GREMLIN Database
DESK - Sensor histidine kinase DesK
UniProt: O34757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (318)
Sequences: 33857 (30043)
Seq/√Len: 1684.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
313_E364_A3.9161.00
319_S360_K3.8661.00
202_S223_V3.5521.00
317_T362_T3.3271.00
317_T360_K3.2161.00
352_H362_T3.1681.00
341_R345_E3.0771.00
206_R224_Q2.9441.00
315_V364_A2.8801.00
199_G227_A2.8081.00
265_I304_R2.6951.00
315_V362_T2.6421.00
306_D317_T2.6391.00
206_R221_K2.5701.00
302_T321_D2.5511.00
340_M351_L2.5291.00
290_A361_L2.4971.00
267_E306_D2.4891.00
310_L315_V2.4771.00
294_V303_C2.4481.00
286_C344_L2.3991.00
308_Q315_V2.3331.00
265_I302_T2.3201.00
198_I227_A2.3141.00
353_I361_L2.2701.00
298_S321_D2.2611.00
344_L363_M2.2231.00
199_G228_R2.2051.00
267_E304_R2.1921.00
205_A220_L2.1781.00
354_D360_K2.1191.00
344_L349_G2.1151.00
350_S364_A2.0341.00
203_D224_Q2.0171.00
304_R319_S1.9781.00
320_D324_F1.9671.00
301_K321_D1.9671.00
309_Q367_N1.9421.00
354_D362_T1.9291.00
210_Y217_A1.9151.00
286_C363_M1.9061.00
308_Q317_T1.8831.00
224_Q228_R1.8751.00
325_K359_T1.8451.00
150_S153_S1.8451.00
306_D319_S1.8051.00
263_M302_T1.7821.00
165_E168_N1.7541.00
153_S157_R1.7531.00
168_N171_I1.7441.00
201_K219_E1.7211.00
213_P216_A1.7081.00
212_D215_Q1.7061.00
231_L235_R1.6911.00
278_L347_A1.6881.00
286_C343_R1.6661.00
252_N256_I1.6621.00
287_L316_I1.6541.00
161_E165_E1.6391.00
316_I363_M1.6381.00
286_C340_M1.6291.00
352_H364_A1.6171.00
249_E253_I1.6151.00
206_R217_A1.6131.00
201_K222_S1.6081.00
292_T296_K1.5751.00
254_K258_E1.5721.00
198_I223_V1.5551.00
355_T359_T1.5271.00
344_L351_L1.5181.00
178_E182_R1.5151.00
320_D358_G1.5081.00
249_E252_N1.4941.00
168_N172_A1.4861.00
290_A318_V1.4621.00
343_R347_A1.4621.00
164_L167_A1.4551.00
154_R157_R1.4481.00
177_L180_R1.4481.00
212_D216_A1.4201.00
164_L168_N1.4181.00
345_E350_S1.4121.00
199_G231_L1.4091.00
298_S303_C1.4041.00
199_G224_Q1.3841.00
205_A216_A1.3811.00
314_V367_N1.3811.00
298_S301_K1.3781.00
160_L163_K1.3731.00
163_K167_A1.3561.00
177_L181_Q1.3391.00
285_M288_K1.3271.00
202_S224_Q1.3171.00
262_I266_Y1.2981.00
276_S279_N1.2971.00
170_R173_E1.2941.00
279_N282_I1.2821.00
167_A171_I1.2781.00
165_E169_E1.2781.00
167_A170_R1.2761.00
158_E161_E1.2741.00
160_L164_L1.2681.00
176_K180_R1.2611.00
304_R321_D1.2561.00
269_E308_Q1.2551.00
299_Q323_T1.2551.00
278_L283_L1.2501.00
310_L364_A1.2371.00
217_A221_K1.2331.00
221_K225_Q1.2291.00
162_E166_D1.2251.00
197_L201_K1.2101.00
289_E340_M1.1991.00
284_S288_K1.1911.00
202_S220_L1.1901.00
199_G203_D1.1871.00
