GREMLIN Database
UXAC - Uronate isomerase
UniProt: O34808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 473 (445)
Sequences: 1200 (869)
Seq/√Len: 41.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_K120_E4.0371.00
259_D270_D3.4771.00
82_E124_S3.2941.00
39_K43_E3.1281.00
157_D181_P3.0031.00
48_Q52_E2.9561.00
124_S128_K2.9011.00
116_E122_S2.8911.00
213_T216_E2.8891.00
432_I452_V2.8471.00
44_N140_G2.8441.00
229_H234_R2.8271.00
89_A118_L2.8211.00
87_A90_K2.7881.00
49_N81_D2.7541.00
252_E273_K2.7081.00
116_E125_A2.6881.00
454_G458_D2.6561.00
86_M124_S2.6451.00
151_K461_K2.6181.00
68_N404_R2.5361.00
386_K440_E2.5211.00
305_T334_N2.4981.00
110_R422_E2.4721.00
249_T252_E2.3991.00
114_I126_I2.3891.00
129_Q133_L2.2961.00
82_E86_M2.2851.00
197_P261_L2.2791.00
390_L430_N2.2791.00
266_V271_E2.2561.00
215_D250_K2.2281.00
34_C418_Y2.2181.00
167_L231_A2.1951.00
229_H291_W2.1740.99
201_Q261_L2.1690.99
167_L171_E2.1670.99
74_Y87_A2.1650.99
15_T437_E2.1370.99
361_M364_S2.1070.99
109_Q115_Y2.1070.99
169_L179_V2.0920.99
165_Y168_L2.0890.99
146_V176_P2.0620.99
12_K430_N2.0400.99
347_L358_I2.0130.99
227_F231_A1.9960.99
18_S443_R1.9960.99
114_I129_Q1.9880.99
319_S364_S1.9710.99
18_S22_N1.9700.99
121_K446_E1.9240.99
154_C235_V1.9130.99
42_Y168_L1.9080.99
44_N142_R1.8820.98
73_T78_D1.8810.98
226_R289_L1.8460.98
154_C182_G1.8340.98
346_I406_I1.8220.98
88_W100_L1.8150.98
431_L435_W1.8100.98
119_N122_S1.7650.98
111_F148_S1.7530.98
27_M458_D1.7380.97
14_E17_V1.7360.97
225_V286_Y1.7320.97
235_V292_A1.7250.97
330_Y361_M1.7000.97
200_V217_F1.6840.97
52_E81_D1.6800.97
284_G339_K1.6660.97
285_L288_E1.6640.97
92_V104_T1.6580.97
94_M454_G1.6530.97
453_Q458_D1.6290.96
254_G257_F1.6260.96
269_E273_K1.6230.96
183_F221_L1.6160.96
154_C180_L1.6110.96
222_E288_E1.6110.96
23_Y453_Q1.6080.96
204_E210_S1.6070.96
182_G235_V1.5960.96
359_A399_V1.5950.96
30_I151_K1.5890.96
212_T216_E1.5890.96
92_V95_A1.5890.96
46_T137_E1.5820.96
128_K132_K1.5730.95
215_D254_G1.5720.95
95_A401_L1.5710.95
204_E207_A1.5690.95
267_S270_D1.5610.95
218_L281_F1.5600.95
371_P404_R1.5510.95
222_E285_L1.5360.95
306_K337_E1.5350.95
44_N137_E1.5310.95
152_V180_L1.5240.94
192_N275_K1.5200.94
209_I223_K1.5180.94
39_K165_Y1.5110.94
307_M317_Y1.4910.94
132_K136_G1.4780.94
393_M431_L1.4740.93
145_I177_V1.4520.93
97_G435_W1.4510.93
13_N434_E1.4500.93
298_N349_S1.4420.93
225_V285_L1.4380.93
67_A399_V1.4320.92
299_A350_L1.4230.92
253_A277_Y1.4200.92
145_I148_S1.4180.92
82_E128_K1.4170.92
160_V206_A1.4100.92
160_V207_A1.3990.91
214_Y277_Y1.3970.91
284_G341_Q1.3960.91
80_P83_E1.3940.91
329_L333_L1.3890.91
86_M120_E1.3870.91
40_E45_K1.3810.91
26_D453_Q1.3760.91
73_T79_A1.3630.90
280_Q335_S1.3500.90
185_P238_H1.3480.90
217_F274_F1.3470.90
27_M453_Q1.3390.90
256_I273_K1.3380.90
145_I175_F1.3270.89
