GREMLIN Database
YVJA - UPF0750 membrane protein YvjA
UniProt: O34792 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (271)
Sequences: 3735 (2696)
Seq/√Len: 163.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L85_A5.7971.00
207_Q210_A5.1471.00
227_S236_D3.9671.00
228_A239_I3.8451.00
213_E217_Q3.4841.00
206_K237_R3.4201.00
205_T211_V3.3991.00
22_A93_V3.0261.00
201_A252_L2.7811.00
113_F175_L2.7431.00
42_V63_I2.5961.00
229_V234_D2.5461.00
214_A255_I2.4541.00
226_I239_I2.4311.00
229_V238_P2.3841.00
205_T208_E2.3561.00
214_A218_K2.2881.00
49_L52_Y2.2721.00
209_Q213_E2.2651.00
227_S238_P2.1241.00
199_K269_D2.1031.00
223_V231_G2.0511.00
13_D82_K2.0021.00
14_Y85_A2.0011.00
88_V92_L1.9541.00
29_N97_T1.9461.00
18_L89_F1.9431.00
25_A93_V1.9351.00
20_G121_G1.9071.00
26_V30_V1.9041.00
24_T90_L1.9031.00
221_R248_E1.8931.00
166_M174_G1.8851.00
27_S118_I1.8601.00
186_K190_V1.8491.00
16_Y128_G1.8401.00
57_A95_F1.7991.00
166_M171_I1.7791.00
125_V132_T1.7511.00
212_K231_G1.7421.00
49_L59_V1.7341.00
106_H176_Y1.7231.00
151_G189_D1.6971.00
35_N110_A1.6871.00
223_V240_L1.6811.00
225_K240_L1.6621.00
256_V263_A1.6601.00
215_V252_L1.6061.00
256_V265_V1.5981.00
208_E238_P1.5791.00
69_I73_I1.5661.00
206_K235_D1.5381.00
219_I252_L1.5381.00
13_D128_G1.5291.00
229_V236_D1.5191.00
214_A259_I1.5091.00
209_Q234_D1.5031.00
170_N173_Q1.5001.00
108_L179_L1.4931.00
212_K234_D1.4891.00
123_G191_V1.4671.00
200_M268_A1.4461.00
206_K262_S1.4341.00
241_M266_I1.4151.00
160_M164_T1.4031.00
212_K225_K1.3931.00
202_L241_M1.3861.00
26_V97_T1.3751.00
45_I49_L1.3681.00
17_I86_G1.3661.00
65_I69_I1.3641.00
79_F131_S1.3461.00
156_I160_M1.3341.00
20_G125_V1.3061.00
210_A259_I1.2941.00
244_V252_L1.2941.00
162_V181_V1.2911.00
228_A237_R1.2851.00
42_V67_L1.2831.00
203_I256_V1.2821.00
262_S276_E1.2781.00
215_V242_C1.2741.00
60_Q94_V1.2701.00
57_A91_P1.2691.00
32_L114_G1.2691.00
22_A97_T1.2661.00
119_G123_G1.2571.00
55_E95_F1.2541.00
155_A185_S1.2321.00
27_S117_G1.2241.00
75_L79_F1.2061.00
253_K272_E1.1951.00
81_L85_A1.1901.00
27_S121_G1.1871.00
36_K173_Q1.1851.00
21_A89_F1.1821.00
202_L268_A1.1791.00
17_I130_G1.1781.00
139_A154_L1.1731.00
72_V77_G1.1631.00
159_G163_V1.1501.00
182_Y186_K1.1451.00
61_W91_P1.1411.00
200_M266_I1.1411.00
71_G80_G1.1381.00
107_E173_Q1.1331.00
249_F267_V1.1301.00
33_L56_A1.1271.00
111_A115_G1.1251.00
214_A258_Q1.1241.00
216_L231_G1.1241.00
225_K238_P1.1221.00
200_M270_A1.1161.00
29_N98_R1.1161.00
14_Y82_K1.1061.00
11_L15_V1.1061.00
72_V80_G1.1001.00
68_F87_S1.0951.00
12_R16_Y1.0821.00
15_V19_I1.0780.99
116_V187_T1.0780.99
201_A249_F1.0780.99
45_I164_T1.0740.99
54_F59_V1.0740.99
109_L113_F1.0710.99
260_D263_A1.0650.99
224_T228_A1.0650.99
212_K223_V1.0500.99
89_F93_V1.0490.99
57_A61_W1.0320.99
225_K231_G1.0280.99
215_V221_R1.0230.99
14_Y18_L1.0220.99
255_I258_Q1.0150.99
230_G233_T1.0110.99
85_A89_F0.9950.99
75_L140_Q0.9870.99
