GREMLIN Database
YOST - SPBc2 prophage-derived putative transcriptional regulator YosT
UniProt: O34775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (144)
Sequences: 1122 (845)
Seq/√Len: 70.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_L143_E3.9051.00
12_R85_V3.3371.00
92_K121_L3.0321.00
55_D66_R2.6761.00
61_P64_E2.5531.00
10_E90_G2.5341.00
13_I70_G2.4121.00
16_F30_L2.3271.00
121_L148_I2.3151.00
17_R68_D2.3131.00
37_W83_A2.2581.00
10_E87_K2.1911.00
131_R143_E2.1811.00
99_D141_L1.9721.00
48_V131_R1.9441.00
15_Y86_G1.9411.00
51_G67_Y1.8921.00
116_I119_N1.8891.00
34_F38_A1.8411.00
48_V72_V1.8321.00
21_E62_K1.7701.00
53_P67_Y1.7451.00
96_F112_I1.7431.00
54_Q86_G1.7421.00
50_L131_R1.7271.00
100_H142_C1.7081.00
89_P126_E1.6881.00
26_Q29_E1.6180.99
68_D86_G1.5750.99
13_I88_L1.5340.99
109_W130_E1.5170.99
133_T141_L1.4800.99
135_Q138_D1.4590.99
51_G69_V1.4450.99
22_Y65_C1.4400.99
11_L48_V1.4370.99
16_F34_F1.4270.98
109_W144_V1.4220.98
31_M67_Y1.4000.98
38_A71_V1.3940.98
53_P130_E1.3750.98
14_A73_L1.3610.98
30_L69_V1.3600.98
129_I145_L1.3510.98
15_Y84_Q1.3400.98
14_A83_A1.3180.97
112_I146_V1.3110.97
97_L141_L1.3060.97
54_Q68_D1.2910.97
53_P65_C1.2810.97
98_L108_F1.2790.97
33_S82_P1.2540.97
8_L129_I1.2230.96
102_K142_C1.2070.96
19_V64_E1.2000.95
96_F108_F1.1950.95
31_M65_C1.1800.95
31_M69_V1.1720.95
51_G132_Y1.1470.94
108_F144_V1.1220.94
27_N69_V1.1110.93
27_N67_Y1.1060.93
98_L104_A1.0900.93
6_E95_V1.0880.92
41_N80_L1.0660.92
6_E143_E1.0560.91
137_I140_H1.0460.91
3_I96_F1.0350.90
31_M100_H1.0300.90
105_V109_W1.0200.90
95_V143_E1.0170.90
8_L11_L1.0150.90
101_T142_C1.0120.89
95_V145_L1.0100.89
109_W128_I1.0100.89
55_D64_E1.0090.89
17_R54_Q1.0090.89
79_V85_V1.0070.89
29_E33_S0.9970.89
16_F33_S0.9930.89
7_E92_K0.9750.88
31_M53_P0.9670.87
100_H105_V0.9610.87
91_G124_R0.9580.87
19_V55_D0.9380.86
34_F71_V0.9300.85
124_R145_L0.9230.85
113_F116_I0.9160.84
116_I123_M0.9110.84
134_S139_N0.9090.84
27_N31_M0.9050.83
16_F83_A0.8960.83
3_I112_I0.8950.83
115_E118_K0.8730.81
6_E145_L0.8610.80
30_L34_F0.8610.80
134_S142_C0.8540.80
55_D130_E0.8400.79
102_K132_Y0.8370.78
18_N27_N0.8350.78
31_M49_I0.8330.78
113_F123_M0.8180.77
131_R145_L0.8090.76
44_F47_S0.8070.76
15_Y81_Q0.8070.76
136_M139_N0.8060.76
56_D59_I0.7970.75
17_R21_E0.7910.74
67_Y105_V0.7910.74
117_E120_S0.7890.74
73_L76_D0.7820.73
32_E36_K0.7760.73
70_G138_D0.7620.72
104_A107_E0.7590.71