116_E126_I1.3250.89
46_T141_A1.3240.89
71_E74_Y1.3210.89
122_S125_A1.3190.89
34_C145_I1.3190.89
68_N91_T1.3170.89
43_E168_L1.3140.89
151_K457_Y1.3140.89
281_F285_L1.3130.89
405_F424_F1.3130.89
334_N338_M1.3120.89
294_Q348_Y1.3070.88
432_I436_V1.3010.88
27_M151_K1.2990.88
203_L221_L1.2960.88
192_N271_E1.2930.88
278_T282_L1.2850.88
145_I153_V1.2800.87
139_F144_L1.2760.87
116_E129_Q1.2720.87
44_N146_V1.2700.87
225_V289_L1.2680.87
285_L289_L1.2660.87
333_L374_I1.2650.87
145_I418_Y1.2560.86
34_C153_V1.2500.86
213_T254_G1.2410.86
457_Y461_K1.2410.86
42_Y169_L1.2400.86
347_L374_I1.2400.86
46_T140_G1.2300.85
434_E438_N1.2260.85
385_T398_N1.2260.85
326_A357_V1.2260.85
104_T118_L1.2250.85
70_I91_T1.2090.84
18_S445_M1.2010.84
214_Y278_T1.2000.84
88_W91_T1.1980.84
20_Y25_K1.1920.83
92_V105_H1.1920.83
187_K314_D1.1880.83
50_I131_N1.1850.83
387_D398_N1.1840.83
67_A362_I1.1810.83
303_T330_Y1.1780.83
15_T436_V1.1780.83
330_Y364_S1.1780.83
248_T253_A1.1750.82
282_L286_Y1.1680.82
305_T338_M1.1670.82
386_K427_I1.1650.82
114_I130_T1.1600.82
379_A382_F1.1550.81
259_D266_V1.1520.81
214_Y253_A1.1520.81
133_L136_G1.1490.81
96_I451_I1.1470.81
125_A129_Q1.1460.81
302_N308_M1.1390.80
211_I216_E1.1380.80
43_E165_Y1.1300.80
133_L139_F1.1290.80
227_F230_S1.1220.79
254_G258_S1.1160.79
195_G198_E1.1150.79
106_L110_R1.1130.79
281_F284_G1.1080.78
108_L126_I1.1070.78
215_D219_K1.1050.78
154_C292_A1.1030.78
302_N314_D1.0920.77
139_F147_K1.0910.77
260_R266_V1.0900.77
287_A341_Q1.0870.77
390_L434_E1.0850.77
54_W107_E1.0850.77
12_K434_E1.0710.76
131_N135_K1.0710.76
64_I100_L1.0690.76
169_L175_F1.0660.76
331_K334_N1.0640.76
170_K231_A1.0590.75
82_E123_G1.0570.75
142_R173_K1.0540.75
386_K390_L1.0500.75
77_G84_K1.0440.74
167_L227_F1.0430.74
191_I260_R1.0400.74
393_M402_F1.0390.74
51_T81_D1.0380.74
12_K438_N1.0380.74
93_P120_E1.0340.73
297_I325_I1.0310.73
209_I219_K1.0270.73
50_I130_T1.0260.73
246_A269_E1.0240.73
386_K438_N1.0200.72
451_I454_G1.0190.72
44_N143_D1.0150.72
246_A273_K1.0090.72
402_F406_I1.0010.71
226_R230_S1.0000.71
138_G147_K0.9960.71
180_L235_V0.9890.70
183_F203_L0.9840.70
106_L422_E0.9840.70
349_S376_F0.9830.70
27_M30_I0.9820.69
41_I179_V0.9800.69
197_P201_Q0.9790.69
68_N401_L0.9770.69
198_E201_Q0.9760.69
15_T433_G0.9700.69
118_L122_S0.9690.68
188_G221_L0.9670.68
88_W92_V0.9610.68
216_E219_K0.9610.68
304_N369_I0.9590.68
175_F179_V0.9560.67
284_G336_V0.9530.67
36_L153_V0.9500.67
208_A223_K0.9460.67
247_E335_S0.9450.66
13_N430_N0.9440.66
160_V202_A0.9440.66
218_L285_L0.9340.66
92_V403_S0.9280.65
108_L114_I0.9260.65
460_A464_F0.9190.64
336_V341_Q0.9180.64
303_T319_S0.9180.64
259_D264_T0.9160.64
222_E284_G0.9160.64
187_K313_P0.9070.63
207_A223_K0.9060.63
183_F225_V0.9040.63
389_M393_M0.9000.63
222_E226_R0.8990.63
330_Y334_N0.8990.63
