GREMLIN Database
YTNP - Probable quorum-quenching lactonase YtnP
UniProt: O34760 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (249)
Sequences: 3334 (2414)
Seq/√Len: 153.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_T197_V6.2601.00
57_Q62_N4.4761.00
141_A145_D4.4081.00
141_A174_E4.4011.00
10_T57_Q3.8661.00
136_V171_K3.5761.00
106_V138_Y3.2221.00
61_L106_V2.9051.00
8_N203_A2.8971.00
65_I110_T2.8961.00
102_A133_P2.6961.00
140_S196_S2.6511.00
100_T103_D2.5461.00
62_N99_L2.5301.00
178_T181_E2.5291.00
62_N104_I2.4831.00
231_Y234_T2.4521.00
199_I206_T2.3651.00
57_Q99_L2.2971.00
245_F249_K2.2731.00
95_A100_T2.2511.00
61_L105_D2.2191.00
178_T182_G2.2161.00
188_T195_H2.2081.00
183_I200_C2.1121.00
189_G238_Q1.9981.00
110_T198_L1.9471.00
195_H211_A1.9391.00
244_A268_E1.9141.00
186_H199_I1.9051.00
55_L99_L1.8791.00
9_I58_K1.8711.00
65_I198_L1.8271.00
109_M120_L1.7961.00
12_T57_Q1.7941.00
184_T201_E1.7921.00
14_L55_L1.7851.00
64_I104_I1.7771.00
56_I65_I1.7251.00
185_M198_L1.7201.00
108_A198_L1.7161.00
213_L242_W1.7141.00
201_E206_T1.6961.00
199_I208_V1.6951.00
234_T237_P1.6601.00
246_A251_A1.5871.00
248_E268_E1.5691.00
55_L64_I1.5381.00
159_W166_V1.5361.00
120_L137_I1.5341.00
173_F196_S1.4971.00
8_N202_D1.4891.00
199_I245_F1.4891.00
99_L103_D1.4851.00
106_V136_V1.4531.00
63_I183_I1.4401.00
244_A248_E1.4311.00
240_Q244_A1.4041.00
237_P241_K1.3941.00
184_T199_I1.3851.00
94_L99_L1.3801.00
11_L207_A1.3761.00
20_H48_E1.3741.00
112_L139_T1.3651.00
62_N105_D1.3631.00
160_K164_E1.3441.00
102_A134_N1.3301.00
202_D205_E1.3171.00
107_I137_I1.3101.00
14_L93_S1.3061.00
35_W39_Y1.2901.00
144_W172_T1.2611.00
210_M253_F1.2271.00
95_A101_V1.2251.00
206_T251_A1.2191.00
201_E204_G1.2131.00
186_H208_V1.2121.00
145_D149_H1.1991.00
246_A253_F1.1951.00
67_A120_L1.1941.00
91_K131_V1.1931.00
31_P34_L1.1771.00
65_I108_A1.1511.00
140_S175_D1.1421.00
252_W265_Q1.1381.00
146_E193_D1.1371.00
189_G234_T1.1361.00
185_M196_S1.1311.00
55_L104_I1.1281.00
245_F251_A1.1231.00
62_N103_D1.1181.00
63_I106_V1.1120.99
65_I209_H1.1090.99
186_H197_V1.1070.99
225_V236_I1.1050.99
209_H254_I1.0990.99
10_T62_N1.0950.99
54_I254_I1.0810.99
144_W148_R1.0790.99
205_E252_W1.0720.99
162_N165_A1.0710.99
55_L62_N1.0700.99
197_V208_V1.0650.99
139_T170_V1.0530.99
237_P240_Q1.0390.99
89_N92_P1.0380.99
143_E147_M1.0380.99
161_E164_E1.0330.99
62_N94_L1.0290.99
110_T211_A1.0250.99
54_I209_H1.0210.99
58_K61_L1.0200.99
206_T249_K1.0140.99
267_E271_S1.0110.99
138_Y173_F1.0070.99
252_W263_A0.9960.99
18_V48_E0.9950.99
92_P95_A0.9890.99
186_H245_F0.9880.99
120_L166_V0.9860.99
138_Y171_K0.9820.99
32_K36_S0.9810.99
175_D187_H0.9780.99
208_V246_A0.9770.99
158_Y165_A0.9730.99
