GREMLIN Database
OXDD - Oxalate decarboxylase OxdD
UniProt: O34767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (371)
Sequences: 453 (270)
Seq/√Len: 14.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_D129_R5.7191.00
190_A330_Q5.0361.00
273_E336_T4.6261.00
109_A142_Y4.4601.00
121_I235_K4.1561.00
366_Q373_S3.8241.00
120_R134_D3.7690.99
294_T338_W3.5020.99
238_L254_V3.4720.99
59_F64_A3.0820.98
119_A151_I2.9730.97
114_M157_C2.9020.97
185_K200_N2.8780.97
115_L293_L2.8530.96
176_I357_M2.8370.96
297_G337_L2.8190.96
114_M119_A2.7890.96
290_Q319_G2.7150.95
299_M321_V2.6720.95
180_L188_L2.6540.94
296_Q334_T2.6100.94
36_R63_D2.5850.94
66_M74_S2.4930.92
312_D332_T2.4910.92
123_A230_V2.4400.91
164_D264_T2.3200.89
271_Q336_T2.2800.88
298_R312_D2.2270.87
133_A237_E2.1940.86
37_D62_S2.1770.86
371_A375_M2.1760.86
294_T335_E2.1530.85
33_N39_Q2.1440.85
67_K74_S2.1280.84
272_I337_L2.1220.84
364_L368_N2.1200.84
296_Q332_T2.1120.84
119_A157_C2.0280.81
59_F77_I2.0040.81
256_S266_A1.9770.80
123_A147_I1.9680.79
236_H241_Q1.9670.79
96_T99_G1.9670.79
112_A140_L1.9600.79
57_L301_V1.9510.79
179_W326_G1.9340.78
272_I339_F1.9340.78
64_A77_I1.9230.78
33_N314_R1.9140.77
162_V342_M1.8330.74
100_V364_L1.8210.74
182_H308_A1.8170.73
97_A155_E1.7910.72
270_V341_E1.7870.72
16_P38_I1.7440.70
290_Q299_M1.7250.69
114_M151_I1.7200.69
182_H353_L1.7090.69
74_S300_T1.6910.68
82_L309_R1.6800.67
354_N379_L1.6800.67
35_I39_Q1.6750.67
270_V339_F1.6540.66
33_N36_R1.6250.65
93_M159_F1.6080.64
292_Y337_L1.5970.63
16_P20_R1.5950.63
27_I94_S1.5740.62
56_N311_F1.5610.61
88_I162_V1.5440.61
142_Y145_A1.5410.60
301_V325_A1.5290.60
233_T260_P1.5060.59
179_W280_L1.4990.58
170_E206_Q1.4760.57
175_T368_N1.4720.57
118_R136_G1.4620.56
287_D323_S1.4610.56
298_R330_Q1.4530.56
32_R37_D1.4480.55
363_E367_S1.4440.55
151_I318_V1.4400.55
362_K377_D1.4360.55
237_E240_N1.4310.55
236_H240_N1.4200.54
232_M261_I1.4180.54
348_Y351_V1.3950.53
174_L303_I1.3940.53
123_A131_F1.3850.52
98_G284_P1.3850.52
290_Q321_V1.3770.52
192_F199_F1.3610.51
87_A320_Y1.3510.50
270_V276_A1.3400.50
245_Q273_E1.3390.50
36_R39_Q1.3390.50
239_L252_R1.3260.49
164_D236_H1.3180.48
142_Y263_K1.3150.48
30_G73_W1.3110.48
266_A346_N1.3080.48
18_P25_G1.3080.48
133_A235_K1.3060.48
175_T210_Y1.3000.47
197_N200_N1.3000.47
76_E108_Q1.3000.47
236_H239_L1.2930.47
372_G375_M1.2920.47
157_C348_Y1.2890.47
182_H284_P1.2880.47
74_S99_G1.2790.46
300_T307_T1.2730.46
97_A153_G1.2670.46
28_D37_D1.2650.46
306_G374_V1.2510.45
136_G237_E1.2490.45
99_G153_G1.2440.44
108_Q172_S1.2440.44
335_E338_W1.2430.44
100_V212_G1.2420.44
79_V167_N1.2320.44
121_I151_I1.2230.43
362_K376_L1.2180.43
284_P353_L1.2100.43
185_K189_S1.2030.42
93_M170_E1.2010.42
172_S260_P1.1960.42
68_L378_S1.1930.42
85_S88_I1.1900.42
210_Y368_N1.1840.41
109_A265_I1.1730.41
251_V348_Y1.1600.40
107_K172_S1.1590.40
180_L202_L1.1580.40
188_L202_L1.1570.40
175_T206_Q1.1500.39
116_L155_E1.1490.39
183_T335_E1.1430.39
