LGT - BACSU - GREMLIN Contacts

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LGT - Prolipoprotein diacylglyceryl transferase

UniProt:	O34752	Sequences: MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEKRGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIGAILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLHLPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIGRYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (246)
Sequences:	4390 (3087)
Seq/√Len:	196.8

ECOLI - LGT
BACSU - LGT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
151_V	156_L	3.707	1.00
85_E	91_K	3.396	1.00
177_H	182_Y	3.394	1.00
252_A	256_F	3.229	1.00
85_E	88_K	3.038	1.00
82_H	85_E	2.964	1.00
190_G	214_W	2.934	1.00
14_Q	19_A	2.853	1.00
221_F	225_M	2.816	1.00
24_G	28_G	2.702	1.00
186_W	218_G	2.612	1.00
88_K	91_K	2.484	1.00
76_W	80_A	2.389	1.00
109_V	113_V	2.353	1.00
216_S	247_I	2.326	1.00
118_F	122_A	2.221	1.00
138_W	184_S	2.142	1.00
206_E	258_R	2.137	1.00
213_I	250_A	2.134	1.00
209_L	253_A	2.133	1.00
209_L	250_A	2.098	1.00
62_I	106_T	2.083	1.00
213_I	247_I	2.050	1.00
51_T	114_K	2.009	1.00
150_A	174_Q	2.005	1.00
220_Y	224_G	1.980	1.00
13_F	20_V	1.974	1.00
153_R	156_L	1.939	1.00
102_G	106_T	1.914	1.00
78_Y	82_H	1.911	1.00
97_H	239_A	1.902	1.00
43_E	49_K	1.896	1.00
48_Q	51_T	1.860	1.00
66_C	102_G	1.859	1.00
14_Q	17_P	1.842	1.00
75_E	78_Y	1.811	1.00
131_L	191_V	1.803	1.00
12_A	25_I	1.801	1.00
80_A	83_P	1.768	1.00
41_E	198_R	1.741	1.00
111_S	121_L	1.731	1.00
192_I	196_L	1.671	1.00
83_P	87_I	1.647	1.00
62_I	102_G	1.636	1.00
156_L	175_Y	1.635	1.00
206_E	254_I	1.628	1.00
203_R	206_E	1.607	1.00
42_S	52_F	1.607	1.00
122_A	208_F	1.594	1.00
38_A	128_S	1.556	1.00
224_G	240_Q	1.540	1.00
12_A	20_V	1.527	1.00
108_Y	112_R	1.522	1.00
58_F	62_I	1.486	1.00
134_A	188_F	1.480	1.00
120_K	204_R	1.474	1.00
10_P	21_H	1.471	1.00
133_Q	211_Y	1.468	1.00
123_D	205_G	1.468	1.00
78_Y	85_E	1.450	1.00
188_F	192_I	1.446	1.00
119_W	205_G	1.433	1.00
40_R	43_E	1.429	1.00
26_I	139_G	1.425	1.00
110_F	114_K	1.395	1.00
141_F	159_L	1.392	1.00
147_H	176_Y	1.389	1.00
33_L	135_I	1.387	1.00
185_L	189_V	1.382	1.00
55_L	121_L	1.353	1.00
72_V	86_I	1.342	1.00
220_Y	240_Q	1.333	1.00
40_R	44_K	1.323	1.00
251_V	255_I	1.323	1.00
244_I	248_V	1.318	1.00
141_F	181_L	1.306	1.00
84_G	88_K	1.296	1.00
160_H	175_Y	1.282	1.00
179_T	222_I	1.273	1.00
