PRPC - BACSU - GREMLIN Contacts

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PRPC - Protein phosphatase PrpC

UniProt:	O34779	Sequences: MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAGDVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGTTIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHPRKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQEKVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (230)
Sequences:	9329 (6465)
Seq/√Len:	426.3

ECOLI - YEGK
BACSU - PRPC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
105_V	124_C	4.267	1.00
20_A	237_T	4.040	1.00
32_A	241_L	3.116	1.00
128_Q	188_D	2.788	1.00
134_Q	203_G	2.601	1.00
123_R	138_D	2.514	1.00
197_L	236_I	2.465	1.00
107_A	190_L	2.464	1.00
38_M	101_G	2.391	1.00
116_V	124_C	2.343	1.00
189_K	242_E	2.334	1.00
113_T	181_S	2.333	1.00
143_N	147_R	2.321	1.00
204_T	208_D	2.213	1.00
113_T	183_D	2.210	1.00
139_H	178_D	2.200	1.00
137_E	147_R	2.130	1.00
127_L	132_F	2.107	1.00
197_L	223_L	1.993	1.00
193_C	198_T	1.972	1.00
191_L	206_L	1.919	1.00
47_A	169_L	1.786	1.00
152_S	155_D	1.757	1.00
46_V	50_M	1.749	1.00
200_K	233_E	1.734	1.00
107_A	192_L	1.726	1.00
226_K	230_N	1.696	1.00
205_E	230_N	1.692	1.00
11_K	228_N	1.664	1.00
47_A	102_T	1.661	1.00
115_S	181_S	1.657	1.00
114_V	182_F	1.646	1.00
58_K	82_S	1.637	1.00
80_I	106_C	1.631	1.00
6_K	221_N	1.627	1.00
54_A	86_K	1.615	1.00
106_C	117_A	1.596	1.00
107_A	114_V	1.578	1.00
35_A	102_T	1.576	1.00
7_T	16_N	1.574	1.00
202_E	205_E	1.550	1.00
80_I	104_I	1.545	1.00
13_R	235_N	1.540	1.00
217_Q	221_N	1.532	1.00
127_L	207_K	1.531	1.00
152_S	156_A	1.526	1.00
137_E	143_N	1.519	1.00
209_I	226_K	1.518	1.00
123_R	203_G	1.502	1.00
114_V	190_L	1.497	1.00
54_A	83_V	1.489	1.00
216_P	240_L	1.470	1.00
144_E	148_T	1.465	1.00
6_K	224_V	1.465	1.00
15_H	45_D	1.444	1.00
77_I	176_S	1.436	1.00
43_A	97_C	1.431	1.00
80_I	117_A	1.423	1.00
105_V	192_L	1.408	1.00
49_K	53_K	1.408	1.00
118_H	136_T	1.407	1.00
50_M	53_K	1.403	1.00
72_C	115_S	1.391	1.00
126_L	133_V	1.383	1.00
221_N	225_D	1.369	1.00
191_L	240_L	1.352	1.00
116_V	180_R	1.326	1.00
228_N	232_G	1.317	1.00
118_H	180_R	1.307	1.00
198_T	206_L	1.302	1.00
107_A	116_V	1.294	1.00
8_D	228_N	1.281	1.00
85_S	89_D	1.278	1.00
103_T	122_S	1.268	1.00
82_S	86_K	1.253	1.00
51_A	169_L	1.246	1.00
225_D	229_Q	1.245	1.00
35_A	104_I	1.243	1.00
224_V	238_A	1.241	1.00
73_E	181_S	1.228	1.00
232_G	236_I	1.223	1.00
32_A	239_V	1.209	1.00
197_L	238_A	1.203	1.00
215_A	218_E	1.201	1.00
205_E	226_K	1.194	1.00
126_L	188_D	1.189	1.00
139_H	167_K	1.185	1.00
128_Q	185_E	1.179	1.00
151_I	159_H	1.175	1.00
55_M	79_Q	1.148	1.00
146_V	156_A	1.147	1.00
74_K	78_E	1.146	1.00
114_V	184_I	1.134	1.00
126_L	190_L	1.131	1.00
112_K	183_D	1.127	1.00
38_M	41_H	1.123	1.00
207_K	211_Q	1.109	1.00
31_L	52_V	1.103	1.00
73_E	77_I	1.097	1.00
54_A	57_E	1.096	1.00
77_I	81_L	1.094	1.00
84_N	88_Y	1.090	1.00
87_I	169_L	1.075	1.00
191_L	210_L	1.071	1.00
33_V	106_C	1.064	1.00
54_A	82_S	1.064	1.00
