GREMLIN Database
YVKC - Uncharacterized phosphotransferase YvkC
UniProt: O34796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 831 (765)
Sequences: 1067 (832)
Seq/√Len: 30.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
740_V810_L9.3921.00
175_N183_E9.3641.00
263_T284_L8.3381.00
737_T817_T8.0461.00
776_A818_V6.2001.00
276_G285_L5.9551.00
740_V816_I5.0741.00
20_G158_V4.9671.00
171_I260_T4.8451.00
663_E681_R4.6441.00
757_V776_A4.6291.00
737_T815_I4.5001.00
330_P658_F4.4021.00
25_K266_L4.3551.00
188_A247_C3.9671.00
277_I282_I3.8831.00
800_V818_V3.8381.00
210_K264_E3.6891.00
81_F91_V3.6571.00
249_T252_Q3.6461.00
739_P815_I3.5541.00
171_I256_L3.5301.00
259_I284_L3.5211.00
187_S205_T3.5031.00
37_F159_V3.4311.00
810_L816_I3.4291.00
271_V287_A3.3501.00
817_T826_T3.3221.00
166_E278_A3.2751.00
263_T273_I3.2741.00
208_V253_V3.2681.00
189_S196_V3.2581.00
651_Q675_Q3.2501.00
165_S276_G3.2261.00
92_A115_L3.0711.00
745_D748_E3.0711.00
819_D822_S2.9871.00
780_D803_T2.9431.00
167_M247_C2.9071.00
735_I817_T2.9071.00
46_R72_E2.8681.00
395_Y398_I2.7881.00
741_K756_D2.7701.00
16_A38_I2.7461.00
418_T421_S2.7161.00
639_K643_L2.7091.00
186_I253_V2.6501.00
817_T828_V2.6151.00
173_S260_T2.6081.00
116_N192_L2.5991.00
756_D812_D2.5931.00
656_L664_V2.4910.99
171_I184_L2.4900.99
189_S195_A2.4100.99
642_E653_R2.4030.99
800_V825_I2.3420.99
174_R181_D2.3260.99
35_D161_G2.2860.99
58_E62_G2.2770.99
174_R290_I2.2680.99
81_F84_L2.2340.99
267_Y287_A2.1380.98
39_I77_L2.1330.98
742_I812_D2.1020.98
95_S106_S2.0900.98
740_V778_I2.0700.98
69_F124_L2.0630.98
51_N67_G2.0630.98
447_Q450_L2.0420.97
332_F546_D2.0270.97
263_T287_A1.9940.97
170_V189_S1.9730.97
811_R814_D1.9390.96
139_V143_K1.9250.96
658_F682_R1.9200.96
757_V816_I1.9090.96
503_A507_N1.8890.96
119_T122_E1.8770.96
21_M25_K1.8400.95
770_L774_A1.8360.95
206_F253_V1.8240.95
755_G775_K1.8210.95
194_E198_S1.8080.95
544_S622_H1.7990.95
394_M398_I1.7950.95
81_F85_R1.7880.94
366_H370_K1.7850.94
544_S801_L1.7690.94
739_P756_D1.7620.94
126_K129_E1.7600.94
174_R293_I1.7540.94
163_I276_G1.7510.94
113_T285_L1.7300.93
76_E682_R1.7110.93
99_S102_L1.7090.93
458_Y462_Q1.7060.93
62_G66_S1.7060.93
491_F526_F1.7050.93
735_I819_D1.7050.93
25_K28_K1.7030.93
394_M397_I1.7010.93
340_L625_I1.6980.93
509_K512_Q1.6880.92
774_A777_I1.6830.92
257_A657_W1.6680.92
213_F254_I1.6660.92
800_V820_G1.6460.92
114_Y126_K1.6310.91
100_E108_A1.6130.91
81_F123_F1.6130.91
