GREMLIN Database
YFMJ - Putative NADP-dependent oxidoreductase YfmJ
UniProt: O34812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (300)
Sequences: 52788 (36800)
Seq/√Len: 2124.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_N317_D3.0011.00
43_L118_P2.8641.00
41_K77_A2.8141.00
43_L75_V2.7321.00
39_L77_A2.6661.00
167_K193_D2.6101.00
38_V109_L2.6081.00
148_T172_R2.5321.00
310_E321_G2.4071.00
117_A120_S2.4021.00
90_D111_K2.4001.00
91_I112_I2.3851.00
87_K90_D2.3291.00
207_A210_N2.3291.00
172_R194_E2.3161.00
41_K75_V2.2321.00
30_V101_F2.1841.00
41_K101_F2.1671.00
71_L97_S2.1101.00
295_E299_A2.0881.00
183_I187_K2.0881.00
119_A309_T2.0731.00
149_V166_A2.0681.00
144_K147_E2.0551.00
85_H106_E2.0541.00
311_G314_N2.0421.00
138_L169_K2.0171.00
163_G192_F1.9891.00
34_K37_E1.9871.00
35_Q81_S1.9871.00
36_G82_D1.9811.00
308_I321_G1.9751.00
184_D189_E1.9551.00
309_T334_K1.9421.00
35_Q82_D1.9141.00
32_E78_E1.8821.00
320_L324_K1.8671.00
115_S298_K1.8621.00
93_I96_L1.8491.00
91_I118_P1.8431.00
147_E240_R1.8341.00
201_A207_A1.8041.00
130_G161_T1.7981.00
150_V176_I1.7871.00
39_L103_A1.7701.00
150_V216_V1.7641.00
180_D184_D1.7601.00
77_A101_F1.7581.00
56_Q323_F1.7571.00
138_L292_Q1.7571.00
317_D320_L1.7541.00
15_Q26_E1.7241.00
310_E318_A1.7201.00
184_D187_K1.7101.00
217_D236_N1.7081.00
174_V216_V1.7051.00
183_I195_A1.7001.00
80_V83_G1.6571.00
112_I118_P1.6511.00
177_A183_I1.6421.00
317_D321_G1.6341.00
321_G326_E1.6331.00
235_L241_I1.6241.00
168_I301_K1.6221.00
72_S118_P1.5971.00
240_R273_L1.5971.00
194_E211_A1.5921.00
152_S231_V1.5741.00
185_Y189_E1.5721.00
86_L111_K1.5611.00
180_D197_N1.5581.00
112_I121_A1.5261.00
197_N200_T1.5241.00
33_P103_A1.5231.00
79_V88_K1.5151.00
141_G218_V1.5091.00
37_E105_S1.5011.00
203_D206_K1.4951.00
119_A334_K1.4951.00
235_L272_S1.4791.00
163_G175_G1.4791.00
240_R275_Q1.4751.00
98_W319_F1.4711.00
78_E88_K1.4701.00
39_L101_F1.4651.00
180_D200_T1.4521.00
42_T71_L1.4471.00
235_L239_A1.4311.00
178_G198_Y1.4291.00
71_L94_G1.4231.00
91_I114_T1.4161.00
307_T321_G1.4041.00
33_P39_L1.4021.00
36_G105_S1.3941.00
75_V91_I1.3831.00
37_E103_A1.3741.00
86_L90_D1.3641.00
219_Y231_V1.3581.00
316_P320_L1.3401.00
76_I86_L1.3211.00
219_Y235_L1.3141.00
155_A175_G1.3041.00
172_R193_D1.3011.00
206_K210_N1.2951.00
39_L78_E1.2851.00
44_Y334_K1.2791.00
38_V86_L1.2781.00
148_T174_V1.2631.00
75_V118_P1.2631.00
55_M319_F1.2611.00
