GREMLIN Database
YKOT - Uncharacterized glycosyltransferase YkoT
UniProt: O34755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (278)
Sequences: 15046 (11908)
Seq/√Len: 714.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_E57_R4.8211.00
51_D76_K4.1961.00
173_K177_E3.8571.00
57_R60_A3.3811.00
126_C201_A3.2101.00
9_T98_S3.1421.00
62_I74_G3.0671.00
59_W76_K2.7011.00
9_T46_K2.5891.00
100_C122_Y2.5661.00
59_W63_A2.5591.00
7_V99_D2.5501.00
121_K124_E2.5401.00
22_Q61_L2.5331.00
22_Q64_M2.4941.00
46_K73_T2.4831.00
121_K201_A2.4011.00
14_C58_T2.3461.00
102_I170_L2.2921.00
25_S65_E2.2901.00
22_Q26_H2.2371.00
51_D54_S2.1861.00
50_V90_G2.1651.00
49_F62_I2.0811.00
61_L64_M2.0791.00
175_S198_F2.0711.00
59_W74_G2.0201.00
127_E172_N2.0071.00
100_C170_L2.0001.00
7_V44_D1.9941.00
122_Y170_L1.9431.00
26_H65_E1.9151.00
121_K203_V1.8511.00
60_A64_M1.8441.00
8_L119_M1.8421.00
57_R61_L1.8141.00
100_C119_M1.8121.00
9_T48_L1.7901.00
102_I115_I1.7721.00
117_D120_L1.7451.00
134_R206_D1.7321.00
117_D205_Y1.7321.00
77_L89_A1.7321.00
16_N55_K1.7241.00
7_V95_K1.7241.00
9_T94_A1.6961.00
11_V50_V1.6781.00
178_E198_F1.6621.00
46_K98_S1.6431.00
101_V176_L1.6331.00
118_F170_L1.6321.00
64_M68_R1.6091.00
17_E106_A1.6021.00
83_H87_L1.5751.00
25_S49_F1.5641.00
23_E26_H1.5621.00
51_D59_W1.5471.00
11_V90_G1.5261.00
63_A76_K1.5221.00
120_L124_E1.5041.00
122_Y172_N1.4941.00
15_F80_N1.4941.00
94_A98_S1.4891.00
26_H30_E1.4871.00
7_V98_S1.4841.00
27_Q113_S1.4801.00
89_A93_K1.4691.00
75_L93_K1.4681.00
29_T69_N1.4671.00
178_E196_I1.4671.00
12_V24_T1.4621.00
25_S69_N1.4521.00
41_I44_D1.4221.00
127_E198_F1.4131.00
91_L101_V1.3991.00
174_R178_E1.3521.00
215_T218_P1.3441.00
26_H68_R1.3441.00
91_L176_L1.3311.00
141_F145_T1.3311.00
152_R156_K1.3191.00
12_V106_A1.3041.00
23_E211_F1.2931.00
128_I200_S1.2871.00
87_L103_S1.2841.00
132_V204_L1.2781.00
14_C106_A1.2711.00
10_I115_I1.2681.00
23_E27_Q1.2641.00
95_K98_S1.2531.00
16_N54_S1.2511.00
46_K95_K1.2401.00
113_S117_D1.2391.00
31_V116_R1.2371.00
50_V86_A1.2341.00
8_L115_I1.2231.00
188_F192_I1.2201.00
152_R155_N1.2161.00
18_E61_L1.2151.00
141_F144_R1.1951.00
221_K224_S1.1721.00
22_Q65_E1.1691.00
21_F61_L1.1541.00
94_A173_K1.1521.00
64_M67_I1.1431.00
27_Q110_D1.1321.00
92_H180_E1.1291.00
148_L151_Y1.1241.00
48_L73_T1.1171.00
25_S72_V1.1161.00
114_V117_D1.1141.00
140_T143_K1.1111.00
118_F131_G1.0991.00
178_E181_R1.0981.00
149_G152_R1.0951.00
60_A63_A1.0871.00
61_L65_E1.0791.00
101_V173_K1.0791.00
121_K125_G1.0771.00
14_C49_F1.0751.00
120_L123_H1.0691.00
29_T71_K1.0681.00
234_S237_P1.0531.00
100_C172_N1.0481.00
88_L92_H1.0481.00
280_W284_G1.0421.00
121_K129_V1.0391.00
10_I102_I1.0351.00
221_K225_F1.0311.00
27_Q30_E1.0291.00
172_N175_S1.0261.00
222_M225_F1.0231.00
45_S71_K1.0141.00
104_I110_D1.0111.00
128_I193_V1.0031.00
43_E123_H0.9861.00
153_L157_L0.9841.00
27_Q109_Q0.9781.00
25_S29_T0.9781.00
41_I116_R0.9771.00
110_D114_V0.9731.00
20_V211_F0.9711.00
