GREMLIN Database
YCDC - Uncharacterized protein YcdC
UniProt: O34772 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (441)
Sequences: 222 (188)
Seq/√Len: 8.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_P22_L3.7910.97
17_P20_Y3.5170.96
20_Y51_I3.2750.94
178_Y419_W3.2590.94
116_Y123_L2.9710.90
312_C317_C2.9640.90
371_V378_I2.9520.90
134_M353_F2.7610.86
61_L88_F2.7460.86
85_A444_D2.7310.85
405_A435_Y2.6430.83
9_K12_E2.5840.82
189_L445_A2.5230.80
160_A164_V2.5210.80
168_Y325_L2.5120.80
56_R59_G2.5040.80
445_A448_R2.5030.80
417_L433_L2.4870.79
88_F140_I2.4480.78
443_I450_K2.4240.77
103_Q117_T2.3540.75
176_L445_A2.3510.75
118_K152_A2.2710.73
37_A274_I2.2510.72
291_D296_K2.2340.71
291_D369_I2.2270.71
15_N18_T2.2100.70
240_G243_S2.2030.70
435_Y445_A2.1750.69
351_N447_I2.1640.69
336_F367_A2.1500.68
125_I128_S2.1310.67
56_R361_P2.0570.65
418_E436_K2.0380.64
405_A445_A2.0010.62
435_Y448_R1.9870.62
71_E378_I1.9870.62
123_L398_P1.9530.60
201_P205_D1.9320.59
317_C419_W1.9240.59
61_L176_L1.9170.59
94_P328_L1.8890.58
159_V164_V1.8820.57
6_L37_A1.8780.57
18_T22_L1.8780.57
155_P324_F1.8280.55
417_L435_Y1.8220.55
118_K147_G1.8140.54
381_F415_V1.8130.54
48_E61_L1.8060.54
224_L336_F1.8050.54
176_L189_L1.7980.54
7_K11_Q1.7960.54
179_D401_S1.7830.53
56_R140_I1.7820.53
400_V415_V1.7810.53
14_G61_L1.7680.52
159_V400_V1.7460.52
64_F415_V1.7260.51
330_P391_L1.7220.50
259_S415_V1.7020.50
52_T55_L1.6760.48
422_D431_C1.6730.48
89_A369_I1.6690.48
82_K410_L1.6690.48
6_L292_K1.6600.48
41_W126_P1.6530.48
89_A359_G1.6460.47
433_L445_A1.6430.47
395_N403_E1.6360.47
16_V22_L1.6220.46
41_W381_F1.6150.46
36_Q62_L1.5930.45
369_I444_D1.5890.45
349_V373_P1.5880.45
55_L292_K1.5870.45
116_Y404_E1.5850.45
312_C316_E1.5830.44
405_A433_L1.5720.44
140_I414_D1.5700.44
58_D228_Q1.5580.43
359_G376_G1.5500.43
81_L200_Y1.5470.43
129_G324_F1.5440.43
58_D81_L1.5410.43
314_T349_V1.5380.43
105_K447_I1.5350.42
165_V407_E1.5320.42
17_P25_E1.5170.42
159_V251_R1.5170.42
405_A448_R1.5080.41
408_A411_A1.5050.41
184_E319_E1.4870.40
116_Y320_I1.4800.40
396_H399_D1.4790.40
140_I143_F1.4600.39
6_L25_E1.4550.39
121_L205_D1.4480.39
146_Y371_V1.4430.39
322_L353_F1.4410.39
37_A81_L1.4400.38
362_L391_L1.4300.38
298_K360_V1.4200.38
433_L448_R1.4180.38
330_P365_G1.4150.37
419_W431_C1.4150.37
150_H288_M1.4140.37
300_A318_Q1.4140.37
173_S402_A1.4140.37
274_I292_K1.4100.37
191_Y321_A1.4060.37
39_F168_Y1.4050.37
444_D451_K1.4020.37
88_F143_F1.4010.37
55_L274_I1.3940.37
152_A375_T1.3930.37
430_H449_K1.3880.36
114_F225_P1.3870.36
11_Q18_T1.3850.36
105_K114_F1.3780.36
8_K200_Y1.3770.36
328_L332_A1.3740.36
185_Q224_L1.3710.36
63_T137_S1.3690.36
126_P129_G1.3680.36
94_P123_L1.3670.36
294_T416_K1.3640.35
120_E152_A1.3630.35
8_K298_K1.3600.35