213_D	219_K	1.057	1.00
50_M	54_A	1.053	1.00
105_V	118_H	1.050	1.00
220_V	238_A	1.049	1.00
19_D	45_D	1.041	1.00
226_K	229_Q	1.039	1.00
201_V	226_K	1.035	1.00
8_D	224_V	1.029	1.00
205_E	208_D	1.029	1.00
19_D	48_S	1.028	1.00
75_W	79_Q	1.028	1.00
189_K	210_L	1.015	1.00
147_R	152_S	1.013	1.00
58_K	61_E	1.006	1.00
201_V	230_N	1.003	1.00
222_L	225_D	0.998	1.00
227_A	236_I	0.988	1.00
132_F	210_L	0.985	1.00
76_L	117_A	0.984	1.00
200_K	232_G	0.983	1.00
146_V	151_I	0.973	1.00
50_M	86_K	0.969	1.00
210_L	219_K	0.968	1.00
167_K	177_I	0.966	1.00
227_A	232_G	0.961	1.00
204_T	207_K	0.958	1.00
29_F	110_T	0.956	1.00
102_T	122_S	0.952	1.00
35_A	52_V	0.952	1.00
220_V	240_L	0.950	1.00
132_F	207_K	0.950	1.00
33_V	55_M	0.948	1.00
123_R	136_T	0.947	1.00
104_I	169_L	0.945	1.00
58_K	78_E	0.943	1.00
127_L	211_Q	0.937	1.00
21_G	56_G	0.931	1.00
185_E	188_D	0.930	1.00
228_N	236_I	0.928	1.00
21_G	33_V	0.922	1.00
16_N	235_N	0.921	1.00
222_L	226_K	0.921	1.00
43_A	87_I	0.920	1.00
201_V	206_L	0.919	1.00
105_V	136_T	0.917	1.00
224_V	228_N	0.917	1.00
76_L	106_C	0.914	1.00
151_I	156_A	0.908	1.00
84_N	87_I	0.906	1.00
167_K	178_D	0.904	1.00
218_E	222_L	0.892	1.00
6_K	220_V	0.890	1.00
119_I	175_V	0.890	1.00
146_V	150_E	0.874	1.00
86_K	89_D	0.874	1.00
150_E	156_A	0.873	1.00
127_L	189_K	0.872	1.00
83_V	87_I	0.871	1.00
74_K	77_I	0.866	1.00
191_L	238_A	0.864	1.00
153_R	156_A	0.864	1.00
195_D	234_D	0.863	1.00
20_A	239_V	0.860	1.00
123_R	134_Q	0.859	1.00
141_L	164_V	0.858	1.00
126_L	135_V	0.855	1.00
223_L	238_A	0.852	1.00
168_A	171_T	0.852	1.00
33_V	52_V	0.850	1.00
55_M	104_I	0.848	1.00
73_E	179_T	0.846	1.00
190_L	243_L	0.846	1.00
82_S	85_S	0.845	1.00
97_C	100_M	0.843	1.00
151_I	155_D	0.841	1.00
189_K	240_L	0.830	1.00
102_T	169_L	0.826	1.00
115_S	179_T	0.822	1.00
22_I	239_V	0.817	1.00
220_V	224_V	0.815	1.00
73_E	115_S	0.811	1.00
103_T	195_D	0.809	1.00
128_Q	131_D	0.803	1.00
206_L	223_L	0.801	1.00
45_D	49_K	0.801	1.00
44_G	48_S	0.798	1.00
189_K	219_K	0.796	1.00
32_A	192_L	0.795	1.00
7_T	237_T	0.793	1.00
81_L	175_V	0.790	1.00
86_K	90_H	0.782	1.00
232_G	235_N	0.776	1.00
138_D	203_G	0.774	1.00
29_F	108_L	0.770	1.00
54_A	58_K	0.759	1.00
44_G	47_A	0.757	1.00
119_I	177_I	0.756	1.00
127_L	210_L	0.756	1.00
125_Y	203_G	0.754	1.00
80_I	83_V	0.751	1.00
78_E	82_S	0.749	1.00
143_N	146_V	0.746	1.00
51_A	102_T	0.739	1.00
140_S	163_N	0.738	1.00
88_Y	175_V	0.736	1.00
24_K	30_I	0.735	1.00
209_I	222_L	0.732	1.00
23_F	56_G	0.732	1.00
125_Y	206_L	0.730	1.00
21_G	35_A	0.728	1.00
218_E	221_N	0.726	1.00
81_L	85_S	0.726	1.00
141_L	161_R	0.723	1.00
159_H	162_K	0.723	1.00
201_V	209_I	0.720	1.00
220_V	227_A	0.719	1.00
132_F	204_T	0.719	1.00
71_E	74_K	0.715	1.00
68_A	71_E	0.713	1.00
209_I	219_K	0.712	1.00
148_T	153_R	0.710	1.00
216_P	242_E	0.709	1.00
84_N	175_V	0.708	1.00
105_V	122_S	0.703	1.00
193_C	197_L	0.702	1.00
141_L	166_T	0.702	1.00
125_Y	198_T	0.697	1.00
38_M	171_T	0.697	1.00
118_H	139_H	0.696	1.00
58_K	62_A	0.694	1.00