186_W	222_I	1.272	1.00
41_E	44_K	1.267	1.00
35_L	56_V	1.267	1.00
186_W	190_G	1.259	1.00
39_M	43_E	1.251	1.00
8_L	142_M	1.251	1.00
213_I	251_V	1.247	1.00
140_N	145_E	1.242	1.00
209_L	254_I	1.242	1.00
36_W	40_R	1.240	1.00
84_G	87_I	1.238	1.00
210_I	254_I	1.231	1.00
34_G	59_A	1.231	1.00
130_L	190_G	1.216	1.00
193_V	197_L	1.201	1.00
213_I	254_I	1.194	1.00
209_L	257_R	1.183	1.00
117_S	204_R	1.173	1.00
73_A	76_W	1.169	1.00
181_L	185_L	1.165	1.00
12_A	22_W	1.153	1.00
127_P	130_L	1.149	1.00
31_A	63_A	1.141	1.00
116_L	121_L	1.123	1.00
51_T	116_L	1.117	1.00
134_A	184_S	1.114	1.00
218_G	222_I	1.108	1.00
191_V	195_L	1.102	1.00
39_M	53_I	1.095	1.00
101_I	105_L	1.094	1.00
108_Y	118_F	1.092	1.00
137_R	219_R	1.092	1.00
31_A	60_I	1.086	1.00
232_L	238_I	1.082	1.00
117_S	120_K	1.080	1.00
11_I	21_H	1.076	1.00
203_R	258_R	1.071	1.00
152_S	156_L	1.068	1.00
41_E	127_P	1.063	1.00
89_I	92_G	1.059	1.00
149_E	227_T	1.051	1.00
82_H	88_K	1.051	1.00
58_F	106_T	1.038	1.00
105_L	109_V	1.034	1.00
210_I	214_W	1.027	1.00
208_F	212_I	1.023	1.00
72_V	79_Y	1.010	1.00
55_L	59_A	1.010	1.00
248_V	252_A	1.007	1.00
256_F	260_K	1.007	1.00
252_A	255_I	0.998	1.00
217_I	247_I	0.993	1.00
138_W	142_M	0.992	1.00
78_Y	81_A	0.987	1.00
220_Y	247_I	0.977	0.99
107_G	122_A	0.971	0.99
63_A	103_A	0.966	0.99
79_Y	86_I	0.966	0.99
191_V	214_W	0.966	0.99
26_I	29_L	0.962	0.99
161_L	180_F	0.959	0.99
236_L	241_V	0.952	0.99
217_I	221_F	0.946	0.99
130_L	191_V	0.940	0.99
216_S	246_L	0.935	0.99
61_P	65_I	0.932	0.99
183_E	222_I	0.928	0.99
212_I	246_L	0.928	0.99
170_Y	174_Q	0.927	0.99
57_L	61_P	0.925	0.99
170_Y	176_Y	0.916	0.99
37_I	195_L	0.908	0.99
96_I	133_Q	0.905	0.99
253_A	257_R	0.901	0.99
100_L	129_I	0.896	0.99
155_F	177_H	0.890	0.99
156_L	159_L	0.886	0.99
11_I	19_A	0.883	0.99
32_L	36_W	0.879	0.99
50_D	53_I	0.877	0.99
134_A	191_V	0.874	0.99
37_I	131_L	0.870	0.99
27_I	30_G	0.857	0.99
212_I	250_A	0.855	0.99
16_G	19_A	0.852	0.99
33_L	131_L	0.849	0.99
69_I	86_I	0.847	0.99
150_A	176_Y	0.846	0.98
243_S	246_L	0.842	0.98
130_L	194_L	0.840	0.98
176_Y	227_T	0.836	0.98
54_D	114_K	0.835	0.98
236_L	244_I	0.832	0.98
140_N	146_A	0.832	0.98
163_E	171_I	0.819	0.98
249_L	252_A	0.818	0.98
22_W	142_M	0.817	0.98
94_I	99_G	0.816	0.98
55_L	110_F	0.811	0.98
258_R	261_G	0.807	0.98
26_I	142_M	0.800	0.98
119_W	253_A	0.799	0.98
26_I	138_W	0.797	0.98
234_D	241_V	0.792	0.98