44_Y119_A1.2471.00
18_P22_D1.2341.00
162_V220_F1.2331.00
295_E298_K1.2271.00
152_S176_I1.2241.00
134_Y138_L1.2131.00
168_I296_W1.2071.00
143_P171_A1.1921.00
86_L109_L1.1831.00
33_P37_E1.1621.00
30_V39_L1.1521.00
18_P24_R1.1501.00
155_A177_A1.1461.00
148_T217_D1.1381.00
43_L91_I1.1351.00
183_I197_N1.1301.00
187_K195_A1.1281.00
187_K194_E1.1031.00
141_G242_P1.1001.00
164_Q303_H1.0971.00
175_G192_F1.0951.00
42_T102_S1.0941.00
36_G106_E1.0931.00
77_A88_K1.0901.00
315_I333_I1.0861.00
292_Q295_E1.0781.00
207_A211_A1.0641.00
15_Q24_R1.0611.00
47_V318_A1.0551.00
147_E217_D1.0551.00
104_V109_L1.0511.00
120_S303_H1.0491.00
180_D183_I1.0421.00
25_F313_E1.0411.00
40_V74_G1.0401.00
178_G199_K1.0401.00
296_W301_K1.0291.00
19_V22_D1.0291.00
179_S197_N1.0261.00
140_I273_L1.0251.00
133_A165_I1.0231.00
55_M323_F1.0201.00
138_L289_G1.0181.00
200_T207_A1.0091.00
311_G334_K1.0081.00
135_F289_G1.0041.00
40_V92_V1.0021.00
185_Y328_K0.9951.00
291_K295_E0.9941.00
233_N266_K0.9941.00
212_C215_G0.9921.00
143_P147_E0.9901.00
44_Y118_P0.9851.00
98_W315_I0.9771.00
133_A162_V0.9731.00
48_D70_A0.9701.00
267_L274_M0.9651.00
223_V227_I0.9541.00
136_G244_C0.9531.00
321_G331_Q0.9521.00
205_Q233_N0.9511.00
221_D224_G0.9511.00
45_V98_W0.9461.00
44_Y332_L0.9461.00
203_D207_A0.9451.00
48_D69_K0.9441.00
174_V194_E0.9371.00
30_V78_E0.9371.00
166_A171_A0.9341.00
130_G293_L0.9251.00
45_V97_S0.9251.00
178_G183_I0.9201.00
163_G173_V0.9171.00
79_V83_G0.9091.00
151_V162_V0.9091.00
176_I198_Y0.9051.00
320_L323_F0.8971.00
84_N106_E0.8901.00
177_A195_A0.8891.00
229_D233_N0.8871.00
83_G106_E0.8861.00
151_V166_A0.8831.00
52_R322_L0.8821.00
41_K100_E0.8811.00
98_W333_I0.8811.00
152_S219_Y0.8811.00
32_E39_L0.8791.00
46_S70_A0.8781.00
205_Q230_A0.8771.00
165_I293_L0.8751.00
134_Y292_Q0.8721.00
87_K111_K0.8661.00
230_A233_N0.8661.00
150_V234_L0.8641.00
208_L216_V0.8641.00
189_E303_H0.8591.00
18_P26_E0.8571.00
160_S185_Y0.8511.00
126_L297_L0.8511.00
181_E184_D0.8481.00
174_V196_I0.8421.00
36_G80_V0.8421.00
30_V77_A0.8391.00
71_L102_S0.8351.00
175_G186_L0.8351.00
322_L331_Q0.8321.00
205_Q209_Q0.8301.00
148_T216_V0.8261.00
25_F312_F0.8151.00
136_G220_F0.8151.00
147_E218_V0.8121.00
43_L72_S0.8101.00
288_E292_Q0.8101.00
186_L192_F0.8091.00
238_F271_K0.8071.00
47_V322_L0.8041.00
114_T298_K0.8011.00
182_K328_K0.7961.00
36_G81_S0.7961.00
48_D51_M0.7931.00
133_A158_V0.7921.00
