YKOT - BACSU - GREMLIN Contacts

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YKOT - Uncharacterized glycosyltransferase YkoT

UniProt:	O34755	Sequences: MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAEDSKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVISIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIKLIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYPLKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLIISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEKKYS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	337 (278)
Sequences:	15046 (11908)
Seq/√Len:	714.2

ECOLI - ARNC GTRB PGAC YAIP YIBD
BACSU - YKOT YKCC CSBB YDAM EPSH TUAG GGAA EPSJ CGED EPSE
HALSA - Q9HQQ6 Q9HSB1 Q9HQP4 Q9HQP8 Q9HQP3 Q9HR08
SULSO - Q97TY0 Q97W52 Q7LXY2 Q97UK7 Q97WK7 Q97YM4 Q97TZ0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_E	57_R	4.821	1.00
51_D	76_K	4.196	1.00
173_K	177_E	3.857	1.00
57_R	60_A	3.381	1.00
126_C	201_A	3.210	1.00
9_T	98_S	3.142	1.00
62_I	74_G	3.067	1.00
59_W	76_K	2.701	1.00
9_T	46_K	2.589	1.00
100_C	122_Y	2.566	1.00
59_W	63_A	2.559	1.00
7_V	99_D	2.550	1.00
121_K	124_E	2.540	1.00
22_Q	61_L	2.533	1.00
22_Q	64_M	2.494	1.00
46_K	73_T	2.483	1.00
121_K	201_A	2.401	1.00
14_C	58_T	2.346	1.00
102_I	170_L	2.292	1.00
25_S	65_E	2.290	1.00
22_Q	26_H	2.237	1.00
51_D	54_S	2.186	1.00
50_V	90_G	2.165	1.00
49_F	62_I	2.081	1.00
61_L	64_M	2.079	1.00
175_S	198_F	2.071	1.00
59_W	74_G	2.020	1.00
127_E	172_N	2.007	1.00
100_C	170_L	2.000	1.00
7_V	44_D	1.994	1.00
122_Y	170_L	1.943	1.00
26_H	65_E	1.915	1.00
121_K	203_V	1.851	1.00
60_A	64_M	1.844	1.00
8_L	119_M	1.842	1.00
57_R	61_L	1.814	1.00
100_C	119_M	1.812	1.00
9_T	48_L	1.790	1.00
102_I	115_I	1.772	1.00
117_D	120_L	1.745	1.00
134_R	206_D	1.732	1.00
117_D	205_Y	1.732	1.00
77_L	89_A	1.732	1.00
16_N	55_K	1.724	1.00
7_V	95_K	1.724	1.00
9_T	94_A	1.696	1.00
11_V	50_V	1.678	1.00
178_E	198_F	1.662	1.00
46_K	98_S	1.643	1.00
101_V	176_L	1.633	1.00
118_F	170_L	1.632	1.00
64_M	68_R	1.609	1.00
17_E	106_A	1.602	1.00
83_H	87_L	1.575	1.00
25_S	49_F	1.564	1.00
23_E	26_H	1.562	1.00
51_D	59_W	1.547	1.00
11_V	90_G	1.526	1.00
63_A	76_K	1.522	1.00
120_L	124_E	1.504	1.00
122_Y	172_N	1.494	1.00
15_F	80_N	1.494	1.00
94_A	98_S	1.489	1.00
26_H	30_E	1.487	1.00
7_V	98_S	1.484	1.00
27_Q	113_S	1.480	1.00
89_A	93_K	1.469	1.00
75_L	93_K	1.468	1.00
29_T	69_N	1.467	1.00
178_E	196_I	1.467	1.00
12_V	24_T	1.462	1.00
25_S	69_N	1.452	1.00
41_I	44_D	1.422	1.00
127_E	198_F	1.413	1.00
91_L	101_V	1.399	1.00
174_R	178_E	1.352	1.00
215_T	218_P	1.344	1.00
26_H	68_R	1.344	1.00
91_L	176_L	1.331	1.00
141_F	145_T	1.331	1.00
152_R	156_K	1.319	1.00
12_V	106_A	1.304	1.00
23_E	211_F	1.293	1.00
