GREMLIN Database
BDHA - (R,R)-butanediol dehydrogenase
UniProt: O34788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (301)
Sequences: 52811 (36223)
Seq/√Len: 2087.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_D327_E2.9861.00
32_K145_Y2.8821.00
30_K77_V2.8081.00
32_K75_E2.7471.00
28_K77_V2.6671.00
27_V136_L2.5971.00
189_K215_I2.5731.00
171_K195_D2.5141.00
144_S147_Q2.5101.00
7_H15_E2.4911.00
91_R139_L2.3921.00
90_D138_K2.3721.00
87_K90_D2.3641.00
319_I331_A2.3181.00
228_E231_E2.3081.00
30_K75_E2.2641.00
195_D216_I2.2601.00
146_E318_K2.2161.00
19_E128_Y2.2001.00
30_K128_Y2.1731.00
72_F124_G2.1691.00
207_Q211_E2.1511.00
85_N133_E2.0981.00
167_K170_D2.0931.00
172_A188_L2.0801.00
302_S306_E2.0661.00
317_K331_A2.0521.00
177_C198_A2.0501.00
206_Q210_E2.0491.00
7_H13_R2.0361.00
25_G82_G2.0051.00
185_I214_A2.0041.00
320_V323_D1.9911.00
24_P81_E1.9851.00
318_K344_R1.9641.00
23_E26_K1.9591.00
5_R15_E1.9391.00
142_E305_K1.9311.00
72_F94_V1.9161.00
73_S145_Y1.9091.00
91_R145_Y1.9071.00
24_P82_G1.8991.00
207_Q210_E1.8661.00
330_G334_K1.8501.00
21_K78_E1.8241.00
170_D262_E1.7851.00
173_A237_V1.7791.00
28_K130_S1.7691.00
77_V128_Y1.7551.00
173_A199_V1.7401.00
327_E330_G1.7331.00
45_L333_I1.7281.00
203_P207_Q1.7181.00
206_Q217_V1.6931.00
238_D258_T1.6761.00
319_I328_G1.6761.00
190_A308_Y1.6711.00
200_E206_Q1.6421.00
155_A183_L1.6421.00
139_L145_Y1.6421.00
197_Y237_V1.6341.00
327_E331_A1.6171.00
331_A336_K1.6151.00
257_T263_T1.6001.00
262_E286_T1.5931.00
203_P219_P1.5911.00
80_G83_V1.5911.00
216_I232_R1.5791.00
175_F253_A1.5791.00
223_D228_E1.5671.00
86_Y138_K1.5591.00
139_L148_G1.5551.00
164_S239_V1.5491.00
4_A324_L1.5411.00
147_Q312_D1.5371.00
79_V88_V1.5101.00
208_K211_E1.5101.00
224_D227_A1.5011.00
26_K132_D1.4851.00
262_E288_K1.4831.00
146_E344_R1.4811.00
257_T285_R1.4711.00
22_T130_S1.4671.00
78_E88_V1.4641.00
31_V72_F1.4531.00
28_K128_Y1.4531.00
86_Y90_D1.4461.00
125_F329_F1.4431.00
257_T261_G1.4341.00
203_P222_T1.4301.00
91_R141_D1.4301.00
75_E91_R1.3981.00
22_T28_K1.3881.00
219_P222_T1.3851.00
25_G132_D1.3761.00
26_K130_S1.3711.00
240_A253_A1.3681.00
76_V86_Y1.3301.00
33_W146_E1.3191.00
326_E330_G1.3161.00
185_I198_A1.3151.00
44_Y329_F1.3051.00
240_A257_T1.3021.00
316_T331_A1.2991.00
195_D215_I1.2971.00
27_V86_Y1.2881.00
28_K78_E1.2801.00
227_A231_E1.2631.00
33_W344_R1.2581.00
75_E145_Y1.2501.00
171_K197_Y1.2361.00
201_L220_S1.2351.00