87_A344_K1.1420.39
91_V170_E1.1370.39
188_L199_F1.1350.39
126_Q349_A1.1340.39
256_S262_S1.1320.39
134_D154_L1.1240.38
261_I342_M1.1210.38
188_L315_A1.1180.38
69_D74_S1.1120.37
76_E171_F1.1120.37
85_S348_Y1.1020.37
169_S319_G1.1020.37
183_T280_L1.0920.36
233_T236_H1.0890.36
189_S195_P1.0840.36
274_P287_D1.0800.36
115_L348_Y1.0770.36
100_V353_L1.0730.36
174_L383_K1.0690.35
258_N348_Y1.0660.35
276_A339_F1.0650.35
118_R134_D1.0600.35
107_K325_A1.0540.35
116_L293_L1.0510.34
153_G208_Y1.0470.34
61_F284_P1.0460.34
131_F233_T1.0210.33
141_W159_F1.0200.33
60_S252_R1.0200.33
355_Q383_K1.0170.33
127_D329_I1.0150.33
17_Q28_D1.0140.33
142_Y234_F1.0110.33
121_I216_G1.0100.32
187_V277_M1.0090.32
109_A263_K1.0080.32
285_N302_F1.0060.32
142_Y262_S1.0010.32
174_L304_G0.9980.32
218_V237_E0.9970.32
85_S250_S0.9900.32
355_Q359_L0.9890.31
238_L241_Q0.9800.31
198_A375_M0.9780.31
272_I329_I0.9760.31
228_G231_P0.9740.31
366_Q376_L0.9740.31
194_V375_M0.9670.30
296_Q335_E0.9650.30
292_Y297_G0.9640.30
194_V381_K0.9630.30
44_F85_S0.9600.30
326_G353_L0.9600.30
55_P291_Y0.9590.30
264_T280_L0.9580.30
286_S324_N0.9560.30
60_S78_T0.9490.30
114_M135_V0.9490.30
303_I325_A0.9450.29
46_P65_P0.9450.29
184_P328_Y0.9430.29
120_R154_L0.9410.29
37_D44_F0.9400.29
69_D170_E0.9340.29
170_E175_T0.9320.29
204_S315_A0.9270.29
59_F290_Q0.9260.29
29_T293_L0.9180.28
29_T94_S0.9160.28
27_I32_R0.9140.28
26_A96_T0.9110.28
236_H254_V0.9040.28
67_K208_Y0.9040.28
151_I332_T0.9040.28
122_T150_S0.9030.28
312_D386_V0.9030.28
148_P156_H0.8940.27
267_A386_V0.8940.27
180_L280_L0.8910.27
380_R384_V0.8900.27
39_Q266_A0.8900.27
264_T326_G0.8870.27
329_I339_F0.8840.27
264_T344_K0.8830.27
57_L311_F0.8800.27
292_Y313_Y0.8780.27
276_A293_L0.8760.26
230_V234_F0.8700.26
212_G367_S0.8680.26
142_Y261_I0.8620.26
225_S228_G0.8590.26
214_V377_D0.8570.26
28_D35_I0.8530.25
28_D32_R0.8520.25
243_P250_S0.8500.25
109_A145_A0.8500.25
74_S175_T0.8490.25
94_S148_P0.8480.25
113_Y340_L0.8280.24
19_I27_I0.8250.24
76_E100_V0.8250.24
118_R162_V0.8240.24
147_I313_Y0.8220.24
16_P32_R0.8220.24
51_E306_G0.8210.24
341_E350_D0.8120.24
275_G308_A0.8110.24
286_S323_S0.8040.24
33_N182_H0.7980.23
297_G329_I0.7980.23
65_P206_Q0.7970.23
292_Y299_M0.7970.23
245_Q250_S0.7960.23
236_H379_L0.7940.23
57_L123_A0.7940.23
257_S347_R0.7920.23
119_A318_V0.7920.23
103_L302_F0.7920.23
82_L315_A0.7860.23
82_L370_N0.7850.23
119_A135_V0.7840.23
218_V222_D0.7840.23
279_E352_S0.7830.23
157_C177_S0.7800.23
179_W353_L0.7800.23
84_I339_F0.7790.23
122_T364_L0.7790.23
107_K174_L0.7790.23
137_P368_N0.7780.23
126_Q147_I0.7750.22
87_A286_S0.7750.22
97_A345_S0.7740.22
291_Y348_Y0.7720.22
132_I169_S0.7720.22
87_A287_D0.7710.22
53_M307_T0.7700.22
146_G356_W0.7690.22
263_K346_N0.7680.22
346_N355_Q0.7660.22
189_S221_E0.7650.22
50_D255_D0.7640.22
74_S170_E0.7640.22
84_I299_M0.7640.22
250_S271_Q0.7590.22
93_M150_S0.7560.22
280_L337_L0.7560.22
74_S169_S0.7560.22
27_I291_Y0.7540.22