128_I	200_S	1.287	1.00
87_L	103_S	1.284	1.00
132_V	204_L	1.278	1.00
14_C	106_A	1.271	1.00
10_I	115_I	1.268	1.00
23_E	27_Q	1.264	1.00
95_K	98_S	1.253	1.00
16_N	54_S	1.251	1.00
46_K	95_K	1.240	1.00
113_S	117_D	1.239	1.00
31_V	116_R	1.237	1.00
50_V	86_A	1.234	1.00
8_L	115_I	1.223	1.00
188_F	192_I	1.220	1.00
152_R	155_N	1.216	1.00
18_E	61_L	1.215	1.00
141_F	144_R	1.195	1.00
221_K	224_S	1.172	1.00
22_Q	65_E	1.169	1.00
21_F	61_L	1.154	1.00
94_A	173_K	1.152	1.00
64_M	67_I	1.143	1.00
27_Q	110_D	1.132	1.00
92_H	180_E	1.129	1.00
148_L	151_Y	1.124	1.00
48_L	73_T	1.117	1.00
25_S	72_V	1.116	1.00
114_V	117_D	1.114	1.00
140_T	143_K	1.111	1.00
118_F	131_G	1.099	1.00
178_E	181_R	1.098	1.00
149_G	152_R	1.095	1.00
60_A	63_A	1.087	1.00
61_L	65_E	1.079	1.00
101_V	173_K	1.079	1.00
121_K	125_G	1.077	1.00
14_C	49_F	1.075	1.00
120_L	123_H	1.069	1.00
29_T	71_K	1.068	1.00
234_S	237_P	1.053	1.00
100_C	172_N	1.048	1.00
88_L	92_H	1.048	1.00
280_W	284_G	1.042	1.00
121_K	129_V	1.039	1.00
10_I	102_I	1.035	1.00
221_K	225_F	1.031	1.00
27_Q	30_E	1.029	1.00
172_N	175_S	1.026	1.00
222_M	225_F	1.023	1.00
45_S	71_K	1.014	1.00
104_I	110_D	1.011	1.00
128_I	193_V	1.003	1.00
43_E	123_H	0.986	1.00
153_L	157_L	0.984	1.00
27_Q	109_Q	0.978	1.00
25_S	29_T	0.978	1.00
41_I	116_R	0.977	1.00
110_D	114_V	0.973	1.00
20_V	211_F	0.971	1.00
52_D	82_G	0.964	1.00
91_L	103_S	0.961	1.00
90_G	94_A	0.960	1.00
162_I	165_H	0.959	1.00
24_T	28_L	0.958	1.00
134_R	204_L	0.954	1.00
228_N	231_T	0.953	1.00
174_R	177_E	0.950	1.00
226_A	229_G	0.946	1.00
66_S	72_V	0.946	1.00
89_A	92_H	0.944	1.00
48_L	94_A	0.942	1.00
142_F	146_T	0.941	1.00
227_F	231_T	0.939	1.00
52_D	80_N	0.939	1.00
282_L	286_Q	0.937	1.00
225_F	228_N	0.936	1.00
148_L	152_R	0.935	1.00
7_V	46_K	0.933	1.00
27_Q	208_K	0.930	1.00
27_Q	31_V	0.917	1.00
110_D	207_R	0.916	1.00
21_F	58_T	0.916	1.00
75_L	89_A	0.912	1.00
151_Y	155_N	0.908	1.00
145_T	149_G	0.907	1.00
127_E	174_R	0.905	1.00
20_V	24_T	0.900	1.00
159_I	162_I	0.897	1.00
94_A	101_V	0.894	1.00
65_E	69_N	0.880	1.00
28_L	47_I	0.878	1.00
49_F	72_V	0.876	1.00
225_F	229_G	0.875	1.00
22_Q	68_R	0.874	1.00
242_T	245_G	0.872	1.00
98_S	173_K	0.866	1.00
114_V	168_F	0.864	1.00
119_M	123_H	0.863	1.00
69_N	72_V	0.860	1.00
193_V	198_F	0.853	1.00
12_V	28_L	0.849	1.00
21_F	49_F	0.846	1.00
15_F	55_K	0.844	1.00
23_E	109_Q	0.841	1.00
143_K	147_A	0.839	1.00
133_R	167_D	0.839	1.00
203_V	206_D	0.831	1.00
73_T	95_K	0.830	1.00
12_V	49_F	0.829	1.00
239_R	295_E	0.828	1.00
30_E	112_I	0.826	1.00
14_C	21_F	0.825	1.00
131_G	168_F	0.821	1.00
171_M	176_L	0.814	1.00
175_S	193_V	0.813	1.00
73_T	93_K	0.813	1.00
290_I	294_G	0.811	1.00
270_A	273_A	0.806	1.00
121_K	126_C	0.802	1.00
10_I	28_L	0.801	1.00