302_S305_K1.2311.00
184_V241_F1.2251.00
201_L206_Q1.2241.00
190_A303_L1.2101.00
162_R299_A1.2101.00
175_F199_V1.2061.00
4_A14_I1.1731.00
151_V304_M1.1681.00
162_R296_I1.1641.00
32_K91_R1.1501.00
206_Q219_P1.1471.00
86_Y136_L1.1471.00
166_L193_A1.1451.00
19_E28_K1.1371.00
22_T26_K1.1351.00
171_K238_D1.1161.00
203_P206_Q1.1141.00
131_V136_L1.0941.00
210_E217_V1.0911.00
29_I74_G1.0801.00
31_V129_V1.0731.00
77_V88_V1.0711.00
8_N11_D1.0671.00
198_A214_A1.0671.00
228_E232_R1.0611.00
299_A302_S1.0571.00
164_S264_V1.0571.00
25_G133_E1.0561.00
14_I322_D1.0501.00
36_I328_G1.0361.00
170_D238_D1.0291.00
294_R298_P1.0241.00
44_Y333_I1.0241.00
324_L343_V1.0201.00
33_W145_Y1.0181.00
159_Y296_I1.0181.00
211_E313_K1.0091.00
303_L308_Y1.0071.00
157_A187_A1.0051.00
255_Q279_D1.0051.00
320_V344_R1.0051.00
163_S286_T1.0031.00
233_T236_G1.0021.00
208_K338_Q1.0011.00
37_C70_H1.0001.00
4_A321_L0.9991.00
224_D228_E0.9981.00
37_C71_E0.9981.00
210_E216_I0.9951.00
244_T249_V0.9831.00
29_I92_V0.9781.00
34_C125_F0.9771.00
32_K73_S0.9711.00
298_P302_S0.9651.00
157_A184_V0.9641.00
166_L170_D0.9631.00
34_C124_G0.9631.00
177_C200_E0.9491.00
5_R17_I0.9451.00
79_V83_V0.9381.00
188_L193_A0.9361.00
125_F324_L0.9361.00
160_A266_V0.9361.00
226_V255_Q0.9341.00
222_T228_E0.9301.00
174_V184_V0.9261.00
66_V122_G0.9261.00
242_E245_G0.9251.00
143_L148_G0.9211.00
331_A341_I0.9201.00
19_E78_E0.9191.00
84_E133_E0.9121.00
83_V133_E0.9101.00
33_W342_L0.9081.00
251_R255_Q0.9071.00
197_Y216_I0.9041.00
185_I196_I0.9001.00
330_G333_I0.8941.00
174_V188_L0.8911.00
41_L332_L0.8911.00
5_R67_T0.8871.00
187_A300_V0.8821.00
226_V252_Q0.8811.00
87_K138_K0.8801.00
25_G80_G0.8791.00
177_C209_A0.8751.00
175_F240_A0.8731.00
30_K127_E0.8701.00
229_I237_V0.8661.00
199_V220_S0.8601.00
35_G71_E0.8601.00
158_L299_A0.8601.00
173_A256_S0.8601.00
200_E217_V0.8591.00
125_F343_V0.8551.00
21_K28_K0.8551.00
201_L221_K0.8551.00
7_H11_D0.8541.00
252_Q255_Q0.8531.00
202_S205_R0.8501.00
177_C185_I0.8501.00
19_E77_V0.8441.00
202_S219_P0.8401.00
182_L208_K0.8371.00
160_A241_F0.8361.00
171_K237_V0.8341.00
17_I122_G0.8331.00
72_F129_V0.8301.00
280_I287_V0.8281.00
332_L341_I0.8261.00
197_Y218_D0.8231.00
204_E207_Q0.8171.00
93_V301_L0.8101.00
279_D283_K0.8061.00
141_D305_K0.8041.00
205_R338_Q0.8021.00
170_D239_V0.8021.00
198_A209_A0.8011.00
226_V230_A0.7901.00
187_A303_L0.7881.00
260_A284_E0.7881.00
25_G81_E0.7871.00
