YEAA - BACSU - GREMLIN Contacts

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YEAA - Uncharacterized protein YeaA

UniProt:	O34803	Sequences: MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVNKREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYNEMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVPLAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSACKQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFKIAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	329 (312)
Sequences:	173 (151)
Seq/√Len:	8.6

BACSU - YEAA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_V	241_A	6.702	1.00
103_E	133_K	4.579	0.99
118_S	241_A	3.594	0.96
140_L	271_K	3.548	0.95
307_A	311_A	3.217	0.92
22_T	49_D	3.048	0.90
186_A	192_K	3.036	0.90
257_I	282_Y	3.027	0.90
26_W	193_G	2.968	0.89
225_I	314_A	2.836	0.86
71_N	94_F	2.817	0.86
68_S	71_N	2.783	0.85
261_L	274_N	2.598	0.81
67_F	182_Y	2.598	0.81
12_H	16_I	2.551	0.80
17_Y	56_L	2.535	0.79
317_I	321_A	2.465	0.77
158_N	194_Q	2.353	0.74
191_K	196_L	2.340	0.73
104_M	119_A	2.296	0.72
179_E	182_Y	2.280	0.71
154_T	197_H	2.217	0.69
154_T	194_Q	2.201	0.68
45_K	288_E	2.135	0.66
119_A	310_A	2.128	0.66
317_I	320_T	2.118	0.65
122_L	139_G	2.117	0.65
139_G	163_V	2.080	0.64
65_G	249_P	2.071	0.63
59_Y	94_F	2.068	0.63
239_D	305_I	2.066	0.63
22_T	62_S	2.024	0.61
142_V	166_G	1.980	0.60
194_Q	238_P	1.976	0.59
312_A	316_I	1.969	0.59
146_M	200_S	1.948	0.58
138_M	175_L	1.942	0.58
189_G	196_L	1.940	0.58
160_P	267_F	1.909	0.57
162_A	233_K	1.852	0.54
315_A	319_S	1.845	0.54
55_D	254_V	1.829	0.53
118_S	163_V	1.824	0.53
154_T	158_N	1.820	0.53
206_Q	245_F	1.689	0.47
177_K	214_L	1.683	0.47
70_L	115_T	1.665	0.46
234_D	319_S	1.633	0.45
35_M	267_F	1.628	0.45
182_Y	238_P	1.627	0.45
238_P	260_E	1.619	0.44
118_S	199_V	1.592	0.43
95_Q	263_Q	1.585	0.43
97_F	160_P	1.578	0.43
225_I	244_T	1.542	0.41
164_L	267_F	1.537	0.41
312_A	315_A	1.520	0.40
62_S	148_K	1.510	0.40
143_Y	197_H	1.496	0.39
178_A	197_H	1.492	0.39
146_M	182_Y	1.460	0.38
205_L	320_T	1.454	0.38
70_L	111_R	1.434	0.37
184_L	212_E	1.426	0.37
26_W	308_Q	1.424	0.37
60_I	79_A	1.416	0.36
118_S	218_C	1.409	0.36
142_V	246_L	1.404	0.36
278_A	303_T	1.396	0.35
199_V	218_C	1.395	0.35
91_K	130_T	1.378	0.35
165_L	243_L	1.364	0.34
67_F	150_H	1.361	0.34
316_I	323_S	1.350	0.34
68_S	203_L	1.342	0.33
14_I	170_K	1.339	0.33