271_G	274_S	0.799	1.00
83_H	105_D	0.798	1.00
47_I	72_V	0.796	1.00
143_K	146_T	0.795	1.00
189_L	193_V	0.794	1.00
150_F	154_M	0.794	1.00
188_F	191_G	0.791	1.00
144_R	147_A	0.790	1.00
284_G	287_L	0.789	1.00
232_S	236_A	0.788	1.00
14_C	17_E	0.784	1.00
117_D	121_K	0.781	1.00
249_F	252_S	0.780	1.00
235_V	239_R	0.779	1.00
24_T	106_A	0.774	1.00
280_W	283_G	0.774	1.00
21_F	62_I	0.772	1.00
116_R	120_L	0.771	1.00
233_F	236_A	0.769	1.00
46_K	94_A	0.758	1.00
65_E	68_R	0.756	1.00
252_S	256_G	0.754	1.00
151_Y	154_M	0.753	1.00
63_A	67_I	0.752	1.00
108_L	208_K	0.749	1.00
117_D	203_V	0.744	1.00
258_G	262_Q	0.742	1.00
11_V	94_A	0.742	1.00
245_G	249_F	0.741	1.00
201_A	204_L	0.740	1.00
255_A	259_A	0.739	1.00
99_D	174_R	0.739	1.00
12_V	104_I	0.739	1.00
17_E	20_V	0.735	1.00
140_T	147_A	0.734	1.00
223_L	227_F	0.730	1.00
232_S	235_V	0.730	1.00
42_A	45_S	0.725	1.00
142_F	147_A	0.725	1.00
24_T	27_Q	0.725	1.00
210_R	213_G	0.723	1.00
66_S	74_G	0.721	1.00
233_F	239_R	0.719	1.00
278_S	282_L	0.717	1.00
66_S	69_N	0.704	1.00
142_F	145_T	0.704	1.00
12_V	47_I	0.702	1.00
99_D	172_N	0.702	1.00
284_G	288_M	0.700	1.00
9_T	173_K	0.699	1.00
161_L	164_N	0.698	1.00
236_A	239_R	0.698	1.00
269_N	272_W	0.697	1.00
154_M	157_L	0.696	1.00
132_V	202_E	0.694	1.00
63_A	66_S	0.693	1.00
16_N	56_D	0.691	1.00
219_L	222_M	0.685	1.00
83_H	166_A	0.683	1.00
54_S	58_T	0.682	1.00
153_L	156_K	0.679	1.00
224_S	228_N	0.679	1.00
102_I	114_V	0.679	1.00
219_L	223_L	0.676	1.00
45_S	115_I	0.675	1.00
10_I	104_I	0.674	1.00
19_E	61_L	0.673	1.00
44_D	71_K	0.668	1.00
221_K	228_N	0.668	1.00
254_V	258_G	0.665	1.00
161_L	165_H	0.665	1.00
175_S	178_E	0.664	1.00
20_V	106_A	0.663	1.00
222_M	226_A	0.661	1.00
126_C	199_K	0.660	1.00
249_F	253_A	0.658	1.00
253_A	256_G	0.658	1.00
241_F	245_G	0.657	1.00
29_T	65_E	0.656	1.00
267_H	273_A	0.656	1.00
81_V	85_K	0.655	1.00
7_V	43_E	0.655	1.00
250_F	254_V	0.654	1.00
275_L	278_S	0.653	1.00
58_T	62_I	0.653	1.00
18_E	56_D	0.652	1.00
146_T	149_G	0.650	1.00
119_M	170_L	0.650	1.00
130_Y	202_E	0.650	1.00
273_A	277_I	0.649	1.00
130_Y	133_R	0.648	1.00
125_G	201_A	0.641	1.00
255_A	258_G	0.640	1.00
248_L	252_S	0.636	1.00
116_R	119_M	0.635	1.00
252_S	281_F	0.634	1.00
279_I	283_G	0.633	1.00
281_F	285_L	0.631	1.00
21_F	26_H	0.631	1.00
122_Y	129_V	0.628	1.00
9_T	95_K	0.621	1.00
75_L	90_G	0.620	1.00
150_F	153_L	0.617	1.00
59_W	62_I	0.616	1.00
234_S	238_I	0.615	1.00
113_S	116_R	0.615	1.00
149_G	153_L	0.613	1.00
245_G	252_S	0.613	1.00
272_W	275_L	0.612	1.00
27_Q	112_I	0.612	1.00
267_H	270_A	0.612	1.00
189_L	192_I	0.611	1.00
240_F	245_G	0.611	1.00
290_I	293_I	0.608	1.00
261_I	265_L	0.607	1.00
213_G	216_K	0.607	1.00
129_V	203_V	0.606	1.00
91_L	94_A	0.606	1.00
