GREMLIN Database
YEAA - Uncharacterized protein YeaA
UniProt: O34803 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (312)
Sequences: 173 (151)
Seq/√Len: 8.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_V241_A6.7021.00
103_E133_K4.5790.99
118_S241_A3.5940.96
140_L271_K3.5480.95
307_A311_A3.2170.92
22_T49_D3.0480.90
186_A192_K3.0360.90
257_I282_Y3.0270.90
26_W193_G2.9680.89
225_I314_A2.8360.86
71_N94_F2.8170.86
68_S71_N2.7830.85
261_L274_N2.5980.81
67_F182_Y2.5980.81
12_H16_I2.5510.80
17_Y56_L2.5350.79
317_I321_A2.4650.77
158_N194_Q2.3530.74
191_K196_L2.3400.73
104_M119_A2.2960.72
179_E182_Y2.2800.71
154_T197_H2.2170.69
154_T194_Q2.2010.68
45_K288_E2.1350.66
119_A310_A2.1280.66
317_I320_T2.1180.65
122_L139_G2.1170.65
139_G163_V2.0800.64
65_G249_P2.0710.63
59_Y94_F2.0680.63
239_D305_I2.0660.63
22_T62_S2.0240.61
142_V166_G1.9800.60
194_Q238_P1.9760.59
312_A316_I1.9690.59
146_M200_S1.9480.58
138_M175_L1.9420.58
189_G196_L1.9400.58
160_P267_F1.9090.57
162_A233_K1.8520.54
315_A319_S1.8450.54
55_D254_V1.8290.53
118_S163_V1.8240.53
154_T158_N1.8200.53
206_Q245_F1.6890.47
177_K214_L1.6830.47
70_L115_T1.6650.46
234_D319_S1.6330.45
35_M267_F1.6280.45
182_Y238_P1.6270.45
238_P260_E1.6190.44
118_S199_V1.5920.43
95_Q263_Q1.5850.43
97_F160_P1.5780.43
225_I244_T1.5420.41
164_L267_F1.5370.41
312_A315_A1.5200.40
62_S148_K1.5100.40
143_Y197_H1.4960.39
178_A197_H1.4920.39
146_M182_Y1.4600.38
205_L320_T1.4540.38
70_L111_R1.4340.37
184_L212_E1.4260.37
26_W308_Q1.4240.37
60_I79_A1.4160.36
118_S218_C1.4090.36
142_V246_L1.4040.36
278_A303_T1.3960.35
199_V218_C1.3950.35
91_K130_T1.3780.35
165_L243_L1.3640.34
67_F150_H1.3610.34
316_I323_S1.3500.34
68_S203_L1.3420.33
14_I170_K1.3390.33
182_Y185_L1.3230.33
105_V115_T1.3220.33
94_F201_H1.3160.32
20_L89_E1.3120.32
218_C241_A1.3100.32
40_A53_F1.3030.32
167_E281_L1.2900.31
12_H42_I1.2900.31
37_I116_Y1.2880.31
147_K318_S1.2780.31
310_A318_S1.2770.31
115_T143_Y1.2640.30
60_I175_L1.2550.30
178_A282_Y1.2540.30
319_S323_S1.2510.30
16_I242_L1.2480.30
86_F324_H1.2390.30
321_A325_T1.2300.29
138_M166_G1.2270.29
166_G169_G1.2250.29
62_S96_T1.2190.29
318_S322_A1.2150.29
58_S217_A1.2120.29
136_M231_K1.2090.29
316_I325_T1.2030.28
27_K227_E1.2030.28
9_K219_K1.2010.28
301_I309_Q1.1980.28
143_Y277_I1.1940.28
57_S79_A1.1940.28
150_H153_L1.1930.28
184_L216_S1.1820.28
282_Y286_H1.1780.27
259_D289_K1.1750.27
62_S317_I1.1660.27
229_V305_I1.1550.27
272_E305_I1.1490.27
59_Y108_G1.1470.26
302_E306_Q1.1470.26
