GREMLIN Database
YTLR - Putative lipid kinase YtlR
UniProt: O34799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 309 (285)
Sequences: 6971 (5172)
Seq/√Len: 306.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_G142_F4.1821.00
275_T297_R3.8021.00
273_D297_R3.6311.00
196_T275_T3.5481.00
129_S299_A3.3411.00
273_D299_A3.3401.00
194_A277_Y3.1481.00
124_T306_R2.9481.00
129_S301_S2.9251.00
66_V76_V2.9211.00
196_T277_Y2.5931.00
42_H45_H2.5001.00
126_H233_K2.4931.00
122_T306_R2.4511.00
271_A274_I2.4471.00
25_Q29_I2.4361.00
241_E267_T2.4181.00
234_T272_K2.3921.00
236_D270_K2.3851.00
234_T270_K2.3251.00
194_A203_E2.2961.00
81_K127_L2.2631.00
128_G235_F2.2351.00
197_T271_A2.2311.00
67_I93_A2.2031.00
146_I298_L2.1481.00
277_Y295_P2.1361.00
63_R87_E2.1181.00
275_T295_P2.0761.00
194_A201_T2.0261.00
87_E122_T1.9821.00
127_L304_P1.9581.00
247_K265_G1.9471.00
123_R231_R1.9181.00
213_S225_A1.8881.00
157_K184_A1.8341.00
147_G285_H1.8291.00
196_T201_T1.7991.00
99_F125_F1.7851.00
109_D112_Q1.7371.00
301_S304_P1.7191.00
27_E115_K1.7111.00
126_H232_E1.6981.00
40_T46_A1.6741.00
73_M90_F1.6721.00
45_H49_L1.6701.00
198_E272_K1.6601.00
207_V239_I1.6491.00
5_F61_L1.6321.00
106_K116_K1.6251.00
237_I271_A1.6181.00
129_S132_F1.6081.00
237_I274_I1.6011.00
44_G75_E1.5961.00
45_H48_V1.5871.00
147_G151_D1.5611.00
103_F307_I1.5541.00
105_I113_E1.5501.00
78_N141_Y1.5131.00
124_T303_S1.4731.00
129_S141_Y1.4591.00
51_R82_D1.4531.00
193_L207_V1.4511.00
81_K141_Y1.4411.00
192_T206_D1.4231.00
40_T75_E1.4211.00
212_V235_F1.3981.00
239_I269_F1.3941.00
153_Y184_A1.3911.00
74_H78_N1.3891.00
254_L263_M1.3721.00
272_K302_P1.3711.00
41_E45_H1.3611.00
74_H140_L1.3591.00
50_A54_S1.3451.00
52_Q59_Y1.3441.00
75_E79_G1.3411.00
5_F38_F1.3381.00
197_T200_E1.3291.00
64_L80_L1.3131.00
77_V143_M1.3011.00
278_T282_I1.2841.00
4_W63_R1.2841.00
244_P247_K1.2711.00
23_S111_I1.2611.00
22_K25_Q1.2611.00
128_G298_L1.2501.00
247_K250_W1.2481.00
50_A79_G1.2461.00
148_I276_F1.2461.00
74_H289_E1.2371.00
48_V52_Q1.2261.00
212_V274_I1.2141.00
48_V51_R1.2131.00
36_R61_L1.2131.00
156_K283_P1.2021.00
235_F300_S1.1841.00
26_K30_K1.1821.00
112_Q115_K1.1781.00
102_G216_P1.1641.00
98_D144_N1.1611.00
54_S83_V1.1571.00
237_I269_F1.1451.00
46_A50_A1.1411.00
130_V298_L1.1271.00
284_F296_F1.1241.00
239_I267_T1.1221.00
4_W65_I1.1161.00
110_L114_I1.1091.00
159_M162_P1.1091.00
99_F144_N1.1081.00
106_K112_Q1.1071.00
8_I39_L1.1061.00
6_F65_I1.0951.00
140_L291_M1.0851.00
142_F146_I1.0841.00
65_I89_S1.0741.00
66_V88_L1.0731.00
127_L141_Y1.0701.00
115_K119_R1.0691.00
199_D273_D1.0671.00
47_E79_G1.0661.00
141_Y301_S1.0651.00
198_E271_A1.0581.00
98_D220_G1.0551.00
192_T203_E1.0521.00
206_D242_N1.0451.00
180_S183_H1.0431.00
212_V298_L1.0371.00
155_N285_H1.0351.00
77_V305_L1.0311.00
85_D124_T1.0251.00
50_A53_I1.0251.00
46_A75_E1.0121.00
150_F154_V1.0111.00
157_K180_S1.0111.00
225_A228_A1.0081.00
232_E236_D1.0071.00
27_E30_K1.0031.00
204_F207_V1.0001.00
281_K293_T0.9961.00
77_V88_L0.9951.00
196_T199_D0.9921.00
156_K290_I0.9901.00
