GREMLIN Database
PRPC - Protein phosphatase PrpC
UniProt: O34779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (230)
Sequences: 9329 (6465)
Seq/√Len: 426.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_V124_C4.2671.00
20_A237_T4.0401.00
32_A241_L3.1161.00
128_Q188_D2.7881.00
134_Q203_G2.6011.00
123_R138_D2.5141.00
197_L236_I2.4651.00
107_A190_L2.4641.00
38_M101_G2.3911.00
116_V124_C2.3431.00
189_K242_E2.3341.00
113_T181_S2.3331.00
143_N147_R2.3211.00
204_T208_D2.2131.00
113_T183_D2.2101.00
139_H178_D2.2001.00
137_E147_R2.1301.00
127_L132_F2.1071.00
197_L223_L1.9931.00
193_C198_T1.9721.00
191_L206_L1.9191.00
47_A169_L1.7861.00
152_S155_D1.7571.00
46_V50_M1.7491.00
200_K233_E1.7341.00
107_A192_L1.7261.00
226_K230_N1.6961.00
205_E230_N1.6921.00
11_K228_N1.6641.00
47_A102_T1.6611.00
115_S181_S1.6571.00
114_V182_F1.6461.00
58_K82_S1.6371.00
80_I106_C1.6311.00
6_K221_N1.6271.00
54_A86_K1.6151.00
106_C117_A1.5961.00
107_A114_V1.5781.00
35_A102_T1.5761.00
7_T16_N1.5741.00
202_E205_E1.5501.00
80_I104_I1.5451.00
13_R235_N1.5401.00
217_Q221_N1.5321.00
127_L207_K1.5311.00
152_S156_A1.5261.00
137_E143_N1.5191.00
209_I226_K1.5181.00
123_R203_G1.5021.00
114_V190_L1.4971.00
54_A83_V1.4891.00
216_P240_L1.4701.00
144_E148_T1.4651.00
6_K224_V1.4651.00
15_H45_D1.4441.00
77_I176_S1.4361.00
43_A97_C1.4311.00
80_I117_A1.4231.00
105_V192_L1.4081.00
49_K53_K1.4081.00
118_H136_T1.4071.00
50_M53_K1.4031.00
72_C115_S1.3911.00
126_L133_V1.3831.00
221_N225_D1.3691.00
191_L240_L1.3521.00
116_V180_R1.3261.00
228_N232_G1.3171.00
118_H180_R1.3071.00
198_T206_L1.3021.00
107_A116_V1.2941.00
8_D228_N1.2811.00
85_S89_D1.2781.00
103_T122_S1.2681.00
82_S86_K1.2531.00
51_A169_L1.2461.00
225_D229_Q1.2451.00
35_A104_I1.2431.00
224_V238_A1.2411.00
73_E181_S1.2281.00
232_G236_I1.2231.00
32_A239_V1.2091.00
197_L238_A1.2031.00
215_A218_E1.2011.00
205_E226_K1.1941.00
126_L188_D1.1891.00
139_H167_K1.1851.00
128_Q185_E1.1791.00
151_I159_H1.1751.00
55_M79_Q1.1481.00
146_V156_A1.1471.00
74_K78_E1.1461.00
114_V184_I1.1341.00
126_L190_L1.1311.00
112_K183_D1.1271.00
38_M41_H1.1231.00
207_K211_Q1.1091.00
31_L52_V1.1031.00
73_E77_I1.0971.00
54_A57_E1.0961.00
77_I81_L1.0941.00
84_N88_Y1.0901.00
87_I169_L1.0751.00
191_L210_L1.0711.00
33_V106_C1.0641.00
54_A82_S1.0641.00
213_D219_K1.0571.00
50_M54_A1.0531.00
105_V118_H1.0501.00
220_V238_A1.0491.00
19_D45_D1.0411.00
226_K229_Q1.0391.00
201_V226_K1.0351.00
8_D224_V1.0291.00
205_E208_D1.0291.00
19_D48_S1.0281.00