182_Y	185_L	1.323	0.33
105_V	115_T	1.322	0.33
94_F	201_H	1.316	0.32
20_L	89_E	1.312	0.32
218_C	241_A	1.310	0.32
40_A	53_F	1.303	0.32
167_E	281_L	1.290	0.31
12_H	42_I	1.290	0.31
37_I	116_Y	1.288	0.31
147_K	318_S	1.278	0.31
310_A	318_S	1.277	0.31
115_T	143_Y	1.264	0.30
60_I	175_L	1.255	0.30
178_A	282_Y	1.254	0.30
319_S	323_S	1.251	0.30
16_I	242_L	1.248	0.30
86_F	324_H	1.239	0.30
321_A	325_T	1.230	0.29
138_M	166_G	1.227	0.29
166_G	169_G	1.225	0.29
62_S	96_T	1.219	0.29
318_S	322_A	1.215	0.29
58_S	217_A	1.212	0.29
136_M	231_K	1.209	0.29
316_I	325_T	1.203	0.28
27_K	227_E	1.203	0.28
9_K	219_K	1.201	0.28
301_I	309_Q	1.198	0.28
143_Y	277_I	1.194	0.28
57_S	79_A	1.194	0.28
150_H	153_L	1.193	0.28
184_L	216_S	1.182	0.28
282_Y	286_H	1.178	0.27
259_D	289_K	1.175	0.27
62_S	317_I	1.166	0.27
229_V	305_I	1.155	0.27
272_E	305_I	1.149	0.27
59_Y	108_G	1.147	0.26
302_E	306_Q	1.147	0.26
226_T	313_T	1.132	0.26
89_E	242_L	1.130	0.26
196_L	237_Y	1.126	0.26
226_T	308_Q	1.119	0.26
36_L	240_L	1.105	0.25
65_G	318_S	1.102	0.25
214_L	240_L	1.100	0.25
116_Y	237_Y	1.084	0.24
310_A	321_A	1.083	0.24
181_C	190_F	1.079	0.24
21_K	321_A	1.077	0.24
56_L	59_Y	1.077	0.24
52_R	119_A	1.072	0.24
150_H	162_A	1.070	0.24
232_T	280_S	1.066	0.24
182_Y	194_Q	1.064	0.24
79_A	301_I	1.061	0.24
82_L	245_F	1.057	0.24
192_K	196_L	1.050	0.23
14_I	172_L	1.047	0.23
57_S	72_S	1.046	0.23
197_H	205_L	1.044	0.23
146_M	162_A	1.041	0.23
14_I	289_K	1.037	0.23
130_T	209_K	1.036	0.23
186_A	189_G	1.029	0.23
122_L	266_A	1.028	0.23
148_K	233_K	1.026	0.23
73_H	227_E	1.026	0.23
50_F	72_S	1.018	0.22
310_A	314_A	1.017	0.22
13_Y	268_K	1.012	0.22
163_V	183_Q	1.011	0.22
138_M	156_T	1.010	0.22
112_D	138_M	1.010	0.22
203_L	214_L	1.002	0.22
33_I	305_I	1.000	0.22
322_A	325_T	0.999	0.22
70_L	282_Y	0.998	0.22
251_I	279_V	0.994	0.22
62_S	91_K	0.992	0.22
115_T	123_L	0.982	0.21
41_Y	46_R	0.980	0.21
42_I	223_Q	0.976	0.21
238_P	320_T	0.970	0.21
42_I	274_N	0.968	0.21
131_N	323_S	0.966	0.21
70_L	270_Q	0.965	0.21
36_L	53_F	0.963	0.21
48_F	184_L	0.961	0.21
79_A	193_G	0.959	0.21
152_F	265_K	0.958	0.21
161_L	179_E	0.958	0.21
64_I	197_H	0.953	0.21
131_N	264_E	0.950	0.20
203_L	253_T	0.950	0.20
70_L	116_Y	0.946	0.20
178_A	200_S	0.945	0.20
77_T	147_K	0.935	0.20
58_S	259_D	0.934	0.20
122_L	319_S	0.932	0.20
306_Q	310_A	0.930	0.20
227_E	324_H	0.921	0.20
43_V	65_G	0.911	0.19
181_C	276_K	0.910	0.19