15_T443_R0.8980.62
66_R369_I0.8930.62
140_G143_D0.8910.62
246_A272_K0.8880.62
129_Q132_K0.8870.62
279_L295_F0.8820.61
298_N364_S0.8800.61
24_A452_V0.8790.61
113_G133_L0.8770.61
196_F217_F0.8760.61
295_F345_T0.8730.60
45_K56_Y0.8700.60
73_T310_R0.8700.60
319_S361_M0.8690.60
274_F278_T0.8670.60
64_I95_A0.8640.59
307_M310_R0.8630.59
344_K465_Q0.8630.59
396_L400_G0.8630.59
390_L394_K0.8620.59
164_E168_L0.8590.59
79_A84_K0.8590.59
100_L104_T0.8570.59
117_I442_P0.8560.59
402_F432_I0.8550.59
52_E56_Y0.8550.59
201_Q205_D0.8550.59
117_I441_V0.8540.59
24_A456_C0.8520.58
88_W95_A0.8510.58
182_G292_A0.8510.58
142_R175_F0.8500.58
211_I257_F0.8420.57
34_C148_S0.8420.57
78_D84_K0.8390.57
51_T84_K0.8380.57
30_I461_K0.8360.57
428_V455_I0.8360.57
189_L278_T0.8320.57
248_T277_Y0.8320.57
89_A126_I0.8310.56
144_L415_F0.8310.56
245_F276_T0.8290.56
66_R304_N0.8280.56
402_F428_V0.8280.56
24_A429_C0.8270.56
201_Q210_S0.8260.56
148_S418_Y0.8230.56
387_D394_K0.8230.56
241_D327_K0.8220.56
41_I169_L0.8210.56
362_I374_I0.8180.55
159_P187_K0.8130.55
51_T55_L0.8130.55
303_T364_S0.8090.54
110_R419_T0.8040.54
441_V447_L0.8040.54
204_E261_L0.8040.54
391_D394_K0.8020.54
96_I432_I0.7980.53
168_L171_E0.7980.53
332_L336_V0.7960.53
13_N16_A0.7950.53
89_A122_S0.7940.53
397_S435_W0.7860.52
280_Q284_G0.7840.52
96_I436_V0.7840.52
104_T122_S0.7840.52
118_L126_I0.7800.52
242_T272_K0.7780.52
82_E120_E0.7780.52
244_V276_T0.7750.51
256_I266_V0.7740.51
391_D395_A0.7730.51
55_L84_K0.7710.51
197_P260_R0.7700.51
67_A359_A0.7700.51
158_D187_K0.7690.51
347_L362_I0.7680.51
214_Y257_F0.7680.51
258_S261_L0.7670.51
30_I457_Y0.7670.51
189_L282_L0.7670.51
202_A205_D0.7650.50
307_M315_T0.7650.50
143_D147_K0.7630.50
133_L137_E0.7620.50
243_M332_L0.7580.50
200_V261_L0.7570.50
456_C460_A0.7540.49
346_I463_Y0.7540.49
450_S454_G0.7540.49
95_A385_T0.7530.49
96_I441_V0.7510.49
324_E327_K0.7500.49
148_S419_T0.7500.49
101_Y105_H0.7480.49
88_W104_T0.7450.49
287_A339_K0.7450.49
222_E289_L0.7430.48
250_K254_G0.7420.48
66_R317_Y0.7390.48
358_I383_N0.7380.48
136_G139_F0.7370.48
349_S364_S0.7350.48
37_S40_E0.7330.47
50_I56_Y0.7320.47
152_V182_G0.7280.47
255_R259_D0.7250.47
333_L347_L0.7250.47
253_A257_F0.7240.47
225_V229_H0.7200.46
97_G394_K0.7180.46
387_D391_D0.7180.46
182_G379_A0.7170.46
210_S216_E0.7140.46
49_N52_E0.7140.46
45_K52_E0.7120.45
300_L331_K0.7110.45
137_E140_G0.7100.45
61_K100_L0.7070.45
18_S194_E0.7060.45
390_L427_I0.7030.45
378_T409_L0.7030.45
378_T406_I0.7020.45
436_V445_M0.7010.44
324_E328_P0.7000.44
305_T309_K0.6990.44
67_A317_Y0.6980.44
89_A116_E0.6930.44
143_D146_V0.6910.44
159_P235_V0.6890.43
122_S129_Q0.6880.43
217_F282_L0.6880.43
225_V282_L0.6880.43
383_N397_S0.6870.43
236_S291_W0.6860.43
311_L314_D0.6860.43
258_S262_Q0.6850.43
243_M329_L0.6840.43
76_T84_K0.6840.43
97_G293_M0.6830.43