86_G130_G0.9790.99
199_K272_E0.9730.99
47_T50_Q0.9670.99
38_A165_A0.9640.99
31_F113_F0.9600.99
10_I13_D0.9550.99
106_H172_E0.9530.99
266_I270_A0.9520.99
38_A158_D0.9470.99
111_A179_L0.9470.99
202_L226_I0.9460.99
36_K51_S0.9340.99
58_Y95_F0.9310.99
59_V63_I0.9300.99
16_Y124_I0.9210.98
142_I146_S0.9200.98
74_L141_I0.9160.98
252_L256_V0.9160.98
216_L223_V0.9150.98
43_S94_V0.9110.98
200_M241_M0.9100.98
74_L145_Y0.9070.98
250_T254_Q0.9000.98
107_E111_A0.8980.98
32_L180_G0.8940.98
189_D246_Q0.8910.98
200_M243_V0.8890.98
66_P69_I0.8840.98
202_L266_I0.8730.98
211_V255_I0.8690.98
131_S140_Q0.8680.98
70_A74_L0.8610.98
68_F83_T0.8590.97
45_I48_I0.8570.97
21_A86_G0.8550.97
151_G188_I0.8540.97
151_G185_S0.8490.97
115_G119_G0.8440.97
58_Y62_I0.8440.97
120_I191_V0.8420.97
184_S188_I0.8400.97
75_L131_S0.8380.97
148_L153_C0.8370.97
198_S242_C0.8340.97
78_K82_K0.8330.97
225_K229_V0.8330.97
116_V182_Y0.8320.97
214_A217_Q0.8290.97
38_A177_A0.8230.97
11_L14_Y0.8220.97
122_I126_Y0.8200.97
216_L222_G0.8190.97
50_Q56_A0.8170.97
10_I82_K0.8120.96
243_V266_I0.8120.96
21_A125_V0.8080.96
245_G248_E0.8060.96
201_A244_V0.8010.96
255_I259_I0.7980.96
122_I188_I0.7970.96
126_Y140_Q0.7970.96
205_T260_D0.7950.96
201_A256_V0.7930.96
226_I241_M0.7930.96
213_E234_D0.7910.96
48_I169_F0.7870.96
154_L158_D0.7860.96
24_T121_G0.7860.96
23_I120_I0.7850.96
253_K274_L0.7800.96
112_I183_V0.7790.96
37_I111_A0.7730.95
22_A89_F0.7720.95
81_L84_L0.7690.95
107_E110_A0.7670.95
109_L175_L0.7630.95
156_I159_G0.7600.95
149_S189_D0.7550.95
61_W88_V0.7540.95
68_F84_L0.7530.95
12_R128_G0.7480.94
48_I164_T0.7470.94
132_T136_A0.7470.94
93_V96_L0.7460.94
21_A90_L0.7450.94
27_S31_F0.7420.94
186_K189_D0.7420.94
142_I153_C0.7410.94
68_F71_G0.7380.94
212_K216_L0.7360.94
61_W65_I0.7340.94
218_K251_K0.7290.94
181_V185_S0.7250.93
254_Q258_Q0.7220.93
62_I66_P0.7180.93
95_F98_R0.7170.93
123_G127_L0.7170.93
218_K255_I0.7150.93
67_L138_A0.7140.93
138_A142_I0.7100.93
207_Q259_I0.7090.93
222_G232_Y0.7080.93
112_I179_L0.7050.93
223_V242_C0.7040.92
46_S60_Q0.7030.92
55_E58_Y0.7010.92
208_E211_V0.6960.92
141_I145_Y0.6960.92
24_T118_I0.6940.92
67_L83_T0.6860.91
257_K274_L0.6860.91
164_T167_I0.6860.91
71_G79_F0.6850.91
135_T157_I0.6850.91
221_R245_G0.6830.91
207_Q260_D0.6830.91
110_A172_E0.6820.91
45_I63_I0.6790.91
66_P70_A0.6790.91
44_G176_Y0.6770.91
152_K189_D0.6760.91
160_M163_V0.6760.91
149_S152_K0.6750.91
155_A182_Y0.6750.91
118_I184_S0.6740.91
199_K267_V0.6730.91
140_Q150_L0.6690.90
125_V130_G0.6670.90
135_T169_F0.6660.90
28_F90_L0.6620.90
49_L63_I0.6610.90
52_Y59_V0.6610.90
209_Q238_P0.6580.90
211_V259_I0.6570.90
30_V101_Q0.6550.90
25_A90_L0.6550.90
28_F33_L0.6520.89
162_V165_A0.6500.89
79_F140_Q0.6500.89
135_T158_D0.6480.89
224_T230_G0.6460.89
126_Y136_A0.6450.89
111_A183_V0.6410.88
154_L188_I0.6410.88
16_Y19_I0.6400.88
19_I23_I0.6400.88
87_S91_P0.6370.88
122_I132_T0.6360.88
