GREMLIN Database
LGT - Prolipoprotein diacylglyceryl transferase
UniProt: O34752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (246)
Sequences: 4390 (3087)
Seq/√Len: 196.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_V156_L3.7071.00
85_E91_K3.3961.00
177_H182_Y3.3941.00
252_A256_F3.2291.00
85_E88_K3.0381.00
82_H85_E2.9641.00
190_G214_W2.9341.00
14_Q19_A2.8531.00
221_F225_M2.8161.00
24_G28_G2.7021.00
186_W218_G2.6121.00
88_K91_K2.4841.00
76_W80_A2.3891.00
109_V113_V2.3531.00
216_S247_I2.3261.00
118_F122_A2.2211.00
138_W184_S2.1421.00
206_E258_R2.1371.00
213_I250_A2.1341.00
209_L253_A2.1331.00
209_L250_A2.0981.00
62_I106_T2.0831.00
213_I247_I2.0501.00
51_T114_K2.0091.00
150_A174_Q2.0051.00
220_Y224_G1.9801.00
13_F20_V1.9741.00
153_R156_L1.9391.00
102_G106_T1.9141.00
78_Y82_H1.9111.00
97_H239_A1.9021.00
43_E49_K1.8961.00
48_Q51_T1.8601.00
66_C102_G1.8591.00
14_Q17_P1.8421.00
75_E78_Y1.8111.00
131_L191_V1.8031.00
12_A25_I1.8011.00
80_A83_P1.7681.00
41_E198_R1.7411.00
111_S121_L1.7311.00
192_I196_L1.6711.00
83_P87_I1.6471.00
62_I102_G1.6361.00
156_L175_Y1.6351.00
206_E254_I1.6281.00
203_R206_E1.6071.00
42_S52_F1.6071.00
122_A208_F1.5941.00
38_A128_S1.5561.00
224_G240_Q1.5401.00
12_A20_V1.5271.00
108_Y112_R1.5221.00
58_F62_I1.4861.00
134_A188_F1.4801.00
120_K204_R1.4741.00
10_P21_H1.4711.00
133_Q211_Y1.4681.00
123_D205_G1.4681.00
78_Y85_E1.4501.00
188_F192_I1.4461.00
119_W205_G1.4331.00
40_R43_E1.4291.00
26_I139_G1.4251.00
110_F114_K1.3951.00
141_F159_L1.3921.00
147_H176_Y1.3891.00
33_L135_I1.3871.00
185_L189_V1.3821.00
55_L121_L1.3531.00
72_V86_I1.3421.00
220_Y240_Q1.3331.00
40_R44_K1.3231.00
251_V255_I1.3231.00
244_I248_V1.3181.00
141_F181_L1.3061.00
84_G88_K1.2961.00
160_H175_Y1.2821.00
179_T222_I1.2731.00
186_W222_I1.2721.00
41_E44_K1.2671.00
35_L56_V1.2671.00
186_W190_G1.2591.00
39_M43_E1.2511.00
8_L142_M1.2511.00
213_I251_V1.2471.00
140_N145_E1.2421.00
209_L254_I1.2421.00
36_W40_R1.2401.00
84_G87_I1.2381.00
210_I254_I1.2311.00
34_G59_A1.2311.00
130_L190_G1.2161.00
193_V197_L1.2011.00
213_I254_I1.1941.00
209_L257_R1.1831.00
117_S204_R1.1731.00
73_A76_W1.1691.00
181_L185_L1.1651.00
12_A22_W1.1531.00
127_P130_L1.1491.00
31_A63_A1.1411.00
116_L121_L1.1231.00
51_T116_L1.1171.00
134_A184_S1.1141.00
218_G222_I1.1081.00
191_V195_L1.1021.00
39_M53_I1.0951.00
101_I105_L1.0941.00
108_Y118_F1.0921.00
137_R219_R1.0921.00
31_A60_I1.0861.00
232_L238_I1.0821.00
117_S120_K1.0801.00
11_I21_H1.0761.00
203_R258_R1.0711.00
152_S156_L1.0681.00
41_E127_P1.0631.00
89_I92_G1.0591.00
149_E227_T1.0511.00
82_H88_K1.0511.00
58_F106_T1.0381.00
105_L109_V1.0341.00
210_I214_W1.0271.00