226_T313_T1.1320.26
89_E242_L1.1300.26
196_L237_Y1.1260.26
226_T308_Q1.1190.26
36_L240_L1.1050.25
65_G318_S1.1020.25
214_L240_L1.1000.25
116_Y237_Y1.0840.24
310_A321_A1.0830.24
181_C190_F1.0790.24
21_K321_A1.0770.24
56_L59_Y1.0770.24
52_R119_A1.0720.24
150_H162_A1.0700.24
232_T280_S1.0660.24
182_Y194_Q1.0640.24
79_A301_I1.0610.24
82_L245_F1.0570.24
192_K196_L1.0500.23
14_I172_L1.0470.23
57_S72_S1.0460.23
197_H205_L1.0440.23
146_M162_A1.0410.23
14_I289_K1.0370.23
130_T209_K1.0360.23
186_A189_G1.0290.23
122_L266_A1.0280.23
148_K233_K1.0260.23
73_H227_E1.0260.23
50_F72_S1.0180.22
310_A314_A1.0170.22
13_Y268_K1.0120.22
163_V183_Q1.0110.22
138_M156_T1.0100.22
112_D138_M1.0100.22
203_L214_L1.0020.22
33_I305_I1.0000.22
322_A325_T0.9990.22
70_L282_Y0.9980.22
251_I279_V0.9940.22
62_S91_K0.9920.22
115_T123_L0.9820.21
41_Y46_R0.9800.21
42_I223_Q0.9760.21
238_P320_T0.9700.21
42_I274_N0.9680.21
131_N323_S0.9660.21
70_L270_Q0.9650.21
36_L53_F0.9630.21
48_F184_L0.9610.21
79_A193_G0.9590.21
152_F265_K0.9580.21
161_L179_E0.9580.21
64_I197_H0.9530.21
131_N264_E0.9500.20
203_L253_T0.9500.20
70_L116_Y0.9460.20
178_A200_S0.9450.20
77_T147_K0.9350.20
58_S259_D0.9340.20
122_L319_S0.9320.20
306_Q310_A0.9300.20
227_E324_H0.9210.20
43_V65_G0.9110.19
181_C276_K0.9100.19
55_D324_H0.9090.19
56_L90_A0.9050.19
108_G234_D0.9020.19
310_A317_I0.9020.19
15_S248_E0.9010.19
163_V241_A0.8940.19
97_F182_Y0.8930.19
186_A305_I0.8890.19
53_F163_V0.8890.19
15_S47_E0.8890.19
100_V114_F0.8870.19
165_L178_A0.8840.19
247_E282_Y0.8790.19
233_K299_T0.8790.19
223_Q257_I0.8760.19
53_F83_D0.8750.18
146_M201_H0.8740.18
14_I173_Q0.8730.18
144_Q323_S0.8710.18
147_K310_A0.8710.18
55_D323_S0.8700.18
35_M214_L0.8630.18
299_T307_A0.8620.18
147_K321_A0.8620.18
47_E173_Q0.8610.18
105_V123_L0.8600.18
25_K94_F0.8560.18
61_K197_H0.8560.18
89_E325_T0.8520.18
289_K317_I0.8510.18
267_F295_S0.8510.18
232_T236_H0.8500.18
91_K323_S0.8500.18
257_I304_V0.8500.18
27_K57_S0.8500.18
208_E276_K0.8490.18
41_Y278_A0.8480.18
63_N83_D0.8450.18
84_I175_L0.8450.18
116_Y152_F0.8420.18
39_S262_N0.8390.18
148_K276_K0.8390.18
62_S184_L0.8380.18
155_S201_H0.8350.17
204_A243_L0.8320.17
157_Q291_L0.8320.17
90_A148_K0.8320.17
149_N248_E0.8290.17
80_S223_Q0.8250.17
159_V197_H0.8210.17
122_L198_Q0.8180.17
16_I48_F0.8170.17
98_I252_K0.8160.17
246_L270_Q0.8150.17
35_M39_S0.8150.17
10_T142_V0.8110.17
151_Y164_L0.7970.17
150_H203_L0.7930.16
82_L151_Y0.7930.16
236_H296_G0.7890.16
249_P271_K0.7880.16
9_K284_S0.7880.16
