OHRR - BACSU - GREMLIN Contacts

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OHRR - Organic hydroperoxide resistance transcriptional regulator

UniProt:	O34777	Sequences: MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYLALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTEDGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	147 (130)
Sequences:	21946 (16345)
Seq/√Len:	1433.6

ECOLI - MARR SLYA MPRA
BACSU - OHRR YCGE YSMB YKOM YFIV YXAD YUSO YWAE YETL YYBA YDCH MHQR YDGG YPOP YWHA YDGJ YWOH YHJH YVMB YVNA YBFA
SULSO - Q97Z53 Q97YG9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
87_K	99_S	2.937	1.00
128_D	138_T	2.893	1.00
54_T	99_S	2.741	1.00
89_S	97_L	2.661	1.00
85_T	99_S	2.556	1.00
56_T	95_S	2.465	1.00
131_Q	135_A	2.450	1.00
131_Q	134_S	2.203	1.00
125_S	128_D	2.195	1.00
88_R	96_V	2.078	1.00
50_W	108_K	2.050	1.00
123_K	142_T	1.963	1.00
42_Q	81_Q	1.951	1.00
56_T	59_K	1.937	1.00
89_S	95_S	1.868	1.00
50_W	100_L	1.800	1.00
124_Q	135_A	1.779	1.00
128_D	131_Q	1.716	1.00
79_E	86_R	1.632	1.00
17_L	137_Y	1.554	1.00
103_D	107_L	1.545	1.00
42_Q	77_R	1.531	1.00
82_G	103_D	1.522	1.00
132_L	135_A	1.514	1.00
107_L	110_K	1.478	1.00
103_D	106_L	1.457	1.00
52_H	63_Q	1.456	1.00
54_T	97_L	1.455	1.00
57_V	75_L	1.451	1.00
75_L	98_I	1.415	1.00
39_T	42_Q	1.387	1.00
76_K	80_Q	1.374	1.00
128_D	134_S	1.374	1.00
48_L	63_Q	1.367	1.00
45_A	74_M	1.356	1.00
17_L	140_L	1.330	1.00
50_W	105_A	1.281	1.00
36_L	110_K	1.275	1.00
135_A	138_T	1.273	1.00
17_L	133_K	1.251	1.00
119_L	122_S	1.249	1.00
32_L	114_I	1.236	1.00
36_L	114_I	1.231	1.00
128_D	135_A	1.217	1.00
57_V	96_V	1.204	1.00
76_K	93_E	1.199	1.00
59_K	62_E	1.197	1.00
134_S	138_T	1.189	1.00
66_L	70_T	1.154	1.00
106_L	110_K	1.153	1.00
20_A	140_L	1.138	1.00
133_K	137_Y	1.117	1.00
21_S	140_L	1.110	1.00
54_T	87_K	1.109	1.00
83_L	107_L	1.108	1.00
58_K	68_S	1.104	1.00
45_A	71_L	1.093	1.00
86_R	96_V	1.091	1.00
30_K	34_D	1.070	1.00
67_D	70_T	1.062	1.00
19_Y	22_S	1.051	1.00
58_K	62_E	1.049	1.00
57_V	98_I	1.039	1.00
35_K	114_I	1.028	1.00
129_L	133_K	1.025	1.00
115_P	119_L	1.014	1.00
72_T	76_K	1.002	1.00
52_H	55_L	0.996	1.00
53_E	105_A	0.986	1.00
57_V	71_L	0.983	1.00
69_G	72_T	0.979	1.00
127_E	131_Q	0.972	1.00
55_L	63_Q	0.965	1.00
32_L	117_T	0.965	1.00
76_K	79_E	0.957	1.00
100_L	104_G	0.956	1.00
57_V	68_S	0.951	1.00
36_L	111_A	0.949	1.00
41_P	74_M	0.944	1.00
55_L	59_K	0.929	1.00
105_A	109_E	0.910	1.00
37_N	81_Q	0.909	1.00
24_E	140_L	0.908	1.00
21_S	136_L	0.901	1.00
70_T	73_P	0.898	1.00
59_K	63_Q	0.896	1.00
32_L	121_L	0.887	1.00
49_L	84_I	0.884	1.00
87_K	97_L	0.881	1.00
22_S	26_T	0.869	1.00
81_Q	103_D	0.865	1.00
81_Q	107_L	0.863	1.00
66_L	71_L	0.861	1.00
85_T	101_T	0.860	1.00
83_L	103_D	0.857	1.00
