DESK - BACSU - GREMLIN Contacts

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DESK - Sensor histidine kinase DesK

UniProt:	O34757	Sequences: MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERLEEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	370 (318)
Sequences:	33857 (30043)
Seq/√Len:	1684.7

ECOLI - UHPB TORS BARA RCSC RCSD ARCB EVGS NARX GLRK NARQ BAES CUSS KDPD CPXA PHOQ ENVZ ZRAS DCUS DPIB CREC YEDV QSEC ATOS RSTB PHOR YPDA
BACSU - DESK YVFT YFIJ YXJM YDFH GLNK KINB COMP LIAS KINE YCLK KINA YVRG CSSS NATK DCTS KIND BCES YYCG YVCQ YHCY YRKQ CITS YKOH RESE YCBM PHOR MALK KINC YXDK LYTS YBDK
HALSA - Q9HQG5 Q9HQ16 Q9HRG1 O51970 Q9HQ15 Q9HRE4 Q9HQE9 Q9HR10 Q9HNM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
313_E	364_A	3.916	1.00
319_S	360_K	3.866	1.00
202_S	223_V	3.552	1.00
317_T	362_T	3.327	1.00
317_T	360_K	3.216	1.00
352_H	362_T	3.168	1.00
341_R	345_E	3.077	1.00
206_R	224_Q	2.944	1.00
315_V	364_A	2.880	1.00
199_G	227_A	2.808	1.00
265_I	304_R	2.695	1.00
315_V	362_T	2.642	1.00
306_D	317_T	2.639	1.00
206_R	221_K	2.570	1.00
302_T	321_D	2.551	1.00
340_M	351_L	2.529	1.00
290_A	361_L	2.497	1.00
267_E	306_D	2.489	1.00
310_L	315_V	2.477	1.00
294_V	303_C	2.448	1.00
286_C	344_L	2.399	1.00
308_Q	315_V	2.333	1.00
265_I	302_T	2.320	1.00
198_I	227_A	2.314	1.00
353_I	361_L	2.270	1.00
298_S	321_D	2.261	1.00
344_L	363_M	2.223	1.00
199_G	228_R	2.205	1.00
267_E	304_R	2.192	1.00
205_A	220_L	2.178	1.00
354_D	360_K	2.119	1.00
344_L	349_G	2.115	1.00
350_S	364_A	2.034	1.00
203_D	224_Q	2.017	1.00
304_R	319_S	1.978	1.00
320_D	324_F	1.967	1.00
301_K	321_D	1.967	1.00
309_Q	367_N	1.942	1.00
354_D	362_T	1.929	1.00
210_Y	217_A	1.915	1.00
286_C	363_M	1.906	1.00
308_Q	317_T	1.883	1.00
224_Q	228_R	1.875	1.00
325_K	359_T	1.845	1.00
150_S	153_S	1.845	1.00
306_D	319_S	1.805	1.00
263_M	302_T	1.782	1.00
165_E	168_N	1.754	1.00
153_S	157_R	1.753	1.00
168_N	171_I	1.744	1.00
201_K	219_E	1.721	1.00
213_P	216_A	1.708	1.00
212_D	215_Q	1.706	1.00
231_L	235_R	1.691	1.00
278_L	347_A	1.688	1.00
286_C	343_R	1.666	1.00
252_N	256_I	1.662	1.00
287_L	316_I	1.654	1.00
161_E	165_E	1.639	1.00
316_I	363_M	1.638	1.00
286_C	340_M	1.629	1.00
352_H	364_A	1.617	1.00
249_E	253_I	1.615	1.00
206_R	217_A	1.613	1.00
201_K	222_S	1.608	1.00
292_T	296_K	1.575	1.00
254_K	258_E	1.572	1.00
198_I	223_V	1.555	1.00
355_T	359_T	1.527	1.00
344_L	351_L	1.518	1.00
178_E	182_R	1.515	1.00
320_D	358_G	1.508	1.00
249_E	252_N	1.494	1.00