153_L185_L0.7870.16
89_E216_S0.7850.16
176_Q288_E0.7840.16
38_S261_L0.7830.16
174_A246_L0.7770.16
68_S117_L0.7770.16
62_S161_L0.7750.16
109_Y115_T0.7740.16
226_T307_A0.7740.16
190_F196_L0.7730.16
50_F134_E0.7710.16
231_K243_L0.7700.16
14_I251_I0.7680.16
26_W155_S0.7670.16
139_G162_A0.7650.16
34_L246_L0.7610.16
98_I324_H0.7610.16
59_Y63_N0.7590.16
63_N186_A0.7590.16
175_L236_H0.7560.16
242_L306_Q0.7550.16
195_Y254_V0.7520.16
147_K322_A0.7510.16
299_T306_Q0.7500.15
183_Q217_A0.7490.15
116_Y233_K0.7480.15
26_W269_W0.7440.15
94_F212_E0.7390.15
197_H278_A0.7370.15
156_T178_A0.7340.15
42_I254_V0.7330.15
72_S75_R0.7330.15
189_G200_S0.7330.15
155_S316_I0.7320.15
196_L245_F0.7290.15
201_H204_A0.7280.15
91_K133_K0.7280.15
48_F53_F0.7250.15
315_A318_S0.7170.15
20_L136_M0.7170.15
119_A139_G0.7160.15
161_L306_Q0.7160.15
184_L227_E0.7160.15
140_L231_K0.7150.15
212_E220_Q0.7150.15
42_I217_A0.7150.15
45_K242_L0.7140.15
38_S321_A0.7130.15
320_T323_S0.7120.15
61_K297_L0.7100.15
63_N94_F0.7090.15
198_Q201_H0.7070.15
281_L300_A0.7070.15
90_A151_Y0.7050.15
119_A154_T0.7040.14
83_D267_F0.7020.14
222_Y275_F0.7010.14
115_T237_Y0.7010.14
169_G310_A0.7000.14
146_M203_L0.6960.14
218_C305_I0.6960.14
175_L179_E0.6960.14
32_Q75_R0.6950.14
27_K54_Y0.6940.14
11_K65_G0.6930.14
116_Y262_N0.6900.14
55_D148_K0.6900.14
45_K322_A0.6890.14
130_T281_L0.6870.14
48_F280_S0.6850.14
229_V318_S0.6830.14
117_L193_G0.6820.14
60_I277_I0.6800.14
214_L274_N0.6790.14
241_A267_F0.6780.14
27_K157_Q0.6750.14
161_L243_L0.6720.14
122_L237_Y0.6720.14
185_L196_L0.6720.14
300_A306_Q0.6710.14
185_L190_F0.6700.14
256_C290_N0.6680.14
118_S172_L0.6670.14
168_N276_K0.6660.14
48_F266_A0.6650.14
80_S316_I0.6640.14
220_Q248_E0.6640.14
161_L307_A0.6640.14
297_L325_T0.6610.14
166_G179_E0.6610.14
143_Y154_T0.6600.14
122_L199_V0.6590.14
130_T300_A0.6580.14
101_Y166_G0.6580.14
220_Q256_C0.6550.13
51_Q254_V0.6540.13
49_D91_K0.6540.13
193_G295_S0.6450.13
101_Y119_A0.6450.13
112_D237_Y0.6450.13
181_C210_E0.6440.13
244_T314_A0.6430.13
152_F267_F0.6420.13
229_V295_S0.6420.13
198_Q241_A0.6410.13
189_G238_P0.6410.13
46_R108_G0.6400.13
225_I239_D0.6400.13
153_L162_A0.6390.13
171_G248_E0.6380.13
97_F225_I0.6360.13
106_K249_P0.6350.13
89_E92_Q0.6330.13
118_S309_Q0.6330.13
233_K250_D0.6310.13
37_I115_T0.6300.13
65_G265_K0.6230.13
179_E198_Q0.6230.13
11_K128_E0.6220.13
63_N95_Q0.6200.13
138_M158_N0.6200.13
114_F157_Q0.6180.13
9_K300_A0.6170.13
135_Q166_G0.6160.13
132_Q169_G0.6130.13
166_G279_V0.6130.13
