GREMLIN Database
PDAC - Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
UniProt: O34798 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 467 (401)
Sequences: 298 (267)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_R329_E7.4041.00
298_D325_R6.9921.00
311_V326_M5.6881.00
332_E455_S4.8371.00
305_G441_I4.4501.00
296_I437_A4.2811.00
303_Y445_T3.7310.99
280_I418_A3.6360.99
298_D329_E3.4020.99
310_F372_L3.3530.98
296_I434_A3.3320.98
301_K329_E3.2120.98
400_E403_K3.0230.97
337_S354_Q3.0040.97
288_P428_D2.8920.96
378_G395_W2.6210.93
284_F437_A2.5500.92
351_A384_L2.5470.92
323_L326_M2.5100.92
288_P293_T2.5010.91
303_Y442_K2.3850.89
311_V323_L2.3390.88
306_H331_N2.2700.87
273_V279_V2.2310.86
293_T297_L2.1740.84
282_L300_L2.1520.84
313_G398_D2.1520.84
333_V424_I2.0670.81
293_T428_D2.0520.80
399_P441_I2.0410.80
414_V440_I2.0340.80
359_Q390_M2.0250.80
300_L307_A2.0190.79
438_D442_K2.0050.79
284_F300_L1.9990.79
280_I424_I1.9970.79
297_L300_L1.9680.78
274_D279_V1.9620.77
374_R401_D1.9260.76
401_D425_L1.9000.75
295_Q435_D1.8870.74
285_D336_H1.8820.74
158_I206_I1.8770.74
299_S434_A1.8580.73
415_M443_K1.8560.73
287_G340_H1.8490.73
153_L296_I1.8400.72
343_L377_Y1.8330.72
441_I451_L1.8120.71
282_L297_L1.8050.71
313_G402_W1.7900.70
286_D336_H1.7870.70
406_N409_T1.7760.70
338_W441_I1.7690.69
433_S437_A1.7670.69
338_W357_D1.7550.69
191_K302_K1.7520.69
353_K357_D1.7340.68
218_Y223_G1.7310.68
305_G399_P1.7300.68
411_V415_M1.7260.67
393_A423_T1.7200.67
289_N292_T1.6990.66
326_M333_V1.6370.63
330_G340_H1.6300.63
212_E280_I1.6250.63
308_T454_V1.6070.62
363_E369_R1.5950.61
436_A440_I1.5910.61
372_L455_S1.5890.61
336_H340_H1.5730.60
410_I432_T1.5590.59
309_F374_R1.5390.58
374_R425_L1.5380.58
287_G336_H1.5350.58
111_Y123_I1.5260.58
377_Y444_L1.5220.57
374_R395_W1.5090.57
281_A402_W1.5090.57
385_R394_L1.5070.57
411_V439_E1.5060.56
209_D296_I1.4940.56
418_A422_R1.4400.53
177_L341_P1.4360.53
278_K319_Y1.4360.53
311_V362_I1.4310.53
336_H376_P1.4270.52
230_I233_K1.4080.51
297_L325_R1.4020.51
316_V414_V1.3860.50
350_E354_Q1.3800.50
288_P297_L1.3770.50
285_D340_H1.3760.50
377_Y398_D1.3740.50
299_S441_I1.3600.49
313_G444_L1.3600.49
398_D402_W1.3530.48
374_R427_H1.3460.48
294_N325_R1.3450.48
379_G428_D1.3430.48
398_D401_D1.3320.47
396_D447_Q1.3270.47
344_T379_G1.3250.47
340_H378_G1.3210.47
425_L428_D1.3200.47
315_R438_D1.3170.47
281_A444_L1.3160.46
402_W444_L1.3150.46
274_D334_G1.3130.46
287_G330_G1.3070.46
297_L329_E1.2910.45
287_G378_G1.2840.45
283_T288_P1.2780.44
286_D340_H1.2730.44
332_E402_W1.2550.43
