GREMLIN Database
PKSE - Polyketide biosynthesis protein PksE
UniProt: O34787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 767 (730)
Sequences: 126 (119)
Seq/√Len: 4.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
496_C558_F9.2211.00
124_M127_V6.5510.99
332_A348_L4.9400.95
595_G685_F4.7490.94
559_I742_T4.5760.93
431_K482_E4.3770.91
3_T260_E4.3600.91
386_I405_L3.8120.83
148_D195_R3.7410.82
110_K114_E3.6910.81
70_L95_M3.6330.80
99_A216_L3.4390.76
384_Y703_Y3.4350.76
144_L170_A3.3700.75
347_K732_D3.3660.74
634_D637_M3.1500.69
542_I548_A2.9660.64
536_V705_I2.9610.64
323_D535_R2.8740.62
353_M735_G2.7580.58
597_M602_S2.6990.56
88_L272_L2.6260.54
23_Q428_Y2.5800.53
340_A417_A2.5760.53
356_F385_G2.5490.52
82_F421_V2.5360.51
430_A486_L2.5300.51
354_M644_K2.5230.51
349_S384_Y2.5230.51
154_T367_V2.5070.51
357_F362_L2.4790.50
584_M607_L2.4470.49
542_I674_K2.4460.49
357_F370_A2.4250.48
469_L487_R2.3340.45
630_I680_I2.3120.45
22_E40_E2.2980.44
430_A469_L2.2930.44
257_G286_L2.2850.44
497_V508_G2.2680.43
577_V705_I2.2620.43
455_E596_D2.2530.43
110_K187_N2.2500.43
148_D196_Y2.2270.42
67_L70_L2.2050.41
576_K703_Y2.2040.41
330_Y735_G2.1990.41
30_Q103_E2.1640.40
360_G594_A2.1610.40
117_G149_V2.1420.40
324_Y494_D2.1180.39
23_Q71_K2.0990.38
494_D535_R2.0920.38
259_G410_V2.0810.38
426_V472_L2.0760.38
638_L642_E2.0730.38
110_K207_Y2.0630.37
482_E512_S2.0550.37
410_V413_V2.0550.37
334_G696_S2.0480.37
62_Y106_L2.0400.37
331_L354_M2.0160.36
390_H418_F2.0090.36
417_A595_G2.0080.36
266_I742_T2.0020.36
330_Y447_L1.9870.35
174_F183_F1.9820.35
495_I609_K1.9790.35
642_E649_S1.9750.35
435_R488_C1.9710.35
676_K703_Y1.9700.35
461_L609_K1.9560.34
216_L231_Q1.9520.34
367_V633_L1.9500.34
334_G419_L1.9430.34
685_F706_H1.9320.34
462_S742_T1.9250.33
135_V312_A1.9240.33
499_A539_A1.9210.33
630_I669_A1.9030.33
504_H706_H1.9010.33
275_L721_S1.8980.33
348_L355_G1.8950.33
149_V244_N1.8900.33
65_N92_N1.8460.31
266_I346_V1.8290.31
417_A596_D1.8260.31
504_H596_D1.8000.30
158_I742_T1.7860.30
191_A624_Y1.7750.30
370_A586_V1.7740.30
245_T608_K1.7690.29
455_E594_A1.7680.29
334_G388_L1.7600.29
165_K495_I1.7590.29
332_A340_A1.7570.29
501_S594_A1.7480.29
8_G12_Q1.7390.29
9_Q12_Q1.7390.29
88_L194_S1.7320.28
82_F436_N1.7140.28
122_G127_V1.7110.28
334_G386_I1.6970.28
497_V586_V1.6920.27
519_S546_E1.6910.27
548_A559_I1.6900.27
233_R671_Q1.6870.27
428_Y445_N1.6850.27
5_V536_V1.6800.27
450_K562_G1.6700.27
417_A504_H1.6690.27
194_S272_L1.6680.27
375_Q384_Y1.6570.27
57_T279_I1.6510.27
347_K476_N1.6500.26
462_S741_E1.6430.26
609_K705_I1.6430.26
699_S702_D1.6400.26
642_E650_I1.6380.26
512_S693_I1.6280.26
417_A685_F1.6260.26
32_D707_C1.6160.26
423_P464_A1.6140.26
83_A218_I1.6070.25
205_K447_L1.5950.25
170_A174_F1.5930.25
328_Y608_K1.5870.25
360_G389_V1.5840.25
455_E587_Q1.5790.25
416_S735_G1.5680.25
371_I417_A1.5660.25
3_T261_M1.5640.25