8_I37_S0.9871.00
27_E114_I0.9811.00
130_V286_A0.9781.00
67_I91_V0.9741.00
66_V72_T0.9741.00
99_F103_F0.9731.00
54_S79_G0.9691.00
91_V113_E0.9661.00
144_N215_H0.9651.00
179_L183_H0.9581.00
91_V110_L0.9531.00
238_V268_M0.9531.00
236_D268_M0.9511.00
38_F49_L0.9511.00
180_S184_A0.9501.00
100_S105_I0.9441.00
286_A291_M0.9431.00
42_H75_E0.9401.00
40_T45_H0.9371.00
47_E51_R0.9341.00
145_H211_V0.9301.00
65_I117_V0.9301.00
127_L143_M0.9241.00
130_V146_I0.9231.00
210_A239_I0.9211.00
101_R217_F0.9201.00
98_D219_G0.9181.00
27_E111_I0.9161.00
200_E269_F0.9111.00
197_T269_F0.9081.00
38_F52_Q0.9011.00
283_P290_I0.8981.00
172_L179_L0.8981.00
31_R115_K0.8971.00
85_D306_R0.8961.00
83_V86_I0.8901.00
151_D218_Y0.8841.00
73_M99_F0.8831.00
7_I50_A0.8801.00
87_E306_R0.8671.00
21_W25_Q0.8641.00
125_F230_P0.8591.00
151_D285_H0.8541.00
231_R303_S0.8451.00
90_F99_F0.8451.00
162_P176_V0.8451.00
222_M255_M0.8441.00
145_H213_S0.8431.00
51_R79_G0.8431.00
192_T279_K0.8391.00
55_T59_Y0.8381.00
66_V73_M0.8341.00
106_K113_E0.8301.00
131_N297_R0.8301.00
96_Y177_Y0.8301.00
51_R55_T0.8291.00
8_I17_G0.8281.00
250_W254_L0.8261.00
198_E273_D0.8261.00
131_N299_A0.8251.00
23_S26_K0.8241.00
47_E78_N0.8221.00
51_R83_V0.8201.00
99_F143_M0.8191.00
98_D221_G0.8151.00
218_Y224_A0.8141.00
100_S107_K0.8131.00
55_T83_V0.8131.00
197_T274_I0.8101.00
254_L259_K0.8081.00
112_Q116_K0.8071.00
142_F286_A0.8071.00
228_A236_D0.8051.00
61_L86_I0.8051.00
216_P223_K0.8031.00
163_L172_L0.7971.00
80_L83_V0.7971.00
44_G48_V0.7971.00
29_I35_H0.7951.00
109_D113_E0.7931.00
130_V296_F0.7931.00
157_K183_H0.7891.00
92_P113_E0.7881.00
173_R177_Y0.7881.00
125_F307_I0.7840.99
132_F140_L0.7840.99
158_A176_V0.7840.99
113_E118_K0.7830.99
214_N236_D0.7820.99
253_C257_F0.7820.99
31_R118_K0.7800.99
163_L176_V0.7790.99
278_T294_T0.7770.99
8_I21_W0.7710.99
215_H230_P0.7700.99
199_D202_R0.7610.99
130_V140_L0.7600.99
96_Y151_D0.7590.99
116_K120_P0.7570.99
190_P242_N0.7560.99
54_S86_I0.7560.99
63_R117_V0.7540.99
77_V141_Y0.7480.99
66_V90_F0.7460.99
126_H214_N0.7460.99
188_F208_W0.7410.99
50_A76_V0.7390.99
8_I67_I0.7390.99
105_I116_K0.7370.99
212_V237_I0.7350.99
222_M256_A0.7340.99
68_G72_T0.7300.99
199_D204_F0.7280.99
111_I114_I0.7260.99
22_K26_K0.7260.99
202_R267_T0.7230.99
63_R89_S0.7210.99
147_G211_V0.7190.99
146_I286_A0.7190.99
27_E31_R0.7160.99
193_L278_T0.7150.99
5_F36_R0.7140.99
102_G230_P0.7020.99
252_L260_H0.7010.99
211_V218_Y0.7010.99
284_F293_T0.6970.99
127_L301_S0.6960.99
194_A279_K0.6960.99
156_K160_E0.6950.99
38_F45_H0.6900.99
50_A64_L0.6850.99
7_I76_V0.6850.99
98_D145_H0.6840.99
150_F208_W0.6830.99
176_V180_S0.6810.99
44_G47_E0.6800.99
78_N140_L0.6720.98
29_I32_K0.6710.98
283_P293_T0.6670.98
18_L22_K0.6670.98
111_I115_K0.6660.98
204_F239_I0.6640.98
49_L53_I0.6630.98
110_L113_E0.6600.98
80_L88_L0.6590.98
42_H48_V0.6590.98
184_A188_F0.6580.98
64_L76_V0.6570.98
98_D101_R0.6550.98
103_F230_P0.6520.98
224_A238_V0.6500.98
144_N285_H0.6500.98
148_I210_A0.6480.98
101_R107_K0.6480.98
47_E82_D0.6480.98