327_L337_S1.2480.43
281_A313_G1.2430.43
401_D427_H1.2420.43
320_P414_V1.2400.42
342_L379_G1.2300.42
334_G371_T1.2210.42
341_P351_A1.2200.41
273_V450_Q1.2100.41
107_L131_I1.2050.41
288_P378_G1.2050.41
293_T425_L1.2010.40
285_D376_P1.2010.40
355_I366_S1.1970.40
161_E164_D1.1970.40
309_F340_H1.1950.40
297_L428_D1.1840.40
437_A451_L1.1680.39
398_D453_T1.1620.39
405_R429_I1.1610.38
309_F401_D1.1610.38
322_T328_K1.1590.38
335_N362_I1.1560.38
419_G422_R1.1550.38
425_L436_A1.1540.38
164_D220_V1.1530.38
444_L449_Y1.1470.38
56_D65_N1.1470.38
410_I437_A1.1420.38
423_T458_E1.1400.37
296_I433_S1.1400.37
426_I433_S1.1320.37
288_P340_H1.1270.37
420_D438_D1.1240.37
283_T293_T1.1230.37
310_F374_R1.1200.36
283_T300_L1.1190.36
282_L307_A1.1190.36
281_A398_D1.1150.36
281_A308_T1.1120.36
375_P398_D1.1120.36
207_K321_E1.1100.36
367_G374_R1.1070.36
286_D376_P1.1010.35
342_L377_Y1.1010.35
398_D433_S1.0960.35
278_K451_L1.0920.35
375_P402_W1.0850.35
213_L242_K1.0780.34
302_K438_D1.0710.34
425_L449_Y1.0660.34
341_P354_Q1.0600.34
300_L340_H1.0600.34
279_V450_Q1.0570.33
57_G61_N1.0570.33
300_L425_L1.0560.33
293_T374_R1.0470.33
375_P394_L1.0410.33
332_E375_P1.0400.33
330_G374_R1.0310.32
281_A452_V1.0300.32
297_L331_N1.0260.32
361_I424_I1.0250.32
287_G310_F1.0210.32
442_K445_T1.0190.32
452_V457_L1.0180.32
335_N358_T1.0180.32
366_S454_V1.0170.32
401_D433_S1.0170.32
338_W361_I1.0170.32
410_I414_V1.0170.32
410_I451_L1.0140.31
283_T425_L1.0130.31
283_T428_D1.0120.31
347_S451_L1.0110.31
305_G454_V1.0060.31
308_T448_G1.0030.31
359_Q415_M0.9960.31
222_A362_I0.9940.30
281_A395_W0.9920.30
295_Q431_R0.9860.30
117_A424_I0.9820.30
377_Y403_K0.9800.30
308_T429_I0.9790.30
288_P425_L0.9760.30
64_V86_V0.9740.30
351_A430_Y0.9720.30
379_G430_Y0.9700.29
338_W358_T0.9690.29
327_L368_Y0.9690.29
155_I204_F0.9680.29
278_K437_A0.9620.29
395_W429_I0.9550.29
300_L309_F0.9540.29
237_L445_T0.9520.29
287_G428_D0.9480.28
404_D409_T0.9460.28
310_F401_D0.9460.28
280_I412_D0.9430.28
265_I268_P0.9400.28
424_I432_T0.9380.28
288_P377_Y0.9370.28
285_D427_H0.9350.28
281_A375_P0.9340.28
307_A367_G0.9330.28
335_N393_A0.9300.28
340_H428_D0.9290.28
395_W401_D0.9250.27
287_G293_T0.9230.27
293_T436_A0.9220.27
312_L355_I0.9220.27
342_L351_A0.9200.27
213_L412_D0.9190.27
340_H374_R0.9190.27
353_K455_S0.9160.27
178_K433_S0.9110.27
158_I358_T0.9100.27
453_T457_L0.9100.27
46_G52_T0.9090.27
56_D61_N0.9070.27
220_V410_I0.9030.27
316_V320_P0.9020.27
335_N455_S0.8970.26
299_S438_D0.8950.26
56_D62_Y0.8950.26
428_D436_A0.8950.26
312_L332_E0.8940.26
151_A155_I0.8930.26
111_Y399_P0.8920.26