52_D82_G0.9641.00
91_L103_S0.9611.00
90_G94_A0.9601.00
162_I165_H0.9591.00
24_T28_L0.9581.00
134_R204_L0.9541.00
228_N231_T0.9531.00
174_R177_E0.9501.00
226_A229_G0.9461.00
66_S72_V0.9461.00
89_A92_H0.9441.00
48_L94_A0.9421.00
142_F146_T0.9411.00
227_F231_T0.9391.00
52_D80_N0.9391.00
282_L286_Q0.9371.00
225_F228_N0.9361.00
148_L152_R0.9351.00
7_V46_K0.9331.00
27_Q208_K0.9301.00
27_Q31_V0.9171.00
110_D207_R0.9161.00
21_F58_T0.9161.00
75_L89_A0.9121.00
151_Y155_N0.9081.00
145_T149_G0.9071.00
127_E174_R0.9051.00
20_V24_T0.9001.00
159_I162_I0.8971.00
94_A101_V0.8941.00
65_E69_N0.8801.00
28_L47_I0.8781.00
49_F72_V0.8761.00
225_F229_G0.8751.00
22_Q68_R0.8741.00
242_T245_G0.8721.00
98_S173_K0.8661.00
114_V168_F0.8641.00
119_M123_H0.8631.00
69_N72_V0.8601.00
193_V198_F0.8531.00
12_V28_L0.8491.00
21_F49_F0.8461.00
15_F55_K0.8441.00
23_E109_Q0.8411.00
143_K147_A0.8391.00
133_R167_D0.8391.00
203_V206_D0.8311.00
73_T95_K0.8301.00
12_V49_F0.8291.00
239_R295_E0.8281.00
30_E112_I0.8261.00
14_C21_F0.8251.00
131_G168_F0.8211.00
171_M176_L0.8141.00
175_S193_V0.8131.00
73_T93_K0.8131.00
290_I294_G0.8111.00
270_A273_A0.8061.00
121_K126_C0.8021.00
10_I28_L0.8011.00
271_G274_S0.7991.00
83_H105_D0.7981.00
47_I72_V0.7961.00
143_K146_T0.7951.00
189_L193_V0.7941.00
150_F154_M0.7941.00
188_F191_G0.7911.00
144_R147_A0.7901.00
284_G287_L0.7891.00
232_S236_A0.7881.00
14_C17_E0.7841.00
117_D121_K0.7811.00
249_F252_S0.7801.00
235_V239_R0.7791.00
24_T106_A0.7741.00
280_W283_G0.7741.00
21_F62_I0.7721.00
116_R120_L0.7711.00
233_F236_A0.7691.00
46_K94_A0.7581.00
65_E68_R0.7561.00
252_S256_G0.7541.00
151_Y154_M0.7531.00
63_A67_I0.7521.00
108_L208_K0.7491.00
117_D203_V0.7441.00
258_G262_Q0.7421.00
11_V94_A0.7421.00
245_G249_F0.7411.00
201_A204_L0.7401.00
255_A259_A0.7391.00
99_D174_R0.7391.00
12_V104_I0.7391.00
17_E20_V0.7351.00
140_T147_A0.7341.00
223_L227_F0.7301.00
232_S235_V0.7301.00
42_A45_S0.7251.00
142_F147_A0.7251.00
24_T27_Q0.7251.00
210_R213_G0.7231.00
66_S74_G0.7211.00
233_F239_R0.7191.00
278_S282_L0.7171.00
66_S69_N0.7041.00
142_F145_T0.7041.00
12_V47_I0.7021.00
99_D172_N0.7021.00
284_G288_M0.7001.00
9_T173_K0.6991.00
161_L164_N0.6981.00
236_A239_R0.6981.00
269_N272_W0.6971.00
154_M157_L0.6961.00
132_V202_E0.6941.00
63_A66_S0.6931.00
16_N56_D0.6911.00
219_L222_M0.6851.00
83_H166_A0.6831.00
54_S58_T0.6821.00
153_L156_K0.6791.00
224_S228_N0.6791.00
102_I114_V0.6791.00
219_L223_L0.6761.00
45_S115_I0.6751.00
10_I104_I0.6741.00
19_E61_L0.6731.00
44_D71_K0.6681.00
221_K228_N0.6681.00
254_V258_G0.6651.00
161_L165_H0.6651.00
175_S178_E0.6641.00
20_V106_A0.6631.00
222_M226_A0.6611.00
126_C199_K0.6601.00
249_F253_A0.6581.00
253_A256_G0.6581.00
241_F245_G0.6571.00
29_T65_E0.6561.00
267_H273_A0.6561.00
81_V85_K0.6551.00
7_V43_E0.6551.00
250_F254_V0.6541.00
275_L278_S0.6531.00
58_T62_I0.6531.00
18_E56_D0.6521.00
146_T149_G0.6501.00
119_M170_L0.6501.00
130_Y202_E0.6501.00
273_A277_I0.6491.00