45_A154_L1.6090.91
111_Y139_V1.6080.91
19_K23_L1.5920.90
736_A776_A1.5830.90
32_P259_I1.5630.89
777_I788_A1.5620.89
114_Y129_E1.5540.89
763_T767_W1.5530.89
495_V526_F1.5530.89
209_N212_S1.5510.89
480_K484_T1.5490.89
546_D788_A1.5480.89
46_R51_N1.5410.89
699_T765_P1.5390.88
20_G27_T1.5330.88
815_I828_V1.5310.88
552_W783_G1.5160.88
246_F253_V1.5070.87
239_S242_M1.5030.87
203_P783_G1.5010.87
39_I73_L1.5010.87
622_H801_L1.4840.87
113_T290_I1.4770.86
112_E138_R1.4740.86
481_S484_T1.4680.86
322_S325_E1.4640.86
537_Y623_F1.4640.86
384_K398_I1.4520.85
84_L91_V1.4500.85
29_H32_P1.4460.85
760_C774_A1.4460.85
17_G23_L1.4420.85
776_A810_L1.4380.85
372_Q375_Q1.4360.85
255_E281_Q1.4330.85
98_A153_P1.4310.84
739_P757_V1.4300.84
365_G368_Y1.4230.84
208_V257_A1.4210.84
239_S243_R1.4190.84
328_V333_S1.4130.84
645_A653_R1.4120.84
786_S790_I1.4090.84
546_D783_G1.4090.84
173_S256_L1.4060.83
487_C536_E1.3960.83
110_Q791_I1.3950.83
385_E388_P1.3930.83
115_L192_L1.3900.83
331_L664_V1.3900.83
746_A760_C1.3880.83
659_L681_R1.3760.82
426_F429_L1.3680.82
175_N207_I1.3670.82
554_E638_L1.3670.82
622_H626_D1.3660.82
803_T825_I1.3570.81
99_S111_Y1.3520.81
101_D108_A1.3500.81
737_T826_T1.3400.80
457_M461_I1.3400.80
322_S332_F1.3350.80
622_H764_T1.3300.80
317_W320_M1.3200.79
22_N271_V1.3070.79
250_D290_I1.3060.79
44_L135_F1.3040.78
176_P793_R1.2970.78
526_F530_V1.2970.78
188_A204_D1.2970.78
10_E25_K1.2950.78
780_D788_A1.2940.78
301_E313_M1.2890.78
686_H689_E1.2880.78
500_N735_I1.2870.77
740_V759_V1.2860.77
780_D804_R1.2790.77
206_F247_C1.2790.77
273_I284_L1.2790.77
332_F481_S1.2740.77
42_N45_A1.2660.76
15_L42_N1.2650.76
71_D74_K1.2650.76
623_F765_P1.2610.76
740_V776_A1.2610.76
122_E125_A1.2580.76
383_G386_L1.2570.76
540_R544_S1.2530.76
540_R801_L1.2480.75
93_V117_I1.2470.75
175_N275_F1.2420.75
778_I810_L1.2390.75
391_S394_M1.2370.75
102_L148_N1.2330.74
111_Y143_K1.2290.74
75_D79_S1.2280.74
780_D805_T1.2260.74
734_G823_G1.2230.74
726_I803_T1.2210.74
89_R161_G1.2200.74
786_S789_A1.2150.73
20_G111_Y1.2140.73
37_F80_S1.2130.73
100_E106_S1.2130.73
740_V758_L1.2120.73
334_S660_Y1.2120.73
102_L111_Y1.2100.73
264_E270_P1.2090.73
74_K124_L1.2080.73
778_I825_I1.2030.72
813_G823_G1.1990.72
18_A158_V1.1950.72
481_S485_D1.1940.72
62_G65_I1.1890.72
453_K603_E1.1890.72
325_E332_F1.1890.72
641_G654_E1.1880.72
279_D654_E1.1870.71
73_L77_L1.1860.71
319_N544_S1.1840.71
97_S111_Y1.1750.71
290_I736_A1.1720.70
19_K34_P1.1700.70