32_D38_S1.5610.24
528_Y531_R1.5490.24
387_N595_G1.5450.24
146_D536_V1.5290.24
247_K250_D1.5180.23
389_V594_A1.5050.23
501_S595_G1.5050.23
252_I716_Q1.5020.23
498_E597_M1.5020.23
35_L105_G1.5000.23
238_L272_L1.4960.23
596_D685_F1.4940.23
350_R377_E1.4880.23
285_P608_K1.4810.23
360_G498_E1.4740.23
402_I722_Q1.4610.22
40_E471_K1.4610.22
76_T475_E1.4580.22
61_L96_A1.4530.22
506_D594_A1.4520.22
503_G506_D1.4500.22
490_P547_A1.4460.22
501_S685_F1.4450.22
603_K609_K1.4430.22
417_A501_S1.4410.22
6_F9_Q1.4340.22
6_F12_Q1.4340.22
360_G597_M1.4330.22
455_E618_N1.4300.22
631_R638_L1.4130.21
286_L749_R1.4110.21
637_M690_K1.4090.21
522_D634_D1.3970.21
683_W704_Q1.3910.21
421_V469_L1.3880.21
185_P535_R1.3880.21
418_F422_T1.3870.21
161_S421_V1.3870.21
50_D56_Y1.3830.21
389_V597_M1.3780.21
389_V602_S1.3780.21
251_S389_V1.3670.20
428_Y493_D1.3640.20
166_E169_K1.3620.20
417_A706_H1.3590.20
412_I428_Y1.3550.20
336_Y504_H1.3540.20
167_I174_F1.3540.20
336_Y360_G1.3530.20
225_Y702_D1.3520.20
720_G724_E1.3480.20
388_L402_I1.3440.20
107_R638_L1.3350.20
611_V614_P1.3300.20
676_K735_G1.3290.20
433_V485_L1.3290.20
634_D707_C1.3230.19
207_Y706_H1.3220.19
161_S607_L1.3210.19
88_L273_T1.3180.19
359_T666_I1.3170.19
350_R571_A1.3170.19
190_G711_L1.3110.19
392_M405_L1.3110.19
52_N82_F1.3090.19
201_K735_G1.3010.19
594_A602_S1.2950.19
55_E247_K1.2940.19
344_M652_D1.2840.19
357_F386_I1.2840.19
421_V495_I1.2820.19
208_I239_S1.2810.19
403_D705_I1.2800.19
160_I552_F1.2760.19
5_V276_I1.2730.19
154_T275_L1.2720.19
207_Y611_V1.2670.18
505_T591_Y1.2660.18
530_Y587_Q1.2660.18
504_H594_A1.2650.18
552_F559_I1.2610.18
311_T314_S1.2570.18
345_V503_G1.2510.18
222_S693_I1.2500.18
118_R203_V1.2490.18
516_A552_F1.2470.18
194_S279_I1.2470.18
56_Y135_V1.2470.18
283_A286_L1.2350.18
500_D557_D1.2330.18
633_L641_L1.2320.18
122_G125_A1.2280.18
360_G501_S1.2260.18
401_M409_Q1.2260.18
47_S103_E1.2250.18
216_L476_N1.2250.18
113_G255_L1.2240.18
396_E656_D1.2220.18
342_K346_V1.2210.18
165_K381_G1.2200.18
349_S392_M1.2130.17
349_S713_A1.2110.17
274_G688_S1.2080.17
513_L586_V1.2080.17
154_T624_Y1.2060.17
379_G382_Q1.2060.17
533_K700_K1.2040.17
7_P12_Q1.2030.17
82_F402_I1.2020.17
34_I728_N1.1980.17
357_F374_I1.1930.17
244_N362_L1.1920.17
163_P166_E1.1900.17
149_V559_I1.1880.17
501_S504_H1.1870.17
135_V174_F1.1860.17
714_F718_V1.1830.17
252_I357_F1.1830.17
350_R405_L1.1790.17
460_F493_D1.1780.17
522_D609_K1.1750.17
323_D532_K1.1740.17
363_S473_L1.1730.17
548_A742_T1.1700.17
367_V533_K1.1690.17
388_L522_D1.1680.17
564_I741_E1.1680.17
121_G127_V1.1670.17
23_Q74_E1.1650.17
334_G560_L1.1650.17
668_K672_N1.1610.17
468_M552_F1.1590.17
276_I514_M1.1580.17
559_I564_I1.1580.17
462_S527_K1.1580.17
596_D706_H1.1580.17
83_A642_E1.1570.17
207_Y211_F1.1570.17
362_L508_G1.1530.16
480_M676_K1.1510.16
654_Y735_G1.1500.16
187_N703_Y1.1480.16
154_T533_K1.1480.16
216_L347_K1.1470.16
