GREMLIN Database
YOBI - Uncharacterized membrane protein YobI
UniProt: O34784 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1201 (1133)
Sequences: 200 (180)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_I323_V5.8420.99
397_Y404_D5.3020.98
50_S78_F4.6860.96
113_Q238_D4.3170.94
110_S113_Q4.2770.94
117_Y295_A3.9220.90
237_F276_L3.8360.89
110_S238_D3.6420.87
392_L396_I3.5150.85
240_Y258_F3.4520.83
63_L323_V3.4190.83
113_Q117_Y2.9060.71
60_N65_G2.8990.71
128_R132_I2.8480.69
665_N698_F2.8000.68
279_L405_F2.7780.67
369_N373_E2.7500.66
112_L116_I2.7060.65
247_F295_A2.6830.64
65_G68_G2.6740.64
865_E919_W2.6670.64
125_P246_Y2.6620.64
413_G619_D2.6590.63
401_Y570_L2.6400.63
30_F319_F2.6090.62
374_F1129_L2.6090.62
128_R131_R2.6020.62
361_I594_L2.5880.61
117_Y128_R2.5850.61
60_N70_G2.5730.61
60_N71_K2.5730.61
370_I396_I2.5610.60
129_F404_D2.4670.57
62_A70_G2.4630.57
62_A71_K2.4630.57
69_S328_N2.4630.57
237_F271_E2.4590.57
113_Q295_A2.4570.57
284_E290_V2.4450.57
247_F251_S2.4360.56
332_S335_I2.4310.56
63_L74_I2.4290.56
247_F608_T2.4210.56
128_R295_A2.4180.56
65_G70_G2.4010.55
65_G71_K2.4010.55
115_M237_F2.3950.55
113_Q619_D2.3930.55
112_L247_F2.3870.55
334_D980_I2.3830.55
258_F328_N2.3820.55
244_I295_A2.3600.54
67_Y70_G2.3170.52
67_Y71_K2.3170.52
68_G72_S2.3150.52
60_N67_Y2.3020.52
33_L65_G2.3000.52
361_I367_L2.2960.52
64_T296_I2.2920.52
237_F613_E2.2910.51
236_I328_N2.2650.51
110_S128_R2.2620.51
354_L360_Y2.2560.50
34_S318_D2.2540.50
919_W950_L2.2530.50
94_A112_L2.2520.50
127_S247_F2.2390.50
89_L684_L2.2370.50
33_L62_A2.2290.49
116_I818_T2.2240.49
374_F1022_E2.2160.49
1168_N1171_N2.2100.49
117_Y244_I2.2100.49
132_I295_A2.2080.49
149_A980_I2.2050.49
72_S92_S2.2040.49
266_N874_L2.2010.48
261_L399_N2.2000.48
56_K570_L2.1940.48
93_L246_Y2.1940.48
327_I433_I2.1850.48
313_R660_N2.1760.48
117_Y131_R2.1690.47
60_N72_S2.1690.47
276_L613_E2.1630.47
112_L319_F2.1520.47
128_R243_E2.1510.47
65_G72_S2.1490.47
247_F253_Y2.1480.47
93_L235_S2.1450.47
89_L279_L2.1360.46
128_R247_F2.1350.46
261_L328_N2.1290.46
369_N1063_L2.1130.46
694_F698_F2.1120.46
408_L603_Y2.1070.45
49_L74_I2.1070.45
62_A65_G2.0970.45
48_A283_S2.0700.44
117_Y127_S2.0660.44
661_F695_I2.0650.44
238_D608_T2.0620.44
261_L459_N2.0470.43
593_L622_F2.0440.43
293_I349_I2.0320.43
51_W354_L2.0300.43
626_I638_L2.0290.43
127_S132_I2.0200.42
332_S830_T1.9990.42
68_G71_K1.9840.41
247_F919_W1.9840.41
252_K432_L1.9780.41
119_V283_S1.9700.41
52_G68_G1.9690.41
62_A72_S1.9590.40