112_L117_A0.9670.99
141_A172_T0.9630.99
13_W52_D0.9540.98
241_K245_F0.9490.98
112_L147_M0.9430.98
208_V251_A0.9430.98
119_G131_V0.9330.98
197_V242_W0.9300.98
143_E192_S0.9290.98
229_D239_K0.9280.98
108_A183_I0.9250.98
158_Y161_E0.9250.98
109_M117_A0.9190.98
91_K101_V0.9130.98
188_T238_Q0.9090.98
34_L37_K0.9090.98
17_G68_G0.9070.98
23_G27_F0.9040.98
12_T97_L0.9000.98
199_I251_A0.8960.98
145_D148_R0.8950.98
159_W162_N0.8950.98
233_M236_I0.8920.98
58_K63_I0.8880.97
197_V213_L0.8770.97
13_W54_I0.8750.97
9_I202_D0.8690.97
243_Q266_W0.8640.97
236_I240_Q0.8610.97
175_D196_S0.8580.97
210_M255_F0.8510.97
234_T238_Q0.8510.97
173_F185_M0.8500.97
130_S133_P0.8480.97
176_T184_T0.8390.96
132_F135_A0.8390.96
9_I182_G0.8330.96
33_P36_S0.8330.96
31_P35_W0.8300.96
174_E177_L0.8200.96
130_S169_Q0.8190.96
36_S39_Y0.8180.96
159_W163_W0.8170.96
235_S239_K0.8160.96
223_L240_Q0.8150.96
11_L254_I0.8120.96
16_G88_S0.8110.96
14_L97_L0.8110.96
176_T187_H0.8090.96
14_L99_L0.8030.95
70_G119_G0.8000.95
209_H256_Y0.8000.95
138_Y177_L0.7970.95
162_N166_V0.7970.95
244_A247_A0.7920.95
95_A270_G0.7890.95
142_V175_D0.7890.95
13_W254_I0.7890.95
30_V35_W0.7870.95
64_I107_I0.7850.95
32_K35_W0.7800.95
254_I263_A0.7790.95
94_L104_I0.7780.95
223_L236_I0.7770.95
144_W170_V0.7740.94
193_D231_Y0.7680.94
36_S40_P0.7670.94
268_E271_S0.7620.94
88_S96_A0.7580.94
68_G109_M0.7550.94
26_M226_L0.7520.94
104_I135_A0.7500.93
205_E265_Q0.7480.93
178_T201_E0.7420.93
64_I94_L0.7410.93
158_Y162_N0.7400.93
109_M137_I0.7380.93
104_I136_V0.7370.93
140_S173_F0.7350.93
16_G70_G0.7250.92
250_D265_Q0.7250.92
247_A266_W0.7250.92
53_P90_V0.7240.92
56_I183_I0.7210.92
215_P219_H0.7190.92
106_V180_T0.7170.92
37_K40_P0.7100.91
21_M49_L0.7090.91
210_M213_L0.7030.91
101_V131_V0.7000.91
69_I82_Y0.6990.91
245_F250_D0.6960.91
142_V145_D0.6940.91
28_G31_P0.6910.90
243_Q247_A0.6900.90
22_D45_N0.6890.90
54_I207_A0.6890.90
215_P226_L0.6870.90
153_R157_T0.6870.90
158_Y166_V0.6840.90
221_N224_W0.6800.90
217_H258_D0.6790.90
50_R215_P0.6770.89
51_T87_E0.6770.89
108_A179_I0.6760.89
15_D89_N0.6750.89
63_I108_A0.6750.89
65_I211_A0.6740.89
64_I67_A0.6720.89
214_M258_D0.6720.89
161_E165_A0.6720.89
142_V174_E0.6710.89
140_S143_E0.6710.89
70_G229_D0.6670.89
143_E195_H0.6650.89
15_D93_S0.6630.88
54_I256_Y0.6610.88
55_L97_L0.6600.88
178_T184_T0.6590.88
22_D25_A0.6590.88
207_A254_I0.6580.88
142_V189_G0.6570.88
67_A117_A0.6570.88
93_S96_A0.6570.88
116_H257_H0.6530.88
199_I249_K0.6500.87
209_H255_F0.6490.87
130_S137_I0.6440.87
56_I63_I0.6370.86
22_D27_F0.6370.86
10_T99_L0.6350.86
200_C209_H0.6350.86
9_I200_C0.6350.86
208_V242_W0.6350.86
137_I166_V0.6330.86
190_G212_D0.6330.86
163_W166_V0.6320.86