75_W79_Q1.0281.00
189_K210_L1.0151.00
147_R152_S1.0131.00
58_K61_E1.0061.00
201_V230_N1.0031.00
222_L225_D0.9981.00
227_A236_I0.9881.00
132_F210_L0.9851.00
76_L117_A0.9841.00
200_K232_G0.9831.00
146_V151_I0.9731.00
50_M86_K0.9691.00
210_L219_K0.9681.00
167_K177_I0.9661.00
227_A232_G0.9611.00
204_T207_K0.9581.00
29_F110_T0.9561.00
102_T122_S0.9521.00
35_A52_V0.9521.00
220_V240_L0.9501.00
132_F207_K0.9501.00
33_V55_M0.9481.00
123_R136_T0.9471.00
104_I169_L0.9451.00
58_K78_E0.9431.00
127_L211_Q0.9371.00
21_G56_G0.9311.00
185_E188_D0.9301.00
228_N236_I0.9281.00
21_G33_V0.9221.00
16_N235_N0.9211.00
222_L226_K0.9211.00
43_A87_I0.9201.00
201_V206_L0.9191.00
105_V136_T0.9171.00
224_V228_N0.9171.00
76_L106_C0.9141.00
151_I156_A0.9081.00
84_N87_I0.9061.00
167_K178_D0.9041.00
218_E222_L0.8921.00
6_K220_V0.8901.00
119_I175_V0.8901.00
146_V150_E0.8741.00
86_K89_D0.8741.00
150_E156_A0.8731.00
127_L189_K0.8721.00
83_V87_I0.8711.00
74_K77_I0.8661.00
191_L238_A0.8641.00
153_R156_A0.8641.00
195_D234_D0.8631.00
20_A239_V0.8601.00
123_R134_Q0.8591.00
141_L164_V0.8581.00
126_L135_V0.8551.00
223_L238_A0.8521.00
168_A171_T0.8521.00
33_V52_V0.8501.00
55_M104_I0.8481.00
73_E179_T0.8461.00
190_L243_L0.8461.00
82_S85_S0.8451.00
97_C100_M0.8431.00
151_I155_D0.8411.00
189_K240_L0.8301.00
102_T169_L0.8261.00
115_S179_T0.8221.00
22_I239_V0.8171.00
220_V224_V0.8151.00
73_E115_S0.8111.00
103_T195_D0.8091.00
128_Q131_D0.8031.00
206_L223_L0.8011.00
45_D49_K0.8011.00
44_G48_S0.7981.00
189_K219_K0.7961.00
32_A192_L0.7951.00
7_T237_T0.7931.00
81_L175_V0.7901.00
86_K90_H0.7821.00
232_G235_N0.7761.00
138_D203_G0.7741.00
29_F108_L0.7701.00
54_A58_K0.7591.00
44_G47_A0.7571.00
119_I177_I0.7561.00
127_L210_L0.7561.00
125_Y203_G0.7541.00
80_I83_V0.7511.00
78_E82_S0.7491.00
143_N146_V0.7461.00
51_A102_T0.7391.00
140_S163_N0.7381.00
88_Y175_V0.7361.00
24_K30_I0.7351.00
209_I222_L0.7321.00
23_F56_G0.7321.00
125_Y206_L0.7301.00
21_G35_A0.7281.00
218_E221_N0.7261.00
81_L85_S0.7261.00
141_L161_R0.7231.00
159_H162_K0.7231.00
201_V209_I0.7201.00
220_V227_A0.7191.00
132_F204_T0.7191.00
71_E74_K0.7151.00
68_A71_E0.7131.00
209_I219_K0.7121.00
148_T153_R0.7101.00
216_P242_E0.7091.00
84_N175_V0.7081.00
105_V122_S0.7031.00
193_C197_L0.7021.00
141_L166_T0.7021.00
125_Y198_T0.6971.00
38_M171_T0.6971.00
118_H139_H0.6961.00
58_K62_A0.6941.00
162_K199_N0.6931.00
157_E202_E0.6931.00
31_L108_L0.6921.00
31_L106_C0.6891.00
135_V180_R0.6881.00
34_V237_T0.6831.00
121_D195_D0.6821.00