113_Q237_F1.9510.40
322_P593_L1.9410.40
110_S240_Y1.9360.40
251_S258_F1.9350.40
129_F660_N1.9150.39
281_N398_K1.9120.39
113_Q459_N1.9080.39
60_N68_G1.9010.39
129_F921_N1.8980.39
35_P65_G1.8940.38
113_Q247_F1.8920.38
402_P413_G1.8920.38
35_P125_P1.8870.38
243_E295_A1.8740.38
33_L70_G1.8730.38
33_L71_K1.8730.38
350_N389_N1.8560.37
280_I290_V1.8560.37
73_S937_L1.8540.37
239_K906_W1.8520.37
265_N269_I1.8470.37
132_I243_E1.8460.37
113_Q495_F1.8360.37
236_I258_F1.8340.37
113_Q132_I1.8320.36
48_A319_F1.8310.36
243_E247_F1.8280.36
113_Q409_Q1.8260.36
243_E597_G1.8250.36
49_L60_N1.8240.36
552_L788_V1.8110.36
324_I413_G1.8100.36
265_N600_D1.8020.36
70_G92_S1.7950.35
71_K92_S1.7950.35
117_Y247_F1.7920.35
77_T495_F1.7910.35
112_L128_R1.7910.35
62_A73_S1.7870.35
238_D247_F1.7830.35
69_S665_N1.7800.35
369_N610_F1.7780.35
113_Q244_I1.7770.35
593_L668_M1.7740.35
326_I1186_S1.7710.35
45_Y62_A1.7700.35
129_F397_Y1.7680.34
116_I720_W1.7670.34
61_I70_G1.7660.34
61_I71_K1.7660.34
140_I290_V1.7650.34
117_Y242_D1.7560.34
248_F295_A1.7520.34
357_V806_V1.7320.33
411_N416_Y1.7290.33
131_R295_A1.7260.33
335_I338_K1.7260.33
73_S115_M1.7230.33
35_P62_A1.7170.33
68_G242_D1.7150.33
32_D55_N1.7140.33
52_G319_F1.7130.33
251_S919_W1.7100.33
110_S247_F1.7030.33
110_S132_I1.7020.33
70_G73_S1.6970.32
440_L548_F1.6940.32
330_S404_D1.6850.32
33_L60_N1.6830.32
117_Y243_E1.6810.32
276_L349_I1.6800.32
360_Y592_Y1.6740.32
110_S236_I1.6660.31
132_I247_F1.6610.31
127_S131_R1.6530.31
290_V1017_L1.6520.31
110_S919_W1.6420.31
35_P70_G1.6350.31
35_P71_K1.6350.31
765_K854_V1.6320.30
49_L67_Y1.6260.30
112_L117_Y1.6240.30
117_Y132_I1.6240.30
130_K276_L1.6220.30
243_E274_R1.6200.30
113_Q131_R1.6150.30
463_L922_V1.6150.30
376_I589_L1.6150.30
110_S127_S1.6130.30
119_V128_R1.6100.30
397_Y608_T1.6090.30
93_L125_P1.6050.30
665_N702_A1.6050.30
65_G92_S1.6040.30
661_F697_G1.6010.30
589_L921_N1.5950.29
94_A408_L1.5930.29
110_S295_A1.5910.29
405_F660_N1.5850.29
35_P92_S1.5820.29
257_I504_I1.5770.29
321_I376_I1.5750.29
737_Y740_D1.5720.29
74_I1130_L1.5680.29
279_L1027_L1.5630.29
61_I72_S1.5620.29
226_E612_P1.5590.28
865_E950_L1.5580.28
128_R242_D1.5580.28
53_L300_I1.5550.28
367_L783_L1.5510.28
87_S616_S1.5500.28
712_I1007_R1.5500.28
608_T613_E1.5500.28
1179_E1182_N1.5430.28
110_S608_T1.5370.28
215_L296_I1.5350.28
933_M1168_N1.5330.28
52_G58_V1.5280.28
49_L72_S1.5270.28
897_D1108_I1.5220.27
217_K395_I1.5210.27
433_I555_L1.5160.27
258_F381_L1.5160.27
49_L71_K1.5150.27
49_L70_G1.5150.27