292_Q296_W0.7901.00
266_K270_T0.7871.00
165_I296_W0.7851.00
131_L289_G0.7831.00
136_G162_V0.7811.00
137_L166_A0.7781.00
28_I66_A0.7771.00
155_A186_L0.7701.00
179_S182_K0.7691.00
34_K103_A0.7691.00
33_P80_V0.7661.00
133_A161_T0.7651.00
174_V208_L0.7631.00
143_P218_V0.7611.00
174_V211_A0.7581.00
206_K209_Q0.7571.00
120_S305_E0.7561.00
116_L121_A0.7551.00
113_D298_K0.7501.00
267_L272_S0.7501.00
205_Q234_L0.7481.00
47_V98_W0.7461.00
38_V106_E0.7461.00
310_E314_N0.7441.00
140_I275_Q0.7441.00
138_L165_I0.7431.00
296_W300_G0.7421.00
169_K292_Q0.7391.00
33_P78_E0.7371.00
204_I230_A0.7371.00
166_A173_V0.7331.00
327_N331_Q0.7331.00
135_F271_K0.7331.00
14_P22_D0.7331.00
231_V241_I0.7311.00
308_I317_D0.7311.00
173_V193_D0.7301.00
296_W299_A0.7291.00
79_V87_K0.7271.00
200_T203_D0.7261.00
203_D230_A0.7251.00
93_I294_A0.7251.00
149_V171_A0.7241.00
288_E291_K0.7221.00
219_Y241_I0.7221.00
92_V109_L0.7211.00
267_L276_G0.7211.00
116_L297_L0.7181.00
310_E333_I0.7171.00
70_A128_M0.7161.00
226_P230_A0.7151.00
321_G324_K0.7141.00
50_Y69_K0.7121.00
148_T214_D0.7121.00
222_N244_C0.7101.00
306_E309_T0.7091.00
48_D128_M0.7081.00
110_R291_K0.7041.00
18_P21_E0.7011.00
151_V175_G0.6961.00
142_R240_R0.6941.00
218_V242_P0.6911.00
214_D236_N0.6901.00
216_V219_Y0.6871.00
133_A137_L0.6871.00
91_I115_S0.6871.00
21_E320_L0.6791.00
310_E331_Q0.6761.00
97_S102_S0.6741.00
243_V274_M0.6681.00
49_P53_G0.6651.00
152_S227_I0.6591.00
110_R290_A0.6581.00
110_R294_A0.6571.00
31_P103_A0.6571.00
228_S241_I0.6551.00
69_K128_M0.6551.00
177_A186_L0.6531.00
171_A218_V0.6531.00
208_L234_L0.6521.00
308_I331_Q0.6511.00
132_T158_V0.6511.00
85_H111_K0.6491.00
237_E270_T0.6481.00
38_V76_I0.6481.00
134_Y296_W0.6471.00
183_I186_L0.6441.00
128_M132_T0.6431.00
17_I63_E0.6411.00
194_E207_A0.6401.00
36_G107_S0.6391.00
129_T157_A0.6381.00
16_G24_R0.6371.00
44_Y309_T0.6351.00
142_R275_Q0.6351.00
209_Q212_C0.6341.00
134_Y293_L0.6331.00
85_H88_K0.6331.00
50_Y54_R0.6321.00
48_D129_T0.6311.00
163_G190_L0.6281.00
142_R273_L0.6281.00
183_I198_Y0.6281.00
167_K173_V0.6271.00
177_A198_Y0.6181.00
176_I196_I0.6151.00
185_Y190_L0.6151.00
43_L334_K0.6141.00
61_Y65_F0.6141.00
14_P18_P0.6141.00
165_I169_K0.6141.00
141_G240_R0.6131.00
125_I332_L0.6121.00
216_V234_L0.6111.00
196_I201_A0.6091.00
90_D114_T0.6081.00
163_G186_L0.6071.00
319_F323_F0.6041.00
294_A298_K0.6041.00
185_Y305_E0.6031.00
