GREMLIN Database
YVRC - Uncharacterized ABC transporter substrate-binding lipoprotein YvrC
UniProt: O34805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (269)
Sequences: 14394 (11246)
Seq/√Len: 685.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_E171_D3.8621.00
161_G170_A3.8611.00
154_Y178_K3.8081.00
249_N274_N3.7991.00
166_A169_K3.3821.00
180_D301_E3.1351.00
44_D50_D2.9871.00
274_N278_H2.9661.00
162_E167_E2.9591.00
62_S68_T2.8051.00
158_E174_V2.8021.00
222_L227_A2.5411.00
169_K172_Q2.5281.00
182_K186_E2.4831.00
42_T50_D2.4141.00
175_K179_S2.4071.00
108_K111_S2.4061.00
171_D175_K2.3861.00
244_A247_K2.3091.00
61_V109_V2.1221.00
45_D51_V2.1061.00
198_S228_K2.0861.00
178_K182_K2.0041.00
60_I164_G2.0031.00
59_K81_V2.0021.00
219_N223_N1.9891.00
71_T164_G1.9791.00
265_E279_H1.9461.00
76_L166_A1.9381.00
76_L164_G1.9091.00
179_S183_D1.8981.00
262_K266_K1.8481.00
183_D187_K1.8241.00
70_I157_I1.8241.00
133_Q136_D1.8221.00
77_G80_V1.7981.00
251_D274_N1.7621.00
252_A282_Y1.7211.00
118_L160_I1.7201.00
273_I276_V1.7041.00
152_E155_K1.7021.00
40_P52_T1.6971.00
252_A280_R1.6921.00
131_I135_K1.6851.00
172_Q176_S1.6671.00
42_T52_T1.6561.00
274_N277_K1.6061.00
182_K185_Q1.6031.00
180_D298_E1.5921.00
82_G112_L1.5741.00
176_S180_D1.5731.00
168_K172_Q1.5621.00
169_K173_L1.5221.00
155_K159_M1.5081.00
155_K158_E1.4861.00
262_K265_E1.4831.00
272_E277_K1.4741.00
41_V162_E1.4641.00
87_D90_P1.4591.00
76_L80_V1.4531.00
105_N108_K1.4491.00
97_E108_K1.4451.00
132_K136_D1.4321.00
154_Y174_V1.4241.00
61_V112_L1.4221.00
104_V109_V1.4021.00
282_Y306_S1.3931.00
91_K94_K1.3921.00
110_I137_A1.3641.00
128_A132_K1.3611.00
132_K135_K1.3491.00
72_Y93_V1.3481.00
81_V112_L1.3461.00
62_S71_T1.3261.00
142_L159_M1.3141.00
167_E171_D1.3101.00
196_E228_K1.3061.00
199_V227_A1.2991.00
186_E189_K1.2951.00
242_D267_R1.2851.00
142_L163_A1.2781.00
175_K178_K1.2751.00
244_A248_L1.2741.00
270_W276_V1.2681.00
173_L176_S1.2651.00
208_D239_Q1.2631.00
253_I275_A1.2571.00
181_L300_V1.2511.00
127_S130_A1.2471.00
180_D183_D1.2381.00
61_V82_G1.2291.00
158_E178_K1.2261.00
71_T76_L1.2251.00
74_L166_A1.2151.00
58_K115_D1.2081.00
179_S182_K1.1911.00
106_V133_Q1.1841.00
184_I300_V1.1811.00
168_K171_D1.1801.00
107_E243_E1.1701.00
198_S251_D1.1671.00
233_D248_L1.1631.00
174_V178_K1.1531.00
86_N90_P1.1511.00
230_A248_L1.1501.00
159_M162_E1.1481.00
183_D186_E1.1481.00
185_Q224_V1.1481.00
230_A233_D1.1471.00
14_A17_M1.1461.00
57_P115_D1.1411.00
119_A143_T1.1391.00
59_K113_K1.1351.00
157_I170_A1.1331.00
231_A248_L1.1331.00
116_L142_L1.1251.00
197_K252_A1.1181.00
53_I56_E1.1091.00
72_Y77_G1.1091.00
200_F211_T1.0971.00
197_K280_R1.0901.00
73_A173_L1.0651.00
90_P93_V1.0591.00
45_D131_I1.0501.00
263_A266_K1.0361.00
60_I116_L1.0331.00
176_S179_S1.0281.00
188_A191_I1.0281.00
202_E267_R1.0221.00
130_A133_Q1.0221.00
214_K223_N1.0191.00
148_Q151_S1.0171.00
228_K232_A1.0111.00
40_P55_K1.0051.00