55_D	324_H	0.909	0.19
56_L	90_A	0.905	0.19
108_G	234_D	0.902	0.19
310_A	317_I	0.902	0.19
15_S	248_E	0.901	0.19
163_V	241_A	0.894	0.19
97_F	182_Y	0.893	0.19
186_A	305_I	0.889	0.19
53_F	163_V	0.889	0.19
15_S	47_E	0.889	0.19
100_V	114_F	0.887	0.19
165_L	178_A	0.884	0.19
247_E	282_Y	0.879	0.19
233_K	299_T	0.879	0.19
223_Q	257_I	0.876	0.19
53_F	83_D	0.875	0.18
146_M	201_H	0.874	0.18
14_I	173_Q	0.873	0.18
144_Q	323_S	0.871	0.18
147_K	310_A	0.871	0.18
55_D	323_S	0.870	0.18
35_M	214_L	0.863	0.18
299_T	307_A	0.862	0.18
147_K	321_A	0.862	0.18
47_E	173_Q	0.861	0.18
105_V	123_L	0.860	0.18
25_K	94_F	0.856	0.18
61_K	197_H	0.856	0.18
89_E	325_T	0.852	0.18
289_K	317_I	0.851	0.18
267_F	295_S	0.851	0.18
232_T	236_H	0.850	0.18
91_K	323_S	0.850	0.18
257_I	304_V	0.850	0.18
27_K	57_S	0.850	0.18
208_E	276_K	0.849	0.18
41_Y	278_A	0.848	0.18
63_N	83_D	0.845	0.18
84_I	175_L	0.845	0.18
116_Y	152_F	0.842	0.18
39_S	262_N	0.839	0.18
148_K	276_K	0.839	0.18
62_S	184_L	0.838	0.18
155_S	201_H	0.835	0.17
204_A	243_L	0.832	0.17
157_Q	291_L	0.832	0.17
90_A	148_K	0.832	0.17
149_N	248_E	0.829	0.17
80_S	223_Q	0.825	0.17
159_V	197_H	0.821	0.17
122_L	198_Q	0.818	0.17
16_I	48_F	0.817	0.17
98_I	252_K	0.816	0.17
246_L	270_Q	0.815	0.17
35_M	39_S	0.815	0.17
10_T	142_V	0.811	0.17
151_Y	164_L	0.797	0.17
150_H	203_L	0.793	0.16
82_L	151_Y	0.793	0.16
236_H	296_G	0.789	0.16
249_P	271_K	0.788	0.16
9_K	284_S	0.788	0.16
153_L	185_L	0.787	0.16
89_E	216_S	0.785	0.16
176_Q	288_E	0.784	0.16
38_S	261_L	0.783	0.16
174_A	246_L	0.777	0.16
68_S	117_L	0.777	0.16
62_S	161_L	0.775	0.16
109_Y	115_T	0.774	0.16
226_T	307_A	0.774	0.16
190_F	196_L	0.773	0.16
50_F	134_E	0.771	0.16
231_K	243_L	0.770	0.16
14_I	251_I	0.768	0.16
26_W	155_S	0.767	0.16
139_G	162_A	0.765	0.16
34_L	246_L	0.761	0.16
98_I	324_H	0.761	0.16
59_Y	63_N	0.759	0.16
63_N	186_A	0.759	0.16
175_L	236_H	0.756	0.16
242_L	306_Q	0.755	0.16
195_Y	254_V	0.752	0.16
147_K	322_A	0.751	0.16
299_T	306_Q	0.750	0.15
183_Q	217_A	0.749	0.15
116_Y	233_K	0.748	0.15
26_W	269_W	0.744	0.15
94_F	212_E	0.739	0.15
197_H	278_A	0.737	0.15
156_T	178_A	0.734	0.15
42_I	254_V	0.733	0.15
72_S	75_R	0.733	0.15
189_G	200_S	0.733	0.15
155_S	316_I	0.732	0.15
196_L	245_F	0.729	0.15
201_H	204_A	0.728	0.15
91_K	133_K	0.728	0.15
48_F	53_F	0.725	0.15
315_A	318_S	0.717	0.15
20_L	136_M	0.717	0.15
119_A	139_G	0.716	0.15
161_L	306_Q	0.716	0.15