108_G272_E0.6090.13
70_L97_F0.6080.13
149_N173_Q0.6080.13
115_T274_N0.6070.13
96_T174_A0.6070.13
90_A142_V0.6060.13
72_S306_Q0.6050.13
60_I248_E0.6040.13
306_Q309_Q0.6030.12
147_K278_A0.6030.12
220_Q250_D0.6030.12
215_V299_T0.6020.12
266_A305_I0.6020.12
138_M231_K0.6020.12
21_K314_A0.6020.12
72_S316_I0.5990.12
85_H202_I0.5990.12
80_S307_A0.5990.12
174_A315_A0.5990.12
81_I297_L0.5990.12
75_R79_A0.5990.12
64_I70_L0.5980.12
291_L300_A0.5970.12
139_G198_Q0.5940.12
104_M273_M0.5930.12
223_Q323_S0.5930.12
110_K233_K0.5900.12
203_L265_K0.5880.12
174_A259_D0.5870.12
218_C240_L0.5870.12
184_L210_E0.5870.12
251_I319_S0.5850.12
13_Y16_I0.5750.12
184_L289_K0.5710.12
227_E239_D0.5680.12
185_L193_G0.5670.12
13_Y274_N0.5670.12
259_D270_Q0.5650.12
293_M297_L0.5640.12
69_T259_D0.5640.12
218_C227_E0.5620.12
220_Q224_S0.5620.12
53_F221_I0.5610.12
262_N292_L0.5590.12
85_H108_G0.5580.12
237_Y302_E0.5580.12
50_F325_T0.5580.12
13_Y83_D0.5570.12
13_Y278_A0.5570.12
45_K119_A0.5560.12
206_Q241_A0.5560.12
13_Y296_G0.5540.12
71_N139_G0.5540.12
62_S244_T0.5540.12
44_N63_N0.5520.12
59_Y301_I0.5520.12
260_E323_S0.5510.12
154_T243_L0.5510.12
314_A318_S0.5500.12
213_M301_I0.5460.11
155_S231_K0.5460.11
122_L306_Q0.5440.11
37_I217_A0.5410.11
64_I282_Y0.5410.11
98_I319_S0.5390.11
93_T123_L0.5380.11
292_L324_H0.5350.11
191_K224_S0.5340.11
65_G244_T0.5340.11
223_Q307_A0.5310.11
203_L307_A0.5310.11
254_V315_A0.5300.11
120_L293_M0.5300.11
25_K42_I0.5280.11
186_A240_L0.5270.11
120_L310_A0.5270.11
72_S160_P0.5270.11
237_Y300_A0.5260.11
133_K136_M0.5240.11
146_M273_M0.5240.11
204_A208_E0.5220.11
17_Y236_H0.5210.11
198_Q267_F0.5200.11
296_G319_S0.5200.11
60_I80_S0.5190.11
199_V283_L0.5190.11
64_I80_S0.5150.11
20_L79_A0.5130.11
196_L269_W0.5130.11
11_K18_A0.5130.11
172_L229_V0.5130.11
140_L144_Q0.5110.11
114_F154_T0.5100.11
37_I270_Q0.5100.11
22_T319_S0.5090.11
146_M150_H0.5090.11
142_V207_S0.5080.11
72_S302_E0.5030.11
139_G244_T0.5020.11
157_Q178_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4me2A 1 0.535 90.6 0.948 Contact Map
4pjrA 1 0.5228 84.7 0.953 Contact Map
4m59A 2 0.7568 74.5 0.957 Contact Map
4leuA 1 0.538 49.6 0.964 Contact Map
4xglA 1 0.5623 47.4 0.964 Contact Map
4g26A 1 0.5927 43.4 0.965 Contact Map
3spaA 1 0.614 27.8 0.968 Contact Map
3gn4A 1 0.3495 21.2 0.97 Contact Map
3hymB 3 0.5684 19.6 0.971 Contact Map
4gpkA 3 0.8632 19 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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