40_P56_E1.0011.00
181_L185_Q0.9951.00
201_I222_L0.9911.00
185_Q189_K0.9851.00
71_T80_V0.9701.00
80_V96_V0.9691.00
255_T283_D0.9671.00
268_D271_S0.9621.00
180_D184_I0.9601.00
71_T118_L0.9531.00
254_V303_L0.9491.00
231_A234_Q0.9451.00
184_I304_A0.9351.00
188_A304_A0.9341.00
270_W273_I0.9321.00
85_T98_K0.9311.00
72_Y80_V0.9281.00
87_D91_K0.9241.00
220_E223_N0.9201.00
160_I164_G0.9191.00
161_G174_V0.9141.00
53_I140_T0.9131.00
220_E224_V0.9111.00
69_E295_R0.9111.00
301_E305_E0.9101.00
183_D301_E0.9081.00
302_E305_E0.8991.00
158_E162_E0.8971.00
40_P54_K0.8941.00
83_V98_K0.8921.00
199_V222_L0.8901.00
74_L173_L0.8891.00
274_N280_R0.8881.00
117_V138_G0.8821.00
83_V96_V0.8811.00
144_V159_M0.8751.00
231_A244_A0.8721.00
70_I160_I0.8601.00
121_E145_N0.8591.00
56_E166_A0.8591.00
84_T87_D0.8581.00
265_E281_V0.8551.00
14_A18_L0.8501.00
170_A174_V0.8451.00
39_F55_K0.8441.00
72_Y92_E0.8441.00
159_M163_A0.8411.00
156_S159_M0.8411.00
177_M181_L0.8381.00
55_K58_K0.8341.00
45_D50_D0.8341.00
171_D174_V0.8311.00
47_S135_K0.8251.00
229_N233_D0.8231.00
63_L117_V0.8221.00
271_S276_V0.8221.00
204_S207_P0.8201.00
201_I256_T0.8191.00
53_I57_P0.8181.00
47_S143_T0.8181.00
64_M120_H0.8141.00
135_K141_V0.8141.00
295_R298_E0.8131.00
177_M224_V0.8121.00
118_L163_A0.8101.00
56_E165_G0.8091.00
57_P116_L0.8071.00
149_S152_E0.8061.00
60_I71_T0.8051.00
16_V19_A0.8021.00
276_V281_V0.8011.00
255_T281_V0.8011.00
62_S80_V0.7971.00
45_D48_N0.7971.00
221_M300_V0.7971.00
74_L164_G0.7951.00
114_P117_V0.7921.00
187_K304_A0.7901.00
285_D302_E0.7881.00
116_L163_A0.7831.00
89_Y93_V0.7801.00
191_I196_E0.7801.00
154_Y158_E0.7781.00
67_N118_L0.7781.00
245_I273_I0.7771.00
86_N89_Y0.7751.00
15_A18_L0.7721.00
172_Q175_K0.7721.00
109_V134_L0.7711.00
151_S155_K0.7651.00
198_S202_E0.7611.00
200_F245_I0.7611.00
240_M248_L0.7581.00
291_R296_L0.7581.00
140_T143_T0.7581.00
97_E100_G0.7571.00
88_T92_E0.7561.00
293_G297_I0.7541.00
181_L224_V0.7521.00
302_E306_S0.7511.00
39_F165_G0.7501.00
173_L177_M0.7501.00
254_V282_Y0.7481.00
41_V53_I0.7451.00
69_E293_G0.7431.00
292_S297_I0.7431.00
74_L169_K0.7381.00
258_G261_A0.7381.00
195_E198_S0.7381.00
39_F56_E0.7371.00
21_C24_P0.7351.00
99_V112_L0.7331.00
212_T237_W0.7281.00
212_T216_T0.7261.00
117_V137_A0.7171.00
129_D132_K0.7151.00
151_S154_Y0.7101.00
299_G302_E0.7101.00
15_A19_A0.7071.00
293_G298_E0.7061.00
246_V273_I0.7011.00
285_D288_L0.7011.00
187_K190_T0.7011.00
191_I195_E0.6991.00
158_E161_G0.6951.00
214_K234_Q0.6941.00
267_R271_S0.6931.00
160_I163_A0.6921.00
241_T244_A0.6901.00
200_F250_P0.6851.00
157_I173_L0.6831.00
246_V272_E0.6821.00
86_N92_E0.6761.00
153_V177_M0.6751.00
246_V250_P0.6741.00
256_T284_V0.6741.00
144_V160_I0.6731.00
67_N144_V0.6721.00
292_S295_R0.6701.00
90_P94_K0.6691.00
75_G169_K0.6641.00
184_I188_A0.6641.00
198_S230_A0.6631.00
77_G92_E0.6631.00
19_A22_G0.6631.00
257_D283_D0.6621.00
196_E200_F0.6601.00
43_I53_I0.6561.00