263_R315_K1.5080.27
281_N313_R1.5070.27
256_V295_A1.5070.27
393_A555_L1.5060.27
846_V1134_I1.5040.27
33_L45_Y1.5020.27
402_P408_L1.4990.27
404_D818_T1.4990.27
62_A67_Y1.4970.27
1017_L1109_T1.4970.27
314_T814_I1.4820.26
376_I786_L1.4790.26
241_L694_F1.4720.26
91_I129_F1.4680.26
386_L600_D1.4640.26
78_F96_F1.4620.26
238_D253_Y1.4610.26
128_R256_V1.4600.26
276_L1043_P1.4580.26
33_L67_Y1.4530.26
117_Y256_V1.4530.26
925_S934_P1.4420.25
215_L334_D1.4400.25
660_N694_F1.4340.25
619_D627_K1.4330.25
258_F288_R1.4330.25
104_E853_F1.4310.25
409_Q891_K1.4290.25
105_N238_D1.4280.25
532_E554_E1.4230.25
664_L806_V1.4220.25
354_L648_L1.4190.25
603_Y790_F1.4170.25
215_L392_L1.4120.25
35_P96_F1.4110.25
805_F809_R1.4110.25
810_N845_Y1.4110.25
849_N888_I1.4080.25
815_N822_I1.4080.25
336_L367_L1.4070.25
35_P60_N1.4070.25
663_L697_G1.3970.24
128_R244_I1.3950.24
295_A865_E1.3950.24
459_N608_T1.3910.24
237_F999_P1.3880.24
64_T813_E1.3870.24
552_L559_K1.3870.24
253_Y295_A1.3850.24
236_I919_W1.3850.24
114_Q874_L1.3850.24
238_D295_A1.3850.24
288_R324_I1.3830.24
97_N844_N1.3830.24
367_L845_Y1.3770.24
1019_L1038_L1.3760.24
814_I1149_I1.3740.24
769_L1024_F1.3720.24
127_S295_A1.3710.24
51_W319_F1.3710.24
78_F322_P1.3660.23
274_R644_I1.3660.23
75_L218_V1.3650.23
374_F895_I1.3610.23
116_I124_I1.3590.23
107_L242_D1.3580.23
290_V403_V1.3580.23
830_T853_F1.3560.23
107_L349_I1.3560.23
237_F774_S1.3540.23
323_V870_F1.3510.23
238_D619_D1.3490.23
242_D295_A1.3470.23
913_N943_N1.3440.23
698_F702_A1.3440.23
87_S594_L1.3430.23
393_A436_K1.3430.23
875_N884_K1.3420.23
112_L295_A1.3420.23
237_F494_F1.3410.23
814_I1077_F1.3380.23
404_D622_F1.3380.23
402_P619_D1.3340.23
129_F853_F1.3310.23
127_S242_D1.3310.23
459_N530_Y1.3310.23
888_I1064_I1.3300.23
211_A328_N1.3300.23
238_D613_E1.3260.23
110_S324_I1.3250.23
783_L811_L1.3250.23
311_R362_D1.3240.23
255_V873_L1.3220.22
331_N609_Y1.3220.22
166_I257_I1.3220.22
907_P934_P1.3210.22
117_Y248_F1.3180.22
265_N1165_I1.3170.22
270_F667_I1.3140.22
396_I611_Y1.3120.22
72_S314_T1.3080.22
113_Q413_G1.3060.22
222_N608_T1.3050.22
258_F291_V1.3040.22
314_T372_N1.3040.22
125_P273_L1.2990.22
68_G127_S1.2980.22
238_D919_W1.2980.22
52_G60_N1.2950.22
112_L830_T1.2950.22
244_I247_F1.2950.22
113_Q128_R1.2930.22
111_I114_Q1.2920.22
262_D315_K1.2900.22
158_F390_K1.2880.22
113_Q608_T1.2860.22
192_L661_F1.2860.22
113_Q416_Y1.2820.22
128_R248_F1.2820.22
49_L399_N1.2810.22
146_F834_V1.2800.21
223_T324_I1.2770.21
416_Y495_F1.2770.21