184_L	227_E	0.716	0.15
140_L	231_K	0.715	0.15
212_E	220_Q	0.715	0.15
42_I	217_A	0.715	0.15
45_K	242_L	0.714	0.15
38_S	321_A	0.713	0.15
320_T	323_S	0.712	0.15
61_K	297_L	0.710	0.15
63_N	94_F	0.709	0.15
198_Q	201_H	0.707	0.15
281_L	300_A	0.707	0.15
90_A	151_Y	0.705	0.15
119_A	154_T	0.704	0.14
83_D	267_F	0.702	0.14
222_Y	275_F	0.701	0.14
115_T	237_Y	0.701	0.14
169_G	310_A	0.700	0.14
146_M	203_L	0.696	0.14
218_C	305_I	0.696	0.14
175_L	179_E	0.696	0.14
32_Q	75_R	0.695	0.14
27_K	54_Y	0.694	0.14
11_K	65_G	0.693	0.14
116_Y	262_N	0.690	0.14
55_D	148_K	0.690	0.14
45_K	322_A	0.689	0.14
130_T	281_L	0.687	0.14
48_F	280_S	0.685	0.14
229_V	318_S	0.683	0.14
117_L	193_G	0.682	0.14
60_I	277_I	0.680	0.14
214_L	274_N	0.679	0.14
241_A	267_F	0.678	0.14
27_K	157_Q	0.675	0.14
161_L	243_L	0.672	0.14
122_L	237_Y	0.672	0.14
185_L	196_L	0.672	0.14
300_A	306_Q	0.671	0.14
185_L	190_F	0.670	0.14
256_C	290_N	0.668	0.14
118_S	172_L	0.667	0.14
168_N	276_K	0.666	0.14
48_F	266_A	0.665	0.14
80_S	316_I	0.664	0.14
220_Q	248_E	0.664	0.14
161_L	307_A	0.664	0.14
297_L	325_T	0.661	0.14
166_G	179_E	0.661	0.14
143_Y	154_T	0.660	0.14
122_L	199_V	0.659	0.14
130_T	300_A	0.658	0.14
101_Y	166_G	0.658	0.14
220_Q	256_C	0.655	0.13
51_Q	254_V	0.654	0.13
49_D	91_K	0.654	0.13
193_G	295_S	0.645	0.13
101_Y	119_A	0.645	0.13
112_D	237_Y	0.645	0.13
181_C	210_E	0.644	0.13
244_T	314_A	0.643	0.13
152_F	267_F	0.642	0.13
229_V	295_S	0.642	0.13
198_Q	241_A	0.641	0.13
189_G	238_P	0.641	0.13
46_R	108_G	0.640	0.13
225_I	239_D	0.640	0.13
153_L	162_A	0.639	0.13
171_G	248_E	0.638	0.13
97_F	225_I	0.636	0.13
106_K	249_P	0.635	0.13
89_E	92_Q	0.633	0.13
118_S	309_Q	0.633	0.13
233_K	250_D	0.631	0.13
37_I	115_T	0.630	0.13
65_G	265_K	0.623	0.13
179_E	198_Q	0.623	0.13
11_K	128_E	0.622	0.13
63_N	95_Q	0.620	0.13
138_M	158_N	0.620	0.13
114_F	157_Q	0.618	0.13
9_K	300_A	0.617	0.13
135_Q	166_G	0.616	0.13
132_Q	169_G	0.613	0.13
166_G	279_V	0.613	0.13
108_G	272_E	0.609	0.13
70_L	97_F	0.608	0.13
149_N	173_Q	0.608	0.13
115_T	274_N	0.607	0.13
96_T	174_A	0.607	0.13
90_A	142_V	0.606	0.13
72_S	306_Q	0.605	0.13
60_I	248_E	0.604	0.13
306_Q	309_Q	0.603	0.12
147_K	278_A	0.603	0.12
220_Q	250_D	0.603	0.12
215_V	299_T	0.602	0.12
266_A	305_I	0.602	0.12
138_M	231_K	0.602	0.12
21_K	314_A	0.602	0.12
72_S	316_I	0.599	0.12
85_H	202_I	0.599	0.12
80_S	307_A	0.599	0.12
174_A	315_A	0.599	0.12
