GREMLIN Database
OHRR - Organic hydroperoxide resistance transcriptional regulator
UniProt: O34777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (130)
Sequences: 21946 (16345)
Seq/√Len: 1433.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_K99_S2.9371.00
128_D138_T2.8931.00
54_T99_S2.7411.00
89_S97_L2.6611.00
85_T99_S2.5561.00
56_T95_S2.4651.00
131_Q135_A2.4501.00
131_Q134_S2.2031.00
125_S128_D2.1951.00
88_R96_V2.0781.00
50_W108_K2.0501.00
123_K142_T1.9631.00
42_Q81_Q1.9511.00
56_T59_K1.9371.00
89_S95_S1.8681.00
50_W100_L1.8001.00
124_Q135_A1.7791.00
128_D131_Q1.7161.00
79_E86_R1.6321.00
17_L137_Y1.5541.00
103_D107_L1.5451.00
42_Q77_R1.5311.00
82_G103_D1.5221.00
132_L135_A1.5141.00
107_L110_K1.4781.00
103_D106_L1.4571.00
52_H63_Q1.4561.00
54_T97_L1.4551.00
57_V75_L1.4511.00
75_L98_I1.4151.00
39_T42_Q1.3871.00
76_K80_Q1.3741.00
128_D134_S1.3741.00
48_L63_Q1.3671.00
45_A74_M1.3561.00
17_L140_L1.3301.00
50_W105_A1.2811.00
36_L110_K1.2751.00
135_A138_T1.2731.00
17_L133_K1.2511.00
119_L122_S1.2491.00
32_L114_I1.2361.00
36_L114_I1.2311.00
128_D135_A1.2171.00
57_V96_V1.2041.00
76_K93_E1.1991.00
59_K62_E1.1971.00
134_S138_T1.1891.00
66_L70_T1.1541.00
106_L110_K1.1531.00
20_A140_L1.1381.00
133_K137_Y1.1171.00
21_S140_L1.1101.00
54_T87_K1.1091.00
83_L107_L1.1081.00
58_K68_S1.1041.00
45_A71_L1.0931.00
86_R96_V1.0911.00
30_K34_D1.0701.00
67_D70_T1.0621.00
19_Y22_S1.0511.00
58_K62_E1.0491.00
57_V98_I1.0391.00
35_K114_I1.0281.00
129_L133_K1.0251.00
115_P119_L1.0141.00
72_T76_K1.0021.00
52_H55_L0.9961.00
53_E105_A0.9861.00
57_V71_L0.9831.00
69_G72_T0.9791.00
127_E131_Q0.9721.00
55_L63_Q0.9651.00
32_L117_T0.9651.00
76_K79_E0.9571.00
100_L104_G0.9561.00
57_V68_S0.9511.00
36_L111_A0.9491.00
41_P74_M0.9441.00
55_L59_K0.9291.00
105_A109_E0.9101.00
37_N81_Q0.9091.00
24_E140_L0.9081.00
21_S136_L0.9011.00
70_T73_P0.8981.00
59_K63_Q0.8961.00
32_L121_L0.8871.00
49_L84_I0.8841.00
87_K97_L0.8811.00
22_S26_T0.8691.00
81_Q103_D0.8651.00
81_Q107_L0.8631.00
66_L71_L0.8611.00
85_T101_T0.8601.00
83_L103_D0.8571.00
28_Q118_I0.8531.00
14_L133_K0.8511.00
126_G130_K0.8471.00
102_E105_A0.8431.00
102_E106_L0.8381.00
131_Q138_T0.8341.00
73_P77_R0.8311.00
18_L22_S0.8301.00
67_D73_P0.8301.00
113_D117_T0.8231.00
75_L84_I0.8181.00
124_Q139_L0.8141.00
89_S92_D0.8101.00
100_L105_A0.7991.00
46_L108_K0.7971.00
44_L64_L0.7891.00
114_I117_T0.7881.00
73_P76_K0.7861.00
117_T121_L0.7801.00
28_Q121_L0.7791.00
50_W112_V0.7781.00
88_R93_E0.7781.00
53_E99_S0.7771.00
32_L35_K0.7741.00
30_K40_Y0.7701.00
90_E97_L0.7671.00
43_Y111_A0.7621.00
41_P70_T0.7571.00
19_Y23_R0.7541.00
45_A60_M0.7531.00
92_D95_S0.7521.00
50_W109_E0.7491.00
117_T120_G0.7431.00
48_L64_L0.7421.00
79_E85_T0.7231.00
21_S139_L0.7151.00
125_S129_L0.7131.00
17_L20_A0.7101.00
137_Y141_E0.7071.00
79_E84_I0.7071.00
77_R80_Q0.7061.00
106_L109_E0.7061.00
75_L79_E0.7011.00
61_G71_L0.6981.00
18_L21_S0.6961.00
48_L55_L0.6851.00
48_L52_H0.6831.00
113_D116_G0.6821.00
110_K113_D0.6771.00
78_M83_L0.6711.00
57_V72_T0.6631.00
52_H59_K0.6611.00
29_Y115_P0.6601.00
127_E130_K0.6591.00
47_L51_E0.6591.00
71_L75_L0.6591.00
118_I121_L0.6561.00
32_L118_I0.6511.00
49_L100_L0.6491.00
45_A64_L0.6471.00
110_K114_I0.6421.00
26_T30_K0.6421.00
61_G68_S0.6401.00
116_G120_G0.6401.00
49_L55_L0.6391.00
130_K134_S0.6361.00
23_R27_K0.6351.00
76_K86_R0.6341.00
130_K133_K0.6301.00
138_T142_T0.6261.00
44_L48_L0.6221.00
77_R81_Q0.6151.00
29_Y32_L0.6121.00
48_L60_M0.6111.00
43_Y108_K0.6021.00
60_M98_I0.5991.00
58_K61_G0.5711.00
43_Y115_P0.5661.00
28_Q31_P0.5641.00
135_A142_T0.5591.00
14_L132_L0.5431.00
47_L112_V0.5401.00
124_Q129_L0.5391.00
17_L136_L0.5361.00
135_A139_L0.5361.00
14_L17_L0.5321.00
109_E113_D0.5271.00
108_K112_V0.5241.00
19_Y40_Y0.5231.00
18_L136_L0.5221.00
26_T29_Y0.5211.00
125_S138_T0.5201.00
133_K140_L0.5171.00
40_Y44_L0.5161.00
82_G85_T0.5151.00
42_Q74_M0.5081.00
20_A24_E0.5051.00
124_Q128_D0.5051.00
27_K31_P0.5011.00
47_L108_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z91A 2 0.932 99.9 0.243 Contact Map
3cjnA 2 0.9592 99.9 0.267 Contact Map
3cdhA 4 0.9116 99.9 0.277 Contact Map
2bv6A 2 0.9252 99.9 0.28 Contact Map
3u2rA 4 0.8912 99.9 0.282 Contact Map
4rguA 4 0.9524 99.9 0.283 Contact Map
3deuA 2 0.8776 99.9 0.283 Contact Map
3hsrA 2 0.898 99.9 0.285 Contact Map
3e6mA 2 0.9932 99.9 0.286 Contact Map
2pexA 2 0.9048 99.9 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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