481_N679_L1.1470.16
585_N716_Q1.1460.16
6_F10_G1.1450.16
332_A573_T1.1440.16
334_G389_V1.1390.16
286_L493_D1.1380.16
474_G633_L1.1370.16
390_H510_A1.1360.16
530_Y594_A1.1360.16
346_V374_I1.1360.16
129_G190_G1.1350.16
165_K422_T1.1330.16
677_M704_Q1.1330.16
608_K643_E1.1290.16
349_S405_L1.1280.16
334_G597_M1.1280.16
417_A594_A1.1270.16
341_S503_G1.1250.16
56_Y421_V1.1240.16
594_A605_Q1.1190.16
222_S536_V1.1190.16
394_H529_Q1.1190.16
592_A596_D1.1190.16
372_H403_D1.1190.16
26_H227_E1.1170.16
113_G422_T1.1140.16
215_P384_Y1.1130.16
275_L650_I1.1110.16
437_Q659_L1.1080.16
609_K619_K1.1070.16
185_P272_L1.1020.16
403_D427_R1.0990.16
280_K738_L1.0930.15
649_S702_D1.0930.15
124_M129_G1.0890.15
25_Q179_D1.0870.15
146_D166_E1.0850.15
92_N643_E1.0840.15
63_V495_I1.0820.15
336_Y706_H1.0820.15
34_I502_G1.0790.15
637_M701_V1.0770.15
394_H642_E1.0770.15
135_V183_F1.0770.15
34_I399_E1.0760.15
66_A92_N1.0740.15
501_S605_Q1.0740.15
374_I741_E1.0700.15
19_G629_S1.0670.15
174_F441_V1.0660.15
53_H478_I1.0640.15
473_L478_I1.0540.15
3_T82_F1.0530.15
498_E706_H1.0530.15
476_N528_Y1.0510.15
3_T168_E1.0470.15
496_C739_M1.0450.15
594_A685_F1.0450.15
455_E530_Y1.0440.15
208_I625_Q1.0440.15
243_D560_L1.0430.15
317_S416_S1.0430.15
508_G523_E1.0430.15
128_I707_C1.0370.15
496_C553_M1.0370.15
185_P438_N1.0360.15
11_S135_V1.0360.15
390_H538_A1.0330.15
374_I603_K1.0320.15
418_F469_L1.0320.15
11_S390_H1.0300.14
14_K203_V1.0280.14
421_V689_S1.0230.14
503_G704_Q1.0230.14
95_M484_E1.0220.14
213_F216_L1.0180.14
452_S594_A1.0180.14
474_G580_L1.0120.14
144_L615_A1.0090.14
106_L190_G1.0080.14
318_A413_V1.0050.14
49_L274_G1.0030.14
503_G646_F1.0030.14
194_S494_D1.0000.14
367_V639_A0.9990.14
130_L624_Y0.9970.14
67_L71_K0.9950.14
105_G567_C0.9930.14
679_L711_L0.9930.14
353_M676_K0.9920.14
5_V525_M0.9920.14
390_H587_Q0.9890.14
208_I272_L0.9890.14
670_E724_E0.9890.14
315_L743_A0.9890.14
631_R676_K0.9890.14
4_Y99_A0.9860.14
25_Q245_T0.9850.14
510_A587_Q0.9850.14
514_M600_S0.9840.14
160_I426_V0.9820.14
342_K357_F0.9800.14
433_V482_E0.9790.14
596_D683_W0.9770.14
443_C489_I0.9740.14
485_L622_E0.9740.14
514_M627_Y0.9720.14
340_A402_I0.9710.14
462_S626_R0.9710.14
677_M730_H0.9690.14
387_N500_D0.9670.14
467_N608_K0.9660.14
354_M377_E0.9650.14
434_K608_K0.9640.14
53_H725_N0.9630.14
331_L355_G0.9630.14
602_S660_H0.9620.13
194_S238_L0.9620.13
35_L38_S0.9600.13
591_Y646_F0.9600.13
252_I608_K0.9600.13
152_E250_D0.9590.13
346_V377_E0.9590.13
257_G284_E0.9590.13
430_A489_I0.9590.13
62_Y492_A0.9580.13
499_A745_L0.9560.13
328_Y734_I0.9560.13
56_Y434_K0.9560.13
448_I706_H0.9540.13
685_F699_S0.9530.13
125_A190_G0.9530.13
423_P703_Y0.9510.13
342_K373_A0.9500.13
282_E399_E0.9480.13
146_D421_V0.9470.13
199_E354_M0.9440.13
34_I328_Y0.9410.13
441_V647_K0.9380.13
111_K728_N0.9370.13
235_K741_E0.9360.13
372_H408_N0.9330.13
412_I427_R0.9330.13
413_V686_R0.9330.13
