GREMLIN Database
SAT1 - Sulfate adenylyltransferase
UniProt: O34764 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (366)
Sequences: 1085 (574)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_D67_S4.7071.00
54_E58_V4.2981.00
94_V106_I4.1221.00
110_D146_G3.9881.00
229_E371_K3.9151.00
111_L145_V3.8991.00
62_E118_K3.8251.00
162_F232_Q3.5091.00
121_V127_D3.4801.00
290_G293_E3.4691.00
26_E97_T3.4041.00
293_E296_E3.3251.00
59_S63_N3.2621.00
172_Q176_K3.0651.00
53_N110_D2.9891.00
135_K139_S2.8581.00
348_G352_D2.8291.00
54_E110_D2.6701.00
88_L108_I2.6641.00
125_K293_E2.6481.00
109_E148_P2.6401.00
84_K87_E2.6141.00
65_R305_E2.5801.00
172_Q175_E2.5560.99
20_V93_T2.5490.99
322_C331_C2.5400.99
93_T107_Q2.5260.99
107_Q150_T2.5190.99
25_K92_E2.5090.99
95_K102_T2.4930.99
183_G273_C2.4850.99
82_A142_N2.4390.99
15_D18_Y2.3510.99
21_S95_K2.3050.99
52_F60_V2.2730.99
73_S262_I2.2290.99
49_E148_P2.2220.99
349_M356_P2.1890.98
116_K142_N2.1850.98
319_C322_C2.1190.98
53_N56_D2.1000.98
321_K337_H2.0760.98
82_A86_A2.0720.98
154_K165_E2.0700.98
209_F247_G2.0660.98
334_G337_H2.0330.97
53_N109_E2.0100.97
82_A113_V2.0060.97
113_V143_T1.9950.97
198_Q239_Y1.9890.97
361_S366_V1.9670.97
33_S79_P1.9510.97
269_K307_G1.9380.96
169_T173_F1.9360.96
236_D241_K1.9150.96
355_L367_E1.9010.96
21_S24_Q1.8740.96
164_F247_G1.8370.95
367_E371_K1.8170.95
249_F263_F1.8110.95
189_P227_R1.7890.94
30_D33_S1.7810.94
322_C333_H1.7720.94
88_L145_V1.7670.94
117_Q127_D1.7470.94
171_R175_E1.7380.93
129_Q138_F1.7210.93
10_L13_R1.7180.93
195_E362_R1.7170.93
104_G152_I1.7030.93
356_P370_I1.6760.92
185_Q253_M1.6750.92
128_E288_Y1.6680.92
125_K300_T1.6530.92
229_E368_V1.6500.92
108_I145_V1.6330.91
62_E122_N1.6290.91
101_E153_K1.6210.91
319_C331_C1.5910.90
299_D312_K1.5690.89
57_Y119_E1.5500.89
27_I106_I1.5220.88
342_S347_R1.4810.86
37_L149_I1.4680.86
233_V368_V1.4660.86
204_T311_L1.4660.86
114_P144_Y1.4630.86
13_R150_T1.4530.85
118_K122_N1.4460.85
222_I227_R1.4350.85
46_S170_R1.4270.84
183_G197_I1.4270.84
12_N167_S1.4130.84
34_F103_Y1.4000.83
28_E97_T1.3850.82
212_P231_Y1.3840.82
71_V301_F1.3780.82
172_Q245_F1.3770.82
28_E100_G1.3700.82
126_T134_V1.3690.82
82_A85_A1.3450.80
20_V24_Q1.3370.80
188_N280_R1.3360.80
363_K367_E1.3280.80
161_E232_Q1.3170.79
30_D140_R1.3120.79
90_L111_L1.3010.78
37_L103_Y1.2960.78
249_F267_V1.2840.77
53_N146_G1.2820.77
185_Q188_N1.2760.77
106_I145_V1.2710.76
315_H340_I1.2360.74
293_E297_L1.2250.74
260_E264_H1.2210.73
77_T144_Y1.2190.73
37_L104_G1.2160.73
316_S327_T1.2070.73
187_R253_M1.1750.71
180_T274_T1.1690.70
217_T227_R1.1650.70
222_I373_M1.1630.70
368_V371_K1.1610.70
24_Q95_K1.1580.69
10_L46_S1.1530.69
15_D19_D1.1500.69
230_S368_V1.1400.68
280_R342_S1.1370.68
223_P226_V1.1340.68
169_T209_F1.1250.67
164_F169_T1.1240.67
53_N148_P1.1230.67
187_R215_G1.1200.67
31_L98_Y1.1130.66
64_M297_L1.0990.65
296_E299_D1.0870.64
