GREMLIN Database
YDJE - Uncharacterized sugar kinase YdjE
UniProt: O34768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (278)
Sequences: 22369 (16462)
Seq/√Len: 987.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G268_Y3.0851.00
5_S129_K2.9231.00
132_H163_S2.8631.00
69_K84_M2.6171.00
54_A78_D2.4461.00
7_V128_A2.4291.00
236_L290_V2.4151.00
229_L235_L2.3911.00
285_K288_E2.3341.00
269_Q284_V2.3081.00
234_T262_F2.2491.00
153_S190_V2.1821.00
5_S52_D2.1571.00
66_Y84_M2.1211.00
46_I51_G2.0861.00
58_K85_D2.0491.00
218_H237_S2.0321.00
152_M162_I1.9641.00
48_K75_V1.9361.00
198_D229_L1.9321.00
155_A160_Q1.9311.00
8_C43_S1.9311.00
163_S267_L1.8821.00
269_Q292_F1.8661.00
243_E287_R1.8531.00
58_K119_D1.8451.00
130_I161_F1.8391.00
261_A296_V1.8171.00
284_V288_E1.7961.00
44_A75_V1.7591.00
195_K263_V1.7511.00
161_F192_D1.7361.00
211_E242_R1.7361.00
192_D223_N1.7301.00
149_L186_K1.6931.00
45_A264_G1.6881.00
73_D79_T1.6821.00
234_T294_N1.6701.00
258_A301_C1.6551.00
70_R74_A1.6501.00
236_L243_E1.6491.00
214_V237_S1.6471.00
130_I163_S1.6431.00
71_T74_A1.6231.00
287_R291_A1.5931.00
69_K73_D1.5921.00
235_L244_I1.5881.00
297_G301_C1.5811.00
266_A289_I1.5811.00
229_L244_I1.5761.00
6_V46_I1.5741.00
265_A296_V1.5611.00
193_F224_I1.5501.00
216_I220_I1.5421.00
248_I295_K1.5391.00
226_A266_A1.5241.00
154_I158_N1.5201.00
150_R153_S1.5141.00
216_I219_E1.5051.00
149_L153_S1.4951.00
165_D228_T1.4921.00
46_I268_Y1.4781.00
130_I267_L1.4691.00
254_D305_G1.4681.00
66_Y70_R1.4591.00
245_I290_V1.4531.00
12_L57_G1.4501.00
224_I238_N1.4481.00
61_K66_Y1.4461.00
236_L286_L1.4401.00
265_A292_F1.4121.00
154_I157_D1.3811.00
35_A68_L1.3781.00
150_R154_I1.3671.00
166_P196_V1.3661.00
209_D212_K1.3631.00
229_L232_S1.3621.00
156_K192_D1.3521.00
191_S194_V1.3511.00
238_N241_D1.3461.00
125_L128_A1.3451.00
207_V216_I1.3451.00
88_A114_L1.3391.00
40_A72_L1.3211.00
5_S54_A1.3191.00
61_K84_M1.3061.00
248_I291_A1.3011.00
161_F193_F1.2921.00
126_N158_N1.2881.00
14_I67_F1.2861.00
211_E215_A1.2831.00
268_Y272_N1.2761.00
65_G90_T1.2741.00
52_D78_D1.2731.00
215_A219_E1.2711.00
156_K190_V1.2661.00
250_V302_T1.2651.00
33_K67_F1.2591.00
19_T30_Q1.2591.00
16_F31_F1.2481.00
245_I294_N1.2471.00
69_K82_L1.2191.00
185_K220_I1.2161.00
266_A270_L1.2131.00
117_L150_R1.2041.00
265_A293_A1.2011.00
161_F223_N1.1941.00
218_H239_G1.1911.00
116_T119_D1.1891.00
215_A242_R1.1841.00
234_T290_V1.1771.00
224_I270_L1.1751.00
229_L233_G1.1731.00
252_S301_C1.1691.00
224_I266_A1.1671.00
228_T262_F1.1661.00
35_A71_T1.1631.00
224_I286_L1.1611.00
49_L265_A1.1571.00
195_K228_T1.1491.00
21_V29_R1.1481.00
71_T75_V1.1461.00
47_A77_V1.1451.00
269_Q289_I1.1381.00
215_A237_S1.1371.00
288_E291_A1.1361.00
237_S242_R1.1361.00
248_I294_N1.1301.00
266_A293_A1.1211.00
272_N284_V1.1131.00
66_Y69_K1.1121.00
299_L303_K1.1101.00
67_F70_R1.1061.00
70_R73_D1.1061.00
153_S157_D1.1051.00
42_V132_H1.1011.00
131_L155_A1.1011.00
250_V301_C1.0981.00
51_G271_A1.0951.00
16_F33_K1.0941.00