162_K	199_N	0.693	1.00
157_E	202_E	0.693	1.00
31_L	108_L	0.692	1.00
31_L	106_C	0.689	1.00
135_V	180_R	0.688	1.00
34_V	237_T	0.683	1.00
121_D	195_D	0.682	1.00
22_I	32_A	0.674	1.00
219_K	242_E	0.668	1.00
140_S	199_N	0.668	1.00
8_D	236_I	0.668	1.00
197_L	227_A	0.661	0.99
31_L	35_A	0.661	0.99
45_D	48_S	0.660	0.99
145_L	159_H	0.657	0.99
215_A	219_K	0.656	0.99
206_L	219_K	0.655	0.99
203_G	206_L	0.645	0.99
95_E	98_Q	0.643	0.99
158_H	162_K	0.643	0.99
144_E	166_T	0.640	0.99
79_Q	83_V	0.637	0.99
140_S	166_T	0.636	0.99
109_F	114_V	0.632	0.99
44_G	102_T	0.631	0.99
128_Q	133_V	0.630	0.99
191_L	197_L	0.629	0.99
80_I	84_N	0.627	0.99
141_L	145_L	0.626	0.99
125_Y	132_F	0.625	0.99
8_D	235_N	0.625	0.99
41_H	45_D	0.625	0.99
209_I	223_L	0.623	0.99
137_E	178_D	0.622	0.99
90_H	97_C	0.620	0.99
51_A	87_I	0.620	0.99
214_S	222_L	0.617	0.99
21_G	52_V	0.612	0.99
47_A	83_V	0.611	0.99
131_D	207_K	0.610	0.99
184_I	190_L	0.609	0.99
38_M	44_G	0.608	0.99
69_P	113_T	0.608	0.99
216_P	219_K	0.605	0.99
140_S	165_L	0.604	0.99
20_A	194_S	0.595	0.99
189_K	216_P	0.593	0.99
13_R	39_G	0.593	0.99
125_Y	193_C	0.591	0.99
118_H	124_C	0.590	0.99
182_F	190_L	0.589	0.99
197_L	201_V	0.588	0.99
69_P	115_S	0.587	0.99
228_N	235_N	0.587	0.99
184_I	243_L	0.583	0.99
40_G	44_G	0.580	0.99
88_Y	92_Q	0.580	0.99
124_C	180_R	0.579	0.99
34_V	105_V	0.579	0.99
56_G	60_N	0.577	0.99
59_W	75_W	0.573	0.99
53_K	57_E	0.569	0.98
125_Y	207_K	0.568	0.98
142_V	159_H	0.568	0.98
33_V	104_I	0.565	0.98
15_H	235_N	0.562	0.98
161_R	164_V	0.561	0.98
51_A	104_I	0.561	0.98
9_T	15_H	0.559	0.98
41_H	44_G	0.559	0.98
69_P	181_S	0.557	0.98
109_F	241_L	0.553	0.98
144_E	147_R	0.550	0.98
116_V	136_T	0.548	0.98
25_G	29_F	0.548	0.98
47_A	51_A	0.547	0.98
19_D	41_H	0.545	0.98
208_D	212_S	0.543	0.98
109_F	190_L	0.541	0.98
43_A	46_V	0.539	0.98
165_L	168_A	0.539	0.98
8_D	11_K	0.536	0.98
50_M	90_H	0.534	0.98
51_A	83_V	0.531	0.98
11_K	231_G	0.531	0.98
109_F	184_I	0.531	0.98
34_V	192_L	0.530	0.98
121_D	234_D	0.529	0.98
58_K	79_Q	0.529	0.98
168_A	175_V	0.528	0.98
78_E	81_L	0.525	0.97
19_D	52_V	0.523	0.97
72_C	108_L	0.523	0.97
91_A	95_E	0.520	0.97
21_G	31_L	0.518	0.97
129_D	187_G	0.518	0.97
110_T	184_I	0.517	0.97
193_C	206_L	0.514	0.97
206_L	238_A	0.510	0.97
11_K	232_G	0.509	0.97
19_D	49_K	0.509	0.97
158_H	161_R	0.509	0.97
37_G	195_D	0.506	0.97
115_S	118_H	0.506	0.97
34_V	194_S	0.504	0.97
150_E	153_R	0.504	0.97
142_V	146_V	0.503	0.97
117_A	179_T	0.502	0.97
169_L	175_V	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qn1B	1	0.9449	100	0.165	Contact Map
4ra2A	1	0.9921	100	0.172	Contact Map
2p8eA	1	0.9291	100	0.176	Contact Map
3kdjB	1	0.937	100	0.181	Contact Map
4oicB	1	0.9488	100	0.182	Contact Map
4n0gA	1	0.9409	100	0.185	Contact Map
2i0oA	2	0.9016	100	0.191	Contact Map
4yzgA	2	0.9606	100	0.196	Contact Map
2iq1A	1	0.9291	100	0.204	Contact Map
2i44A	1	0.9488	100	0.207	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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