221_D241_I0.6021.00
25_F315_I0.6011.00
42_T45_V0.6001.00
160_S305_E0.6001.00
155_A163_G0.5961.00
218_V240_R0.5931.00
164_Q190_L0.5921.00
136_G277_F0.5901.00
53_G58_T0.5891.00
162_V244_C0.5871.00
219_Y234_L0.5871.00
134_Y289_G0.5861.00
33_P82_D0.5861.00
132_T244_C0.5861.00
31_P39_L0.5831.00
48_D330_K0.5831.00
117_A121_A0.5831.00
149_V218_V0.5821.00
177_A197_N0.5821.00
221_D245_G0.5811.00
209_Q215_G0.5811.00
93_I112_I0.5801.00
189_E305_E0.5761.00
79_V90_D0.5761.00
52_R323_F0.5751.00
266_K272_S0.5751.00
31_P101_F0.5741.00
196_I211_A0.5741.00
186_L195_A0.5731.00
227_I231_V0.5731.00
14_P17_I0.5701.00
129_T161_T0.5701.00
16_G22_D0.5691.00
266_K269_K0.5681.00
84_N87_K0.5661.00
297_L304_Y0.5611.00
30_V103_A0.5561.00
137_L165_I0.5551.00
167_K192_F0.5551.00
50_Y53_G0.5541.00
174_V212_C0.5531.00
49_P156_G0.5531.00
201_A204_I0.5521.00
20_H320_L0.5501.00
40_V109_L0.5481.00
297_L302_L0.5481.00
321_G327_N0.5481.00
161_T165_I0.5471.00
150_V219_Y0.5471.00
148_T212_C0.5461.00
242_P277_F0.5461.00
30_V33_P0.5431.00
42_T97_S0.5421.00
117_A309_T0.5421.00
155_A182_K0.5411.00
271_K281_D0.5411.00
196_I207_A0.5401.00
177_A182_K0.5371.00
204_I208_L0.5351.00
226_P229_D0.5341.00
61_Y64_P0.5331.00
145_E169_K0.5321.00
64_P68_D0.5321.00
60_S63_E0.5311.00
23_F319_F0.5281.00
33_P36_G0.5271.00
127_G290_A0.5251.00
106_E109_L0.5251.00
29_P32_E0.5251.00
62_V65_F0.5241.00
68_D98_W0.5231.00
125_I304_Y0.5231.00
93_I110_R0.5211.00
134_Y169_K0.5211.00
250_Y253_E0.5211.00
45_V333_I0.5201.00
161_T302_L0.5191.00
146_G171_A0.5191.00
15_Q18_P0.5161.00
86_L106_E0.5151.00
14_P65_F0.5141.00
52_R56_Q0.5131.00
178_G197_N0.5111.00
28_I100_E0.5101.00
145_E170_G0.5081.00
265_S268_I0.5081.00
72_S112_I0.5071.00
196_I204_I0.5071.00
161_T164_Q0.5061.00
310_E317_D0.5051.00
70_A330_K0.5041.00
290_A294_A0.5041.00
181_E326_E0.5031.00
112_I116_L0.5021.00
22_D316_P0.5011.00
268_I276_G0.5011.00
79_V86_L0.5011.00
318_A333_I0.5001.00
47_V333_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j6fA 2 0.9292 100 0.193 Contact Map
4gi2A 2 0.9499 100 0.196 Contact Map
3uogA 4 0.9145 100 0.202 Contact Map
4hfmA 2 0.9528 100 0.208 Contact Map
4a27A 2 0.8909 100 0.208 Contact Map
4dupA 2 0.944 100 0.21 Contact Map
1f8fA 4 0.9204 100 0.212 Contact Map
4oaqA 2 0.9292 100 0.214 Contact Map
3qwbA 2 0.944 100 0.216 Contact Map
1rjwA 4 0.9027 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.