GREMLIN Database
COAD - Phosphopantetheine adenylyltransferase
UniProt: O34797 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (156)
Sequences: 3532 (2125)
Seq/√Len: 170.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Q66_T4.7571.00
68_E77_Y3.5931.00
14_V55_L3.3791.00
4_I31_Q3.2081.00
68_E81_K2.9971.00
25_G87_L2.9561.00
23_K61_D2.6871.00
26_A64_N2.5311.00
6_V78_A2.1871.00
58_V149_E2.1811.00
14_V22_I2.1581.00
50_E157_K2.1371.00
47_S50_E2.0931.00
10_S44_P1.9911.00
54_L153_A1.8881.00
108_V144_E1.8741.00
52_C56_R1.8031.00
53_E56_R1.7791.00
79_K110_D1.7751.00
135_V140_G1.7741.00
88_R102_G1.7611.00
151_E155_Q1.7381.00
29_F32_V1.6291.00
72_G80_R1.6131.00
59_T62_I1.5911.00
33_Y81_K1.5741.00
19_L59_T1.5691.00
79_K112_S1.5591.00
24_R114_E1.5441.00
19_L147_P1.5421.00
52_C69_T1.5161.00
57_E149_E1.4851.00
86_I113_I1.4791.00
152_L156_Q1.4781.00
78_A113_I1.4751.00
57_E153_A1.4651.00
53_E57_E1.4591.00
75_I110_D1.4521.00
77_Y81_K1.4391.00
105_V135_V1.4201.00
74_L86_I1.4001.00
5_A32_V1.3961.00
105_V131_I1.3771.00
20_D121_N1.3591.00
22_I34_V1.3481.00
4_I33_Y1.3431.00
37_L70_S1.3421.00
57_E60_K1.3401.00
46_F54_L1.3321.00
35_C70_S1.3141.00
48_V69_T1.2811.00
134_E138_Y1.2801.00
153_A156_Q1.2591.00
41_S134_E1.2401.00
72_G76_D1.2261.00
76_D79_K1.2131.00
28_I116_F1.2061.00
26_A62_I1.1811.00
143_S151_E1.1691.00
90_L96_F1.1471.00
36_V52_C1.1331.00
6_V77_Y1.1241.00
75_I113_I1.1231.00
90_L117_F1.0891.00
148_P152_L1.0781.00
35_C77_Y1.0691.00
28_I118_M1.0661.00
23_K62_I1.0621.00
142_V154_L1.0570.99
62_I65_I1.0550.99
146_V150_V1.0420.99
29_F85_A1.0340.99
3_S84_K1.0250.99
8_P74_L1.0120.99
58_V147_P1.0090.99
4_I82_N1.0080.99
3_S30_E1.0040.99
4_I83_A1.0040.99
92_A101_Q0.9990.99
92_A100_M0.9960.99
150_V154_L0.9900.99
8_P86_I0.9890.99
78_A83_A0.9810.99
124_Y127_L0.9790.99
21_I118_M0.9780.99
16_Y147_P0.9780.99
40_S138_Y0.9700.99
29_F87_L0.9640.99
93_V97_E0.9570.99
5_A29_F0.9510.99
104_S125_S0.9450.99
52_C67_V0.9410.99
137_R158_F0.9390.99
10_S37_L0.9320.99
103_T117_F0.9250.99
5_A87_L0.9180.99
66_T81_K0.9100.98
22_I32_V0.9040.98
33_Y83_A0.9010.98
142_V146_V0.8950.98
38_N71_Q0.8930.98
45_L158_F0.8900.98
5_A85_A0.8740.98
100_M119_M0.8680.98
94_S101_Q0.8660.98
54_L150_V0.8620.98
38_N48_V0.8480.98
37_L138_Y0.8470.98
110_D113_I0.8470.98
36_V69_T0.8420.97
3_S85_A0.8330.97
100_M104_S0.8300.97
7_C88_R0.8120.97
120_T125_S0.8080.97
141_S144_E0.8040.97
55_L67_V0.8040.97
57_E152_L0.7970.96
6_V83_A0.7930.96
33_Y66_T0.7910.96
148_P151_E0.7860.96
45_L157_K0.7800.96
53_E153_A0.7700.96
14_V150_V0.7690.96
19_L58_V0.7680.96
49_E53_E0.7670.96