353_I359_T1.1871.00
202_S227_A1.1821.00
161_E164_L1.1811.00
251_I254_K1.1641.00
268_E307_I1.1611.00
253_I257_L1.1591.00
254_K257_L1.1581.00
159_R163_K1.1551.00
180_R184_A1.1521.00
208_L216_A1.1491.00
249_E257_L1.1381.00
158_E162_E1.1211.00
305_V318_V1.1161.00
338_L342_E1.1151.00
283_L365_I1.0921.00
153_S156_E1.0891.00
290_A340_M1.0861.00
157_R161_E1.0781.00
150_S154_R1.0761.00
255_Q258_E1.0731.00
282_I285_M1.0681.00
349_G365_I1.0551.00
179_E182_R1.0521.00
282_I343_R1.0501.00
192_G235_R1.0431.00
232_N236_K1.0281.00
200_L204_L1.0251.00
163_K166_D1.0231.00
222_S226_T1.0231.00
342_E346_F1.0171.00
218_R221_K1.0151.00
190_T285_M1.0141.00
197_L226_T1.0021.00
191_L234_V0.9971.00
291_V303_C0.9851.00
214_E217_A0.9801.00
273_E309_Q0.9771.00
144_A148_P0.9721.00
213_P217_A0.9681.00
191_L230_S0.9631.00
202_S206_R0.9581.00
169_E173_E0.9561.00
51_S55_F0.9551.00
280_E284_S0.9521.00
151_I155_K0.9491.00
287_L291_V0.9481.00
153_S158_E0.9481.00
249_E258_E0.9461.00
269_E306_D0.9461.00
259_A262_I0.9451.00
282_I346_F0.9441.00
157_R160_L0.9441.00
182_R186_D0.9411.00
294_V298_S0.9391.00
226_T229_T0.9361.00
47_L51_S0.9361.00
49_F53_Y0.9361.00
325_K361_L0.9311.00
227_A231_L0.9291.00
291_V305_V0.9271.00
256_I284_S0.9271.00
176_K179_E0.9221.00
151_I154_R0.9211.00
290_A363_M0.9201.00
344_L365_I0.9111.00
251_I255_Q0.9101.00
253_I256_I0.9071.00
282_I347_A0.9031.00
236_K282_I0.9001.00
342_E345_E0.8991.00
252_N255_Q0.8991.00
218_R222_S0.8991.00
190_T233_E0.8991.00
100_E103_P0.8981.00
219_E222_S0.8961.00
210_Y213_P0.8941.00
183_I187_L0.8911.00
160_L165_E0.8871.00
325_K355_T0.8871.00
221_K224_Q0.8831.00
162_E165_E0.8821.00
272_P309_Q0.8801.00
145_I149_F0.8761.00
215_Q219_E0.8731.00
283_L347_A0.8731.00
326_G356_E0.8721.00
205_A223_V0.8711.00
140_T144_A0.8641.00
154_R158_E0.8631.00
287_L318_V0.8601.00
160_L167_A0.8551.00
349_G363_M0.8551.00
320_D359_T0.8551.00
260_A295_V0.8481.00
351_L361_L0.8461.00
153_S161_E0.8431.00
225_Q229_T0.8391.00
303_C307_I0.8381.00
335_H339_G0.8301.00
166_D170_R0.8251.00
195_L230_S0.8251.00
220_L223_V0.8251.00
310_L313_E0.8241.00
206_R220_L0.8231.00
161_E167_A0.8101.00
355_T358_G0.8091.00
193_Q197_L0.8091.00
120_N123_L0.8091.00
166_D169_E0.8081.00
216_A219_E0.8031.00
137_V141_L0.8011.00
136_F140_T0.8001.00
235_R239_S0.7981.00
99_K102_V0.7971.00
283_L314_V0.7951.00
97_N100_E0.7921.00
324_F359_T0.7901.00
197_L200_L0.7891.00
83_S87_F0.7891.00
313_E350_S0.7891.00
189_D193_Q0.7871.00
226_T230_S0.7861.00
93_Y97_N0.7851.00
297_H323_T0.7821.00
283_L316_I0.7801.00
192_G231_L0.7791.00
249_E256_I0.7771.00