149_G	156_K	0.606	1.00
141_F	146_T	0.606	1.00
103_S	169_R	0.606	1.00
171_M	193_V	0.605	1.00
140_T	144_R	0.604	1.00
283_G	287_L	0.604	1.00
287_L	291_G	0.604	1.00
115_I	170_L	0.602	1.00
160_K	163_Y	0.601	1.00
28_L	104_I	0.600	1.00
285_L	289_G	0.600	1.00
118_F	203_V	0.595	1.00
15_F	53_G	0.593	1.00
58_T	106_A	0.590	1.00
118_F	206_D	0.589	1.00
13_P	86_A	0.589	1.00
41_I	45_S	0.586	1.00
220_K	223_L	0.584	1.00
256_G	259_A	0.583	1.00
234_S	239_R	0.583	1.00
118_F	122_Y	0.583	1.00
77_L	80_N	0.579	1.00
18_E	60_A	0.578	1.00
282_L	287_L	0.578	1.00
111_D	114_V	0.577	1.00
18_E	22_Q	0.576	1.00
102_I	118_F	0.575	1.00
164_N	169_R	0.573	1.00
21_F	65_E	0.570	1.00
144_R	148_L	0.569	1.00
10_I	45_S	0.568	1.00
288_M	291_G	0.568	1.00
31_V	115_I	0.568	1.00
77_L	81_V	0.567	1.00
148_L	156_K	0.567	1.00
262_Q	267_H	0.565	1.00
11_V	101_V	0.563	1.00
226_A	230_I	0.562	1.00
177_E	180_E	0.561	1.00
152_R	157_L	0.560	1.00
8_L	43_E	0.558	1.00
249_F	256_G	0.557	1.00
179_L	196_I	0.556	1.00
31_V	113_S	0.555	1.00
15_F	51_D	0.555	1.00
111_D	209_E	0.553	1.00
78_A	89_A	0.552	1.00
21_F	106_A	0.551	1.00
17_E	58_T	0.550	1.00
287_L	294_G	0.550	1.00
266_G	269_N	0.550	1.00
208_K	211_F	0.549	1.00
16_N	58_T	0.548	1.00
245_G	248_L	0.547	1.00
190_R	197_G	0.544	1.00
52_D	105_D	0.542	1.00
28_L	110_D	0.542	1.00
242_T	249_F	0.542	1.00
272_W	276_I	0.541	1.00
78_A	81_V	0.539	1.00
130_Y	166_A	0.537	1.00
220_K	224_S	0.537	1.00
277_I	280_W	0.536	1.00
277_I	281_F	0.535	1.00
84_Q	88_L	0.534	1.00
184_E	187_L	0.533	1.00
7_V	45_S	0.531	1.00
269_N	273_A	0.528	1.00
16_N	51_D	0.528	1.00
130_Y	200_S	0.527	1.00
66_S	70_K	0.526	1.00
235_V	238_I	0.525	1.00
256_G	260_F	0.521	1.00
242_T	246_F	0.521	1.00
187_L	190_R	0.520	1.00
245_G	284_G	0.520	1.00
243_L	247_V	0.520	1.00
27_Q	108_L	0.519	1.00
110_D	168_F	0.519	1.00
257_I	261_I	0.518	1.00
29_T	72_V	0.517	1.00
175_S	196_I	0.517	1.00
291_G	294_G	0.516	1.00
108_L	210_R	0.512	1.00
223_L	226_A	0.512	1.00
140_T	146_T	0.511	1.00
53_G	80_N	0.511	1.00
279_I	282_L	0.510	1.00
99_D	173_K	0.510	1.00
246_F	249_F	0.508	0.99
179_L	193_V	0.507	0.99
232_S	239_R	0.504	0.99
263_K	273_A	0.504	0.99
48_L	93_K	0.503	0.99
175_S	179_L	0.501	0.99
151_Y	156_K	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4p02A	1	0.9614	100	0.491	Contact Map
3bcvA	2	0.5134	100	0.5	Contact Map
2z86A	2	0.724	100	0.5	Contact Map
3l7iA	4	0.1009	100	0.513	Contact Map
2d7iA	1	0.8427	100	0.513	Contact Map
1qg8A	1	0.6409	100	0.515	Contact Map
1xhbA	1	0.9347	100	0.519	Contact Map
2bo4A	4	0.8398	100	0.531	Contact Map
5ajoA	1	0.9407	100	0.533	Contact Map
3f1yA	2	0.8101	100	0.542	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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