335_E372_G0.7540.22
16_P34_I0.7500.21
167_N172_S0.7490.21
242_P245_Q0.7440.21
168_F350_D0.7440.21
56_N160_L0.7420.21
64_A330_Q0.7400.21
172_S277_M0.7380.21
175_T209_I0.7370.21
59_F311_F0.7370.21
218_V236_H0.7370.21
270_V358_A0.7340.21
126_Q234_F0.7330.21
178_D326_G0.7330.21
91_V159_F0.7330.21
201_S335_E0.7270.21
277_M339_F0.7240.21
345_S355_Q0.7240.21
194_V199_F0.7220.20
165_D208_Y0.7220.20
140_L260_P0.7210.20
181_A297_G0.7210.20
375_M379_L0.7190.20
74_S208_Y0.7160.20
132_I151_I0.7140.20
179_W182_H0.7140.20
94_S171_F0.7130.20
112_A364_L0.7130.20
93_M169_S0.7110.20
159_F275_G0.7100.20
186_D330_Q0.7090.20
98_G353_L0.7090.20
178_D237_E0.7060.20
212_G229_K0.7060.20
332_T344_K0.7050.20
67_K153_G0.7040.20
47_P268_A0.7030.20
252_R372_G0.7010.20
118_R262_S0.6990.20
232_M260_P0.6990.20
178_D280_L0.6990.20
230_V235_K0.6960.20
132_I162_V0.6960.20
261_I276_A0.6950.20
162_V311_F0.6920.19
127_D195_P0.6880.19
120_R323_S0.6870.19
58_R300_T0.6870.19
192_F255_D0.6870.19
57_L125_D0.6860.19
129_R230_V0.6860.19
154_L214_V0.6860.19
272_I276_A0.6860.19
194_V200_N0.6850.19
238_L263_K0.6830.19
89_A162_V0.6830.19
148_P369_L0.6820.19
34_I185_K0.6810.19
27_I315_A0.6810.19
296_Q314_R0.6800.19
57_L63_D0.6800.19
180_L357_M0.6790.19
74_S202_L0.6780.19
84_I272_I0.6780.19
135_V324_N0.6780.19
266_A344_K0.6770.19
109_A264_T0.6760.19
217_S220_S0.6760.19
158_E255_D0.6740.19
19_I26_A0.6740.19
230_V233_T0.6730.19
170_E368_N0.6730.19
176_I261_I0.6720.19
113_Y305_N0.6710.19
134_D218_V0.6700.19
98_G153_G0.6700.19
122_T132_I0.6670.19
188_L195_P0.6650.19
241_Q253_I0.6620.18
76_E216_G0.6620.18
90_G250_S0.6610.18
29_T116_L0.6590.18
320_Y333_G0.6590.18
186_D277_M0.6560.18
61_F291_Y0.6530.18
140_L254_V0.6520.18
124_V230_V0.6510.18
33_N71_G0.6490.18
37_D126_Q0.6480.18
202_L360_T0.6470.18
341_E352_S0.6450.18
292_Y329_I0.6450.18
165_D372_G0.6420.18
205_E306_G0.6420.18
302_F353_L0.6420.18
193_G276_A0.6420.18
181_A371_A0.6410.18
124_V386_V0.6390.18
59_F168_F0.6390.18
291_Y299_M0.6390.18
45_V63_D0.6380.18
88_I155_E0.6380.18
60_S188_L0.6360.18
251_V339_F0.6350.18
265_I344_K0.6330.17
301_V319_G0.6310.17
121_I352_S0.6300.17
26_A314_R0.6300.17
83_P300_T0.6290.17
217_S221_E0.6290.17
165_D344_K0.6260.17
54_I115_L0.6250.17
109_A114_M0.6240.17
257_S334_T0.6230.17
129_R228_G0.6220.17
112_A166_G0.6220.17
123_A350_D0.6210.17
103_L285_N0.6200.17
68_L162_V0.6200.17
128_G142_Y0.6190.17
83_P169_S0.6190.17
88_I265_I0.6180.17
154_L246_M0.6140.17
127_D157_C0.6130.17
31_P92_N0.6120.17
331_N337_L0.6090.17
68_L344_K0.6090.17
140_L258_N0.6090.17
165_D234_F0.6080.17
76_E370_N0.6080.17
84_I87_A0.6080.17
168_F306_G0.6080.17
253_I261_I0.6070.17
186_D371_A0.6020.17
269_L338_W0.6000.16
36_R60_S0.5980.16
348_Y368_N0.5980.16
235_K261_I0.5970.16
301_V321_V0.5960.16
188_L260_P0.5960.16
223_I226_P0.5950.16
39_Q329_I0.5950.16
151_I157_C0.5940.16
72_G75_R0.5940.16
294_T313_Y0.5930.16
35_I38_I0.5920.16
236_H252_R0.5910.16
54_I280_L0.5910.16