208_F212_I1.0231.00
72_V79_Y1.0101.00
55_L59_A1.0101.00
248_V252_A1.0071.00
256_F260_K1.0071.00
252_A255_I0.9981.00
217_I247_I0.9931.00
138_W142_M0.9921.00
78_Y81_A0.9871.00
220_Y247_I0.9770.99
107_G122_A0.9710.99
63_A103_A0.9660.99
79_Y86_I0.9660.99
191_V214_W0.9660.99
26_I29_L0.9620.99
161_L180_F0.9590.99
236_L241_V0.9520.99
217_I221_F0.9460.99
130_L191_V0.9400.99
216_S246_L0.9350.99
61_P65_I0.9320.99
183_E222_I0.9280.99
212_I246_L0.9280.99
170_Y174_Q0.9270.99
57_L61_P0.9250.99
170_Y176_Y0.9160.99
37_I195_L0.9080.99
96_I133_Q0.9050.99
253_A257_R0.9010.99
100_L129_I0.8960.99
155_F177_H0.8900.99
156_L159_L0.8860.99
11_I19_A0.8830.99
32_L36_W0.8790.99
50_D53_I0.8770.99
134_A191_V0.8740.99
37_I131_L0.8700.99
27_I30_G0.8570.99
212_I250_A0.8550.99
16_G19_A0.8520.99
33_L131_L0.8490.99
69_I86_I0.8470.99
150_A176_Y0.8460.98
243_S246_L0.8420.98
130_L194_L0.8400.98
176_Y227_T0.8360.98
54_D114_K0.8350.98
236_L244_I0.8320.98
140_N146_A0.8320.98
163_E171_I0.8190.98
249_L252_A0.8180.98
22_W142_M0.8170.98
94_I99_G0.8160.98
55_L110_F0.8110.98
258_R261_G0.8070.98
26_I142_M0.8000.98
119_W253_A0.7990.98
26_I138_W0.7970.98
234_D241_V0.7920.98
37_I191_V0.7800.97
33_L37_I0.7790.97
69_I73_A0.7780.97
97_H216_S0.7730.97
9_N22_W0.7710.97
190_G218_G0.7670.97
135_I184_S0.7670.97
126_A208_F0.7650.97
34_G128_S0.7650.97
37_I128_S0.7630.97
136_G215_Y0.7620.97
254_I258_R0.7610.97
192_I195_L0.7600.97
119_W209_L0.7540.97
194_L207_M0.7480.97
200_A206_E0.7470.97
206_E257_R0.7460.97
47_L116_L0.7430.97
231_M238_I0.7390.96
97_H243_S0.7360.96
193_V196_L0.7350.96
145_E180_F0.7310.96
134_A189_V0.7290.96
151_V177_H0.7280.96
29_L135_I0.7260.96
23_Y140_N0.7250.96
126_A129_I0.7250.96
214_W218_G0.7220.96
12_A19_A0.7210.96
209_L213_I0.7210.96
171_I174_Q0.7210.96
155_F182_Y0.7190.96
40_R46_G0.7170.96
179_T225_M0.7130.96
140_N143_N0.7110.96
62_I66_C0.7080.96
99_G103_A0.7070.95
239_A242_I0.7050.95
38_A129_I0.7050.95
238_I242_I0.7050.95
83_P86_I0.7050.95
13_F19_A0.7030.95
194_L218_G0.6980.95
241_V245_V0.6970.95
198_R207_M0.6970.95
39_M49_K0.6830.95
250_A253_A0.6820.95
104_I118_F0.6790.94
77_D81_A0.6760.94
133_Q187_S0.6740.94
30_G136_G0.6720.94
134_A187_S0.6710.94
38_A124_I0.6680.94
236_L240_Q0.6670.94
11_I14_Q0.6670.94
100_L126_A0.6670.94
207_M210_I0.6660.94
150_A175_Y0.6660.94
51_T110_F0.6570.93
45_R124_I0.6570.93
111_S118_F0.6560.93
170_Y173_G0.6560.93
213_I217_I0.6540.93
202_L206_E0.6540.93
23_Y145_E0.6530.93
184_S189_V0.6520.93
161_L175_Y0.6510.93
109_V114_K0.6500.93
10_P19_A0.6490.93
230_L237_R0.6480.93
131_L134_A0.6460.93
197_L210_I0.6450.93
104_I108_Y0.6440.93
149_E177_H0.6440.93
95_A146_A0.6410.93
68_R94_I0.6400.92