351_L363_M0.7771.00
117_V120_N0.7771.00
63_T67_W0.7761.00
274_N314_V0.7711.00
50_F54_R0.7701.00
215_Q218_R0.7671.00
297_H330_S0.7651.00
323_T330_S0.7611.00
132_T136_F0.7611.00
161_E168_N0.7601.00
222_S225_Q0.7591.00
291_V295_V0.7571.00
101_R105_H0.7531.00
210_Y216_A0.7531.00
63_T66_L0.7511.00
175_V178_E0.7481.00
269_E272_P0.7441.00
281_N284_S0.7441.00
223_V227_A0.7441.00
95_I99_K0.7431.00
232_N281_N0.7401.00
196_S200_L0.7401.00
230_S234_V0.7401.00
201_K226_T0.7391.00
187_L237_I0.7381.00
288_K292_T0.7331.00
87_F91_I0.7331.00
230_S233_E0.7321.00
274_N277_L0.7311.00
96_G100_E0.7311.00
339_G343_R0.7301.00
68_G71_L0.7301.00
169_E172_A0.7271.00
190_T194_K0.7261.00
274_N309_Q0.7201.00
133_Q136_F0.7191.00
203_D206_R0.7171.00
262_I298_S0.7131.00
122_S126_K0.7131.00
48_L52_V0.7121.00
322_G358_G0.7121.00
62_W65_Y0.7111.00
204_L208_L0.7101.00
279_N347_A0.7091.00
196_S199_G0.7091.00
52_V55_F0.7081.00
216_A220_L0.7071.00
198_I202_S0.7071.00
201_K204_L0.7071.00
201_K223_V0.7061.00
117_V121_F0.7051.00
249_E254_K0.7041.00
131_L134_I0.7041.00
282_I286_C0.7031.00
303_C318_V0.7031.00
150_S157_R0.7011.00
337_L340_M0.7001.00
51_S54_R0.7001.00
129_F133_Q0.6991.00
203_D207_K0.6931.00
191_L194_K0.6911.00
317_T354_D0.6861.00
238_V242_K0.6861.00
66_L69_F0.6831.00
289_E292_T0.6831.00
100_E104_F0.6811.00
97_N101_R0.6801.00
88_A92_A0.6801.00
231_L234_V0.6781.00
204_L219_E0.6781.00
137_V140_T0.6751.00
160_L168_N0.6741.00
93_Y98_I0.6721.00
127_K131_L0.6721.00
220_L224_Q0.6721.00
300_A321_D0.6711.00
307_I314_V0.6711.00
202_S205_A0.6701.00
133_Q137_V0.6701.00
65_Y68_G0.6681.00
94_F97_N0.6671.00
194_K230_S0.6641.00
305_V316_I0.6641.00
115_A118_A0.6621.00
227_A230_S0.6581.00
287_L305_V0.6581.00
163_K168_N0.6551.00
64_I67_W0.6541.00
92_A97_N0.6541.00
178_E181_Q0.6531.00
208_L211_K0.6521.00
146_L149_F0.6501.00
267_E308_Q0.6501.00
67_W71_L0.6461.00
94_F99_K0.6441.00
129_F132_T0.6421.00
96_G99_K0.6411.00
70_L74_I0.6361.00
243_G246_L0.6311.00
130_F134_I0.6301.00
233_E236_K0.6261.00
234_V237_I0.6241.00
237_I241_M0.6241.00
84_Y88_A0.6231.00
251_I268_E0.6231.00
94_F98_I0.6221.00
184_A188_H0.6221.00
296_K329_N0.6211.00
182_R342_E0.6191.00
189_D289_E0.6191.00
340_M344_L0.6171.00
208_L215_Q0.6161.00
290_A344_L0.6151.00
47_L50_F0.6131.00
253_I258_E0.6101.00
307_I316_I0.6091.00
208_L212_D0.6081.00
263_M266_Y0.6071.00
132_T135_P0.6071.00
286_C347_A0.6051.00
240_S244_I0.6041.00
156_E160_L0.6031.00
249_E255_Q0.6031.00
181_Q186_D0.5981.00
262_I295_V0.5971.00
80_T83_S0.5971.00
240_S338_L0.5971.00
101_R104_F0.5971.00
265_I268_E0.5971.00