432_T454_V0.8920.26
301_K325_R0.8910.26
279_V460_V0.8910.26
173_A306_H0.8910.26
355_I381_N0.8880.26
154_S361_I0.8870.26
111_Y306_H0.8850.26
391_D438_D0.8800.26
313_G375_P0.8800.26
196_P200_N0.8750.25
218_Y226_G0.8720.25
286_D428_D0.8700.25
75_D81_F0.8700.25
303_Y441_I0.8680.25
282_L288_P0.8670.25
111_Y119_Q0.8670.25
381_N395_W0.8670.25
309_F330_G0.8650.25
293_T401_D0.8620.25
287_G376_P0.8620.25
343_L430_Y0.8580.25
156_D423_T0.8560.25
283_T307_A0.8520.25
294_N458_E0.8490.24
309_F425_L0.8470.24
340_H376_P0.8450.24
340_H425_L0.8430.24
386_S400_E0.8400.24
290_P341_P0.8400.24
335_N453_T0.8390.24
354_Q458_E0.8380.24
407_K436_A0.8380.24
422_R451_L0.8350.24
206_I209_D0.8350.24
58_K62_Y0.8300.24
296_I429_I0.8290.24
326_M329_E0.8290.24
418_A443_K0.8270.24
289_N334_G0.8250.23
398_D444_L0.8200.23
56_D89_F0.8190.23
44_Q333_V0.8170.23
270_E433_S0.8160.23
330_G336_H0.8150.23
437_A441_I0.8150.23
90_Q94_K0.8140.23
350_E355_I0.8140.23
285_D288_P0.8130.23
378_G429_I0.8120.23
92_E142_T0.8110.23
287_G401_D0.8110.23
320_P444_L0.8090.23
283_T395_W0.8090.23
292_T441_I0.8020.23
360_D369_R0.8010.23
335_N351_A0.7990.22
395_W428_D0.7970.22
335_N377_Y0.7960.22
349_K396_D0.7940.22
336_H378_G0.7910.22
374_R428_D0.7880.22
366_S456_Q0.7860.22
331_N451_L0.7850.22
292_T320_P0.7840.22
60_F68_V0.7840.22
119_Q412_D0.7830.22
304_K409_T0.7830.22
444_L452_V0.7810.22
177_L426_I0.7790.22
393_A458_E0.7780.22
51_A58_K0.7780.22
96_V290_P0.7730.22
358_T452_V0.7700.21
345_R403_K0.7700.21
295_Q323_L0.7680.21
393_A402_W0.7680.21
277_Q450_Q0.7660.21
369_R441_I0.7620.21
407_K411_V0.7620.21
308_T395_W0.7610.21
63_A67_P0.7600.21
335_N444_L0.7600.21
56_D60_F0.7580.21
44_Q56_D0.7580.21
288_P375_P0.7570.21
300_L436_A0.7510.21
309_F367_G0.7510.21
150_Q207_K0.7510.21
48_V64_V0.7500.21
377_Y402_W0.7500.21
293_T449_Y0.7500.21
300_L449_Y0.7470.21
315_R434_A0.7460.21
283_T378_G0.7440.21
366_S414_V0.7390.20
202_S206_I0.7380.20
377_Y430_Y0.7370.20
428_D444_L0.7370.20
266_S348_V0.7340.20
284_F309_F0.7340.20
294_N437_A0.7320.20
284_F425_L0.7320.20
62_Y65_N0.7320.20
347_S382_D0.7310.20
288_P336_H0.7300.20
126_N449_Y0.7280.20
287_G309_F0.7240.20
419_G433_S0.7240.20
355_I373_V0.7240.20
414_V426_I0.7210.20
220_V313_G0.7190.20
374_R433_S0.7170.20
293_T427_H0.7150.20
330_G378_G0.7140.20
375_P430_Y0.7130.19
84_K304_K0.7120.19
430_Y438_D0.7120.19
431_R435_D0.7110.19
312_L377_Y0.7110.19
232_I395_W0.7090.19
405_R430_Y0.7080.19
423_T454_V0.7060.19
284_F449_Y0.7060.19
283_T309_F0.7060.19
294_N361_I0.7060.19
339_S354_Q0.7040.19
119_Q125_F0.7020.19
404_D410_I0.7020.19