130_Y133_R0.6481.00
125_G201_A0.6411.00
255_A258_G0.6401.00
248_L252_S0.6361.00
116_R119_M0.6351.00
252_S281_F0.6341.00
279_I283_G0.6331.00
281_F285_L0.6311.00
21_F26_H0.6311.00
122_Y129_V0.6281.00
9_T95_K0.6211.00
75_L90_G0.6201.00
150_F153_L0.6171.00
59_W62_I0.6161.00
234_S238_I0.6151.00
113_S116_R0.6151.00
149_G153_L0.6131.00
245_G252_S0.6131.00
272_W275_L0.6121.00
27_Q112_I0.6121.00
267_H270_A0.6121.00
189_L192_I0.6111.00
240_F245_G0.6111.00
290_I293_I0.6081.00
261_I265_L0.6071.00
213_G216_K0.6071.00
129_V203_V0.6061.00
91_L94_A0.6061.00
149_G156_K0.6061.00
141_F146_T0.6061.00
103_S169_R0.6061.00
171_M193_V0.6051.00
140_T144_R0.6041.00
283_G287_L0.6041.00
287_L291_G0.6041.00
115_I170_L0.6021.00
160_K163_Y0.6011.00
28_L104_I0.6001.00
285_L289_G0.6001.00
118_F203_V0.5951.00
15_F53_G0.5931.00
58_T106_A0.5901.00
118_F206_D0.5891.00
13_P86_A0.5891.00
41_I45_S0.5861.00
220_K223_L0.5841.00
256_G259_A0.5831.00
234_S239_R0.5831.00
118_F122_Y0.5831.00
77_L80_N0.5791.00
18_E60_A0.5781.00
282_L287_L0.5781.00
111_D114_V0.5771.00
18_E22_Q0.5761.00
102_I118_F0.5751.00
164_N169_R0.5731.00
21_F65_E0.5701.00
144_R148_L0.5691.00
10_I45_S0.5681.00
288_M291_G0.5681.00
31_V115_I0.5681.00
77_L81_V0.5671.00
148_L156_K0.5671.00
262_Q267_H0.5651.00
11_V101_V0.5631.00
226_A230_I0.5621.00
177_E180_E0.5611.00
152_R157_L0.5601.00
8_L43_E0.5581.00
249_F256_G0.5571.00
179_L196_I0.5561.00
31_V113_S0.5551.00
15_F51_D0.5551.00
111_D209_E0.5531.00
78_A89_A0.5521.00
21_F106_A0.5511.00
17_E58_T0.5501.00
287_L294_G0.5501.00
266_G269_N0.5501.00
208_K211_F0.5491.00
16_N58_T0.5481.00
245_G248_L0.5471.00
190_R197_G0.5441.00
52_D105_D0.5421.00
28_L110_D0.5421.00
242_T249_F0.5421.00
272_W276_I0.5411.00
78_A81_V0.5391.00
130_Y166_A0.5371.00
220_K224_S0.5371.00
277_I280_W0.5361.00
277_I281_F0.5351.00
84_Q88_L0.5341.00
184_E187_L0.5331.00
7_V45_S0.5311.00
269_N273_A0.5281.00
16_N51_D0.5281.00
130_Y200_S0.5271.00
66_S70_K0.5261.00
235_V238_I0.5251.00
256_G260_F0.5211.00
242_T246_F0.5211.00
187_L190_R0.5201.00
245_G284_G0.5201.00
243_L247_V0.5201.00
27_Q108_L0.5191.00
110_D168_F0.5191.00
257_I261_I0.5181.00
29_T72_V0.5171.00
175_S196_I0.5171.00
291_G294_G0.5161.00
108_L210_R0.5121.00
223_L226_A0.5121.00
140_T146_T0.5111.00
53_G80_N0.5111.00
279_I282_L0.5101.00
99_D173_K0.5101.00
246_F249_F0.5080.99
179_L193_V0.5070.99
232_S239_R0.5040.99
263_K273_A0.5040.99
48_L93_K0.5030.99
175_S179_L0.5010.99
151_Y156_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9614 100 0.491 Contact Map
3bcvA 2 0.5134 100 0.5 Contact Map
2z86A 2 0.724 100 0.5 Contact Map
3l7iA 4 0.1009 100 0.513 Contact Map
2d7iA 1 0.8427 100 0.513 Contact Map
1qg8A 1 0.6409 100 0.515 Contact Map
1xhbA 1 0.9347 100 0.519 Contact Map
2bo4A 4 0.8398 100 0.531 Contact Map
5ajoA 1 0.9407 100 0.533 Contact Map
3f1yA 2 0.8101 100 0.542 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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