40_T79_G0.6460.98
204_F267_T0.6460.98
35_H38_F0.6450.98
89_S116_K0.6430.98
250_W264_D0.6430.98
175_L178_P0.6390.98
102_G215_H0.6390.98
7_I46_A0.6380.98
117_V120_P0.6370.98
74_H141_Y0.6370.98
99_F214_N0.6370.98
213_S236_D0.6340.98
26_K29_I0.6340.98
126_H231_R0.6330.98
259_K262_K0.6320.98
40_T44_G0.6320.98
197_T202_R0.6320.98
95_A144_N0.6300.98
182_L186_A0.6300.98
173_R176_V0.6290.98
10_P40_T0.6280.98
89_S113_E0.6280.98
44_G79_G0.6270.98
171_R175_L0.6260.98
274_I298_L0.6240.98
250_W263_M0.6210.97
98_D102_G0.6200.97
73_M307_I0.6200.97
284_F294_T0.6190.97
155_N159_M0.6150.97
81_K304_P0.6140.97
125_F305_L0.6130.97
281_K294_T0.6120.97
232_E270_K0.6120.97
114_I118_K0.6100.97
144_N155_N0.6100.97
153_Y283_P0.6070.97
89_S117_V0.6060.97
212_V276_F0.6050.97
81_K301_S0.6020.97
89_S118_K0.6010.97
145_H285_H0.6000.97
90_F100_S0.5980.97
96_Y221_G0.5980.97
46_A79_G0.5950.97
245_F248_K0.5950.97
200_E203_E0.5900.97
126_H236_D0.5890.96
116_K119_R0.5870.96
46_A49_L0.5860.96
13_G95_A0.5840.96
98_D155_N0.5830.96
221_G224_A0.5810.96
40_T43_P0.5800.96
152_A285_H0.5790.96
49_L52_Q0.5740.96
227_L261_T0.5740.96
46_A76_V0.5730.96
38_F53_I0.5730.96
195_C276_F0.5720.96
103_F215_H0.5700.96
21_W39_L0.5690.96
209_F213_S0.5690.96
21_W35_H0.5670.96
54_S60_K0.5660.96
183_H187_T0.5610.95
155_N158_A0.5600.95
146_I284_F0.5580.95
194_A202_R0.5570.95
18_L39_L0.5560.95
148_I284_F0.5550.95
80_L86_I0.5550.95
74_H77_V0.5550.95
153_Y156_K0.5540.95
45_H50_A0.5540.95
249_Y257_F0.5540.95
43_P75_E0.5540.95
72_T76_V0.5530.95
148_I282_I0.5510.95
191_F282_I0.5500.95
6_F67_I0.5500.95
62_K87_E0.5490.95
16_N20_V0.5490.95
157_K187_T0.5480.95
42_H46_A0.5480.95
255_M260_H0.5480.95
17_G20_V0.5470.95
162_P172_L0.5460.95
183_H186_A0.5460.95
225_A238_V0.5450.95
250_W253_C0.5450.95
163_L173_R0.5430.95
207_V210_A0.5400.94
77_V81_K0.5390.94
223_K226_P0.5380.94
72_T147_G0.5380.94
5_F62_K0.5380.94
243_Q247_K0.5360.94
243_Q251_L0.5350.94
144_N219_G0.5350.94
127_L305_L0.5320.94
151_D154_V0.5310.94
99_F217_F0.5280.94
158_A172_L0.5270.94
140_L286_A0.5260.94
145_H215_H0.5250.93
290_I293_T0.5240.93
144_N217_F0.5230.93
260_H266_V0.5220.93
238_V260_H0.5210.93
173_R220_G0.5210.93
43_P46_A0.5200.93
98_D285_H0.5200.93
252_L256_A0.5170.93
109_D116_K0.5160.93
247_K251_L0.5160.93
227_L268_M0.5150.93
154_V158_A0.5150.93
28_L114_I0.5140.93
158_A162_P0.5140.93
251_L265_G0.5120.93
177_Y219_G0.5120.93
123_R230_P0.5120.93
203_E206_D0.5110.93
241_E265_G0.5050.92
52_Q55_T0.5040.92
28_L118_K0.5020.92
247_K263_M0.5000.92
41_E44_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v24A 1 0.9579 100 0.171 Contact Map
4werA 2 0.8997 100 0.188 Contact Map
2qv7A 2 0.8997 100 0.194 Contact Map
3s40A 3 0.932 100 0.211 Contact Map
2bonA 1 0.8867 100 0.222 Contact Map
1u0tA 4 0.7573 100 0.577 Contact Map
2an1A 4 0.7799 100 0.585 Contact Map
1z0sA 4 0.7087 100 0.593 Contact Map
1yt5A 4 0.7249 100 0.602 Contact Map
2i2cA 3 0.7605 100 0.607 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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