377_Y429_I0.7000.19
361_I365_I0.6990.19
57_G68_V0.6970.19
155_I337_S0.6970.19
82_A168_K0.6920.19
56_D68_V0.6910.19
402_W421_G0.6900.19
237_L389_K0.6890.19
285_D428_D0.6880.19
310_F330_G0.6870.19
436_A441_I0.6870.19
354_Q417_Q0.6860.19
245_Y279_V0.6840.19
292_T434_A0.6800.18
288_P374_R0.6800.18
293_T340_H0.6800.18
213_L324_I0.6770.18
293_T309_F0.6770.18
288_P367_G0.6770.18
132_G424_I0.6760.18
288_P330_G0.6740.18
285_D310_F0.6740.18
378_G428_D0.6720.18
89_F107_L0.6720.18
282_L436_A0.6710.18
441_I445_T0.6710.18
309_F395_W0.6700.18
343_L426_I0.6700.18
167_H397_V0.6690.18
337_S392_V0.6670.18
313_G433_S0.6650.18
194_T201_F0.6640.18
53_L64_V0.6620.18
79_K83_E0.6620.18
220_V232_I0.6610.18
332_E372_L0.6590.18
310_F340_H0.6570.18
428_D449_Y0.6560.18
427_H448_G0.6550.18
288_P395_W0.6530.18
279_V451_L0.6480.17
79_K304_K0.6470.17
377_Y405_R0.6470.17
424_I435_D0.6410.17
71_N75_D0.6410.17
406_N447_Q0.6400.17
45_Y52_T0.6400.17
62_Y68_V0.6380.17
293_T395_W0.6380.17
174_Y178_K0.6370.17
358_T402_W0.6360.17
299_S306_H0.6350.17
134_A218_Y0.6340.17
276_N280_I0.6340.17
111_Y129_K0.6310.17
297_L441_I0.6310.17
266_S406_N0.6280.17
272_T332_E0.6280.17
285_D309_F0.6260.17
335_N365_I0.6260.17
226_G331_N0.6250.17
217_T226_G0.6230.17
274_D277_Q0.6220.17
288_P436_A0.6210.17
121_V145_Y0.6190.17
343_L403_K0.6190.17
424_I429_I0.6180.17
278_K303_Y0.6170.16
202_S400_E0.6170.16
161_E165_Y0.6160.16
297_L425_L0.6140.16
243_E457_L0.6140.16
350_E381_N0.6130.16
277_Q397_V0.6120.16
119_Q128_Y0.6110.16
387_Q433_S0.6100.16
381_N405_R0.6100.16
341_P403_K0.6090.16
332_E453_T0.6080.16
359_Q369_R0.6060.16
232_I378_G0.6040.16
282_L330_G0.6040.16
285_D330_G0.6030.16
412_D422_R0.6030.16
424_I456_Q0.6010.16
216_D362_I0.6010.16
282_L430_Y0.6010.16
58_K77_A0.5970.16
283_T287_G0.5970.16
288_P379_G0.5970.16
47_N56_D0.5950.16
47_N75_D0.5950.16
293_T378_G0.5950.16
196_P201_F0.5930.16
244_Q365_I0.5920.16
355_I420_D0.5920.16
300_L331_N0.5910.16
297_L322_T0.5890.16
73_K304_K0.5880.16
48_V59_T0.5870.16
169_L182_D0.5870.16
261_K264_V0.5840.16
275_P341_P0.5840.16
116_Y119_Q0.5840.16
226_G322_T0.5830.16
206_I426_I0.5830.16
55_N62_Y0.5820.15
364_K447_Q0.5790.15
82_A90_Q0.5790.15
414_V434_A0.5790.15
293_T451_L0.5780.15
343_L373_V0.5770.15
266_S337_S0.5770.15
131_I327_L0.5760.15
282_L290_P0.5740.15
285_D378_G0.5730.15
362_I419_G0.5730.15
367_G401_D0.5720.15
62_Y70_K0.5720.15
444_L453_T0.5720.15
336_H428_D0.5710.15
394_L430_Y0.5710.15
158_I179_K0.5710.15
306_H453_T0.5700.15
330_G401_D0.5690.15
284_F428_D0.5690.15
297_L305_G0.5680.15
44_Q54_V0.5670.15