29_L33_S1.0850.64
38_E151_L1.0810.64
292_Y295_Q1.0780.64
55_K67_S1.0770.64
345_K349_M1.0760.64
81_D141_G1.0740.63
163_T228_M1.0700.63
81_D84_K1.0660.63
280_R344_T1.0660.63
32_I136_K1.0580.62
39_L104_G1.0570.62
250_L271_Y1.0530.62
122_N125_K1.0420.61
209_F273_C1.0370.61
190_V210_L1.0230.60
189_P222_I1.0200.59
221_D253_M1.0160.59
39_L44_A1.0120.59
343_G347_R1.0120.59
188_N347_R1.0080.58
355_L358_A1.0060.58
344_T347_R0.9990.58
319_C333_H0.9980.58
184_F260_E0.9910.57
27_I94_V0.9870.57
126_T273_C0.9830.57
193_A341_L0.9790.56
215_G268_R0.9770.56
171_R174_A0.9730.56
173_F209_F0.9730.56
346_V356_P0.9730.56
356_P366_V0.9720.56
188_N342_S0.9670.55
108_I111_L0.9670.55
12_N18_Y0.9590.55
189_P217_T0.9470.54
341_L346_V0.9460.54
314_E341_L0.9450.54
168_E171_R0.9450.54
280_R343_G0.9440.53
253_M264_H0.9370.53
24_Q93_T0.9350.53
61_V122_N0.9340.53
183_G276_F0.9340.53
15_D150_T0.9310.52
190_V227_R0.9300.52
280_R347_R0.9290.52
281_D284_G0.9260.52
29_L37_L0.9210.52
36_D254_R0.9200.52
12_N16_E0.9160.51
40_I46_S0.9140.51
188_N194_H0.9090.51
58_V118_K0.9080.51
54_E113_V0.9050.50
188_N279_G0.9000.50
141_G145_V0.8980.50
323_G358_A0.8910.49
125_K296_E0.8880.49
297_L302_K0.8820.49
152_I287_D0.8810.48
345_K348_G0.8800.48
88_L111_L0.8790.48
185_Q221_D0.8770.48
280_R283_A0.8760.48
11_V124_Y0.8730.48
119_E144_Y0.8720.48
164_F172_Q0.8710.48
187_R221_D0.8700.48
27_I310_P0.8680.47
264_H343_G0.8660.47
36_D252_A0.8640.47
80_V145_V0.8620.47
215_G221_D0.8610.47
111_L146_G0.8600.47
312_K327_T0.8560.47
146_G356_P0.8440.46
28_E99_E0.8440.46
232_Q236_D0.8410.45
116_K144_Y0.8390.45
113_V142_N0.8390.45
323_G354_V0.8360.45
88_L371_K0.8360.45
355_L363_K0.8350.45
23_I105_V0.8340.45
163_T250_L0.8340.45
120_A137_L0.8290.44
70_V266_L0.8220.44
95_K104_G0.8210.44
17_S20_V0.8190.44
55_K110_D0.8190.44
118_K121_V0.8140.43
188_N221_D0.8120.43
326_G330_T0.8110.43
260_E283_A0.8080.43
33_S140_R0.8040.42
253_M268_R0.8010.42
290_G296_E0.8000.42
188_N343_G0.7990.42
349_M354_V0.7960.42
50_G72_W0.7940.42
188_N218_K0.7930.42
12_N86_A0.7930.42
268_R342_S0.7870.41
63_N89_S0.7840.41
268_R280_R0.7840.41
215_G347_R0.7830.41
39_L42_I0.7820.41
188_N344_T0.7820.41
183_G198_Q0.7790.40
318_F323_G0.7780.40
196_Y317_F0.7770.40
10_L17_S0.7770.40
148_P232_Q0.7740.40
58_V61_V0.7710.40
187_R279_G0.7710.40
215_G253_M0.7690.40
202_L243_R0.7670.40
32_I45_Y0.7640.39
93_T150_T0.7610.39
117_Q129_Q0.7600.39
42_I266_L0.7600.39
10_L15_D0.7600.39
29_L247_G0.7600.39
265_A278_V0.7590.39
183_G201_A0.7550.39
11_V41_G0.7550.39
211_N268_R0.7530.39
85_A143_T0.7520.38
133_G260_E0.7480.38
187_R347_R0.7470.38
175_E336_E0.7460.38
69_G181_I0.7450.38
217_T222_I0.7430.38
131_H283_A0.7430.38
264_H283_A0.7420.38
22_G26_E0.7420.38
124_Y156_S0.7380.37
57_Y144_Y0.7340.37
43_G170_R0.7320.37
14_V18_Y0.7300.37
210_L228_M0.7300.37
104_G146_G0.7280.37
21_S102_T0.7280.37
27_I145_V0.7250.36
124_Y137_L0.7240.36
