_T	212_C	0.546	1.00
242_P	277_F	0.546	1.00
30_V	33_P	0.543	1.00
42_T	97_S	0.542	1.00
117_A	309_T	0.542	1.00
155_A	182_K	0.541	1.00
271_K	281_D	0.541	1.00
196_I	207_A	0.540	1.00
177_A	182_K	0.537	1.00
204_I	208_L	0.535	1.00
226_P	229_D	0.534	1.00
61_Y	64_P	0.533	1.00
145_E	169_K	0.532	1.00
64_P	68_D	0.532	1.00
60_S	63_E	0.531	1.00
23_F	319_F	0.528	1.00
33_P	36_G	0.527	1.00
127_G	290_A	0.525	1.00
106_E	109_L	0.525	1.00
29_P	32_E	0.525	1.00
62_V	65_F	0.524	1.00
68_D	98_W	0.523	1.00
125_I	304_Y	0.523	1.00
93_I	110_R	0.521	1.00
134_Y	169_K	0.521	1.00
250_Y	253_E	0.521	1.00
45_V	333_I	0.520	1.00
161_T	302_L	0.519	1.00
146_G	171_A	0.519	1.00
15_Q	18_P	0.516	1.00
86_L	106_E	0.515	1.00
14_P	65_F	0.514	1.00
52_R	56_Q	0.513	1.00
178_G	197_N	0.511	1.00
28_I	100_E	0.510	1.00
145_E	170_G	0.508	1.00
265_S	268_I	0.508	1.00
72_S	112_I	0.507	1.00
196_I	204_I	0.507	1.00
161_T	164_Q	0.506	1.00
310_E	317_D	0.505	1.00
70_A	330_K	0.504	1.00
290_A	294_A	0.504	1.00
181_E	326_E	0.503	1.00
112_I	116_L	0.502	1.00
22_D	316_P	0.501	1.00
268_I	276_G	0.501	1.00
79_V	86_L	0.501	1.00
318_A	333_I	0.500	1.00
47_V	333_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4j6fA	2	0.9292	100	0.193	Contact Map
4gi2A	2	0.9499	100	0.196	Contact Map
3uogA	4	0.9145	100	0.202	Contact Map
4hfmA	2	0.9528	100	0.208	Contact Map
4a27A	2	0.8909	100	0.208	Contact Map
4dupA	2	0.944	100	0.21	Contact Map
1f8fA	4	0.9204	100	0.212	Contact Map
4oaqA	2	0.9292	100	0.214	Contact Map
3qwbA	2	0.944	100	0.216	Contact Map
1rjwA	4	0.9027	100	0.218	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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