75_E79_Y0.6400.92
155_F178_P0.6380.92
15_L18_L0.6360.92
144_Q163_E0.6340.92
201_N204_R0.6310.92
30_G33_L0.6300.92
96_I211_Y0.6250.92
153_R177_H0.6220.91
107_G125_A0.6180.91
13_F16_G0.6180.91
67_A94_I0.6180.91
63_A67_A0.6170.91
149_E225_M0.6140.91
88_K92_G0.6140.91
173_G176_Y0.6110.91
36_W39_M0.6070.90
231_M237_R0.6020.90
68_R92_G0.6000.90
70_Y95_A0.5980.90
9_N144_Q0.5980.90
178_P181_L0.5970.90
224_G237_R0.5970.90
144_Q162_P0.5940.89
66_C94_I0.5940.89
104_I122_A0.5930.89
35_L39_M0.5920.89
160_H173_G0.5910.89
42_S124_I0.5900.89
144_Q171_I0.5900.89
147_H179_T0.5890.89
146_A179_T0.5880.89
58_F110_F0.5860.89
41_E45_R0.5850.89
78_Y88_K0.5850.89
77_D80_A0.5830.89
38_A125_A0.5810.88
71_Y231_M0.5810.88
222_I225_M0.5810.88
96_I100_L0.5770.88
221_F224_G0.5770.88
33_L36_W0.5760.88
12_A21_H0.5730.88
55_L107_G0.5720.88
146_A229_S0.5700.87
156_L160_H0.5690.87
172_N176_Y0.5670.87
256_F259_V0.5670.87
106_T109_V0.5640.87
134_A192_I0.5640.87
79_Y85_E0.5630.87
11_I22_W0.5630.87
62_I109_V0.5620.87
136_G211_Y0.5610.87
74_F242_I0.5610.87
22_W140_N0.5600.86
179_T228_D0.5600.86
75_E231_M0.5590.86
179_T237_R0.5580.86
100_L104_I0.5550.86
102_G105_L0.5510.86
114_K117_S0.5500.85
26_I33_L0.5470.85
206_E210_I0.5440.85
67_A99_G0.5440.85
255_I259_V0.5440.85
104_I107_G0.5440.85
160_H163_E0.5410.85
151_V159_L0.5400.84
9_N12_A0.5390.84
203_R254_I0.5380.84
116_L120_K0.5380.84
78_Y84_G0.5370.84
125_A129_I0.5360.84
134_A139_G0.5350.84
160_H170_Y0.5320.84
65_I69_I0.5320.84
52_F121_L0.5310.83
257_R260_K0.5280.83
70_Y242_I0.5280.83
30_G131_L0.5260.83
196_L200_A0.5260.83
163_E173_G0.5220.82
127_P207_M0.5210.82
132_G136_G0.5210.82
228_D231_M0.5200.82
249_L253_A0.5190.82
47_L121_L0.5190.82
31_A58_F0.5140.81
243_S247_I0.5130.81
189_V193_V0.5120.81
12_A15_L0.5110.81
220_Y236_L0.5110.81
146_A228_D0.5110.81
238_I241_V0.5100.81
235_S241_V0.5090.81
42_S47_L0.5090.81
45_R120_K0.5090.81
29_L33_L0.5080.81
23_Y143_N0.5070.81
15_L19_A0.5070.81
160_H176_Y0.5070.81
9_N14_Q0.5060.80
155_F159_L0.5060.80
151_V155_F0.5060.80
76_W79_Y0.5040.80
133_Q136_G0.5020.80
219_R223_E0.5010.80
153_R225_M0.5010.80
108_Y111_S0.5000.80
187_S211_Y0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rddB 1 0.1227 17.8 0.96 Contact Map
2m20A 2 0.1413 13.5 0.962 Contact Map
2kluA 1 0.1673 12.9 0.963 Contact Map
3qnqA 2 0.8885 8.3 0.966 Contact Map
2l2tA 2 0.1599 8.1 0.966 Contact Map
4px7A 1 0.7844 7.5 0.966 Contact Map
2jwaA 2 0.1636 5.9 0.968 Contact Map
1fftB 1 0.1896 5.9 0.968 Contact Map
2kncA 1 0.1784 4.8 0.969 Contact Map
2ls4A 1 0.0892 4.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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