GREMLIN Database
PCRB - Heptaprenylglyceryl phosphate synthase
UniProt: O34790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (215)
Sequences: 639 (495)
Seq/√Len: 33.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_I127_A7.6851.00
190_K194_T4.6281.00
178_L183_L3.8961.00
191_D194_T3.8911.00
89_N132_E3.6221.00
37_I55_V3.6161.00
119_C157_F3.4331.00
90_A93_I2.8661.00
83_S154_L2.8601.00
149_S157_F2.6961.00
182_T204_V2.6021.00
10_V206_V2.5861.00
142_I174_T2.5321.00
139_M143_V2.4371.00
142_I170_A2.3540.99
190_K213_E2.2820.99
91_D96_M2.2600.99
13_L51_M2.1510.99
72_I79_Y2.1490.99
150_E181_S2.1420.99
66_V81_I2.0770.98
128_A135_A2.0640.98
36_I80_F2.0320.98
37_I52_M2.0050.98
41_D126_K1.9880.98
20_P23_Q1.8500.97
9_H32_T1.8360.97
147_R177_V1.8090.96
165_L197_Q1.7710.96
23_Q215_F1.7520.95
168_I198_Y1.7440.95
156_I184_F1.7380.95
16_N41_D1.7340.95
16_N42_G1.6970.95
195_A205_I1.6920.95
147_R151_L1.6840.94
192_A196_K1.6680.94
99_K138_N1.6280.93
45_E73_V1.6250.93
102_K141_D1.6220.93
214_D217_R1.6200.93
217_R220_K1.6180.93
122_N136_D1.6100.93
143_V173_K1.5400.91
117_G154_L1.5130.90
37_I62_C1.5090.90
165_L198_Y1.4880.90
139_M173_K1.4620.89
49_L73_V1.4580.89
172_K176_A1.4370.88
123_P136_D1.4240.88
169_E172_K1.4210.87
98_Q148_V1.4100.87
184_F206_V1.4070.87
80_F116_E1.3980.87
48_V64_L1.3900.86
49_L75_G1.3840.86
90_A95_G1.3710.85
10_V34_A1.3630.85
27_L35_V1.3600.85
10_V36_I1.3520.85
83_S152_L1.3450.84
171_V198_Y1.3360.84
56_R62_C1.3310.84
117_G146_A1.3240.83
13_L30_S1.2870.82
68_A71_A1.2870.82
24_L27_L1.2700.81
153_Q201_H1.2690.81
191_D197_Q1.2510.80
189_I195_A1.2480.79
125_C133_A1.2370.79
94_V152_L1.2330.79
9_H207_V1.2250.78
40_S198_Y1.2040.77
167_D198_Y1.1940.76
63_V78_L1.1880.76
13_L19_L1.1800.76
104_Y113_I1.1640.75
52_M56_R1.1630.74
53_S75_G1.1610.74
78_L114_V1.1530.74
114_V191_D1.1490.74
24_L54_K1.1470.73
82_P131_T1.1320.72
120_I133_A1.1190.72
143_V177_V1.1180.71
64_L174_T1.0610.67
11_F32_T1.0510.67
54_K57_R1.0500.67
191_D205_I1.0410.66
143_V175_K1.0360.65
215_F219_L1.0120.64
210_A217_R1.0110.64
11_F211_V1.0060.63
94_V101_M0.9960.62
145_Y149_S0.9930.62
165_L168_I0.9910.62
27_L30_S0.9900.62
146_A171_V0.9900.62
28_C60_V0.9870.62
114_V156_I0.9670.60
93_I148_V0.9520.59
85_L152_L0.9500.59
50_R54_K0.9500.59
94_V148_V0.9460.58
97_H152_L0.9410.58
173_K176_A0.9390.58
13_L123_P0.9370.58
16_N126_K0.9320.57
30_S51_M0.9320.57
32_T160_E0.9300.57
143_V174_T0.9260.57
86_N145_Y0.9210.56
85_L117_G0.9200.56
55_V59_L0.9160.56
209_N212_Y0.9060.55
85_L149_S0.9060.55
86_N120_I0.9030.55
128_A133_A0.8960.54
46_D50_R0.8960.54
55_V62_C0.8950.54
65_E84_V0.8920.54
19_L54_K0.8840.53
84_V131_T0.8670.52
87_S131_T0.8670.52
161_Y166_G0.8630.51
158_Y186_G0.8560.51
122_N127_A0.8400.50
47_N50_R0.8380.49
42_G47_N0.8310.49
94_V98_Q0.8310.49
170_A201_H0.8300.49
168_I197_Q0.8300.49
114_V181_S0.8240.48
178_L181_S0.8220.48
159_L185_Y0.8100.47
72_I104_Y0.8020.46
94_V115_A0.7970.46
101_M151_L0.7970.46
11_F218_A0.7880.45
120_I125_C0.7880.45
40_S93_I0.7860.45
22_E140_D0.7850.45
52_M182_T0.7830.45
66_V124_D0.7830.45
117_G157_F0.7830.45
124_D164_V0.7740.44
71_A87_S0.7690.44
81_I97_H0.7650.43
17_K126_K0.7640.43
88_K132_E0.7630.43
7_W203_D0.7600.43
90_A135_A0.7550.42
196_K199_A0.7550.42
103_E157_F0.7530.42
100_A107_L0.7500.42
9_H86_N0.7430.41
115_A151_L0.7410.41
52_M60_V0.7350.41
56_R200_E0.7300.40
45_E170_A0.7300.40
52_M62_C0.7270.40
119_C174_T0.7230.40
85_L154_L0.7220.40
87_S145_Y0.7220.40
83_S170_A0.7170.39
176_A179_E0.7160.39