133_F162_I1.0831.00
61_K87_K1.0831.00
207_V212_K1.0821.00
85_D88_A1.0781.00
299_L302_T1.0731.00
201_L227_V1.0641.00
46_I53_A1.0601.00
248_I298_A1.0551.00
212_K215_A1.0481.00
43_S53_A1.0471.00
193_F266_A1.0411.00
252_S255_S1.0401.00
198_D232_S1.0391.00
104_D107_F1.0331.00
63_P66_Y1.0321.00
273_T284_V1.0301.00
12_L68_L1.0301.00
201_L213_G1.0121.00
269_Q272_N1.0111.00
106_V109_R1.0081.00
294_N297_G1.0051.00
214_V227_V1.0011.00
247_S294_N0.9991.00
45_A261_A0.9971.00
132_H267_L0.9941.00
224_I236_L0.9931.00
273_T285_K0.9861.00
44_A48_K0.9801.00
51_G272_N0.9781.00
121_D150_R0.9761.00
261_A300_V0.9751.00
85_D114_L0.9751.00
9_I131_L0.9721.00
193_F270_L0.9721.00
19_T32_L0.9661.00
54_A124_K0.9651.00
195_K266_A0.9651.00
223_N239_G0.9621.00
164_F191_S0.9561.00
47_A76_H0.9551.00
16_F92_L0.9531.00
59_V65_G0.9491.00
131_L160_Q0.9471.00
46_I264_G0.9471.00
62_D90_T0.9431.00
59_V69_K0.9421.00
268_Y292_F0.9381.00
146_S150_R0.9371.00
291_A295_K0.9361.00
132_H263_V0.9351.00
54_A128_A0.9331.00
60_G90_T0.9331.00
205_S213_G0.9321.00
17_F34_S0.9301.00
54_A81_M0.9271.00
12_L55_F0.9251.00
8_C39_P0.9231.00
266_A286_L0.9211.00
241_D287_R0.9141.00
289_I293_A0.9121.00
49_L296_V0.8961.00
103_R107_F0.8921.00
35_A67_F0.8911.00
7_V56_S0.8891.00
67_F71_T0.8871.00
69_K79_T0.8831.00
133_F152_M0.8801.00
133_F148_Y0.8791.00
16_F64_F0.8731.00
165_D195_K0.8721.00
128_A160_Q0.8691.00
284_V292_F0.8691.00
79_T82_L0.8671.00
47_A52_D0.8671.00
153_S186_K0.8611.00
9_I151_L0.8611.00
59_V82_L0.8601.00
21_V99_Q0.8591.00
83_V119_D0.8591.00
18_C94_F0.8581.00
252_S302_T0.8581.00
125_L160_Q0.8561.00
232_S244_I0.8491.00
196_V201_L0.8481.00
198_D202_E0.8481.00
12_L40_A0.8471.00
270_L289_I0.8471.00
186_K189_A0.8461.00
233_G247_S0.8451.00
251_T302_T0.8451.00
181_V185_K0.8381.00
40_A307_I0.8271.00
197_S200_E0.8261.00
285_K289_I0.8251.00
68_L90_T0.8241.00
59_V84_M0.8241.00
163_S195_K0.8161.00
28_G106_V0.8141.00
243_E290_V0.8111.00
13_L91_T0.8081.00
261_A265_A0.7861.00
14_I33_K0.7851.00
6_V271_A0.7841.00
58_K83_V0.7831.00
42_V263_V0.7821.00
262_F294_N0.7811.00
5_S127_E0.7791.00
189_A221_G0.7741.00
215_A218_H0.7731.00
165_D196_V0.7731.00
188_I191_S0.7701.00
245_I291_A0.7681.00
189_A220_I0.7651.00
214_V225_V0.7621.00
147_A151_L0.7621.00
265_A269_Q0.7611.00
105_F109_R0.7591.00
47_A53_A0.7571.00
245_I287_R0.7541.00
15_D36_G0.7541.00
6_V130_I0.7541.00
238_N286_L0.7511.00
295_K299_L0.7491.00
69_K83_V0.7491.00
261_A297_G0.7481.00
130_I271_A0.7471.00
152_M190_V0.7471.00
7_V124_K0.7461.00
253_I304_I0.7451.00
7_V54_A0.7451.00
250_V298_A0.7431.00
231_K249_P0.7401.00
149_L190_V0.7391.00
124_K128_A0.7381.00
14_I64_F0.7341.00
104_D108_N0.7321.00
218_H238_N0.7321.00
135_S164_F0.7251.00
294_N298_A0.7241.00
212_K216_I0.7101.00
214_V218_H0.7091.00
105_F108_N0.7071.00
297_G300_V0.7071.00
49_L268_Y0.7061.00
43_S55_F0.7041.00
235_L242_R0.7021.00
201_L217_L0.7011.00
44_A307_I0.7001.00
143_P146_S0.7001.00
131_L151_L0.6921.00
62_D65_G0.6891.00
226_A236_L0.6821.00