23_I117_G0.6330.88
106_H111_A0.6310.88
197_R246_Q0.6310.88
122_I184_S0.6280.87
218_K258_Q0.6240.87
251_K254_Q0.6240.87
158_D177_A0.6240.87
230_G237_R0.6220.87
30_V97_T0.6210.87
28_F46_S0.6210.87
221_R277_G0.6200.87
70_A141_I0.6190.87
254_Q257_K0.6190.87
33_L47_T0.6190.87
158_D277_G0.6190.87
201_A267_V0.6180.87
59_V62_I0.6180.87
82_K129_K0.6170.87
203_I252_L0.6160.86
195_F198_S0.6160.86
113_F178_M0.6130.86
104_T172_E0.6100.86
124_I128_G0.6100.86
46_S241_M0.6080.86
204_I241_M0.6060.86
69_I72_V0.6040.85
111_A180_G0.6040.85
208_E212_K0.6020.85
37_I104_T0.6010.85
137_L151_G0.6000.85
105_H172_E0.5980.85
86_G132_T0.5980.85
38_A47_T0.5980.85
83_T137_L0.5960.85
115_G183_V0.5930.84
49_L54_F0.5930.84
193_V271_S0.5910.84
146_S153_C0.5900.84
33_L50_Q0.5900.84
243_V270_A0.5870.84
133_G136_A0.5860.84
43_S90_L0.5840.83
56_A60_Q0.5810.83
107_E172_E0.5790.83
221_R278_F0.5780.83
50_Q59_V0.5770.83
152_K155_A0.5770.83
46_S63_I0.5760.83
177_A244_V0.5760.83
165_A174_G0.5760.83
267_V272_E0.5740.82
68_F106_H0.5730.82
30_V34_P0.5720.82
199_K237_R0.5720.82
203_I242_C0.5700.82
104_T110_A0.5690.82
92_L96_L0.5660.82
107_E176_Y0.5660.82
47_T51_S0.5650.81
253_K257_K0.5640.81
24_T122_I0.5640.81
83_T87_S0.5640.81
39_A136_A0.5630.81
150_L189_D0.5620.81
82_K177_A0.5610.81
73_I91_P0.5560.80
140_Q144_K0.5560.80
244_V249_F0.5540.80
157_I161_I0.5510.80
264_F273_V0.5500.80
174_G180_G0.5490.80
47_T241_M0.5490.80
170_N174_G0.5490.80
68_F138_A0.5470.79
51_S169_F0.5470.79
84_L87_S0.5430.79
224_T264_F0.5380.78
163_V167_I0.5380.78
50_Q53_G0.5360.78
156_I164_T0.5360.78
77_G80_G0.5350.78
169_F173_Q0.5350.78
12_R258_Q0.5330.78
126_Y192_Q0.5310.77
119_G188_I0.5310.77
143_H146_S0.5290.77
211_V256_V0.5270.77
202_L239_I0.5260.77
225_K234_D0.5260.77
12_R127_L0.5250.76
109_L182_Y0.5230.76
76_G198_S0.5220.76
220_D276_E0.5210.76
101_Q104_T0.5210.76
34_P127_L0.5200.76
70_A73_I0.5190.76
22_A26_V0.5180.76
202_L270_A0.5170.75
120_I187_T0.5160.75
46_S56_A0.5160.75
37_I107_E0.5160.75
196_N201_A0.5150.75
118_I126_Y0.5130.75
126_Y139_A0.5120.75
37_I114_G0.5110.75
164_T178_M0.5110.75
166_M170_N0.5100.74
28_F43_S0.5100.74
68_F137_L0.5080.74
47_T56_A0.5080.74
115_G184_S0.5070.74
18_L93_V0.5060.74
108_L118_I0.5040.74
66_P186_K0.5040.74
140_Q158_D0.5030.73
137_L188_I0.5020.73
205_T238_P0.5020.73
148_L152_K0.5020.73
233_T262_S0.5020.73
29_N99_D0.5000.73
232_Y264_F0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hluA 2 0.2598 99.9 0.69 Contact Map
4rwwA 3 0.2989 80 0.943 Contact Map
4affA 3 0.306 79.1 0.944 Contact Map
2dclA 5 0.3167 78 0.944 Contact Map
2eg2A 5 0.2918 76.8 0.945 Contact Map
3ncqA 4 0.306 76.5 0.945 Contact Map
3t9zA 3 0.2989 76.1 0.945 Contact Map
4co3A 3 0.3025 75.9 0.945 Contact Map
2gw8A 3 0.3025 75.3 0.946 Contact Map
4r25A 3 0.3132 74.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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