GREMLIN Database
OHRA - Organic hydroperoxide resistance protein OhrA
UniProt: O34762 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (133)
Sequences: 1898 (1153)
Seq/√Len: 99.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_E117_K3.3591.00
71_E118_K3.2271.00
108_S111_E3.1421.00
109_A113_E2.7971.00
67_V122_V2.6501.00
99_T136_T2.6061.00
101_Q138_E2.4371.00
104_G112_L2.4111.00
20_V54_A2.2331.00
9_T82_N2.1851.00
83_V98_V2.1451.00
21_I28_E2.0641.00
88_D127_K2.0601.00
99_T138_E1.9951.00
24_D50_Q1.9361.00
116_V139_V1.8331.00
61_D77_T1.8171.00
102_V116_V1.7971.00
114_A118_K1.7801.00
84_S97_G1.7641.00
19_K30_D1.7521.00
111_E114_A1.7261.00
71_E114_A1.7231.00
81_A100_L1.7151.00
82_N101_Q1.7131.00
66_L70_T1.6611.00
9_T23_S1.6591.00
19_K28_E1.6491.00
86_L97_G1.5871.00
26_V45_A1.5591.00
11_S80_T1.5361.00
86_L95_K1.5311.00
64_L115_L1.5191.00
73_V111_E1.5011.00
20_V29_L1.4931.00
12_A20_V1.4371.00
61_D65_Q1.4331.00
129_T133_I1.4281.00
56_Y98_V1.3670.99
46_T50_Q1.3640.99
21_I25_R1.3520.99
10_V22_S1.3420.99
68_A75_V1.3230.99
117_K121_G1.3210.99
60_F116_V1.3150.99
8_A23_S1.3080.99
128_A132_N1.2510.99
12_A57_A1.2470.99
5_L37_P1.2280.99
7_T82_N1.2230.99
97_G136_T1.2170.99
26_V42_L1.2030.99
32_A45_A1.2010.99
10_V53_A1.1750.98
12_A61_D1.1610.98
120_H126_S1.1600.98
107_V111_E1.1570.98
98_V133_I1.1510.98
42_L45_A1.0990.97
78_E103_K1.0580.97
33_M37_P1.0470.96
52_F129_T1.0330.96
121_G130_S1.0210.96
22_S54_A1.0180.96
129_T132_N0.9830.95
22_S26_V0.9820.95
22_S46_T0.9780.95
102_V137_L0.9770.95
11_S23_S0.9680.95
69_R74_K0.9660.94
120_H135_V0.9580.94
52_F125_Y0.9450.94
114_A117_K0.9400.94
66_L122_V0.9300.93
35_G39_A0.9240.93
32_A42_L0.9210.93
32_A44_K0.9080.92
110_S113_E0.8850.91
39_A43_E0.8810.91
33_M42_L0.8710.91
36_T39_A0.8680.91
88_D91_D0.8610.90
68_A115_L0.8610.90
82_N99_T0.8560.90
7_T84_S0.8500.90
17_E33_M0.8500.90
80_T103_K0.8480.90
9_T80_T0.8470.90
69_R72_R0.8450.89
70_T118_K0.8350.89
84_S99_T0.8280.89
79_V102_V0.8260.88
62_S65_Q0.8200.88
66_L69_R0.8190.88
95_K134_D0.8180.88
56_Y126_S0.8160.88
64_L71_E0.8030.87
26_V44_K0.8020.87
116_V137_L0.7910.86
35_G38_R0.7880.86
104_G107_V0.7870.86
81_A85_L0.7860.86
10_V54_A0.7840.86
64_L119_A0.7780.85
55_G125_Y0.7650.84
62_S96_L0.7650.84
60_F137_L0.7570.84
7_T97_G0.7520.83
27_L46_T0.7480.83
84_S87_K0.7450.83
103_K139_V0.7410.82
109_A139_V0.7380.82
66_L94_Y0.7370.82
6_F47_N0.7340.82
47_N50_Q0.7270.81
32_A36_T0.7250.81
62_S66_L0.7250.81
91_D127_K0.7220.81
26_V46_T0.7220.81
64_L102_V0.7090.79
97_G133_I0.7090.79
83_V87_K0.6970.78
68_A77_T0.6970.78
81_A87_K0.6960.78
76_E105_E0.6930.78
78_E81_A0.6890.78
26_V32_A0.6880.77
71_E111_E0.6870.77
57_A81_A0.6860.77
76_E83_V0.6850.77
59_C120_H0.6750.76
31_V68_A0.6730.76
23_S46_T0.6710.76
15_G18_G0.6710.76
107_V112_L0.6650.75
130_S135_V0.6650.75
37_P43_E0.6620.75
87_K127_K0.6610.75
88_D95_K0.6520.74
110_S114_A0.6510.73
103_K109_A0.6510.73
74_K106_G0.6500.73
122_V127_K0.6490.73
4_P84_S0.6420.72
113_E139_V0.6420.72
30_D44_K0.6360.72
113_E137_L0.6350.72
67_V71_E0.6300.71
118_K121_G0.6270.71
56_Y120_H0.6230.70
100_L135_V0.6180.70
36_T42_L0.6080.68
31_V46_T0.6070.68
64_L73_V0.5990.67
25_R28_E0.5980.67
76_E81_A0.5970.67
38_R43_E0.5910.66
57_A83_V0.5900.66
93_G127_K0.5880.66
64_L107_V0.5810.65
70_T107_V0.5780.64
37_P85_L0.5710.63
52_F135_V0.5700.63
16_R128_A0.5680.63
6_F50_Q0.5680.63
29_L46_T0.5670.63
117_K137_L0.5570.62
61_D69_R0.5560.61
85_L93_G0.5530.61
128_A131_G0.5480.60
92_Q127_K0.5440.60
61_D78_E0.5390.59
72_R111_E0.5370.59
128_A133_I0.5360.59
52_F56_Y0.5360.59
81_A84_S0.5360.59
67_V118_K0.5350.59
23_S50_Q0.5330.58
57_A61_D0.5310.58
47_N55_G0.5310.58
28_E54_A0.5280.58
104_G139_V0.5250.57
127_K130_S0.5240.57
92_Q121_G0.5190.56
5_L58_A0.5180.56
97_G134_D0.5180.56
36_T43_E0.5170.56
14_G18_G0.5160.56
52_F59_C0.5160.56
79_V83_V0.5150.56
95_K127_K0.5150.56
118_K122_V0.5140.56
10_V45_A0.5100.55
76_E79_V0.5100.55
79_V104_G0.5090.55
22_S25_R0.5060.54
88_D92_Q0.5040.54
12_A31_V0.5030.54
6_F39_A0.5020.54
46_T54_A0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nozA 2 0.9645 100 0.46 Contact Map
1n2fA 2 0.9716 100 0.474 Contact Map
1uspA 2 0.9574 100 0.475 Contact Map
2ql8A 2 0.9433 100 0.478 Contact Map
1zb9A 2 0.9716 100 0.485 Contact Map
2bjoA 2 0.9504 100 0.487 Contact Map
3eerA 2 0.9645 100 0.488 Contact Map
4mh4A 2 0.9433 100 0.488 Contact Map
2d7vA 2 0.9362 100 0.518 Contact Map
1nyeA 5 0.9504 100 0.524 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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