GREMLIN Database
YTWI - UPF0756 membrane protein YtwI
UniProt: O34811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (141)
Sequences: 407 (226)
Seq/√Len: 19.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_V136_L3.2190.99
39_L45_P2.9460.99
9_L68_A2.9310.99
121_T125_V2.8770.99
124_A138_G2.8120.99
10_I14_A2.6910.98
102_N144_L2.5490.97
21_N125_V2.4810.97
67_I123_L2.4670.97
21_N97_A2.3810.96
94_I123_L2.3370.95
7_L11_L2.3110.95
99_I108_E2.2060.94
88_I145_A2.1870.93
14_A18_I2.1720.93
102_N143_Y2.0480.91
97_A121_T1.9870.89
82_R146_M1.8400.85
96_V137_I1.8150.84
100_A137_I1.6950.80
90_L124_A1.6560.78
97_A125_V1.6400.78
13_L29_S1.6090.76
6_N32_L1.5520.74
46_T54_W1.5180.72
132_A143_Y1.5140.72
21_N121_T1.4750.70
33_I37_V1.4710.69
125_V137_I1.4640.69
87_W91_G1.4580.69
39_L43_L1.4510.68
96_V125_V1.4130.66
13_L105_T1.4080.66
83_S94_I1.3440.62
84_S129_G1.3430.62
13_L113_I1.3310.61
96_V121_T1.3170.61
53_N143_Y1.3070.60
56_V96_V1.3050.60
98_L101_K1.2900.59
31_L69_T1.2830.59
93_G138_G1.2710.58
101_K113_I1.2640.57
44_F65_V1.2630.57
10_I17_L1.2610.57
27_A73_G1.2600.57
118_V122_I1.2600.57
63_V139_A1.2590.57
21_N56_V1.2580.57
59_I114_T1.2470.56
21_N137_I1.2460.56
6_N129_G1.2320.55
24_L60_T1.2230.55
63_V136_L1.1790.52
12_L139_A1.1710.52
28_V64_L1.1630.51
29_S33_I1.1320.49
35_K68_A1.1310.49
23_S67_I1.1190.48
121_T137_I1.1060.47
20_K118_V1.0920.47
44_F81_M1.0840.46
100_A131_V1.0800.46
39_L136_L1.0740.45
40_D104_L1.0690.45
16_A24_L1.0670.45
47_I61_I1.0600.45
29_S61_I1.0530.44
90_L131_V1.0470.44
81_M90_L1.0380.43
21_N96_V1.0340.43
19_A24_L1.0130.42
126_A131_V1.0070.41
31_L63_V0.9940.40
102_N138_G0.9900.40
91_G95_A0.9870.40
13_L28_V0.9780.39
47_I119_I0.9660.39
10_I32_L0.9540.38
34_I146_M0.9440.37
123_L127_L0.9430.37
93_G111_P0.9430.37
20_K33_I0.9370.37
65_V69_T0.9270.36
101_K108_E0.9180.36
67_I127_L0.9180.36
36_I68_A0.9130.36
60_T140_G0.9080.35
9_L101_K0.8970.35
77_L145_A0.8960.35
87_W132_A0.8790.34
36_I40_D0.8750.33
19_A122_I0.8720.33
30_V47_I0.8620.33
25_L33_I0.8580.33
27_A36_I0.8570.32
100_A126_A0.8560.32
29_S47_I0.8530.32
43_L119_I0.8500.32
29_S113_I0.8400.32
13_L49_S0.8400.32
26_F119_I0.8340.31
34_I44_F0.8320.31
81_M131_V0.8310.31
118_V132_A0.8280.31
44_F119_I0.8280.31
99_I124_A0.8250.31
31_L100_A0.8230.31
56_V100_A0.8220.31
64_L118_V0.8030.30
12_L141_I0.7920.29
26_F30_V0.7920.29
23_S137_I0.7900.29