81_I	297_L	0.599	0.12
75_R	79_A	0.599	0.12
64_I	70_L	0.598	0.12
291_L	300_A	0.597	0.12
139_G	198_Q	0.594	0.12
104_M	273_M	0.593	0.12
223_Q	323_S	0.593	0.12
110_K	233_K	0.590	0.12
203_L	265_K	0.588	0.12
174_A	259_D	0.587	0.12
218_C	240_L	0.587	0.12
184_L	210_E	0.587	0.12
251_I	319_S	0.585	0.12
13_Y	16_I	0.575	0.12
184_L	289_K	0.571	0.12
227_E	239_D	0.568	0.12
185_L	193_G	0.567	0.12
13_Y	274_N	0.567	0.12
259_D	270_Q	0.565	0.12
293_M	297_L	0.564	0.12
69_T	259_D	0.564	0.12
218_C	227_E	0.562	0.12
220_Q	224_S	0.562	0.12
53_F	221_I	0.561	0.12
262_N	292_L	0.559	0.12
85_H	108_G	0.558	0.12
237_Y	302_E	0.558	0.12
50_F	325_T	0.558	0.12
13_Y	83_D	0.557	0.12
13_Y	278_A	0.557	0.12
45_K	119_A	0.556	0.12
206_Q	241_A	0.556	0.12
13_Y	296_G	0.554	0.12
71_N	139_G	0.554	0.12
62_S	244_T	0.554	0.12
44_N	63_N	0.552	0.12
59_Y	301_I	0.552	0.12
260_E	323_S	0.551	0.12
154_T	243_L	0.551	0.12
314_A	318_S	0.550	0.12
213_M	301_I	0.546	0.11
155_S	231_K	0.546	0.11
122_L	306_Q	0.544	0.11
37_I	217_A	0.541	0.11
64_I	282_Y	0.541	0.11
98_I	319_S	0.539	0.11
93_T	123_L	0.538	0.11
292_L	324_H	0.535	0.11
191_K	224_S	0.534	0.11
65_G	244_T	0.534	0.11
223_Q	307_A	0.531	0.11
203_L	307_A	0.531	0.11
254_V	315_A	0.530	0.11
120_L	293_M	0.530	0.11
25_K	42_I	0.528	0.11
186_A	240_L	0.527	0.11
120_L	310_A	0.527	0.11
72_S	160_P	0.527	0.11
237_Y	300_A	0.526	0.11
133_K	136_M	0.524	0.11
146_M	273_M	0.524	0.11
204_A	208_E	0.522	0.11
17_Y	236_H	0.521	0.11
198_Q	267_F	0.520	0.11
296_G	319_S	0.520	0.11
60_I	80_S	0.519	0.11
199_V	283_L	0.519	0.11
64_I	80_S	0.515	0.11
20_L	79_A	0.513	0.11
196_L	269_W	0.513	0.11
11_K	18_A	0.513	0.11
172_L	229_V	0.513	0.11
140_L	144_Q	0.511	0.11
114_F	154_T	0.510	0.11
37_I	270_Q	0.510	0.11
22_T	319_S	0.509	0.11
146_M	150_H	0.509	0.11
142_V	207_S	0.508	0.11
72_S	302_E	0.503	0.11
139_G	244_T	0.502	0.11
157_Q	178_A	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4me2A	1	0.535	90.6	0.948	Contact Map
4pjrA	1	0.5228	84.7	0.953	Contact Map
4m59A	2	0.7568	74.5	0.957	Contact Map
4leuA	1	0.538	49.6	0.964	Contact Map
4xglA	1	0.5623	47.4	0.964	Contact Map
4g26A	1	0.5927	43.4	0.965	Contact Map
3spaA	1	0.614	27.8	0.968	Contact Map
3gn4A	1	0.3495	21.2	0.97	Contact Map
3hymB	3	0.5684	19.6	0.971	Contact Map
4gpkA	3	0.8632	19	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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