157_K163_T0.7220.36
156_S163_T0.7220.36
284_G344_T0.7210.36
184_F264_H0.7200.36
173_F245_F0.7200.36
280_R284_G0.7200.36
279_G343_G0.7160.36
231_Y246_L0.7160.36
239_Y313_F0.7160.36
187_R264_H0.7150.36
32_I140_R0.7130.36
83_Q86_A0.7120.35
253_M283_A0.7110.35
292_Y314_E0.7100.35
180_T309_T0.7090.35
253_M280_R0.7080.35
94_V145_V0.7050.35
264_H280_R0.7050.35
302_K305_E0.6990.35
184_F212_P0.6970.34
61_V118_K0.6960.34
227_R250_L0.6950.34
141_G310_P0.6940.34
213_L251_A0.6940.34
339_V345_K0.6940.34
260_E343_G0.6920.34
315_H341_L0.6910.34
320_K339_V0.6900.34
355_L370_I0.6900.34
149_I165_E0.6900.34
68_S232_Q0.6860.34
316_S325_M0.6860.34
14_V17_S0.6850.34
279_G284_G0.6850.34
33_S146_G0.6840.33
107_Q148_P0.6840.33
188_N253_M0.6830.33
325_M329_K0.6820.33
192_R227_R0.6810.33
317_F338_H0.6800.33
331_C338_H0.6760.33
126_T133_G0.6740.33
27_I84_K0.6720.33
115_D118_K0.6710.33
210_L235_L0.6680.32
215_G258_P0.6670.32
41_G149_I0.6660.32
44_A267_V0.6640.32
145_V236_D0.6630.32
43_G47_P0.6620.32
88_L94_V0.6610.32
230_S372_G0.6610.32
111_L143_T0.6610.32
319_C326_G0.6610.32
199_K205_V0.6600.32
63_N103_Y0.6600.32
217_T251_A0.6560.32
220_D351_R0.6560.32
264_H282_H0.6550.31
117_Q138_F0.6530.31
194_H342_S0.6530.31
103_Y229_E0.6530.31
208_L307_G0.6520.31
64_M256_A0.6510.31
185_Q268_R0.6500.31
194_H279_G0.6500.31
349_M357_P0.6480.31
25_K88_L0.6470.31
185_Q283_A0.6450.31
14_V87_E0.6450.31
114_P143_T0.6430.31
186_T308_I0.6430.31
15_D20_V0.6430.31
64_M259_R0.6420.31
100_G153_K0.6410.31
215_G280_R0.6390.30
25_K95_K0.6390.30
54_E118_K0.6370.30
39_L239_Y0.6370.30
31_L88_L0.6330.30
20_V25_K0.6330.30
119_E250_L0.6320.30
185_Q215_G0.6310.30
104_G165_E0.6300.30
18_Y23_I0.6290.30
103_Y372_G0.6280.30
113_V290_G0.6280.30
185_Q280_R0.6270.30
22_G25_K0.6270.30
97_T102_T0.6270.30
19_D95_K0.6260.30
218_K280_R0.6240.29
73_S263_F0.6210.29
197_I300_T0.6200.29
85_A88_L0.6200.29
9_T19_D0.6200.29
131_H260_E0.6160.29
71_V94_V0.6140.29
190_V198_Q0.6130.29
260_E268_R0.6120.29
92_E209_F0.6100.28
221_D347_R0.6090.28
105_V175_E0.6080.28
260_E282_H0.6080.28
279_G347_R0.6080.28
20_V150_T0.6080.28
187_R343_G0.6060.28
19_D23_I0.6060.28
165_E168_E0.6060.28
128_E138_F0.6040.28
187_R268_R0.6010.28
12_N370_I0.6010.28
81_D90_L0.6010.28
266_L306_L0.6010.28
218_K343_G0.6000.28
214_V248_V0.5990.28
217_T250_L0.5990.28
304_E309_T0.5980.28
35_A45_Y0.5980.28
187_R280_R0.5980.28
224_A227_R0.5970.28
187_R255_Y0.5960.28
149_I152_I0.5960.28
123_V186_T0.5960.28
27_I31_L0.5940.27
176_K245_F0.5930.27
157_K160_P0.5900.27
20_V95_K0.5900.27
17_S22_G0.5890.27
361_S365_V0.5890.27
193_A315_H0.5870.27
268_R281_D0.5870.27
218_K344_T0.5870.27
253_M343_G0.5870.27
199_K238_Y0.5870.27
319_C324_N0.5860.27
223_P227_R0.5860.27
231_Y252_A0.5850.27
31_L216_E0.5850.27
55_K94_V0.5850.27
90_L148_P0.5840.27
40_I55_K0.5840.27
24_Q135_K0.5830.27
298_F312_K0.5810.27
316_S340_I0.5810.27
322_C326_G0.5810.27