295_D299_A0.7871.00
36_I332_L0.7861.00
209_A214_A0.7851.00
163_S288_K0.7771.00
319_I323_D0.7731.00
37_C40_D0.7701.00
299_A303_L0.7691.00
14_I321_L0.7631.00
4_A12_I0.7621.00
23_E130_S0.7591.00
157_A183_L0.7581.00
253_A263_T0.7541.00
295_D298_P0.7541.00
225_V252_Q0.7541.00
160_A184_V0.7491.00
197_Y229_I0.7461.00
161_V188_L0.7451.00
157_A180_I0.7441.00
143_L304_M0.7441.00
166_L239_V0.7431.00
276_H279_D0.7371.00
36_I125_F0.7371.00
201_L209_A0.7361.00
172_A193_A0.7351.00
303_L307_G0.7341.00
240_A263_T0.7341.00
224_D252_Q0.7321.00
92_V136_L0.7321.00
226_V256_S0.7311.00
39_S70_H0.7281.00
175_F249_V0.7281.00
22_T78_E0.7261.00
17_I67_T0.7241.00
197_Y232_R0.7241.00
303_L306_E0.7221.00
227_A230_A0.7211.00
319_I343_V0.7211.00
73_S149_A0.7211.00
94_V131_V0.7181.00
248_V252_Q0.7161.00
165_K262_E0.7151.00
196_I215_I0.7141.00
79_V87_K0.7071.00
317_K327_E0.7061.00
191_A299_A0.7051.00
152_E155_A0.7051.00
37_C153_P0.7041.00
159_Y284_E0.7041.00
331_A334_K0.7021.00
237_V240_A0.7011.00
93_V139_L0.7011.00
315_V318_K0.6911.00
243_V266_V0.6911.00
22_T80_G0.6901.00
187_A191_A0.6851.00
157_A161_V0.6851.00
239_V264_V0.6851.00
193_A196_I0.6841.00
265_I287_V0.6831.00
319_I341_I0.6831.00
188_L196_I0.6821.00
4_A326_E0.6811.00
137_F298_P0.6761.00
27_V133_E0.6741.00
137_F297_F0.6731.00
70_H153_P0.6701.00
158_L300_V0.6701.00
174_V198_A0.6691.00
165_K288_K0.6631.00
91_R142_E0.6611.00
124_G129_V0.6551.00
133_E136_L0.6521.00
280_I289_G0.6491.00
38_G42_H0.6491.00
85_N138_K0.6471.00
27_V76_V0.6461.00
144_S148_G0.6461.00
229_I256_S0.6461.00
90_D141_D0.6431.00
317_K341_I0.6431.00
137_F301_L0.6421.00
10_K330_G0.6411.00
165_K286_T0.6391.00
193_A239_V0.6391.00
250_L263_T0.6381.00
158_L303_L0.6371.00
6_W11_D0.6371.00
259_I283_K0.6351.00
33_W318_K0.6341.00
301_L305_K0.6331.00
200_E219_P0.6311.00
155_A300_V0.6311.00
73_S139_L0.6301.00
20_P130_S0.6261.00
251_R279_D0.6251.00
32_K344_R0.6231.00
33_W73_S0.6221.00
73_S91_R0.6221.00
280_I285_R0.6211.00
206_Q220_S0.6201.00
208_K212_L0.6201.00
140_P305_K0.6201.00
85_N294_R0.6191.00
164_S262_E0.6191.00
189_K196_I0.6191.00
93_V152_E0.6181.00
29_I94_V0.6151.00
152_E156_V0.6151.00
216_I228_E0.6151.00
329_F333_I0.6141.00
25_G134_E0.6101.00
156_V180_I0.6101.00
272_G276_H0.6071.00
31_V34_C0.6021.00
85_N88_V0.6001.00
246_V249_V0.6001.00
230_A236_G0.5991.00
95_E137_F0.5981.00
200_E220_S0.5971.00
237_V256_S0.5971.00
242_E263_T0.5971.00