88_L107_E0.7570.71
81_Q84_Q0.7560.71
33_S64_E0.7530.71
93_Y126_E0.7490.70
19_V66_R0.7470.70
22_Y55_D0.7390.69
43_V78_N0.7290.68
12_R76_D0.7250.68
7_E90_G0.7250.68
99_D133_T0.7230.68
13_I86_G0.7200.67
65_C69_V0.7190.67
3_I119_N0.7120.66
93_Y129_I0.7110.66
36_K40_L0.7020.65
107_E111_N0.6950.64
47_S72_V0.6860.63
110_G114_S0.6800.63
28_K32_E0.6780.63
53_P104_A0.6780.63
29_E118_K0.6770.62
111_N115_E0.6770.62
55_D109_W0.6770.62
52_I147_P0.6710.62
41_N78_N0.6650.61
47_S71_V0.6640.61
54_Q60_T0.6610.61
38_A44_F0.6590.60
102_K134_S0.6550.60
53_P129_I0.6550.60
8_L145_L0.6490.59
14_A37_W0.6490.59
13_I50_L0.6460.59
137_I143_E0.6450.59
102_K105_V0.6420.58
15_Y68_D0.6410.58
8_L93_Y0.6400.58
11_L88_L0.6390.58
105_V142_C0.6340.57
14_A35_K0.6340.57
29_E32_E0.6330.57
18_N28_K0.6230.56
136_M140_H0.6180.56
34_F69_V0.6120.55
8_L120_S0.6110.55
15_Y69_V0.6100.55
14_A95_V0.6090.54
10_E89_P0.6090.54
100_H109_W0.6070.54
105_V122_T0.6060.54
97_L129_I0.6050.54
69_V135_Q0.6010.53
52_I70_G0.5980.53
14_A71_V0.5970.53
18_N30_L0.5960.53
51_G127_P0.5940.53
68_D90_G0.5940.53
42_G89_P0.5910.52
94_A116_I0.5870.52
33_S119_N0.5850.52
3_I117_E0.5840.51
4_T79_V0.5790.51
32_E41_N0.5740.50
74_N77_F0.5730.50
122_T127_P0.5720.50
12_R73_L0.5710.50
27_N35_K0.5690.50
75_E120_S0.5680.49
66_R130_E0.5660.49
94_A119_N0.5620.49
89_P93_Y0.5590.48
56_D111_N0.5580.48
31_M102_K0.5560.48
106_S122_T0.5530.48
53_P132_Y0.5530.48
12_R122_T0.5530.48
22_Y109_W0.5470.47
17_R86_G0.5450.47
100_H139_N0.5430.46
107_E114_S0.5410.46
39_Q44_F0.5410.46
75_E90_G0.5400.46
73_L85_V0.5390.46
73_L77_F0.5330.45
77_F88_L0.5290.45
18_N69_V0.5260.44
15_Y70_G0.5260.44
104_A148_I0.5230.44
4_T44_F0.5220.44
32_E95_V0.5220.44
9_P12_R0.5210.44
98_L143_E0.5190.44
37_W41_N0.5190.44
70_G79_V0.5170.43
18_N51_G0.5130.43
4_T95_V0.5120.43
21_E56_D0.5120.43
62_K80_L0.5090.42
133_T142_C0.5060.42
9_P21_E0.5050.42
57_P66_R0.5030.42
130_E142_C0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jyhA 1 0.9866 100 0.341 Contact Map
3b49A 1 1 100 0.351 Contact Map
3gk6A 1 0.9329 100 0.405 Contact Map
3lurA 1 0.9664 100 0.432 Contact Map
3e0hA 1 0.9664 99.9 0.449 Contact Map
1r8eA 2 0.9799 99.9 0.463 Contact Map
1d5yA 1 0.9866 99.9 0.479 Contact Map
4b0yA 1 0.9463 98.7 0.77 Contact Map
2govA 1 0.9799 97.2 0.838 Contact Map
3r8jA 1 0.9799 97 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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