150_E204_V0.7150.39
32_T60_V0.7140.39
45_E142_I0.7130.39
46_D53_S0.7120.39
46_D172_K0.7110.39
213_E216_D0.7100.39
83_S93_I0.7050.38
102_K144_A0.7010.38
93_I124_D0.6990.38
48_V106_E0.6970.38
48_V61_P0.6960.38
153_Q200_E0.6940.37
10_V125_C0.6890.37
34_A160_E0.6890.37
60_V114_V0.6890.37
129_A132_E0.6870.37
139_M142_I0.6840.37
25_E57_R0.6790.36
32_T207_V0.6780.36
112_E216_D0.6710.36
129_A141_D0.6670.35
53_S56_R0.6660.35
65_E185_Y0.6660.35
37_I60_V0.6650.35
153_Q190_K0.6650.35
97_H115_A0.6610.35
11_F51_M0.6600.35
61_P125_C0.6590.35
71_A120_I0.6570.35
140_D191_D0.6550.34
52_M73_V0.6520.34
92_W110_M0.6500.34
192_A217_R0.6490.34
150_E179_E0.6460.34
72_I106_E0.6440.34
16_N47_N0.6420.33
89_N93_I0.6420.33
25_E168_I0.6400.33
25_E58_F0.6380.33
48_V117_G0.6380.33
139_M170_A0.6370.33
111_E114_V0.6360.33
25_E81_I0.6340.33
157_F181_S0.6340.33
83_S107_L0.6330.33
138_N141_D0.6330.33
36_I116_E0.6320.33
13_L52_M0.6290.33
67_S127_A0.6280.32
161_Y185_Y0.6250.32
78_L190_K0.6210.32
37_I217_R0.6200.32
98_Q164_V0.6200.32
89_N206_V0.6190.32
100_A157_F0.6160.32
124_D206_V0.6130.31
27_L193_E0.6080.31
159_L174_T0.6070.31
56_R157_F0.6070.31
86_N133_A0.6050.31
121_A170_A0.6030.31
99_K102_K0.6030.31
58_F62_C0.6020.31
117_G203_D0.6010.30
104_Y201_H0.6010.30
40_S47_N0.6000.30
132_E170_A0.5990.30
9_H195_A0.5980.30
210_A213_E0.5970.30
66_V142_I0.5930.30
87_S93_I0.5920.30
194_T197_Q0.5920.30
151_L213_E0.5910.30
20_P203_D0.5880.30
69_I125_C0.5790.29
141_D144_A0.5790.29
22_E177_V0.5780.29
115_A149_S0.5780.29
178_L182_T0.5770.29
87_S133_A0.5750.29
129_A138_N0.5720.28
78_L182_T0.5720.28
23_Q190_K0.5710.28
40_S114_V0.5710.28
89_N134_D0.5700.28
76_F79_Y0.5700.28
175_K193_E0.5700.28
6_E179_E0.5690.28
34_A63_V0.5670.28
69_I96_M0.5660.28
123_P217_R0.5650.28
97_H144_A0.5640.28
106_E147_R0.5630.28
143_V170_A0.5610.28
32_T222_V0.5600.28
69_I100_A0.5590.28
105_G147_R0.5570.27
98_Q141_D0.5570.27
171_V203_D0.5570.27
77_D175_K0.5560.27
56_R60_V0.5560.27
103_E183_L0.5550.27
172_K206_V0.5540.27
158_Y163_G0.5540.27
30_S155_P0.5540.27
55_V114_V0.5530.27
25_E85_L0.5510.27
68_A89_N0.5510.27
30_S219_L0.5490.27
35_V79_Y0.5490.27
86_N128_A0.5490.27
101_M204_V0.5480.27
214_D218_A0.5470.27
156_I211_V0.5460.27
100_A122_N0.5450.27
9_H31_G0.5430.27
44_T166_G0.5420.26
90_A94_V0.5400.26
8_K18_D0.5400.26
214_D219_L0.5370.26
82_P86_N0.5340.26
29_E49_L0.5340.26
29_E216_D0.5330.26
171_V213_E0.5330.26
101_M106_E0.5320.26
170_A173_K0.5320.26
64_L76_F0.5310.26
12_K65_E0.5290.26
31_G222_V0.5270.25
34_A72_I0.5250.25
163_G206_V0.5240.25
160_E186_G0.5230.25
83_S90_A0.5220.25
65_E82_P0.5220.25
83_S112_E0.5220.25
149_S160_E0.5220.25
24_L51_M0.5210.25
172_K200_E0.5200.25
27_L200_E0.5190.25
94_V223_A0.5190.25
52_M78_L0.5180.25
138_N196_K0.5170.25
42_G48_V0.5130.25
85_L167_D0.5110.24
16_N201_H0.5110.24
142_I175_K0.5090.24
80_F83_S0.5080.24
120_I169_E0.5070.24
88_K210_A0.5060.24
57_R216_D0.5050.24
113_I133_A0.5050.24
161_Y164_V0.5030.24
63_V80_F0.5010.24
86_N131_T0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f6uA 2 0.9737 100 0.562 Contact Map
3vzxA 2 1 100 0.574 Contact Map
3w01A 2 0.9956 100 0.589 Contact Map
4nafA 2 0.9737 100 0.642 Contact Map
3vk5A 2 0.9474 100 0.67 Contact Map
4mm1A 3 0.9605 100 0.678 Contact Map
3ktsA 1 0.7939 99.9 0.716 Contact Map
4jejA 2 0.9518 99.9 0.718 Contact Map
3thaA 2 0.8553 99.6 0.806 Contact Map
1ujpA 1 0.8202 99.5 0.82 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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