294_T432_K1.3560.35
242_T299_A1.3510.35
324_F378_I1.3470.35
376_G405_A1.3440.35
160_A264_G1.3440.35
222_A225_P1.3410.35
178_Y393_A1.3350.34
140_I449_K1.3300.34
159_V360_V1.3290.34
64_F360_V1.3280.34
182_D447_I1.3260.34
249_S371_V1.3260.34
138_G353_F1.3100.33
394_I414_D1.3030.33
242_T451_K1.2950.33
156_T341_V1.2910.33
200_Y204_V1.2890.32
17_P51_I1.2880.32
98_M168_Y1.2820.32
317_C349_V1.2670.32
6_L55_L1.2660.32
248_V375_T1.2550.31
371_V444_D1.2510.31
136_R316_E1.2500.31
8_K18_T1.2490.31
58_D140_I1.2490.31
405_A417_L1.2460.31
134_M140_I1.2450.31
55_L351_N1.2420.31
102_F114_F1.2310.30
186_E290_T1.2220.30
18_T31_Q1.2200.30
10_A39_F1.2100.30
41_W114_F1.2020.29
82_K106_E1.1980.29
75_K110_Q1.1980.29
164_V292_K1.1890.29
215_D415_V1.1830.29
369_I403_E1.1780.28
132_I323_Q1.1770.28
335_F419_W1.1760.28
140_I172_M1.1740.28
376_G435_Y1.1690.28
193_P409_F1.1680.28
27_Y409_F1.1670.28
359_G434_V1.1660.28
167_H200_Y1.1640.28
309_N409_F1.1560.28
24_I37_A1.1530.28
6_L10_A1.1530.28
191_Y435_Y1.1520.28
6_L254_G1.1510.27
167_H375_T1.1310.27
409_F437_P1.1290.27
10_A53_V1.1250.27
118_K125_I1.1250.27
37_A292_K1.1240.27
337_R442_Y1.1220.26
246_Q305_D1.1210.26
6_L431_C1.1190.26
83_L313_S1.1190.26
88_F134_M1.1140.26
21_E150_H1.1140.26
7_K15_N1.1110.26
248_V290_T1.1100.26
59_G88_F1.1010.26
134_M204_V1.0980.26
360_V438_V1.0970.26
316_E366_A1.0960.26
63_T84_T1.0950.26
76_L378_I1.0940.26
239_L248_V1.0910.25
81_L259_S1.0890.25
77_P159_V1.0830.25
161_K414_D1.0820.25
394_I419_W1.0810.25
169_L357_Y1.0770.25
6_L273_S1.0750.25
48_E72_T1.0740.25
135_T201_P1.0720.25
12_E270_K1.0710.25
294_T381_F1.0680.25
251_R362_L1.0680.25
53_V112_I1.0680.25
398_P446_H1.0630.25
89_A312_C1.0620.25
87_Q91_A1.0610.24
208_V211_Q1.0540.24
359_G369_I1.0520.24
106_E359_G1.0460.24
433_L444_D1.0380.24
245_M419_W1.0360.24
290_T333_A1.0330.24
173_S200_Y1.0310.24
302_S364_F1.0270.23
117_T365_G1.0240.23
321_A435_Y1.0220.23
154_V419_W1.0210.23
116_Y165_V1.0190.23
140_I294_T1.0190.23
202_A419_W1.0180.23
234_D371_V1.0110.23
22_L61_L1.0080.23
200_Y393_A1.0080.23
374_E378_I1.0050.23
93_H362_L1.0050.23
34_Y191_Y1.0010.23
20_Y422_D0.9990.23
284_N293_R0.9980.23
92_N317_C0.9960.22
248_V450_K0.9950.22
382_M451_K0.9940.22
39_F308_N0.9940.22
193_P294_T0.9900.22
13_I20_Y0.9900.22
401_S404_E0.9840.22
138_G435_Y0.9820.22
355_V361_P0.9780.22
21_E369_I0.9780.22
77_P313_S0.9780.22
174_F409_F0.9780.22
29_Q96_T0.9760.22
176_L433_L0.9760.22
415_V439_Y0.9740.22
158_F393_A0.9730.22
198_Y449_K0.9710.22
106_E132_I0.9710.22
160_A259_S0.9690.22
313_S376_G0.9600.21
123_L419_W0.9590.21
31_Q39_F0.9580.21
316_E319_E0.9580.21
101_H175_E0.9530.21
96_T358_K0.9510.21
151_K322_L0.9500.21
264_G447_I0.9490.21
13_I140_I0.9440.21
95_G98_M0.9370.21
91_A316_E0.9360.21
110_Q360_V0.9360.21