168_N	172_A	1.486	1.00
290_A	318_V	1.462	1.00
343_R	347_A	1.462	1.00
164_L	167_A	1.455	1.00
154_R	157_R	1.448	1.00
177_L	180_R	1.448	1.00
212_D	216_A	1.420	1.00
164_L	168_N	1.418	1.00
345_E	350_S	1.412	1.00
199_G	231_L	1.409	1.00
298_S	303_C	1.404	1.00
199_G	224_Q	1.384	1.00
205_A	216_A	1.381	1.00
314_V	367_N	1.381	1.00
298_S	301_K	1.378	1.00
160_L	163_K	1.373	1.00
163_K	167_A	1.356	1.00
177_L	181_Q	1.339	1.00
285_M	288_K	1.327	1.00
202_S	224_Q	1.317	1.00
262_I	266_Y	1.298	1.00
276_S	279_N	1.297	1.00
170_R	173_E	1.294	1.00
279_N	282_I	1.282	1.00
167_A	171_I	1.278	1.00
165_E	169_E	1.278	1.00
167_A	170_R	1.276	1.00
158_E	161_E	1.274	1.00
160_L	164_L	1.268	1.00
176_K	180_R	1.261	1.00
304_R	321_D	1.256	1.00
269_E	308_Q	1.255	1.00
299_Q	323_T	1.255	1.00
278_L	283_L	1.250	1.00
310_L	364_A	1.237	1.00
217_A	221_K	1.233	1.00
221_K	225_Q	1.229	1.00
162_E	166_D	1.225	1.00
197_L	201_K	1.210	1.00
289_E	340_M	1.199	1.00
284_S	288_K	1.191	1.00
202_S	220_L	1.190	1.00
199_G	203_D	1.187	1.00
353_I	359_T	1.187	1.00
202_S	227_A	1.182	1.00
161_E	164_L	1.181	1.00
251_I	254_K	1.164	1.00
268_E	307_I	1.161	1.00
253_I	257_L	1.159	1.00
254_K	257_L	1.158	1.00
159_R	163_K	1.155	1.00
180_R	184_A	1.152	1.00
208_L	216_A	1.149	1.00
249_E	257_L	1.138	1.00
158_E	162_E	1.121	1.00
305_V	318_V	1.116	1.00
338_L	342_E	1.115	1.00
283_L	365_I	1.092	1.00
153_S	156_E	1.089	1.00
290_A	340_M	1.086	1.00
157_R	161_E	1.078	1.00
150_S	154_R	1.076	1.00
255_Q	258_E	1.073	1.00
282_I	285_M	1.068	1.00
349_G	365_I	1.055	1.00
179_E	182_R	1.052	1.00
282_I	343_R	1.050	1.00
192_G	235_R	1.043	1.00
232_N	236_K	1.028	1.00
200_L	204_L	1.025	1.00
163_K	166_D	1.023	1.00
222_S	226_T	1.023	1.00
342_E	346_F	1.017	1.00
218_R	221_K	1.015	1.00
190_T	285_M	1.014	1.00
197_L	226_T	1.002	1.00
191_L	234_V	0.997	1.00
291_V	303_C	0.985	1.00
214_E	217_A	0.980	1.00
273_E	309_Q	0.977	1.00
144_A	148_P	0.972	1.00
213_P	217_A	0.968	1.00
191_L	230_S	0.963	1.00
202_S	206_R	0.958	1.00
169_E	173_E	0.956	1.00
51_S	55_F	0.955	1.00
280_E	284_S	0.952	1.00
151_I	155_K	0.949	1.00
287_L	291_V	0.948	1.00
153_S	158_E	0.948	1.00
249_E	258_E	0.946	1.00
269_E	306_D	0.946	1.00
259_A	262_I	0.945	1.00
282_I	346_F	0.944	1.00
157_R	160_L	0.944	1.00
182_R	186_D	0.941	1.00
294_V	298_S	0.939	1.00
226_T	229_T	0.936	1.00
47_L	51_S	0.936	1.00
49_F	53_Y	0.936	1.00
325_K	361_L	0.931	1.00
227_A	231_L	0.929	1.00
291_V	305_V	0.927	1.00
256_I	284_S	0.927	1.00
176_K	179_E	0.922	1.00