323_N545_H1.1670.70
185_L207_I1.1640.70
774_A791_I1.1610.70
117_I155_M1.1590.70
190_Y204_D1.1580.70
615_A776_A1.1560.69
106_S794_E1.1540.69
190_Y243_R1.1530.69
40_Q43_A1.1520.69
622_H731_A1.1480.69
47_F235_E1.1420.68
793_R823_G1.1420.68
323_N622_H1.1410.68
169_G794_E1.1400.68
329_S546_D1.1390.68
321_E765_P1.1330.68
546_D622_H1.1280.67
260_T273_I1.1270.67
501_L526_F1.1210.67
367_I547_L1.1200.67
90_S118_K1.1170.67
263_T267_Y1.1150.67
461_I464_E1.1110.66
48_M59_N1.1100.66
242_M245_R1.1060.66
169_G199_G1.1060.66
483_E486_R1.1040.66
278_A283_Y1.1020.66
238_T242_M1.1020.66
59_N63_G1.1000.65
134_F143_K1.0990.65
580_T583_K1.0980.65
783_G788_A1.0950.65
238_T243_R1.0940.65
337_V342_Y1.0930.65
98_A102_L1.0930.65
787_H794_E1.0910.65
320_M545_H1.0890.65
805_T809_R1.0890.65
51_N64_I1.0850.64
68_T128_K1.0850.64
393_H397_I1.0820.64
85_R91_V1.0790.64
47_F67_G1.0790.64
113_T194_E1.0750.64
165_S168_S1.0740.64
14_Q75_D1.0740.64
168_S244_S1.0680.63
483_E487_C1.0680.63
389_I398_I1.0660.63
113_T429_L1.0660.63
319_N322_S1.0650.63
23_L34_P1.0630.63
167_M252_Q1.0620.63
16_A20_G1.0620.63
50_D63_G1.0600.63
594_S682_R1.0550.62
125_A129_E1.0520.62
541_S622_H1.0510.62
18_A771_F1.0510.62
746_A774_A1.0490.62
173_S619_D1.0480.62
10_E21_M1.0470.62
155_M776_A1.0430.61
322_S786_S1.0410.61
387_F390_L1.0390.61
368_Y372_Q1.0380.61
60_V64_I1.0360.61
78_T120_E1.0330.61
252_Q656_L1.0330.61
584_R588_Y1.0330.61
190_Y238_T1.0320.60
17_G34_P1.0290.60
248_L252_Q1.0290.60
452_N455_Q1.0280.60
537_Y770_L1.0270.60
390_L394_M1.0270.60
73_L78_T1.0240.60
95_S100_E1.0150.59
625_I783_G1.0140.59
501_L825_I1.0110.59
60_V66_S1.0110.59
622_H785_L1.0110.59
545_H629_L1.0100.59
78_T123_F1.0090.59
642_E646_E1.0080.59
820_G823_G1.0060.58
60_V63_G1.0050.58
533_F552_W1.0050.58
204_D248_L1.0050.58
64_I650_I1.0040.58
751_Q812_D1.0030.58
814_D827_V1.0020.58
82_Y120_E1.0010.58
447_Q454_L1.0010.58
453_K462_Q0.9990.58
116_N170_V0.9990.58
196_V203_P0.9980.58
764_T780_D0.9980.58
655_D678_A0.9980.58
340_L374_G0.9980.58
385_E389_I0.9960.58
658_F685_F0.9950.58
325_E545_H0.9940.58
59_N62_G0.9920.57
778_I816_I0.9890.57
741_K812_D0.9880.57
650_I653_R0.9870.57
736_A757_V0.9860.57
818_V825_I0.9860.57
75_D582_E0.9820.57
323_N544_S0.9790.56
167_M204_D0.9760.56
19_K33_V0.9760.56
759_V810_L0.9740.56
77_L82_Y0.9730.56
198_S290_I0.9730.56
184_L257_A0.9690.56
328_V625_I0.9680.55
113_T189_S0.9680.55
381_D389_I0.9670.55
555_N558_F0.9670.55