22_I32_A0.6741.00
219_K242_E0.6681.00
140_S199_N0.6681.00
8_D236_I0.6681.00
197_L227_A0.6610.99
31_L35_A0.6610.99
45_D48_S0.6600.99
145_L159_H0.6570.99
215_A219_K0.6560.99
206_L219_K0.6550.99
203_G206_L0.6450.99
95_E98_Q0.6430.99
158_H162_K0.6430.99
144_E166_T0.6400.99
79_Q83_V0.6370.99
140_S166_T0.6360.99
109_F114_V0.6320.99
44_G102_T0.6310.99
128_Q133_V0.6300.99
191_L197_L0.6290.99
80_I84_N0.6270.99
141_L145_L0.6260.99
125_Y132_F0.6250.99
8_D235_N0.6250.99
41_H45_D0.6250.99
209_I223_L0.6230.99
137_E178_D0.6220.99
90_H97_C0.6200.99
51_A87_I0.6200.99
214_S222_L0.6170.99
21_G52_V0.6120.99
47_A83_V0.6110.99
131_D207_K0.6100.99
184_I190_L0.6090.99
38_M44_G0.6080.99
69_P113_T0.6080.99
216_P219_K0.6050.99
140_S165_L0.6040.99
20_A194_S0.5950.99
189_K216_P0.5930.99
13_R39_G0.5930.99
125_Y193_C0.5910.99
118_H124_C0.5900.99
182_F190_L0.5890.99
197_L201_V0.5880.99
69_P115_S0.5870.99
228_N235_N0.5870.99
184_I243_L0.5830.99
40_G44_G0.5800.99
88_Y92_Q0.5800.99
124_C180_R0.5790.99
34_V105_V0.5790.99
56_G60_N0.5770.99
59_W75_W0.5730.99
53_K57_E0.5690.98
125_Y207_K0.5680.98
142_V159_H0.5680.98
33_V104_I0.5650.98
15_H235_N0.5620.98
161_R164_V0.5610.98
51_A104_I0.5610.98
9_T15_H0.5590.98
41_H44_G0.5590.98
69_P181_S0.5570.98
109_F241_L0.5530.98
144_E147_R0.5500.98
116_V136_T0.5480.98
25_G29_F0.5480.98
47_A51_A0.5470.98
19_D41_H0.5450.98
208_D212_S0.5430.98
109_F190_L0.5410.98
43_A46_V0.5390.98
165_L168_A0.5390.98
8_D11_K0.5360.98
50_M90_H0.5340.98
51_A83_V0.5310.98
11_K231_G0.5310.98
109_F184_I0.5310.98
34_V192_L0.5300.98
121_D234_D0.5290.98
58_K79_Q0.5290.98
168_A175_V0.5280.98
78_E81_L0.5250.97
19_D52_V0.5230.97
72_C108_L0.5230.97
91_A95_E0.5200.97
21_G31_L0.5180.97
129_D187_G0.5180.97
110_T184_I0.5170.97
193_C206_L0.5140.97
206_L238_A0.5100.97
11_K232_G0.5090.97
19_D49_K0.5090.97
158_H161_R0.5090.97
37_G195_D0.5060.97
115_S118_H0.5060.97
34_V194_S0.5040.97
150_E153_R0.5040.97
142_V146_V0.5030.97
117_A179_T0.5020.97
169_L175_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qn1B 1 0.9449 100 0.165 Contact Map
4ra2A 1 0.9921 100 0.172 Contact Map
2p8eA 1 0.9291 100 0.176 Contact Map
3kdjB 1 0.937 100 0.181 Contact Map
4oicB 1 0.9488 100 0.182 Contact Map
4n0gA 1 0.9409 100 0.185 Contact Map
2i0oA 2 0.9016 100 0.191 Contact Map
4yzgA 2 0.9606 100 0.196 Contact Map
2iq1A 1 0.9291 100 0.204 Contact Map
2i44A 1 0.9488 100 0.207 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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