152_V178_S0.6820.43
226_R229_H0.6810.43
300_L327_K0.6790.42
42_Y165_Y0.6780.42
304_N317_Y0.6760.42
82_E127_W0.6760.42
326_A364_S0.6750.42
217_F278_T0.6740.42
458_D462_H0.6730.42
429_C460_A0.6710.42
326_A361_M0.6710.42
201_Q204_E0.6700.42
249_T273_K0.6670.41
25_K168_L0.6660.41
146_V177_V0.6660.41
222_E281_F0.6650.41
300_L326_A0.6640.41
196_F274_F0.6640.41
97_G397_S0.6640.41
89_A104_T0.6630.41
144_L419_T0.6630.41
217_F257_F0.6630.41
283_C336_V0.6620.41
68_N371_P0.6620.41
432_I451_I0.6610.41
324_E353_N0.6600.41
110_R148_S0.6590.41
376_F379_A0.6590.41
215_D258_S0.6590.41
79_A83_E0.6580.41
196_F200_V0.6580.41
367_D370_T0.6580.41
86_M123_G0.6550.40
20_Y422_E0.6540.40
102_N427_I0.6520.40
74_Y83_E0.6500.40
436_V441_V0.6500.40
304_N337_E0.6500.40
127_W435_W0.6500.40
27_M457_Y0.6480.40
319_S326_A0.6480.40
304_N338_M0.6480.40
49_N131_N0.6480.40
205_D223_K0.6470.40
283_C295_F0.6450.39
308_M313_P0.6440.39
247_E328_P0.6440.39
153_V305_T0.6430.39
224_R227_F0.6410.39
290_D465_Q0.6410.39
335_S338_M0.6380.39
348_Y378_T0.6380.39
241_D275_K0.6380.39
191_I256_I0.6380.39
162_S331_K0.6360.39
157_D182_G0.6350.38
245_F248_T0.6350.38
157_D161_D0.6350.38
121_K125_A0.6350.38
13_N437_E0.6340.38
314_D415_F0.6320.38
317_Y369_I0.6310.38
430_N438_N0.6300.38
250_K281_F0.6290.38
245_F335_S0.6280.38
59_H156_T0.6260.38
246_A276_T0.6250.38
64_I67_A0.6240.38
134_L143_D0.6240.38
207_A210_S0.6240.38
214_Y281_F0.6230.37
225_V291_W0.6220.37
182_G349_S0.6220.37
270_D273_K0.6190.37
253_A273_K0.6190.37
190_E275_K0.6190.37
379_A385_T0.6180.37
219_K223_K0.6180.37
17_V434_E0.6180.37
424_F428_V0.6170.37
86_M90_K0.6160.37
124_S130_T0.6160.37
248_T273_K0.6150.37
117_I447_L0.6150.37
50_I82_E0.6150.37
19_L24_A0.6140.37
359_A362_I0.6140.37
349_S383_N0.6130.37
82_E122_S0.6120.36
20_Y109_Q0.6120.36
91_T100_L0.6110.36
441_V451_I0.6100.36
32_Y463_Y0.6100.36
83_E164_E0.6070.36
200_V257_F0.6060.36
385_T403_S0.6050.36
252_E255_R0.6050.36
52_E131_N0.6030.36
244_V272_K0.6020.36
190_E193_R0.6020.36
87_A120_E0.6020.36
311_L315_T0.6000.35
200_V260_R0.6000.35
62_W72_E0.5990.35
256_I274_F0.5990.35
243_M333_L0.5990.35
344_K375_Q0.5980.35
188_G199_W0.5980.35
301_R314_D0.5970.35
359_A376_F0.5970.35
279_L332_L0.5950.35
247_E331_K0.5950.35
119_N450_S0.5940.35
283_C332_L0.5940.35
53_A416_L0.5940.35
349_S358_I0.5930.35
229_H235_V0.5930.35
14_E18_S0.5920.35
204_E211_I0.5910.35
117_I444_D0.5900.35
252_E256_I0.5900.35
433_G437_E0.5900.35
197_P207_A0.5890.35
66_R72_E0.5870.34
158_D199_W0.5860.34
363_N399_V0.5850.34
317_Y337_E0.5850.34
266_V270_D0.5850.34
142_R174_D0.5840.34
190_E239_A0.5820.34
22_N445_M0.5810.34
78_D210_S0.5810.34
393_M397_S0.5800.34
284_G335_S0.5780.34
218_L222_E0.5780.34
376_F396_L0.5780.34
151_K458_D0.5760.33
167_L170_K0.5760.33
51_T56_Y0.5750.33
391_D398_N0.5750.33