100_E272_D0.9670.55
325_E762_M0.9620.55
540_R626_D0.9620.55
388_P391_S0.9610.55
322_S621_H0.9570.55
46_R49_E0.9570.55
92_A193_G0.9570.55
16_A156_G0.9560.55
504_I664_V0.9550.54
16_A40_Q0.9550.54
317_W322_S0.9530.54
17_G20_G0.9510.54
383_G391_S0.9470.54
94_R109_G0.9450.54
45_A71_D0.9450.54
148_N153_P0.9450.54
622_H766_L0.9440.54
586_K589_N0.9430.54
391_S397_I0.9420.53
23_L106_S0.9420.53
737_T828_V0.9390.53
10_E16_A0.9380.53
321_E545_H0.9380.53
99_S153_P0.9320.53
585_E676_E0.9300.52
255_E280_H0.9290.52
111_Y155_M0.9280.52
623_F699_T0.9260.52
50_D71_D0.9250.52
374_G625_I0.9250.52
94_R101_D0.9240.52
529_N532_E0.9220.52
20_G23_L0.9210.52
679_E683_Q0.9210.52
500_N646_E0.9190.52
123_F754_P0.9170.51
37_F84_L0.9170.51
76_E79_S0.9160.51
544_S626_D0.9160.51
62_G281_Q0.9160.51
258_E777_I0.9140.51
95_S169_G0.9140.51
391_S395_Y0.9120.51
493_V559_A0.9100.51
329_S548_I0.9100.51
290_I722_T0.9070.51
748_E751_Q0.9070.51
383_G393_H0.9060.51
763_T791_I0.9050.51
68_T76_E0.9050.51
13_S21_M0.9050.51
329_S685_F0.9040.50
545_H626_D0.9030.50
614_S623_F0.9020.50
323_N795_Y0.9010.50
186_I248_L0.9000.50
66_S519_Q0.8950.50
187_S199_G0.8950.50
252_Q277_I0.8950.50
106_S764_T0.8930.50
204_D247_C0.8930.50
23_L95_S0.8920.49
114_Y664_V0.8910.49
639_K642_E0.8910.49
455_Q563_I0.8900.49
332_F622_H0.8900.49
119_T139_V0.8900.49
272_D288_R0.8890.49
544_S551_I0.8880.49
768_T774_A0.8860.49
324_I786_S0.8850.49
18_A755_G0.8820.49
114_Y130_C0.8820.49
166_E654_E0.8820.49
193_G197_V0.8810.49
819_D824_K0.8800.49
389_I393_H0.8790.48
340_L630_D0.8790.48
113_T417_H0.8750.48
553_V630_D0.8700.48
741_K753_A0.8700.48
786_S802_G0.8700.48
206_F246_F0.8690.48
511_E744_R0.8690.48
259_I263_T0.8680.48
778_I806_A0.8650.47
114_Y117_I0.8640.47
693_A697_L0.8640.47
779_T788_A0.8630.47
97_S134_F0.8620.47
197_V763_T0.8620.47
324_I545_H0.8600.47
111_Y153_P0.8600.47
116_N195_A0.8590.47
793_R813_G0.8580.47
164_D278_A0.8580.47
386_L394_M0.8570.47
36_G788_A0.8570.47
638_L657_W0.8570.47
192_L768_T0.8560.47
94_R100_E0.8560.47
728_G823_G0.8560.47
671_P675_Q0.8550.47
769_S791_I0.8550.47
366_H375_Q0.8550.47
44_L189_S0.8540.46
79_S258_E0.8540.46
736_A810_L0.8520.46
168_S276_G0.8520.46
173_S730_A0.8500.46
281_Q776_A0.8480.46
65_I129_E0.8470.46
370_K375_Q0.8470.46
768_T771_F0.8470.46
45_A50_D0.8460.46
415_T648_G0.8450.46
619_D622_H0.8450.46
235_E239_S0.8440.46
388_P392_E0.8430.46
373_G378_P0.8430.46
256_L282_I0.8420.46
236_K241_D0.8390.45
532_E535_Q0.8370.45