93_Y99_K0.5961.00
252_N284_S0.5951.00
128_E132_T0.5941.00
197_L222_S0.5941.00
99_K103_P0.5931.00
205_A219_E0.5931.00
122_S125_L0.5921.00
159_R162_E0.5881.00
69_F72_I0.5881.00
323_T359_T0.5861.00
92_A95_I0.5841.00
65_Y69_F0.5841.00
102_V106_I0.5831.00
192_G230_S0.5821.00
64_I68_G0.5811.00
224_Q227_A0.5781.00
86_Y90_F0.5781.00
95_I100_E0.5761.00
48_L51_S0.5761.00
229_T233_E0.5751.00
102_V105_H0.5741.00
188_H194_K0.5731.00
257_L295_V0.5731.00
290_A351_L0.5711.00
145_I148_P0.5691.00
327_E355_T0.5681.00
69_F74_I0.5661.00
172_A175_V0.5661.00
352_H363_M0.5651.00
319_S358_G0.5641.00
106_I109_Y0.5631.00
242_K335_H0.5621.00
62_W66_L0.5621.00
183_I186_D0.5621.00
48_L55_F0.5611.00
228_R231_L0.5591.00
189_D192_G0.5581.00
228_R232_N0.5571.00
130_F133_Q0.5561.00
312_K367_N0.5561.00
264_F305_V0.5551.00
264_F268_E0.5541.00
132_T148_P0.5531.00
272_P276_S0.5531.00
93_Y96_G0.5521.00
53_Y56_A0.5521.00
203_D228_R0.5501.00
118_A122_S0.5491.00
47_L55_F0.5481.00
117_V123_L0.5471.00
129_F136_F0.5461.00
341_R350_S0.5451.00
344_L347_A0.5441.00
90_F94_F0.5441.00
349_G366_P0.5411.00
269_E307_I0.5401.00
175_V179_E0.5401.00
69_F73_G0.5401.00
271_W309_Q0.5391.00
55_F58_V0.5391.00
204_L207_K0.5391.00
188_H238_V0.5381.00
208_L219_E0.5371.00
71_L74_I0.5361.00
321_D357_N0.5361.00
190_T289_E0.5351.00
325_K353_I0.5351.00
54_R57_F0.5311.00
181_Q244_I0.5311.00
92_A99_K0.5311.00
53_Y57_F0.5311.00
239_S285_M0.5301.00
183_I188_H0.5291.00
289_E296_K0.5271.00
262_I301_K0.5261.00
186_D237_I0.5241.00
83_S86_Y0.5231.00
59_S62_W0.5231.00
250_L257_L0.5231.00
113_I117_V0.5211.00
118_A121_F0.5201.00
127_K130_F0.5191.00
89_F92_A0.5181.00
91_I95_I0.5171.00
172_A176_K0.5171.00
252_N257_L0.5171.00
205_A208_L0.5161.00
211_K216_A0.5151.00
74_I77_A0.5151.00
262_I302_T0.5151.00
296_K330_S0.5141.00
191_L195_L0.5111.00
180_R185_R0.5111.00
184_A187_L0.5111.00
46_T49_F0.5111.00
69_F76_T0.5111.00
294_V318_V0.5071.00
85_I88_A0.5061.00
173_E178_E0.5041.00
127_K148_P0.5041.00
250_L253_I0.5041.00
194_K226_T0.5031.00
91_I94_F0.5021.00
225_Q228_R0.5001.00
194_K233_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ehhA 2 0.5297 100 0.431 Contact Map
4i5sA 2 0.6973 100 0.48 Contact Map
4r39A 1 0.5162 100 0.483 Contact Map
4q20A 2 0.5432 100 0.483 Contact Map
2c2aA 2 0.5595 100 0.496 Contact Map
4bixA 2 0.5432 100 0.496 Contact Map
3d36A 2 0.5243 100 0.502 Contact Map
3jz3A 2 0.3892 100 0.511 Contact Map
3a0rA 2 0.8108 100 0.512 Contact Map
4ctiA 2 0.5946 100 0.516 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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