134_M359_G0.9340.21
124_P312_C0.9340.21
435_Y444_D0.9320.21
178_Y202_A0.9290.21
50_H378_I0.9270.20
350_R370_I0.9270.20
89_A309_N0.9260.20
293_R319_E0.9260.20
163_K353_F0.9260.20
183_G306_W0.9210.20
42_K53_V0.9200.20
110_Q378_I0.9200.20
37_A41_W0.9190.20
316_E342_R0.9190.20
76_L112_I0.9160.20
143_F239_L0.9110.20
148_E369_I0.9100.20
109_G114_F0.9100.20
168_Y328_L0.9080.20
392_E450_K0.9070.20
141_V279_E0.9070.20
220_N300_A0.9070.20
412_A446_H0.9060.20
61_L129_G0.9050.20
97_F158_F0.9040.20
117_T354_S0.9030.20
28_D36_Q0.9000.20
347_G374_E0.9000.20
256_Q404_E0.8980.20
27_Y141_V0.8970.20
81_L205_D0.8970.20
84_T415_V0.8970.20
186_E224_L0.8930.20
124_P295_G0.8920.19
18_T51_I0.8910.19
89_A225_P0.8890.19
83_L200_Y0.8890.19
12_E114_F0.8880.19
8_K11_Q0.8840.19
239_L297_L0.8830.19
48_E143_F0.8820.19
134_M260_T0.8790.19
393_A404_E0.8780.19
357_Y384_P0.8730.19
168_Y369_I0.8720.19
320_I327_A0.8700.19
134_M216_E0.8690.19
295_G370_I0.8680.19
160_A399_D0.8680.19
10_A25_E0.8680.19
169_L222_A0.8660.19
194_I399_D0.8650.19
178_Y181_I0.8640.19
125_I152_A0.8640.19
130_F373_P0.8630.19
102_F338_V0.8620.19
61_L351_N0.8610.19
66_T73_D0.8600.19
66_T125_I0.8600.19
124_P417_L0.8600.19
86_L116_Y0.8600.19
156_T319_E0.8590.19
224_L382_M0.8580.19
362_L376_G0.8580.19
228_Q414_D0.8580.19
317_C351_N0.8550.18
190_V381_F0.8510.18
65_S375_T0.8500.18
35_G41_W0.8500.18
80_E83_L0.8490.18
132_I177_M0.8450.18
165_V244_D0.8450.18
94_P214_A0.8430.18
92_N190_V0.8430.18
155_P254_G0.8410.18
48_E319_E0.8360.18
87_Q311_Q0.8280.18
144_L149_G0.8280.18
135_T294_T0.8250.18
135_T377_L0.8190.18
94_P335_F0.8180.18
129_G335_F0.8160.17
415_V433_L0.8150.17
418_E422_D0.8090.17
52_T132_I0.8090.17
23_E316_E0.8080.17
135_T338_V0.8060.17
19_H43_D0.8040.17
371_V376_G0.7990.17
243_S366_A0.7990.17
402_A406_K0.7980.17
82_K122_G0.7940.17
41_W92_N0.7920.17
121_L326_Y0.7840.17
116_Y286_I0.7820.17
14_G371_V0.7790.17
13_I25_E0.7770.17
168_Y332_A0.7770.17
228_Q329_Y0.7750.16
87_Q93_H0.7740.16
6_L274_I0.7730.16
300_A335_F0.7730.16
126_P431_C0.7700.16
326_Y336_F0.7680.16
11_Q83_L0.7650.16
45_K369_I0.7650.16
112_I355_V0.7630.16
29_Q271_D0.7630.16
218_I344_D0.7630.16
376_G417_L0.7630.16
43_D55_L0.7630.16
55_L61_L0.7620.16
158_F431_C0.7620.16
406_K414_D0.7610.16
125_I371_V0.7590.16
122_G295_G0.7570.16
193_P443_I0.7560.16
58_D205_D0.7540.16
89_A268_E0.7510.16
135_T139_Q0.7510.16
10_A133_D0.7450.16
19_H367_A0.7450.16
294_T317_C0.7450.16
235_I419_W0.7420.16
178_Y394_I0.7420.16
154_V200_Y0.7390.16
349_V406_K0.7370.16
351_N448_R0.7360.16
125_I431_C0.7360.16
114_F295_G0.7350.16
324_F381_F0.7350.16
169_L329_Y0.7340.16
201_P204_V0.7340.16
191_Y448_R0.7330.16
116_Y408_A0.7330.16
88_F447_I0.7320.15
183_G438_V0.7310.15
292_K354_S0.7300.15
166_S206_E0.7300.15
121_L419_W0.7290.15