59_K115_D0.6521.00
211_T231_A0.6501.00
202_E205_P0.6481.00
213_G219_N0.6471.00
17_M20_G0.6471.00
73_A157_I0.6371.00
74_L161_G0.6351.00
74_L157_I0.6341.00
292_S299_G0.6341.00
298_E302_E0.6311.00
87_D92_E0.6301.00
229_N232_A0.6291.00
53_I116_L0.6281.00
61_V114_P0.6261.00
197_K227_A0.6261.00
203_V207_P0.6261.00
154_Y177_M0.6251.00
184_I297_I0.6221.00
82_G100_G0.6191.00
88_T91_K0.6131.00
214_K232_A0.6131.00
74_L170_A0.6121.00
267_R270_W0.6111.00
43_I142_L0.6081.00
164_G167_E0.6071.00
227_A252_A0.6061.00
202_E253_I0.6051.00
180_D297_I0.6041.00
144_V156_S0.6021.00
292_S296_L0.5991.00
291_R294_P0.5971.00
62_S67_N0.5971.00
106_V130_A0.5961.00
154_Y181_L0.5941.00
264_V267_R0.5911.00
100_G104_V0.5901.00
158_E167_E0.5891.00
39_F54_K0.5871.00
199_V254_V0.5841.00
225_I300_V0.5841.00
71_T160_I0.5831.00
75_G166_A0.5831.00
219_N232_A0.5831.00
197_K201_I0.5831.00
135_K140_T0.5821.00
88_T93_V0.5801.00
157_I174_V0.5791.00
64_M67_N0.5781.00
216_T219_N0.5781.00
87_D93_V0.5771.00
77_G95_K0.5771.00
107_E110_I0.5771.00
20_G23_N0.5751.00
151_S178_K0.5711.00
212_T218_M0.5711.00
108_K112_L0.5711.00
177_M180_D0.5671.00
185_Q225_I0.5661.00
253_I270_W0.5641.00
174_V177_M0.5641.00
199_V202_E0.5601.00
61_V81_V0.5601.00
67_N160_I0.5571.00
89_Y92_E0.5571.00
117_V134_L0.5561.00
106_V109_V0.5561.00
51_V142_L0.5551.00
177_M297_I0.5551.00
215_D219_N0.5551.00
96_V100_G0.5541.00
67_N70_I0.5541.00
231_A240_M0.5521.00
53_I163_A0.5491.00
216_T236_G0.5471.00
61_V117_V0.5461.00
110_I243_E0.5451.00
20_G24_P0.5451.00
215_D235_T0.5451.00
57_P164_G0.5431.00
70_I73_A0.5421.00
221_M296_L0.5411.00
154_Y224_V0.5391.00
184_I187_K0.5381.00
41_V55_K0.5381.00
106_V137_A0.5361.00
288_L302_E0.5351.00
214_K233_D0.5351.00
298_E301_E0.5351.00
196_E199_V0.5341.00
249_N275_A0.5341.00
107_E241_T0.5331.00
130_A134_L0.5331.00
153_V157_I0.5321.00
209_I212_T0.5291.00
222_L225_I0.5281.00
184_I225_I0.5281.00
181_L184_I0.5251.00
37_E40_P0.5251.00
210_Y239_Q0.5241.00
200_F253_I0.5221.00
242_D270_W0.5221.00
291_R295_R0.5211.00
36_T39_F0.5190.99
96_V99_V0.5150.99
128_A131_I0.5150.99
187_K301_E0.5150.99
131_I143_T0.5140.99
137_A140_T0.5140.99
264_V268_D0.5140.99
117_V141_V0.5110.99
185_Q188_A0.5110.99
294_P298_E0.5090.99
86_N91_K0.5090.99
93_V96_V0.5090.99
196_E226_H0.5080.99
62_S83_V0.5070.99
89_Y295_R0.5060.99
178_K181_L0.5030.99
202_E207_P0.5030.99
212_T219_N0.5020.99
134_L141_V0.5010.99
225_I304_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.8631 100 0.188 Contact Map
4mlzA 1 0.8662 100 0.216 Contact Map
4hn9A 1 0.8822 100 0.228 Contact Map
4mo9A 1 0.8662 100 0.243 Contact Map
4ovkA 1 0.8535 100 0.249 Contact Map
3pshA 1 0.8567 100 0.252 Contact Map
4ljsA 1 0.9013 100 0.254 Contact Map
4pagA 2 0.8662 100 0.257 Contact Map
4m7oA 1 0.8057 100 0.257 Contact Map
2r79A 5 0.8153 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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