30_F48_A1.2760.21
33_L61_I1.2750.21
65_G114_Q1.2730.21
35_P72_S1.2710.21
551_E562_I1.2710.21
1146_L1194_L1.2690.21
815_N1181_K1.2680.21
37_N80_K1.2660.21
112_L859_L1.2640.21
245_L819_L1.2630.21
258_F327_I1.2620.21
73_S386_L1.2590.21
96_F276_L1.2590.21
276_L627_K1.2590.21
249_E1130_L1.2580.21
322_P376_I1.2580.21
1135_K1165_I1.2510.21
1174_L1178_L1.2510.21
254_N529_N1.2460.21
69_S607_I1.2440.21
110_S117_Y1.2440.21
599_I874_L1.2390.21
60_N92_S1.2390.21
35_P597_G1.2390.21
95_T247_F1.2340.20
96_F619_D1.2320.20
242_D248_F1.2290.20
68_G92_S1.2290.20
49_L987_V1.2280.20
293_I355_E1.2270.20
96_F695_I1.2270.20
40_D149_A1.2220.20
73_S92_S1.2200.20
67_Y72_S1.2200.20
46_S78_F1.2190.20
770_L831_Y1.2130.20
615_L818_T1.2110.20
131_R243_E1.2100.20
65_G111_I1.2090.20
400_I614_S1.2080.20
66_P112_L1.2010.20
105_N276_L1.2000.20
814_I845_Y1.2000.20
850_I901_L1.2000.20
324_I533_R1.1990.20
789_K845_Y1.1980.20
74_I1129_L1.1980.20
77_T94_A1.1950.20
238_D251_S1.1940.20
843_I1019_L1.1940.20
313_R398_K1.1920.20
276_L312_D1.1900.20
74_I334_D1.1880.19
246_Y301_F1.1880.19
215_L271_E1.1880.19
243_E290_V1.1870.19
213_L681_I1.1870.19
247_F950_L1.1850.19
314_T369_N1.1840.19
280_I1149_I1.1840.19
70_G114_Q1.1820.19
71_K114_Q1.1820.19
194_F477_I1.1820.19
296_I925_S1.1780.19
243_E262_D1.1780.19
324_I558_E1.1750.19
224_T985_F1.1730.19
822_I1138_D1.1720.19
807_V842_V1.1710.19
437_I555_L1.1710.19
74_I289_R1.1690.19
225_L633_P1.1680.19
96_F615_L1.1660.19
300_I324_I1.1640.19
437_I622_F1.1640.19
327_I386_L1.1620.19
127_S243_E1.1620.19
374_F850_I1.1600.19
1192_E1195_R1.1590.19
253_Y865_E1.1560.19
240_Y409_Q1.1530.19
381_L408_L1.1530.19
113_Q276_L1.1510.19
393_A716_W1.1490.19
113_Q613_E1.1490.19
112_L857_V1.1470.19
255_V318_D1.1470.19
131_R459_N1.1470.19
241_L659_L1.1450.19
258_F269_I1.1440.19
35_P61_I1.1440.19
60_N73_S1.1440.19
1027_L1146_L1.1440.19
30_F96_F1.1430.19
223_T909_V1.1430.19
295_A919_W1.1410.19
62_A92_S1.1370.18
244_I459_N1.1360.18
236_I240_Y1.1340.18
408_L1007_R1.1330.18
116_I367_L1.1300.18
91_I397_Y1.1230.18
369_N395_I1.1170.18
1063_L1178_L1.1150.18
249_E906_W1.1140.18
297_K593_L1.1130.18
94_A117_Y1.1120.18
236_I327_I1.1120.18
45_Y61_I1.1110.18
262_D597_G1.1100.18
1182_N1189_E1.1100.18
269_I566_S1.1090.18
1021_P1025_K1.1090.18
356_D627_K1.1080.18
272_R285_Q1.1070.18
117_Y238_D1.1050.18
236_I271_E1.1050.18
257_I293_I1.1040.18
258_F638_L1.1040.18
324_I416_Y1.1030.18
112_L251_S1.1020.18
831_Y862_E1.1020.18
237_F240_Y1.1010.18
91_I111_I1.0990.18