25_E37_A0.7280.15
355_V419_W0.7280.15
355_V378_I0.7230.15
122_G218_I0.7230.15
369_I428_D0.7210.15
168_Y175_E0.7210.15
254_G359_G0.7200.15
92_N419_W0.7200.15
299_A361_P0.7190.15
86_L299_A0.7180.15
27_Y360_V0.7180.15
121_L236_F0.7170.15
56_R60_A0.7150.15
400_V442_Y0.7140.15
417_L445_A0.7130.15
376_G445_A0.7130.15
59_G205_D0.7120.15
162_E182_D0.7120.15
159_V422_D0.7120.15
166_S447_I0.7100.15
79_A217_R0.7060.15
178_Y331_R0.7040.15
120_E378_I0.7040.15
115_V256_Q0.7040.15
39_F348_R0.7030.15
372_N375_T0.7030.15
223_P404_E0.7030.15
118_K181_I0.7030.15
290_T404_E0.7020.15
132_I189_L0.7010.15
221_T371_V0.7000.15
367_A381_F0.6990.15
372_N419_W0.6990.15
332_A367_A0.6980.15
143_F147_G0.6970.15
201_P432_K0.6940.15
193_P362_L0.6900.15
22_L26_D0.6900.15
409_F438_V0.6890.15
93_H367_A0.6880.15
58_D116_Y0.6860.14
89_A197_G0.6850.14
405_A444_D0.6840.14
163_K416_K0.6830.14
443_I451_K0.6810.14
261_W292_K0.6800.14
288_M441_S0.6790.14
202_A417_L0.6790.14
25_E325_L0.6780.14
209_P434_V0.6770.14
321_A405_A0.6760.14
311_Q403_E0.6750.14
91_A290_T0.6740.14
140_I418_E0.6700.14
403_E435_Y0.6650.14
130_F349_V0.6650.14
60_A380_A0.6650.14
45_K134_M0.6650.14
118_K128_S0.6640.14
118_K419_W0.6640.14
26_D41_W0.6620.14
255_E262_R0.6610.14
89_A306_W0.6600.14
167_H301_L0.6600.14
73_D360_V0.6580.14
14_G64_F0.6560.14
80_E90_A0.6510.14
153_E201_P0.6480.14
252_D369_I0.6480.14
84_T170_N0.6470.14
200_Y322_L0.6470.14
37_A59_G0.6460.14
319_E416_K0.6460.14
15_N22_L0.6430.14
13_I237_A0.6420.14
121_L258_G0.6410.14
409_F441_S0.6390.13
37_A318_Q0.6390.13
44_P89_A0.6370.13
128_S378_I0.6360.13
247_K250_E0.6360.13
361_P433_L0.6350.13
380_A450_K0.6330.13
134_M315_E0.6320.13
26_D34_Y0.6310.13
50_H377_L0.6310.13
189_L321_A0.6300.13
153_E419_W0.6290.13
226_P412_A0.6280.13
269_R281_R0.6270.13
161_K443_I0.6270.13
140_I237_A0.6250.13
300_A401_S0.6240.13
41_W336_F0.6230.13
319_E351_N0.6230.13
355_V450_K0.6220.13
217_R373_P0.6210.13
200_Y351_N0.6210.13
66_T360_V0.6200.13
351_N408_A0.6200.13
419_W435_Y0.6180.13
127_N336_F0.6180.13
239_L367_A0.6170.13
254_G299_A0.6160.13
226_P229_N0.6130.13
41_W400_V0.6100.13
83_L322_L0.6080.13
191_Y405_A0.6070.13
59_G135_T0.6060.13
307_R346_R0.6060.13
24_I143_F0.6050.13
41_W94_P0.6050.13
391_L398_P0.6040.13
190_V206_E0.6040.13
10_A327_A0.6020.13
206_E292_K0.6010.13
157_E288_M0.6000.13
140_I242_T0.5990.13
125_I356_W0.5990.13
170_N202_A0.5940.13
56_R173_S0.5940.13
66_T396_H0.5940.13
145_Y305_D0.5930.13
29_Q52_T0.5900.13
69_H423_F0.5900.13
387_E400_V0.5890.13
126_P154_V0.5890.13
358_K429_Q0.5880.12
201_P206_E0.5880.12
184_E398_P0.5870.12
204_V289_K0.5870.12
406_K451_K0.5860.12
291_D438_V0.5860.12
108_R150_H0.5850.12
121_L414_D0.5850.12
435_Y447_I0.5820.12
287_K303_F0.5810.12
126_P135_T0.5810.12
201_P372_N0.5800.12