151_I	154_R	0.921	1.00
290_A	363_M	0.920	1.00
344_L	365_I	0.911	1.00
251_I	255_Q	0.910	1.00
253_I	256_I	0.907	1.00
282_I	347_A	0.903	1.00
236_K	282_I	0.900	1.00
342_E	345_E	0.899	1.00
252_N	255_Q	0.899	1.00
218_R	222_S	0.899	1.00
190_T	233_E	0.899	1.00
100_E	103_P	0.898	1.00
219_E	222_S	0.896	1.00
210_Y	213_P	0.894	1.00
183_I	187_L	0.891	1.00
160_L	165_E	0.887	1.00
325_K	355_T	0.887	1.00
221_K	224_Q	0.883	1.00
162_E	165_E	0.882	1.00
272_P	309_Q	0.880	1.00
145_I	149_F	0.876	1.00
215_Q	219_E	0.873	1.00
283_L	347_A	0.873	1.00
326_G	356_E	0.872	1.00
205_A	223_V	0.871	1.00
140_T	144_A	0.864	1.00
154_R	158_E	0.863	1.00
287_L	318_V	0.860	1.00
160_L	167_A	0.855	1.00
349_G	363_M	0.855	1.00
320_D	359_T	0.855	1.00
260_A	295_V	0.848	1.00
351_L	361_L	0.846	1.00
153_S	161_E	0.843	1.00
225_Q	229_T	0.839	1.00
303_C	307_I	0.838	1.00
335_H	339_G	0.830	1.00
166_D	170_R	0.825	1.00
195_L	230_S	0.825	1.00
220_L	223_V	0.825	1.00
310_L	313_E	0.824	1.00
206_R	220_L	0.823	1.00
161_E	167_A	0.810	1.00
355_T	358_G	0.809	1.00
193_Q	197_L	0.809	1.00
120_N	123_L	0.809	1.00
166_D	169_E	0.808	1.00
216_A	219_E	0.803	1.00
137_V	141_L	0.801	1.00
136_F	140_T	0.800	1.00
235_R	239_S	0.798	1.00
99_K	102_V	0.797	1.00
283_L	314_V	0.795	1.00
97_N	100_E	0.792	1.00
324_F	359_T	0.790	1.00
197_L	200_L	0.789	1.00
83_S	87_F	0.789	1.00
313_E	350_S	0.789	1.00
189_D	193_Q	0.787	1.00
226_T	230_S	0.786	1.00
93_Y	97_N	0.785	1.00
297_H	323_T	0.782	1.00
283_L	316_I	0.780	1.00
192_G	231_L	0.779	1.00
249_E	256_I	0.777	1.00
351_L	363_M	0.777	1.00
117_V	120_N	0.777	1.00
63_T	67_W	0.776	1.00
274_N	314_V	0.771	1.00
50_F	54_R	0.770	1.00
215_Q	218_R	0.767	1.00
297_H	330_S	0.765	1.00
323_T	330_S	0.761	1.00
132_T	136_F	0.761	1.00
161_E	168_N	0.760	1.00
222_S	225_Q	0.759	1.00
291_V	295_V	0.757	1.00
101_R	105_H	0.753	1.00
210_Y	216_A	0.753	1.00
63_T	66_L	0.751	1.00
175_V	178_E	0.748	1.00
269_E	272_P	0.744	1.00
281_N	284_S	0.744	1.00
223_V	227_A	0.744	1.00
95_I	99_K	0.743	1.00
232_N	281_N	0.740	1.00
196_S	200_L	0.740	1.00
230_S	234_V	0.740	1.00
201_K	226_T	0.739	1.00
187_L	237_I	0.738	1.00
288_K	292_T	0.733	1.00
87_F	91_I	0.733	1.00
230_S	233_E	0.732	1.00
274_N	277_L	0.731	1.00
96_G	100_E	0.731	1.00
339_G	343_R	0.730	1.00
68_G	71_L	0.730	1.00
169_E	172_A	0.727	1.00
190_T	194_K	0.726	1.00
274_N	309_Q	0.720	1.00
133_Q	136_F	0.719	1.00
203_D	206_R	0.717	1.00
262_I	298_S	0.713	1.00
122_S	126_K	0.713	1.00
48_L	52_V	0.712	1.00
322_G	358_G	0.712	1.00