353_L364_L0.5900.16
169_S181_A0.5890.16
299_M329_I0.5890.16
156_H210_Y0.5890.16
313_Y329_I0.5870.16
303_I306_G0.5860.16
79_V306_G0.5830.16
152_Q357_M0.5830.16
65_P73_W0.5790.16
83_P322_P0.5790.16
29_T35_I0.5790.16
33_N261_I0.5780.16
137_P344_K0.5770.16
55_P264_T0.5760.16
220_S379_L0.5740.16
30_G294_T0.5720.16
88_I224_Q0.5700.16
147_I270_V0.5700.16
155_E348_Y0.5690.16
346_N380_R0.5670.16
120_R218_V0.5670.16
17_Q27_I0.5660.15
242_P372_G0.5650.15
245_Q380_R0.5640.15
321_V372_G0.5630.15
162_V261_I0.5630.15
191_N255_D0.5620.15
241_Q254_V0.5620.15
239_L285_N0.5610.15
183_T337_L0.5600.15
208_Y350_D0.5580.15
80_R151_I0.5570.15
268_A341_E0.5560.15
107_K165_D0.5560.15
133_A371_A0.5560.15
165_D260_P0.5550.15
160_L344_K0.5550.15
188_L267_A0.5540.15
190_A211_Q0.5530.15
92_N153_G0.5530.15
177_S312_D0.5520.15
213_N335_E0.5520.15
157_C235_K0.5520.15
78_T170_E0.5510.15
54_I77_I0.5510.15
166_G253_I0.5490.15
145_A176_I0.5450.15
98_G182_H0.5440.15
251_V386_V0.5440.15
56_N59_F0.5440.15
252_R378_S0.5430.15
132_I189_S0.5420.15
99_G314_R0.5410.15
74_S91_V0.5410.15
63_D186_D0.5390.15
371_A376_L0.5390.15
187_V328_Y0.5380.15
251_V319_G0.5380.15
221_E332_T0.5370.15
60_S90_G0.5360.15
241_Q379_L0.5360.15
291_Y337_L0.5360.15
197_N344_K0.5350.15
164_D344_K0.5350.15
237_E260_P0.5350.15
256_S260_P0.5350.15
186_D386_V0.5340.15
234_F247_P0.5320.15
241_Q251_V0.5320.15
93_M141_W0.5310.15
29_T132_I0.5310.15
83_P226_P0.5310.15
109_A273_E0.5300.14
232_M377_D0.5300.14
254_V381_K0.5300.14
133_A225_S0.5290.14
224_Q332_T0.5280.14
265_I349_A0.5260.14
30_G325_A0.5260.14
265_I354_N0.5240.14
76_E169_S0.5230.14
116_L177_S0.5230.14
161_L265_I0.5230.14
75_R328_Y0.5220.14
18_P28_D0.5200.14
262_S375_M0.5200.14
358_A379_L0.5200.14
357_M376_L0.5190.14
179_W302_F0.5190.14
267_A329_I0.5190.14
86_T169_S0.5180.14
223_I228_G0.5170.14
269_L299_M0.5160.14
26_A54_I0.5160.14
255_D258_N0.5150.14
137_P338_W0.5140.14
311_F359_L0.5140.14
28_D314_R0.5140.14
15_V212_G0.5130.14
92_N158_E0.5130.14
145_A368_N0.5130.14
159_F170_E0.5120.14
292_Y321_V0.5110.14
189_S197_N0.5100.14
47_P156_H0.5090.14
145_A346_N0.5090.14
125_D302_F0.5090.14
21_S26_A0.5080.14
234_F272_I0.5080.14
129_R231_P0.5070.14
354_N380_R0.5060.14
275_G318_V0.5060.14
25_G311_F0.5060.14
297_G332_T0.5060.14
88_I124_V0.5050.14
131_F253_I0.5030.14
45_V59_F0.5030.14
102_E208_Y0.5030.14
127_D186_D0.5020.14
321_V343_F0.5020.14
241_Q269_L0.5010.14
60_S63_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j58A 5 0.9464 100 0.613 Contact Map
2vqaA 3 0.8929 100 0.672 Contact Map
2e9qA 6 0.8214 100 0.707 Contact Map
2ea7A 3 0.8673 100 0.708 Contact Map
4lejA 3 0.8087 100 0.709 Contact Map
3kscA 4 0.8265 100 0.712 Contact Map
3qacA 3 0.8214 100 0.713 Contact Map
1uijA 3 0.8495 100 0.715 Contact Map
3kglA 3 0.8469 100 0.716 Contact Map
2cavA 3 0.7959 100 0.718 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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