233_G244_I0.6801.00
95_V105_F0.6741.00
214_V242_R0.6741.00
119_D122_Q0.6691.00
211_E244_I0.6691.00
118_E121_D0.6681.00
146_S149_L0.6661.00
145_C183_V0.6541.00
95_V256_T0.6501.00
64_F92_L0.6501.00
262_F290_V0.6461.00
49_L292_F0.6441.00
102_E105_F0.6421.00
71_T307_I0.6421.00
238_N243_E0.6401.00
262_F293_A0.6401.00
75_V312_S0.6351.00
88_A111_A0.6341.00
98_K102_E0.6311.00
211_E235_L0.6311.00
163_S193_F0.6301.00
284_V289_I0.6261.00
207_V213_G0.6261.00
210_H229_L0.6241.00
36_G41_N0.6221.00
6_V51_G0.6211.00
103_R109_R0.6191.00
43_S77_V0.6141.00
211_E214_V0.6141.00
182_S185_K0.6131.00
117_L146_S0.6081.00
54_A80_S0.6061.00
211_E237_S0.6051.00
33_K64_F0.6051.00
163_S263_V0.6011.00
182_S186_K0.6001.00
38_A167_N0.5991.00
32_L304_I0.5971.00
234_T245_I0.5971.00
111_A114_L0.5971.00
18_C31_F0.5961.00
110_G113_A0.5961.00
46_I267_L0.5921.00
185_K189_A0.5921.00
117_L147_A0.5911.00
165_D260_D0.5901.00
81_M124_K0.5901.00
155_A162_I0.5881.00
149_L152_M0.5861.00
49_L264_G0.5861.00
57_G82_L0.5831.00
264_G268_Y0.5821.00
11_E136_A0.5801.00
226_A262_F0.5771.00
194_V225_V0.5771.00
81_M84_M0.5741.00
63_P67_F0.5711.00
273_T289_I0.5701.00
85_D119_D0.5671.00
286_L290_V0.5671.00
112_D115_F0.5661.00
96_S104_D0.5651.00
262_F297_G0.5651.00
96_S106_V0.5651.00
8_C46_I0.5641.00
151_L154_I0.5601.00
218_H240_K0.5591.00
245_I248_I0.5581.00
290_V294_N0.5581.00
210_H213_G0.5571.00
40_A55_F0.5571.00
104_D109_R0.5541.00
38_A136_A0.5521.00
222_A225_V0.5521.00
8_C53_A0.5501.00
130_I193_F0.5501.00
162_I191_S0.5471.00
115_F119_D0.5451.00
66_Y73_D0.5431.00
230_G233_G0.5421.00
144_F147_A0.5411.00
145_C149_L0.5391.00
210_H214_V0.5371.00
18_C28_G0.5351.00
19_T304_I0.5351.00
39_P43_S0.5341.00
129_K160_Q0.5341.00
35_A307_I0.5331.00
91_T112_D0.5331.00
16_F94_F0.5321.00
256_T306_A0.5301.00
288_E292_F0.5291.00
213_G217_L0.5291.00
63_P70_R0.5281.00
218_H222_A0.5271.00
230_G255_S0.5261.00
102_E108_N0.5261.00
118_E122_Q0.5251.00
130_I270_L0.5221.00
163_S270_L0.5211.00
231_K252_S0.5191.00
164_F187_A0.5181.00
93_A107_F0.5171.00
169_R181_V0.5161.00
124_K127_E0.5151.00
42_V46_I0.5141.00
195_K226_A0.5141.00
72_L77_V0.5141.00
155_A158_N0.5141.00
129_K161_F0.5131.00
198_D230_G0.5121.00
11_E167_N0.5121.00
201_L237_S0.5121.00
199_E203_I0.5111.00
122_Q154_I0.5101.00
221_G225_V0.5081.00
202_E208_K0.5081.00
286_L289_I0.5071.00
218_H221_G0.5051.00
218_H225_V0.5051.00
47_A75_V0.5041.00
168_Y181_V0.5031.00
25_L38_A0.5021.00
42_V267_L0.5011.00
205_S216_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hj6A 2 0.8688 100 0.188 Contact Map
3pl2A 2 0.9563 100 0.19 Contact Map
3iq0A 2 0.95 100 0.191 Contact Map
4du5A 2 0.9125 100 0.194 Contact Map
2rbcA 2 0.9125 100 0.196 Contact Map
3ljsA 2 0.975 100 0.196 Contact Map
4k8kA 2 0.9469 100 0.202 Contact Map
2qcvA 3 0.9469 100 0.205 Contact Map
3vasA 1 0.925 100 0.209 Contact Map
2v78A 5 0.9406 100 0.211 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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