11_L54_I0.6310.86
220_R258_D0.6310.86
139_T172_T0.6290.86
131_V137_I0.6290.86
57_Q104_I0.6280.86
117_A120_L0.6270.86
24_G35_W0.6260.85
177_L185_M0.6260.85
174_E187_H0.6250.85
53_P256_Y0.6230.85
15_D52_D0.6220.85
120_L130_S0.6210.85
27_F35_W0.6180.85
213_L238_Q0.6170.85
30_V34_L0.6150.84
29_V34_L0.6140.84
192_S229_D0.6100.84
171_K177_L0.6070.84
63_I180_T0.6050.83
226_L229_D0.6000.83
130_S168_G0.5990.83
233_M237_P0.5990.83
239_K243_Q0.5980.83
242_W246_A0.5980.83
8_N36_S0.5950.82
202_D206_T0.5920.82
183_I198_L0.5920.82
57_Q103_D0.5920.82
66_D257_H0.5910.82
33_P37_K0.5880.82
253_F266_W0.5850.81
154_S157_T0.5830.81
151_N154_S0.5810.81
89_N96_A0.5810.81
137_I172_T0.5810.81
71_Y92_P0.5810.81
101_V135_A0.5810.81
167_A170_V0.5770.80
115_D257_H0.5730.80
82_Y114_F0.5680.79
124_E271_S0.5660.79
94_L97_L0.5630.79
38_K41_V0.5620.79
160_K163_W0.5620.79
211_A256_Y0.5600.78
54_I215_P0.5600.78
136_V169_Q0.5570.78
56_I205_E0.5540.78
176_T186_H0.5530.78
36_S41_V0.5510.77
56_I133_P0.5480.77
86_Q92_P0.5480.77
146_E192_S0.5470.77
68_G194_G0.5440.76
9_I56_I0.5420.76
71_Y89_N0.5410.76
220_R255_F0.5400.76
47_I216_T0.5390.76
107_I132_F0.5380.76
214_M255_F0.5380.76
224_W228_Y0.5380.76
225_V233_M0.5380.76
58_K202_D0.5370.76
210_M256_Y0.5350.75
116_H191_H0.5350.75
144_W167_A0.5340.75
54_I219_H0.5340.75
54_I255_F0.5330.75
59_D141_A0.5330.75
21_M228_Y0.5320.75
33_P184_T0.5320.75
58_K182_G0.5310.75
29_V32_K0.5300.75
71_Y123_Y0.5300.75
69_I84_V0.5280.74
117_A158_Y0.5270.74
93_S97_L0.5240.74
119_G239_K0.5240.74
56_I180_T0.5220.74
42_N250_D0.5220.74
134_N207_A0.5210.73
64_I90_V0.5210.73
197_V209_H0.5200.73
114_F157_T0.5170.73
23_G45_N0.5170.73
58_K180_T0.5160.73
13_W16_G0.5160.73
64_I100_T0.5150.73
138_Y185_M0.5140.72
182_G201_E0.5140.72
214_M243_Q0.5130.72
26_M32_K0.5130.72
9_I183_I0.5120.72
54_I65_I0.5120.72
42_N45_N0.5110.72
222_P239_K0.5100.72
220_R243_Q0.5100.72
11_L56_I0.5090.72
112_L143_E0.5090.72
11_L200_C0.5080.72
130_S165_A0.5070.71
108_A196_S0.5060.71
92_P96_A0.5050.71
96_A149_H0.5050.71
12_T99_L0.5040.71
140_S187_H0.5040.71
238_Q242_W0.5040.71
107_I120_L0.5040.71
27_F30_V0.5030.71
186_H241_K0.5020.71
110_T219_H0.5010.70
215_P256_Y0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4le6A 4 0.8327 100 0.355 Contact Map
4zo2A 2 0.9537 100 0.373 Contact Map
1p9eA 3 0.9502 100 0.375 Contact Map
3eshA 5 0.9786 100 0.429 Contact Map
3aj3A 2 0.879 100 0.471 Contact Map
2r2dA 5 0.9146 100 0.479 Contact Map
3dhaA 1 0.8683 100 0.503 Contact Map
1ztcA 4 0.6975 100 0.591 Contact Map
4d1tA 1 0.7829 100 0.619 Contact Map
4eybA 2 0.8007 100 0.626 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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