13_L32_L0.7900.29
15_I18_I0.7880.29
97_A104_L0.7850.29
57_T129_G0.7850.29
51_G89_A0.7790.28
96_V100_A0.7750.28
88_I142_A0.7740.28
35_K51_G0.7740.28
18_I46_T0.7650.28
119_I127_L0.7620.27
22_Q81_M0.7520.27
106_L109_N0.7510.27
67_I115_T0.7490.27
18_I91_G0.7480.27
100_A125_V0.7460.27
16_A52_I0.7450.27
6_N38_G0.7390.26
43_L83_S0.7380.26
21_N100_A0.7330.26
14_A33_I0.7270.26
18_I117_L0.7260.26
27_A107_L0.7220.25
100_A121_T0.7090.25
94_I104_L0.7080.25
142_A146_M0.7050.25
17_L25_L0.7030.25
93_G124_A0.6970.24
19_A109_N0.6970.24
34_I57_T0.6820.24
24_L84_S0.6790.23
85_Y91_G0.6770.23
44_F89_A0.6760.23
51_G117_L0.6750.23
47_I71_E0.6710.23
7_L65_V0.6700.23
97_A100_A0.6680.23
43_L47_I0.6670.23
11_L70_G0.6630.23
63_V99_I0.6580.23
11_L46_T0.6570.22
19_A110_D0.6560.22
27_A72_I0.6500.22
58_I107_L0.6450.22
30_V61_I0.6390.22
48_Q53_N0.6290.21
82_R113_I0.6270.21
47_I65_V0.6200.21
83_S86_A0.6160.21
18_I37_V0.6150.21
124_A142_A0.6070.20
19_A46_T0.5960.20
60_T117_L0.5930.20
102_N131_V0.5920.20
25_L59_I0.5890.20
60_T139_A0.5870.20
107_L112_H0.5850.19
81_M144_L0.5850.19
18_I129_G0.5850.19
31_L133_V0.5830.19
56_V137_I0.5820.19
50_K76_Q0.5800.19
16_A106_L0.5800.19
116_A132_A0.5740.19
52_I56_V0.5660.19
73_G87_W0.5660.19
23_S96_V0.5610.19
33_I81_M0.5590.18
54_W63_V0.5510.18
8_F50_K0.5490.18
45_P123_L0.5490.18
8_F87_W0.5480.18
50_K53_N0.5470.18
53_N125_V0.5440.18
20_K104_L0.5440.18
97_A133_V0.5430.18
123_L128_F0.5400.18
46_T83_S0.5380.18
44_F61_I0.5370.18
22_Q41_Q0.5360.18
36_I57_T0.5290.17
99_I105_T0.5270.17
33_I119_I0.5250.17
73_G76_Q0.5240.17
9_L35_K0.5230.17
56_V97_A0.5230.17
23_S64_L0.5210.17
119_I126_A0.5160.17
28_V49_S0.5150.17
131_V137_I0.5140.17
19_A146_M0.5120.17
29_S49_S0.5110.17
33_I82_R0.5080.17
34_I47_I0.5080.17
12_L113_I0.5070.17
93_G125_V0.5060.17
27_A38_G0.5030.16
8_F64_L0.5020.16
44_F146_M0.5000.16
59_I118_V0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9uB 2 0.6883 22.9 0.942 Contact Map
4o93B 1 0.8052 21.4 0.943 Contact Map
2qi9A 2 0.7597 4.5 0.958 Contact Map
2nq2A 2 0.6558 3.9 0.959 Contact Map
4bemA 3 0.487 3.4 0.961 Contact Map
1wu0A 1 0.4675 3 0.962 Contact Map
1a91A 1 0.474 3 0.962 Contact Map
1i5pA 1 0.526 2.5 0.963 Contact Map
4u9nA 2 0.8961 2.4 0.963 Contact Map
2jlnA 1 0.8636 2.4 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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