199_G794_E0.8350.45
443_I730_A0.8330.45
546_D551_I0.8330.45
385_E398_I0.8320.45
20_G38_I0.8310.45
383_G388_P0.8300.45
117_I570_G0.8290.44
752_F756_D0.8290.44
655_D682_R0.8280.44
60_V589_N0.8280.44
110_Q293_I0.8260.44
17_G33_V0.8260.44
659_L678_A0.8250.44
323_N546_D0.8250.44
101_D109_G0.8240.44
319_N332_F0.8240.44
74_K78_T0.8210.44
129_E755_G0.8210.44
113_T683_Q0.8200.44
615_A626_D0.8200.44
561_A641_G0.8170.44
366_H779_T0.8170.44
382_C393_H0.8160.43
728_G793_R0.8150.43
734_G820_G0.8150.43
143_K188_A0.8150.43
58_E65_I0.8140.43
754_P775_K0.8140.43
753_A756_D0.8130.43
394_M766_L0.8130.43
540_R622_H0.8120.43
196_V786_S0.8110.43
734_G793_R0.8100.43
539_W771_F0.8100.43
634_R638_L0.8100.43
493_V502_L0.8090.43
764_T803_T0.8040.43
728_G734_G0.8040.43
551_I622_H0.8030.42
91_V127_V0.8020.42
752_F770_L0.8020.42
450_L660_Y0.8000.42
142_Y763_T0.7980.42
253_V257_A0.7960.42
622_H765_P0.7950.42
544_S619_D0.7940.42
638_L653_R0.7920.42
45_A48_M0.7920.42
380_E391_S0.7920.42
680_K684_I0.7910.42
505_F513_L0.7910.42
346_K825_I0.7870.41
253_V493_V0.7870.41
530_V560_L0.7860.41
339_A625_I0.7850.41
46_R73_L0.7840.41
744_R750_S0.7810.41
51_N255_E0.7790.41
734_G767_W0.7780.41
37_F81_F0.7780.41
323_N801_L0.7780.41
61_E137_G0.7770.40
332_F616_N0.7760.40
259_I282_I0.7760.40
540_R763_T0.7760.40
163_I656_L0.7740.40
673_S676_E0.7740.40
256_L260_T0.7730.40
384_K394_M0.7720.40
447_Q533_F0.7710.40
95_S101_D0.7700.40
819_D826_T0.7700.40
386_L389_I0.7690.40
341_E625_I0.7690.40
156_G170_V0.7680.40
552_W789_A0.7670.40
92_A192_L0.7670.40
173_S184_L0.7660.40
417_H421_S0.7640.39
592_L601_R0.7640.39
324_I541_S0.7630.39
316_F699_T0.7610.39
544_S760_C0.7610.39
106_S169_G0.7610.39
166_E547_L0.7600.39
167_M658_F0.7600.39
541_S630_D0.7590.39
522_E797_I0.7590.39
102_L768_T0.7590.39
77_L124_L0.7580.39
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124_L127_V0.5010.22
410_D775_K0.5000.22
550_Q558_F0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2olsA 2 0.4404 100 0.54 Contact Map
1vbgA 2 0.4874 100 0.648 Contact Map
2x0sA 2 0.5138 100 0.651 Contact Map
1kblA 2 0.4729 100 0.663 Contact Map
2e28A 3 0.6582 99.9 0.89 Contact Map
3t05A 3 0.657 99.9 0.89 Contact Map
1zymA 2 0.2756 99.9 0.897 Contact Map
2hwgA 2 0.2647 99.9 0.901 Contact Map
2wqdA 2 0.2732 99.9 0.903 Contact Map
2hi6A 1 0.1239 98.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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