37_I	191_V	0.780	0.97
33_L	37_I	0.779	0.97
69_I	73_A	0.778	0.97
97_H	216_S	0.773	0.97
9_N	22_W	0.771	0.97
190_G	218_G	0.767	0.97
135_I	184_S	0.767	0.97
126_A	208_F	0.765	0.97
34_G	128_S	0.765	0.97
37_I	128_S	0.763	0.97
136_G	215_Y	0.762	0.97
254_I	258_R	0.761	0.97
192_I	195_L	0.760	0.97
119_W	209_L	0.754	0.97
194_L	207_M	0.748	0.97
200_A	206_E	0.747	0.97
206_E	257_R	0.746	0.97
47_L	116_L	0.743	0.97
231_M	238_I	0.739	0.96
97_H	243_S	0.736	0.96
193_V	196_L	0.735	0.96
145_E	180_F	0.731	0.96
134_A	189_V	0.729	0.96
151_V	177_H	0.728	0.96
29_L	135_I	0.726	0.96
23_Y	140_N	0.725	0.96
126_A	129_I	0.725	0.96
214_W	218_G	0.722	0.96
12_A	19_A	0.721	0.96
209_L	213_I	0.721	0.96
171_I	174_Q	0.721	0.96
155_F	182_Y	0.719	0.96
40_R	46_G	0.717	0.96
179_T	225_M	0.713	0.96
140_N	143_N	0.711	0.96
62_I	66_C	0.708	0.96
99_G	103_A	0.707	0.95
239_A	242_I	0.705	0.95
38_A	129_I	0.705	0.95
238_I	242_I	0.705	0.95
83_P	86_I	0.705	0.95
13_F	19_A	0.703	0.95
194_L	218_G	0.698	0.95
241_V	245_V	0.697	0.95
198_R	207_M	0.697	0.95
39_M	49_K	0.683	0.95
250_A	253_A	0.682	0.95
104_I	118_F	0.679	0.94
77_D	81_A	0.676	0.94
133_Q	187_S	0.674	0.94
30_G	136_G	0.672	0.94
134_A	187_S	0.671	0.94
38_A	124_I	0.668	0.94
236_L	240_Q	0.667	0.94
11_I	14_Q	0.667	0.94
100_L	126_A	0.667	0.94
207_M	210_I	0.666	0.94
150_A	175_Y	0.666	0.94
51_T	110_F	0.657	0.93
45_R	124_I	0.657	0.93
111_S	118_F	0.656	0.93
170_Y	173_G	0.656	0.93
213_I	217_I	0.654	0.93
202_L	206_E	0.654	0.93
23_Y	145_E	0.653	0.93
184_S	189_V	0.652	0.93
161_L	175_Y	0.651	0.93
109_V	114_K	0.650	0.93
10_P	19_A	0.649	0.93
230_L	237_R	0.648	0.93
131_L	134_A	0.646	0.93
197_L	210_I	0.645	0.93
104_I	108_Y	0.644	0.93
149_E	177_H	0.644	0.93
95_A	146_A	0.641	0.93
68_R	94_I	0.640	0.92
75_E	79_Y	0.640	0.92
155_F	178_P	0.638	0.92
15_L	18_L	0.636	0.92
144_Q	163_E	0.634	0.92
201_N	204_R	0.631	0.92
30_G	33_L	0.630	0.92
96_I	211_Y	0.625	0.92
153_R	177_H	0.622	0.91
107_G	125_A	0.618	0.91
13_F	16_G	0.618	0.91
67_A	94_I	0.618	0.91
63_A	67_A	0.617	0.91
149_E	225_M	0.614	0.91
88_K	92_G	0.614	0.91
173_G	176_Y	0.611	0.91
36_W	39_M	0.607	0.90
231_M	237_R	0.602	0.90
68_R	92_G	0.600	0.90
70_Y	95_A	0.598	0.90
9_N	144_Q	0.598	0.90
178_P	181_L	0.597	0.90
224_G	237_R	0.597	0.90
144_Q	162_P	0.594	0.89
66_C	94_I	0.594	0.89
104_I	122_A	0.593	0.89
35_L	39_M	0.592	0.89
160_H	173_G	0.591	0.89
42_S	124_I	0.590	0.89