127_V190_G0.9310.13
257_G283_A0.9260.13
669_A679_L0.9260.13
118_R211_F0.9250.13
611_V711_L0.9230.13
266_I384_Y0.9210.13
270_T274_G0.9210.13
142_H218_I0.9200.13
24_Y676_K0.9200.13
250_D283_A0.9180.13
25_Q438_N0.9180.13
454_P704_Q0.9160.13
113_G550_A0.9160.13
249_T286_L0.9150.13
469_L473_L0.9150.13
426_V592_A0.9120.13
657_I667_E0.9110.13
7_P10_G0.9100.13
367_V512_S0.9100.13
455_E517_M0.9090.13
470_Q627_Y0.9090.13
384_Y410_V0.9070.13
428_Y614_P0.9060.13
641_L650_I0.9060.13
409_Q502_G0.9050.13
130_L536_V0.9040.13
530_Y535_R0.9030.13
405_L522_D0.9020.13
62_Y173_V0.8990.13
114_E459_S0.8980.13
32_D538_A0.8920.13
265_E362_L0.8890.12
136_T350_R0.8880.12
359_T533_K0.8860.12
719_K728_N0.8850.12
24_Y106_L0.8850.12
355_G573_T0.8840.12
266_I374_I0.8820.12
263_F682_R0.8820.12
417_A498_E0.8820.12
386_I401_M0.8780.12
357_F621_Y0.8780.12
447_L584_M0.8780.12
263_F701_V0.8760.12
265_E281_N0.8760.12
340_A419_L0.8730.12
99_A682_R0.8720.12
372_H627_Y0.8710.12
506_D704_Q0.8710.12
584_M611_V0.8690.12
534_I741_E0.8670.12
215_P365_K0.8670.12
552_F739_M0.8670.12
119_I200_A0.8660.12
416_S502_G0.8640.12
221_I251_S0.8610.12
341_S345_V0.8610.12
81_D558_F0.8610.12
575_D727_R0.8610.12
618_N646_F0.8610.12
409_Q631_R0.8590.12
217_A413_V0.8580.12
14_K259_G0.8580.12
245_T630_I0.8570.12
322_Q480_M0.8560.12
446_R642_E0.8540.12
344_M533_K0.8530.12
334_G362_L0.8520.12
612_F701_V0.8510.12
318_A517_M0.8490.12
103_E252_I0.8470.12
29_D615_A0.8460.12
117_G739_M0.8460.12
239_S609_K0.8450.12
347_K357_F0.8440.12
103_E440_D0.8420.12
194_S269_G0.8420.12
165_K309_G0.8420.12
130_L154_T0.8410.12
397_S671_Q0.8410.12
343_E469_L0.8370.12
5_V682_R0.8360.12
365_K413_V0.8360.12
417_A506_D0.8340.12
455_E501_S0.8320.12
252_I697_E0.8320.12
668_K688_S0.8320.12
141_E487_R0.8310.12
73_V651_E0.8300.12
625_Q749_R0.8300.12
602_S685_F0.8300.12
421_V602_S0.8270.12
435_R621_Y0.8260.12
142_H173_V0.8240.12
229_Y329_A0.8240.12
125_A128_I0.8230.12
251_S449_A0.8220.12
2_I461_L0.8220.12
506_D683_W0.8220.12
32_D127_V0.8200.12
110_K484_E0.8190.12
250_D366_E0.8190.12
264_A672_N0.8190.12
519_S634_D0.8170.12
88_L390_H0.8170.12
30_Q635_A0.8150.12
348_L590_A0.8140.12
371_I511_Y0.8120.11
369_D480_M0.8110.11
575_D639_A0.8090.11
371_I705_I0.8080.11
504_H685_F0.8060.11
334_G474_G0.8060.11
99_A512_S0.8050.11
148_D194_S0.8030.11
119_I625_Q0.8030.11
242_M512_S0.8020.11
265_E272_L0.8020.11
194_S324_Y0.8010.11
334_G371_I0.8010.11
237_T642_E0.8010.11
166_E629_S0.8010.11
686_R745_L0.8000.11
225_Y624_Y0.7960.11
280_K622_E0.7950.11
253_R286_L0.7930.11
646_F653_I0.7920.11
374_I641_L0.7910.11
77_G266_I0.7870.11
553_M649_S0.7870.11
346_V742_T0.7870.11
348_L735_G0.7860.11
165_K411_S0.7850.11
249_T403_D0.7850.11
330_Y496_C0.7850.11
430_A614_P0.7840.11
239_S263_F0.7820.11
95_M702_D0.7820.11
388_L498_E0.7820.11
354_M607_L0.7810.11
254_F619_K0.7800.11
167_I274_G0.7790.11
308_A344_M0.7760.11