283_C293_M0.5740.33
162_S165_Y0.5730.33
283_C341_Q0.5730.33
78_D83_E0.5730.33
200_V206_A0.5720.33
23_Y27_M0.5710.33
329_L347_L0.5710.33
161_D202_A0.5700.33
287_A340_N0.5700.33
19_L452_V0.5700.33
235_V348_Y0.5680.33
191_I274_F0.5670.33
202_A206_A0.5660.33
218_L278_T0.5660.33
26_D149_N0.5640.32
133_L149_N0.5640.32
43_E164_E0.5630.32
126_I129_Q0.5630.32
36_L322_D0.5620.32
160_V217_F0.5620.32
359_A364_S0.5610.32
389_M427_I0.5610.32
225_V371_P0.5610.32
204_E216_E0.5590.32
293_M435_W0.5590.32
263_G334_N0.5590.32
325_I328_P0.5570.32
148_S153_V0.5570.32
86_M128_K0.5550.32
268_C272_K0.5550.32
325_I357_V0.5540.32
84_K344_K0.5530.32
289_L398_N0.5530.32
288_E341_Q0.5520.31
394_K397_S0.5520.31
56_Y84_K0.5500.31
21_H24_A0.5500.31
361_M376_F0.5490.31
197_P200_V0.5490.31
152_V465_Q0.5490.31
193_R302_N0.5480.31
63_R421_H0.5470.31
393_M424_F0.5470.31
348_Y409_L0.5470.31
338_M369_I0.5470.31
427_I430_N0.5450.31
205_D406_I0.5440.31
196_F257_F0.5440.31
104_T108_L0.5440.31
239_A313_P0.5430.31
379_A392_Q0.5420.31
253_A256_I0.5410.31
145_I456_C0.5410.31
21_H25_K0.5370.30
187_K195_G0.5370.30
91_T404_R0.5350.30
197_P263_G0.5340.30
212_T261_L0.5340.30
192_N266_V0.5340.30
342_L350_L0.5330.30
428_V454_G0.5330.30
153_V179_V0.5330.30
49_N127_W0.5330.30
349_S361_M0.5320.30
292_A435_W0.5310.30
209_I216_E0.5310.30
104_T392_Q0.5300.30
225_V260_R0.5300.30
198_E260_R0.5280.30
62_W66_R0.5270.30
136_G143_D0.5270.30
30_I187_K0.5270.30
152_V235_V0.5260.29
392_Q396_L0.5260.29
154_C431_L0.5260.29
182_G225_V0.5250.29
320_M352_P0.5220.29
300_L330_Y0.5210.29
169_L173_K0.5190.29
202_A443_R0.5180.29
66_R338_M0.5170.29
295_F328_P0.5170.29
47_F53_A0.5160.29
182_G406_I0.5160.29
141_A283_C0.5160.29
383_N435_W0.5160.29
138_G143_D0.5160.29
236_S239_A0.5150.29
247_E277_Y0.5150.29
379_A460_A0.5150.29
430_N434_E0.5140.29
218_L290_D0.5140.29
46_T138_G0.5130.28
120_E124_S0.5130.28
168_L259_D0.5130.28
145_I415_F0.5130.28
306_K310_R0.5120.28
158_D206_A0.5110.28
219_K222_E0.5110.28
38_P165_Y0.5100.28
50_I127_W0.5100.28
13_N17_V0.5090.28
281_F289_L0.5080.28
86_M119_N0.5080.28
79_A87_A0.5060.28
135_K198_E0.5060.28
229_H289_L0.5050.28
317_Y399_V0.5030.28
32_Y349_S0.5030.28
401_L441_V0.5020.28
379_A396_L0.5020.28
145_I419_T0.5010.28
142_R177_V0.5010.28
462_H465_Q0.5000.27
264_T270_D0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iacA 3 0.9852 100 0.15 Contact Map
2q01A 3 0.9725 100 0.239 Contact Map
1j5sA 3 0.9471 100 0.261 Contact Map
4i6vA 3 0.8901 100 0.389 Contact Map
2qeeA 5 0.8499 100 0.416 Contact Map
2qpxA 3 0.7653 100 0.648 Contact Map
3irsA 3 0.5539 97.3 0.964 Contact Map
4l6dA 4 0.6004 96.4 0.968 Contact Map
4mupA 1 0.5455 96.2 0.969 Contact Map
3nurA 2 0.5666 95.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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