144_Q	171_I	0.590	0.89
147_H	179_T	0.589	0.89
146_A	179_T	0.588	0.89
58_F	110_F	0.586	0.89
41_E	45_R	0.585	0.89
78_Y	88_K	0.585	0.89
77_D	80_A	0.583	0.89
38_A	125_A	0.581	0.88
71_Y	231_M	0.581	0.88
222_I	225_M	0.581	0.88
96_I	100_L	0.577	0.88
221_F	224_G	0.577	0.88
33_L	36_W	0.576	0.88
12_A	21_H	0.573	0.88
55_L	107_G	0.572	0.88
146_A	229_S	0.570	0.87
156_L	160_H	0.569	0.87
172_N	176_Y	0.567	0.87
256_F	259_V	0.567	0.87
106_T	109_V	0.564	0.87
134_A	192_I	0.564	0.87
79_Y	85_E	0.563	0.87
11_I	22_W	0.563	0.87
62_I	109_V	0.562	0.87
136_G	211_Y	0.561	0.87
74_F	242_I	0.561	0.87
22_W	140_N	0.560	0.86
179_T	228_D	0.560	0.86
75_E	231_M	0.559	0.86
179_T	237_R	0.558	0.86
100_L	104_I	0.555	0.86
102_G	105_L	0.551	0.86
114_K	117_S	0.550	0.85
26_I	33_L	0.547	0.85
206_E	210_I	0.544	0.85
67_A	99_G	0.544	0.85
255_I	259_V	0.544	0.85
104_I	107_G	0.544	0.85
160_H	163_E	0.541	0.85
151_V	159_L	0.540	0.84
9_N	12_A	0.539	0.84
203_R	254_I	0.538	0.84
116_L	120_K	0.538	0.84
78_Y	84_G	0.537	0.84
125_A	129_I	0.536	0.84
134_A	139_G	0.535	0.84
160_H	170_Y	0.532	0.84
65_I	69_I	0.532	0.84
52_F	121_L	0.531	0.83
257_R	260_K	0.528	0.83
70_Y	242_I	0.528	0.83
30_G	131_L	0.526	0.83
196_L	200_A	0.526	0.83
163_E	173_G	0.522	0.82
127_P	207_M	0.521	0.82
132_G	136_G	0.521	0.82
228_D	231_M	0.520	0.82
249_L	253_A	0.519	0.82
47_L	121_L	0.519	0.82
31_A	58_F	0.514	0.81
243_S	247_I	0.513	0.81
189_V	193_V	0.512	0.81
12_A	15_L	0.511	0.81
220_Y	236_L	0.511	0.81
146_A	228_D	0.511	0.81
238_I	241_V	0.510	0.81
235_S	241_V	0.509	0.81
42_S	47_L	0.509	0.81
45_R	120_K	0.509	0.81
29_L	33_L	0.508	0.81
23_Y	143_N	0.507	0.81
15_L	19_A	0.507	0.81
160_H	176_Y	0.507	0.81
9_N	14_Q	0.506	0.80
155_F	159_L	0.506	0.80
151_V	155_F	0.506	0.80
76_W	79_Y	0.504	0.80
133_Q	136_G	0.502	0.80
219_R	223_E	0.501	0.80
153_R	225_M	0.501	0.80
108_Y	111_S	0.500	0.80
187_S	211_Y	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rddB	1	0.1227	17.8	0.96	Contact Map
2m20A	2	0.1413	13.5	0.962	Contact Map
2kluA	1	0.1673	12.9	0.963	Contact Map
3qnqA	2	0.8885	8.3	0.966	Contact Map
2l2tA	2	0.1599	8.1	0.966	Contact Map
4px7A	1	0.7844	7.5	0.966	Contact Map
2jwaA	2	0.1636	5.9	0.968	Contact Map
1fftB	1	0.1896	5.9	0.968	Contact Map
2kncA	1	0.1784	4.8	0.969	Contact Map
2ls4A	1	0.0892	4.4	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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