15_T132_V0.7660.96
36_V55_L0.7660.96
6_V35_C0.7610.95
27_H84_K0.7560.95
108_V145_F0.7550.95
22_I59_T0.7490.95
150_V153_A0.7420.95
59_T64_N0.7330.94
149_E152_L0.7280.94
46_F50_E0.7270.94
59_T65_I0.7270.94
92_A97_E0.7260.94
106_N115_T0.7260.94
152_L155_Q0.7240.94
25_G32_V0.7190.94
44_P48_V0.7190.94
76_D80_R0.7140.94
28_I85_A0.7110.93
22_I65_I0.7100.93
109_L135_V0.7090.93
32_V87_L0.7060.93
34_V55_L0.7040.93
104_S122_N0.7030.93
55_L59_T0.7020.93
56_R66_T0.7010.93
7_C120_T0.7010.93
100_M125_S0.6960.93
122_N125_S0.6950.93
72_G77_Y0.6940.93
7_C22_I0.6810.92
96_F100_M0.6800.92
20_D24_R0.6760.92
16_Y19_L0.6700.91
14_V19_L0.6690.91
48_V52_C0.6640.91
8_P88_R0.6620.91
19_L23_K0.6600.91
35_C74_L0.6510.90
23_K27_H0.6470.90
102_G106_N0.6460.90
53_E149_E0.6390.89
106_N109_L0.6380.89
15_T20_D0.6330.89
46_F153_A0.6320.89
46_F157_K0.6320.89
144_E148_P0.6290.89
33_Y68_E0.6280.88
5_A116_F0.6260.88
143_S148_P0.6200.88
39_N44_P0.6160.88
39_N133_K0.6150.87
92_A119_M0.6150.87
10_S39_N0.6080.87
47_S157_K0.6050.87
54_L149_E0.6020.86
14_V58_V0.6020.86
7_C32_V0.6000.86
49_E69_T0.5990.86
39_N129_S0.5970.86
84_K112_S0.5970.86
21_I87_L0.5950.86
34_V59_T0.5940.86
22_I26_A0.5930.85
40_S102_G0.5930.85
74_L102_G0.5880.85
132_V135_V0.5870.85
149_E153_A0.5850.85
6_V81_K0.5850.85
130_S133_K0.5750.84
108_V127_L0.5750.84
92_A126_F0.5740.84
50_E153_A0.5650.83
68_E80_R0.5640.83
7_C21_I0.5620.82
136_A142_V0.5600.82
107_R121_N0.5580.82
131_I135_V0.5560.82
108_V123_Q0.5520.81
146_V151_E0.5510.81
73_L140_G0.5490.81
37_L100_M0.5480.81
70_S74_L0.5470.81
4_I66_T0.5450.80
143_S155_Q0.5440.80
146_V154_L0.5430.80
41_S137_R0.5430.80
3_S28_I0.5400.80
133_K136_A0.5370.79
16_Y124_Y0.5350.79
27_H31_Q0.5340.79
108_V126_F0.5290.78
104_S145_F0.5290.78
136_A158_F0.5270.78
39_N138_Y0.5250.78
108_V122_N0.5220.77
75_I106_N0.5210.77
6_V74_L0.5180.77
75_I109_L0.5130.76
14_V54_L0.5110.76
88_R120_T0.5090.76
93_V101_Q0.5080.76
92_A96_F0.5080.76
75_I78_A0.5050.75
35_C81_K0.5030.75
102_G131_I0.5020.75
136_A154_L0.5010.75
105_V145_F0.5010.75
78_A82_N0.5010.75
142_V151_E0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vlhA 5 0.9752 100 0.468 Contact Map
3k9wA 5 1 100 0.471 Contact Map
3nbkA 5 0.9814 100 0.478 Contact Map
3nd5A 5 0.9379 100 0.481 Contact Map
4natA 5 0.9627 100 0.489 Contact Map
1o6bA 5 0.9938 100 0.49 Contact Map
1od6A 5 0.9503 100 0.491 Contact Map
3nv7A 4 0.9627 100 0.493 Contact Map
1qjcA 4 0.9752 100 0.494 Contact Map
4f3rA 5 0.9255 100 0.499 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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