62_W	65_Y	0.711	1.00
204_L	208_L	0.710	1.00
279_N	347_A	0.709	1.00
196_S	199_G	0.709	1.00
52_V	55_F	0.708	1.00
216_A	220_L	0.707	1.00
198_I	202_S	0.707	1.00
201_K	204_L	0.707	1.00
201_K	223_V	0.706	1.00
117_V	121_F	0.705	1.00
249_E	254_K	0.704	1.00
131_L	134_I	0.704	1.00
282_I	286_C	0.703	1.00
303_C	318_V	0.703	1.00
150_S	157_R	0.701	1.00
337_L	340_M	0.700	1.00
51_S	54_R	0.700	1.00
129_F	133_Q	0.699	1.00
203_D	207_K	0.693	1.00
191_L	194_K	0.691	1.00
317_T	354_D	0.686	1.00
238_V	242_K	0.686	1.00
66_L	69_F	0.683	1.00
289_E	292_T	0.683	1.00
100_E	104_F	0.681	1.00
97_N	101_R	0.680	1.00
88_A	92_A	0.680	1.00
231_L	234_V	0.678	1.00
204_L	219_E	0.678	1.00
137_V	140_T	0.675	1.00
160_L	168_N	0.674	1.00
93_Y	98_I	0.672	1.00
127_K	131_L	0.672	1.00
220_L	224_Q	0.672	1.00
300_A	321_D	0.671	1.00
307_I	314_V	0.671	1.00
202_S	205_A	0.670	1.00
133_Q	137_V	0.670	1.00
65_Y	68_G	0.668	1.00
94_F	97_N	0.667	1.00
194_K	230_S	0.664	1.00
305_V	316_I	0.664	1.00
115_A	118_A	0.662	1.00
227_A	230_S	0.658	1.00
287_L	305_V	0.658	1.00
163_K	168_N	0.655	1.00
64_I	67_W	0.654	1.00
92_A	97_N	0.654	1.00
178_E	181_Q	0.653	1.00
208_L	211_K	0.652	1.00
146_L	149_F	0.650	1.00
267_E	308_Q	0.650	1.00
67_W	71_L	0.646	1.00
94_F	99_K	0.644	1.00
129_F	132_T	0.642	1.00
96_G	99_K	0.641	1.00
70_L	74_I	0.636	1.00
243_G	246_L	0.631	1.00
130_F	134_I	0.630	1.00
233_E	236_K	0.626	1.00
234_V	237_I	0.624	1.00
237_I	241_M	0.624	1.00
84_Y	88_A	0.623	1.00
251_I	268_E	0.623	1.00
94_F	98_I	0.622	1.00
184_A	188_H	0.622	1.00
296_K	329_N	0.621	1.00
182_R	342_E	0.619	1.00
189_D	289_E	0.619	1.00
340_M	344_L	0.617	1.00
208_L	215_Q	0.616	1.00
290_A	344_L	0.615	1.00
47_L	50_F	0.613	1.00
253_I	258_E	0.610	1.00
307_I	316_I	0.609	1.00
208_L	212_D	0.608	1.00
263_M	266_Y	0.607	1.00
132_T	135_P	0.607	1.00
286_C	347_A	0.605	1.00
240_S	244_I	0.604	1.00
156_E	160_L	0.603	1.00
249_E	255_Q	0.603	1.00
181_Q	186_D	0.598	1.00
262_I	295_V	0.597	1.00
80_T	83_S	0.597	1.00
240_S	338_L	0.597	1.00
101_R	104_F	0.597	1.00
265_I	268_E	0.597	1.00
93_Y	99_K	0.596	1.00
252_N	284_S	0.595	1.00
128_E	132_T	0.594	1.00
197_L	222_S	0.594	1.00
99_K	103_P	0.593	1.00
205_A	219_E	0.593	1.00
122_S	125_L	0.592	1.00
159_R	162_E	0.588	1.00
69_F	72_I	0.588	1.00
323_T	359_T	0.586	1.00
92_A	95_I	0.584	1.00
65_Y	69_F	0.584	1.00
102_V	106_I	0.583	1.00
192_G	230_S	0.582	1.00
64_I	68_G	0.581	1.00
224_Q	227_A	0.578	1.00
86_Y	90_F	0.578	1.00
95_I	100_E	0.576	1.00
48_L	51_S	0.576	1.00
229_T	233_E	0.575	1.00