262_E389_V0.7740.11
68_S71_K0.7730.11
96_A398_E0.7720.11
103_E728_N0.7720.11
597_M604_V0.7720.11
161_S590_A0.7710.11
203_V459_S0.7700.11
396_E516_A0.7670.11
503_G688_S0.7670.11
374_I700_K0.7670.11
269_G275_L0.7660.11
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68_S166_E0.5580.09
121_G274_G0.5580.09
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210_S687_Y0.5570.09
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444_S688_S0.5550.09
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321_K332_A0.5530.09
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333_G566_Q0.5500.09
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224_V582_Q0.5420.09
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167_I523_E0.5400.09
352_G461_L0.5400.09
247_K514_M0.5400.09
198_N462_S0.5390.09
735_G739_M0.5380.09
369_D401_M0.5380.09
70_L735_G0.5380.09
496_C710_A0.5360.08
242_M558_F0.5360.08
336_Y602_S0.5340.08
66_A69_Y0.5320.08
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566_Q573_T0.5230.08
61_L346_V0.5230.08
544_T716_Q0.5220.08
110_K173_V0.5210.08
629_S652_D0.5210.08
37_Y105_G0.5200.08
504_H704_Q0.5200.08
360_G596_D0.5190.08
276_I279_I0.5190.08
499_A521_R0.5190.08
40_E652_D0.5190.08
340_A502_G0.5190.08
216_L325_H0.5190.08
196_Y347_K0.5190.08
674_K700_K0.5180.08
78_R475_E0.5180.08
604_V633_L0.5180.08
6_F539_A0.5180.08
461_L723_L0.5170.08
131_S247_K0.5170.08
426_V497_V0.5170.08
257_G285_P0.5160.08
362_L502_G0.5140.08
517_M667_E0.5130.08
110_K311_T0.5130.08
430_A478_I0.5130.08
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657_I662_P0.5120.08
163_P580_L0.5120.08
413_V528_Y0.5120.08
11_S268_P0.5120.08
24_Y82_F0.5120.08
464_A647_K0.5120.08
266_I507_G0.5110.08
167_I252_I0.5110.08
506_D602_S0.5100.08
326_L353_M0.5090.08
334_G479_T0.5090.08
354_M640_Q0.5090.08
606_V642_E0.5090.08
20_L106_L0.5070.08
340_A597_M0.5070.08
355_G580_L0.5070.08
387_N706_H0.5070.08
491_M691_L0.5070.08
369_D447_L0.5070.08
202_Q703_Y0.5060.08
170_A257_G0.5060.08
456_V602_S0.5050.08
69_Y544_T0.5050.08
454_P503_G0.5050.08
165_K621_Y0.5040.08
245_T560_L0.5040.08
489_I546_E0.5040.08
341_S679_L0.5030.08
125_A614_P0.5030.08
129_G693_I0.5030.08
4_Y654_Y0.5020.08
249_T257_G0.5020.08
407_R741_E0.5020.08
461_L571_A0.5020.08
422_T627_Y0.5010.08
503_G594_A0.5010.08
25_Q549_M0.5010.08
503_G596_D0.5000.08
28_T165_K0.5000.08
355_G627_Y0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zenD 6 0.8475 100 0.72 Contact Map
2uv8G 3 0.9022 100 0.732 Contact Map
4cw5A 2 0.5711 100 0.734 Contact Map
2uvaG 3 0.8918 100 0.738 Contact Map
3g87A 1 0.369 100 0.781 Contact Map
3sbmA 1 0.3664 100 0.786 Contact Map
4rr5A 1 0.3768 100 0.799 Contact Map
3ptwA 1 0.4003 100 0.8 Contact Map
3ezoA 1 0.3872 100 0.801 Contact Map
3im8A 1 0.3885 100 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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