283_T340_H0.5660.15
410_I436_A0.5660.15
345_R354_Q0.5650.15
248_K251_N0.5650.15
54_V69_F0.5640.15
281_A377_Y0.5610.15
424_I447_Q0.5610.15
117_A420_D0.5590.15
344_T377_Y0.5580.15
393_A421_G0.5580.15
286_D312_L0.5550.15
305_G445_T0.5550.15
413_R424_I0.5530.15
290_P319_Y0.5530.15
284_F340_H0.5530.15
112_K431_R0.5520.15
322_T329_E0.5510.15
440_I446_D0.5510.15
421_G453_T0.5500.15
411_V436_A0.5500.15
393_A454_V0.5490.15
66_Y201_F0.5480.15
336_H427_H0.5470.15
343_L375_P0.5460.15
402_W452_V0.5460.15
285_D448_G0.5440.14
115_H123_I0.5440.14
332_E454_V0.5430.14
401_D428_D0.5430.14
306_H378_G0.5420.14
119_Q126_N0.5420.14
281_A394_L0.5420.14
45_Y65_N0.5420.14
281_A346_L0.5410.14
234_K426_I0.5400.14
355_I406_N0.5370.14
84_K230_I0.5370.14
294_N430_Y0.5370.14
360_D455_S0.5370.14
313_G427_H0.5360.14
123_I143_F0.5360.14
69_F75_D0.5350.14
313_G424_I0.5350.14
52_T60_F0.5340.14
330_G367_G0.5330.14
374_R448_G0.5330.14
45_Y61_N0.5330.14
315_R456_Q0.5330.14
46_G85_E0.5330.14
266_S408_K0.5320.14
351_A375_P0.5310.14
399_P414_V0.5310.14
357_D403_K0.5310.14
282_L293_T0.5300.14
287_G374_R0.5300.14
421_G452_V0.5280.14
111_Y120_T0.5260.14
398_D424_I0.5250.14
290_P454_V0.5250.14
110_D354_Q0.5250.14
392_V404_D0.5250.14
293_T300_L0.5240.14
380_I385_R0.5220.14
186_D334_G0.5220.14
303_Y407_K0.5220.14
288_P401_D0.5210.14
349_K418_A0.5210.14
414_V443_K0.5210.14
280_I422_R0.5210.14
335_N402_W0.5200.14
70_K75_D0.5190.14
295_Q344_T0.5190.14
45_Y133_G0.5190.14
299_S445_T0.5180.14
313_G374_R0.5180.14
316_V426_I0.5180.14
109_V396_D0.5160.14
374_R398_D0.5160.14
311_V428_D0.5150.14
283_T374_R0.5150.14
235_S265_I0.5140.14
294_N299_S0.5140.14
287_G427_H0.5130.14
343_L402_W0.5110.14
61_N441_I0.5110.14
333_V363_E0.5100.14
297_L374_R0.5100.14
407_K439_E0.5090.14
350_E455_S0.5090.14
306_H430_Y0.5070.14
403_K429_I0.5070.14
328_K446_D0.5070.14
444_L447_Q0.5060.13
286_D330_G0.5060.13
213_L372_L0.5060.13
375_P444_L0.5060.13
194_T200_N0.5050.13
344_T426_I0.5040.13
333_V409_T0.5040.13
347_S435_D0.5030.13
46_G55_N0.5030.13
288_P300_L0.5000.13
228_Q314_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c1iA 1 0.8009 100 0.421 Contact Map
2j13A 1 0.4347 100 0.532 Contact Map
2c71A 1 0.4047 100 0.538 Contact Map
1ny1A 1 0.4882 100 0.539 Contact Map
2cc0A 2 0.4069 100 0.54 Contact Map
2y8uA 1 0.4347 100 0.541 Contact Map
4l1gA 1 0.4411 100 0.543 Contact Map
4m1bA 1 0.4154 100 0.548 Contact Map
2iw0A 1 0.4325 100 0.55 Contact Map
2vyoA 1 0.4197 100 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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