158_L296_I0.5951.00
184_V266_V0.5951.00
39_S43_E0.5931.00
186_E212_L0.5931.00
199_V218_D0.5911.00
251_R274_E0.5911.00
9_Q330_G0.5901.00
230_A233_T0.5891.00
240_A256_S0.5881.00
239_V262_E0.5881.00
337_S341_I0.5871.00
206_Q209_A0.5871.00
42_H47_G0.5861.00
200_E209_A0.5861.00
37_C154_S0.5851.00
182_L314_L0.5821.00
151_V155_A0.5781.00
20_P128_Y0.5771.00
185_I212_L0.5751.00
154_S340_K0.5741.00
14_I324_L0.5721.00
249_V253_A0.5701.00
151_V300_V0.5681.00
162_R191_A0.5661.00
22_T82_G0.5651.00
84_E87_K0.5621.00
173_A240_A0.5611.00
41_L333_I0.5601.00
8_N13_R0.5591.00
162_R295_D0.5581.00
39_S42_H0.5571.00
172_A239_V0.5561.00
86_Y133_E0.5551.00
209_A217_V0.5541.00
20_P28_K0.5511.00
168_A192_G0.5511.00
18_E21_K0.5511.00
67_T123_G0.5501.00
154_S183_L0.5501.00
38_G178_G0.5501.00
156_V266_V0.5501.00
242_E267_S0.5471.00
225_V229_I0.5471.00
19_E130_S0.5461.00
279_D282_I0.5461.00
29_I136_L0.5451.00
34_C343_V0.5441.00
153_P156_V0.5441.00
161_V187_A0.5431.00
208_K314_L0.5431.00
323_D326_E0.5391.00
94_V136_L0.5391.00
79_V90_D0.5391.00
62_E66_V0.5371.00
43_E48_P0.5371.00
218_D232_R0.5341.00
189_K214_A0.5311.00
317_K338_Q0.5311.00
19_E22_T0.5311.00
150_L342_L0.5281.00
69_G125_F0.5281.00
168_A191_A0.5271.00
183_L187_A0.5271.00
158_L191_A0.5261.00
282_I291_I0.5261.00
171_K233_T0.5261.00
185_I209_A0.5251.00
169_G193_A0.5241.00
31_V94_V0.5231.00
145_Y148_G0.5211.00
197_Y233_T0.5211.00
218_D223_D0.5181.00
183_L186_E0.5171.00
29_I72_F0.5161.00
331_A337_S0.5161.00
37_C340_K0.5141.00
63_T66_V0.5141.00
264_V290_I0.5131.00
201_L219_P0.5131.00
279_D285_R0.5121.00
132_D135_L0.5111.00
304_M309_F0.5101.00
20_P26_K0.5101.00
73_S148_G0.5101.00
144_S318_K0.5101.00
248_V251_R0.5091.00
175_F225_V0.5061.00
165_K170_D0.5051.00
137_F294_R0.5041.00
316_T339_V0.5031.00
139_L143_L0.5031.00
218_D228_E0.5031.00
182_L212_L0.5031.00
200_E205_R0.5011.00
36_I343_V0.5011.00
281_V289_G0.5001.00
31_V124_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ilkA 2 0.9509 100 0.158 Contact Map
4ej6A 1 0.9566 100 0.159 Contact Map
2dq4A 4 0.9624 100 0.164 Contact Map
4oh1A 4 0.9595 100 0.175 Contact Map
1e3jA 4 0.9682 100 0.176 Contact Map
3m6iA 4 0.9682 100 0.179 Contact Map
3ukoA 4 0.9595 100 0.18 Contact Map
4uejA 2 0.9566 100 0.181 Contact Map
1f8fA 4 0.9538 100 0.182 Contact Map
4gkvA 4 0.9451 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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