169_L316_E0.5790.12
6_L128_S0.5790.12
11_Q186_E0.5790.12
25_E55_L0.5780.12
36_Q39_F0.5780.12
15_N136_R0.5770.12
178_Y434_V0.5770.12
80_E102_F0.5760.12
28_D34_Y0.5750.12
329_Y332_A0.5740.12
20_Y125_I0.5720.12
167_H313_S0.5720.12
26_D277_Y0.5710.12
314_T327_A0.5710.12
320_I415_V0.5700.12
356_W381_F0.5680.12
71_E429_Q0.5670.12
70_S411_A0.5650.12
140_I351_N0.5630.12
313_S430_H0.5630.12
383_A400_V0.5630.12
94_P367_A0.5610.12
175_E293_R0.5610.12
405_A409_F0.5610.12
176_L443_I0.5600.12
188_R247_K0.5600.12
362_L367_A0.5590.12
297_L328_L0.5580.12
17_P55_L0.5550.12
7_K40_I0.5540.12
193_P351_N0.5530.12
100_F125_I0.5520.12
11_Q14_G0.5510.12
104_G206_E0.5510.12
299_A390_Q0.5500.12
86_L449_K0.5500.12
98_M185_Q0.5500.12
164_V418_E0.5500.12
40_I43_D0.5490.12
120_E234_D0.5490.12
231_E446_H0.5480.12
67_T168_Y0.5480.12
400_V404_E0.5460.12
88_F162_E0.5460.12
70_S73_D0.5450.12
140_I218_I0.5430.12
83_L173_S0.5430.12
325_L365_G0.5430.12
41_W129_G0.5430.12
308_N312_C0.5420.12
24_I46_D0.5420.12
124_P369_I0.5390.12
407_E415_V0.5390.12
152_A335_F0.5370.12
200_Y373_P0.5370.12
56_R135_T0.5360.12
164_V200_Y0.5350.12
356_W359_G0.5340.12
303_F371_V0.5340.12
144_L242_T0.5340.12
80_E328_L0.5330.11
326_Y329_Y0.5300.11
112_I172_M0.5300.11
247_K412_A0.5300.11
291_D404_E0.5300.11
283_K287_K0.5290.11
65_S170_N0.5290.11
123_L178_Y0.5280.11
77_P329_Y0.5280.11
113_R133_D0.5270.11
407_E432_K0.5260.11
79_A290_T0.5250.11
82_K250_E0.5250.11
364_F367_A0.5250.11
200_Y210_D0.5240.11
316_E341_V0.5230.11
168_Y401_S0.5220.11
39_F401_S0.5220.11
400_V449_K0.5210.11
321_A353_F0.5210.11
53_V415_V0.5200.11
27_Y35_G0.5190.11
118_K297_L0.5190.11
242_T345_E0.5180.11
30_K402_A0.5180.11
50_H425_A0.5170.11
120_E191_Y0.5170.11
260_T409_F0.5150.11
134_M309_N0.5150.11
168_Y372_N0.5150.11
80_E162_E0.5130.11
153_E297_L0.5130.11
254_G259_S0.5120.11
206_E360_V0.5120.11
141_V247_K0.5120.11
300_A336_F0.5120.11
64_F157_E0.5100.11
121_L136_R0.5100.11
163_K167_H0.5100.11
162_E166_S0.5090.11
411_A432_K0.5090.11
62_L446_H0.5090.11
174_F192_E0.5080.11
261_W271_D0.5070.11
161_K432_K0.5070.11
172_M316_E0.5070.11
401_S416_K0.5070.11
228_Q255_E0.5060.11
224_L359_G0.5060.11
6_L276_S0.5050.11
29_Q79_A0.5020.11
56_R62_L0.5020.11
64_F191_Y0.5010.11
76_L372_N0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k90B 1 0.3333 99.7 0.826 Contact Map
3nqzA 1 0.3201 99.6 0.846 Contact Map
2o3oA 2 0.4437 98.1 0.914 Contact Map
4exrA 2 0.2804 98 0.917 Contact Map
2fgtA 1 0.3753 97.4 0.926 Contact Map
3u1wA 3 0.3929 89.9 0.951 Contact Map
3db7A 2 0.2627 89.2 0.952 Contact Map
4dsdA 1 0.2627 84.3 0.955 Contact Map
4qoaA 2 0.2649 83.9 0.955 Contact Map
2gu3A 1 0.2605 83.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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