406_S607_I1.0990.18
61_I65_G1.0980.18
292_F317_F1.0980.18
292_F365_R1.0980.18
317_F365_R1.0980.18
95_T107_L1.0970.18
815_N818_T1.0970.18
374_F710_Q1.0960.18
601_E660_N1.0960.18
248_F256_V1.0950.18
238_D950_L1.0940.18
298_D313_R1.0940.18
66_P222_N1.0920.18
62_A68_G1.0910.18
440_L663_L1.0880.17
47_K297_K1.0870.17
254_N644_I1.0870.17
235_S594_L1.0870.17
119_V647_K1.0860.17
517_I521_A1.0850.17
91_I694_F1.0850.17
917_A940_F1.0820.17
322_P644_I1.0810.17
272_R887_M1.0800.17
58_V157_L1.0790.17
261_L295_A1.0780.17
404_D802_I1.0780.17
1127_L1130_L1.0780.17
256_V261_L1.0760.17
357_V429_Q1.0730.17
74_I144_L1.0680.17
327_I1149_I1.0680.17
607_I660_N1.0640.17
378_Q388_P1.0640.17
61_I67_Y1.0630.17
112_L248_F1.0620.17
402_P607_I1.0620.17
108_E238_D1.0600.17
437_I868_E1.0600.17
277_N322_P1.0580.17
286_I699_K1.0580.17
241_L313_R1.0570.17
457_E533_R1.0550.17
53_L323_V1.0540.17
402_P601_E1.0540.17
433_I457_E1.0520.17
77_T594_L1.0510.17
327_I1171_N1.0510.17
45_Y74_I1.0500.17
73_S463_L1.0490.17
322_P909_V1.0470.17
1172_K1175_V1.0470.17
235_S1134_I1.0470.17
258_F1019_L1.0460.17
127_S281_N1.0460.17
332_S722_F1.0450.17
594_L884_K1.0440.17
238_D865_E1.0420.17
349_I925_S1.0400.17
253_Y919_W1.0400.17
30_F615_L1.0370.17
400_I593_L1.0370.17
759_M812_Y1.0360.16
131_R242_D1.0350.16
243_E246_Y1.0350.16
87_S914_K1.0340.16
215_L1130_L1.0320.16
432_L440_L1.0320.16
144_L199_L1.0320.16
112_L533_R1.0290.16
94_A533_R1.0280.16
510_N537_I1.0280.16
819_L1124_D1.0280.16
394_M1146_L1.0260.16
95_T295_A1.0260.16
132_I238_D1.0250.16
481_G922_V1.0250.16
450_E533_R1.0240.16
119_V132_I1.0230.16
227_K570_L1.0230.16
75_L358_T1.0190.16
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131_R941_L0.5050.09
344_P418_I0.5040.09
259_E372_N0.5040.09
462_Y716_W0.5040.09
694_F716_W0.5030.09
58_V622_F0.5030.09
596_H750_I0.5030.09
874_L1167_N0.5030.09
217_K608_T0.5020.09
477_I708_F0.5020.09
30_F269_I0.5020.09
248_F264_F0.5010.09
419_F934_P0.5010.09
64_T716_W0.5010.09
292_F318_D0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2chgA 1 0.1815 96.9 0.977 Contact Map
4xgcA 1 0.2415 96.8 0.977 Contact Map
1l8qA 1 0.2381 96.6 0.977 Contact Map
3bosA 2 0.189 96.5 0.978 Contact Map
1d2nA 3 0.1873 96.5 0.978 Contact Map
2v1uA 1 0.2998 96.4 0.978 Contact Map
1njgA 1 0.1973 96.4 0.978 Contact Map
1fnnA 1 0.2948 96.3 0.978 Contact Map
2qbyA 1 0.2864 96 0.978 Contact Map
3te6A 1 0.2123 96 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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