102_V	105_H	0.574	1.00
188_H	194_K	0.573	1.00
257_L	295_V	0.573	1.00
290_A	351_L	0.571	1.00
145_I	148_P	0.569	1.00
327_E	355_T	0.568	1.00
69_F	74_I	0.566	1.00
172_A	175_V	0.566	1.00
352_H	363_M	0.565	1.00
319_S	358_G	0.564	1.00
106_I	109_Y	0.563	1.00
242_K	335_H	0.562	1.00
62_W	66_L	0.562	1.00
183_I	186_D	0.562	1.00
48_L	55_F	0.561	1.00
228_R	231_L	0.559	1.00
189_D	192_G	0.558	1.00
228_R	232_N	0.557	1.00
130_F	133_Q	0.556	1.00
312_K	367_N	0.556	1.00
264_F	305_V	0.555	1.00
264_F	268_E	0.554	1.00
132_T	148_P	0.553	1.00
272_P	276_S	0.553	1.00
93_Y	96_G	0.552	1.00
53_Y	56_A	0.552	1.00
203_D	228_R	0.550	1.00
118_A	122_S	0.549	1.00
47_L	55_F	0.548	1.00
117_V	123_L	0.547	1.00
129_F	136_F	0.546	1.00
341_R	350_S	0.545	1.00
344_L	347_A	0.544	1.00
90_F	94_F	0.544	1.00
349_G	366_P	0.541	1.00
269_E	307_I	0.540	1.00
175_V	179_E	0.540	1.00
69_F	73_G	0.540	1.00
271_W	309_Q	0.539	1.00
55_F	58_V	0.539	1.00
204_L	207_K	0.539	1.00
188_H	238_V	0.538	1.00
208_L	219_E	0.537	1.00
71_L	74_I	0.536	1.00
321_D	357_N	0.536	1.00
190_T	289_E	0.535	1.00
325_K	353_I	0.535	1.00
54_R	57_F	0.531	1.00
181_Q	244_I	0.531	1.00
92_A	99_K	0.531	1.00
53_Y	57_F	0.531	1.00
239_S	285_M	0.530	1.00
183_I	188_H	0.529	1.00
289_E	296_K	0.527	1.00
262_I	301_K	0.526	1.00
186_D	237_I	0.524	1.00
83_S	86_Y	0.523	1.00
59_S	62_W	0.523	1.00
250_L	257_L	0.523	1.00
113_I	117_V	0.521	1.00
118_A	121_F	0.520	1.00
127_K	130_F	0.519	1.00
89_F	92_A	0.518	1.00
91_I	95_I	0.517	1.00
172_A	176_K	0.517	1.00
252_N	257_L	0.517	1.00
205_A	208_L	0.516	1.00
211_K	216_A	0.515	1.00
74_I	77_A	0.515	1.00
262_I	302_T	0.515	1.00
296_K	330_S	0.514	1.00
191_L	195_L	0.511	1.00
180_R	185_R	0.511	1.00
184_A	187_L	0.511	1.00
46_T	49_F	0.511	1.00
69_F	76_T	0.511	1.00
294_V	318_V	0.507	1.00
85_I	88_A	0.506	1.00
173_E	178_E	0.504	1.00
127_K	148_P	0.504	1.00
250_L	253_I	0.504	1.00
194_K	226_T	0.503	1.00
91_I	94_F	0.502	1.00
225_Q	228_R	0.500	1.00
194_K	233_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ehhA	2	0.5297	100	0.431	Contact Map
4i5sA	2	0.6973	100	0.48	Contact Map
4r39A	1	0.5162	100	0.483	Contact Map
4q20A	2	0.5432	100	0.483	Contact Map
2c2aA	2	0.5595	100	0.496	Contact Map
4bixA	2	0.5432	100	0.496	Contact Map
3d36A	2	0.5243	100	0.502	Contact Map
3jz3A	2	0.3892	100	0.511	Contact Map
3a0rA	2	0.8108	100	0.512	Contact Map
4ctiA	2	0.5946	100	0.516	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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