15_D24_Q0.5800.27
192_R196_Y0.5790.26
233_V237_H0.5790.26
320_K337_H0.5790.26
27_I30_D0.5770.26
208_L306_L0.5760.26
200_T204_T0.5760.26
45_Y110_D0.5750.26
40_I266_L0.5750.26
16_E367_E0.5750.26
346_V361_S0.5720.26
100_G177_G0.5710.26
40_I214_V0.5710.26
322_C334_G0.5710.26
348_G356_P0.5700.26
169_T310_P0.5700.26
218_K253_M0.5690.26
58_V62_E0.5680.26
44_A163_T0.5670.26
194_H347_R0.5650.26
195_E322_C0.5650.26
80_V111_L0.5650.26
82_A174_A0.5640.26
219_S225_D0.5640.26
281_D344_T0.5630.26
260_E342_S0.5620.25
194_H284_G0.5620.25
161_E172_Q0.5600.25
264_H347_R0.5600.25
81_D86_A0.5590.25
77_T197_I0.5580.25
121_V176_K0.5580.25
281_D342_S0.5570.25
220_D223_P0.5560.25
346_V360_F0.5560.25
104_G163_T0.5550.25
194_H281_D0.5550.25
220_D251_A0.5540.25
333_H362_R0.5530.25
45_Y71_V0.5530.25
194_H343_G0.5510.25
233_V236_D0.5510.25
100_G138_F0.5490.25
196_Y203_E0.5480.25
141_G181_I0.5480.25
195_E199_K0.5470.25
75_P191_H0.5460.25
185_Q217_T0.5450.24
23_I117_Q0.5450.24
45_Y241_K0.5420.24
199_K362_R0.5410.24
53_N67_S0.5410.24
210_L213_L0.5410.24
225_D229_E0.5390.24
158_Q163_T0.5390.24
47_P265_A0.5390.24
176_K181_I0.5380.24
40_I292_Y0.5380.24
184_F231_Y0.5370.24
188_N260_E0.5370.24
123_V259_R0.5370.24
36_D45_Y0.5360.24
188_N215_G0.5360.24
190_V220_D0.5360.24
28_E98_Y0.5360.24
90_L110_D0.5350.24
328_A356_P0.5350.24
11_V49_E0.5350.24
19_D24_Q0.5320.24
16_E20_V0.5320.24
281_D289_Y0.5310.24
149_I291_T0.5280.23
274_T307_G0.5280.23
19_D98_Y0.5270.23
56_D109_E0.5270.23
212_P276_F0.5250.23
29_L104_G0.5250.23
50_G146_G0.5240.23
57_Y77_T0.5240.23
193_A361_S0.5230.23
43_G50_G0.5230.23
301_F305_E0.5220.23
67_S70_V0.5220.23
52_F95_K0.5220.23
108_I274_T0.5210.23
25_K152_I0.5210.23
22_G146_G0.5210.23
184_F343_G0.5200.23
26_E175_E0.5200.23
19_D150_T0.5190.23
93_T105_V0.5190.23
218_K221_D0.5180.23
213_L341_L0.5170.23
133_G275_H0.5160.23
194_H280_R0.5160.23
125_K258_P0.5140.23
40_I151_L0.5130.23
53_N299_D0.5110.23
201_A276_F0.5100.22
281_D347_R0.5100.22
45_Y251_A0.5090.22
123_V254_R0.5080.22
217_T313_F0.5080.22
47_P257_G0.5080.22
57_Y246_L0.5060.22
83_Q87_E0.5060.22
88_L304_E0.5060.22
139_S156_S0.5050.22
21_S167_S0.5050.22
185_Q218_K0.5050.22
266_L271_Y0.5040.22
128_E134_V0.5040.22
186_T282_H0.5040.22
93_T153_K0.5030.22
218_K313_F0.5020.22
173_F178_W0.5020.22
9_T20_V0.5020.22
187_R220_D0.5010.22
195_E346_V0.5010.22
112_Y230_S0.5000.22
185_Q342_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r6xA 1 0.9607 100 0.1 Contact Map
1x6vB 2 0.9921 100 0.11 Contact Map
4mafA 2 0.9843 100 0.114 Contact Map
1m8pA 5 0.9895 100 0.129 Contact Map
1g8fA 5 0.9869 100 0.136 Contact Map
2gksA 2 0.9084 100 0.175 Contact Map
3cr8A 4 0.8927 100 0.225 Contact Map
1v47A 2 0.9031 100 0.299 Contact Map
4dnxA 2 0.9817 100 0.33 Contact Map
1qjcA 4 0.411 99.4 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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