28_Q	118_I	0.853	1.00
14_L	133_K	0.851	1.00
126_G	130_K	0.847	1.00
102_E	105_A	0.843	1.00
102_E	106_L	0.838	1.00
131_Q	138_T	0.834	1.00
73_P	77_R	0.831	1.00
18_L	22_S	0.830	1.00
67_D	73_P	0.830	1.00
113_D	117_T	0.823	1.00
75_L	84_I	0.818	1.00
124_Q	139_L	0.814	1.00
89_S	92_D	0.810	1.00
100_L	105_A	0.799	1.00
46_L	108_K	0.797	1.00
44_L	64_L	0.789	1.00
114_I	117_T	0.788	1.00
73_P	76_K	0.786	1.00
117_T	121_L	0.780	1.00
28_Q	121_L	0.779	1.00
50_W	112_V	0.778	1.00
88_R	93_E	0.778	1.00
53_E	99_S	0.777	1.00
32_L	35_K	0.774	1.00
30_K	40_Y	0.770	1.00
90_E	97_L	0.767	1.00
43_Y	111_A	0.762	1.00
41_P	70_T	0.757	1.00
19_Y	23_R	0.754	1.00
45_A	60_M	0.753	1.00
92_D	95_S	0.752	1.00
50_W	109_E	0.749	1.00
117_T	120_G	0.743	1.00
48_L	64_L	0.742	1.00
79_E	85_T	0.723	1.00
21_S	139_L	0.715	1.00
125_S	129_L	0.713	1.00
17_L	20_A	0.710	1.00
137_Y	141_E	0.707	1.00
79_E	84_I	0.707	1.00
77_R	80_Q	0.706	1.00
106_L	109_E	0.706	1.00
75_L	79_E	0.701	1.00
61_G	71_L	0.698	1.00
18_L	21_S	0.696	1.00
48_L	55_L	0.685	1.00
48_L	52_H	0.683	1.00
113_D	116_G	0.682	1.00
110_K	113_D	0.677	1.00
78_M	83_L	0.671	1.00
57_V	72_T	0.663	1.00
52_H	59_K	0.661	1.00
29_Y	115_P	0.660	1.00
127_E	130_K	0.659	1.00
47_L	51_E	0.659	1.00
71_L	75_L	0.659	1.00
118_I	121_L	0.656	1.00
32_L	118_I	0.651	1.00
49_L	100_L	0.649	1.00
45_A	64_L	0.647	1.00
110_K	114_I	0.642	1.00
26_T	30_K	0.642	1.00
61_G	68_S	0.640	1.00
116_G	120_G	0.640	1.00
49_L	55_L	0.639	1.00
130_K	134_S	0.636	1.00
23_R	27_K	0.635	1.00
76_K	86_R	0.634	1.00
130_K	133_K	0.630	1.00
138_T	142_T	0.626	1.00
44_L	48_L	0.622	1.00
77_R	81_Q	0.615	1.00
29_Y	32_L	0.612	1.00
48_L	60_M	0.611	1.00
43_Y	108_K	0.602	1.00
60_M	98_I	0.599	1.00
58_K	61_G	0.571	1.00
43_Y	115_P	0.566	1.00
28_Q	31_P	0.564	1.00
135_A	142_T	0.559	1.00
14_L	132_L	0.543	1.00
47_L	112_V	0.540	1.00
124_Q	129_L	0.539	1.00
17_L	136_L	0.536	1.00
135_A	139_L	0.536	1.00
14_L	17_L	0.532	1.00
109_E	113_D	0.527	1.00
108_K	112_V	0.524	1.00
19_Y	40_Y	0.523	1.00
18_L	136_L	0.522	1.00
26_T	29_Y	0.521	1.00
125_S	138_T	0.520	1.00
133_K	140_L	0.517	1.00
40_Y	44_L	0.516	1.00
82_G	85_T	0.515	1.00
42_Q	74_M	0.508	1.00
20_A	24_E	0.505	1.00
124_Q	128_D	0.505	1.00
27_K	31_P	0.501	1.00
47_L	108_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1z91A	2	0.932	99.9	0.243	Contact Map
3cjnA	2	0.9592	99.9	0.267	Contact Map
3cdhA	4	0.9116	99.9	0.277	Contact Map
2bv6A	2	0.9252	99.9	0.28	Contact Map
3u2rA	4	0.8912	99.9	0.282	Contact Map
4rguA	4	0.9524	99.9	0.283	Contact Map
3deuA	2	0.8776	99.9	0.283	Contact Map
3hsrA	2	0.898	99.9	0.285	Contact Map
3e6mA	2	0.9932	99.9	0.286	Contact Map
2pexA	2	0.9048	99.9	0.29	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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