GREMLIN Database
FABH1 - 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1
UniProt: O34746 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (278)
Sequences: 40831 (24470)
Seq/√Len: 1467.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A135_L2.7651.00
131_Y134_V2.6301.00
123_K127_E2.5431.00
227_S230_D2.5421.00
60_K64_E2.4981.00
56_V97_Q2.4571.00
120_V196_R2.4441.00
180_L183_D2.3521.00
69_A72_D2.3431.00
280_E292_V2.3391.00
106_M121_T2.3001.00
124_Q130_T2.2981.00
124_Q128_S2.2241.00
230_D291_V2.2191.00
122_G134_V2.2171.00
62_A177_S2.1901.00
214_G218_V2.1511.00
156_L263_H2.0761.00
58_A173_R2.0751.00
55_A94_I2.0721.00
254_P257_K2.0151.00
226_L291_V2.0151.00
191_Y281_L1.9791.00
75_M134_V1.9501.00
277_L308_I1.9281.00
55_A78_V1.9231.00
147_D152_N1.9121.00
220_V224_A1.8881.00
24_K28_T1.8871.00
190_L285_K1.8791.00
278_V282_E1.8791.00
61_N64_E1.8671.00
157_F236_P1.8421.00
77_L125_F1.8171.00
286_I289_G1.8071.00
133_H167_G1.7721.00
65_Q190_L1.7361.00
126_I180_L1.7321.00
218_V222_E1.7061.00
125_F131_Y1.7021.00
79_A114_G1.6941.00
59_A94_I1.6851.00
280_E284_G1.6701.00
74_D133_H1.6701.00
80_T90_V1.6691.00
62_A66_A1.6481.00
248_R255_V1.6171.00
179_E187_G1.6121.00
277_L294_M1.6021.00
78_V175_I1.6011.00
58_A175_I1.5981.00
21_D24_K1.5911.00
53_H97_Q1.5631.00
119_V277_L1.5511.00
23_E27_E1.5371.00
24_K29_S1.5161.00
215_E219_N1.4981.00
39_I47_D1.4941.00
78_V137_V1.4921.00
51_S139_V1.4861.00
268_T275_I1.4851.00
124_Q127_E1.4821.00
34_R40_E1.4641.00
179_E185_T1.4581.00
61_N65_Q1.4541.00
25_M30_D1.4411.00
165_V168_P1.4381.00
60_K97_Q1.4311.00
137_V175_I1.4001.00
118_G136_V1.3901.00
120_V124_Q1.3831.00
132_K183_D1.3671.00
24_K27_E1.3571.00
50_F54_M1.3561.00
91_S107_D1.3411.00
121_T124_Q1.3331.00
280_E283_A1.3321.00
125_F130_T1.3161.00
122_G136_V1.3141.00
123_K193_N1.3071.00
92_C300_G1.2931.00
194_E291_V1.2741.00
293_V305_A1.2661.00
56_V60_K1.2561.00
58_A61_N1.2551.00
117_Y304_G1.2521.00
21_D25_M1.2481.00
179_E183_D1.2461.00
179_E184_G1.2331.00
295_V305_A1.2281.00
226_L230_D1.2231.00
57_A60_K1.2211.00
155_V160_G1.2101.00
226_L231_V1.2041.00
233_F280_E1.1981.00
199_I303_W1.1891.00
215_E218_V1.1871.00
293_V307_A1.1751.00
60_K98_L1.1751.00
253_L257_K1.1721.00
219_N223_K1.1701.00
33_I36_R1.1691.00
221_I226_L1.1681.00
141_K144_S1.1681.00
219_N222_E1.1681.00
132_K180_L1.1641.00
95_Q105_A1.1601.00
23_E29_S1.1601.00
50_F53_H1.1581.00
232_D291_V1.1531.00
110_A113_A1.1521.00
57_A61_N1.1491.00
75_M125_F1.1331.00
133_H179_E1.1301.00
174_G274_P1.1291.00
55_A175_I1.1241.00
281_L286_I1.1231.00
221_I231_V1.1141.00
56_V94_I1.1141.00
59_A98_L1.1111.00
130_T223_K1.1011.00
135_L177_S1.0961.00
175_I178_F1.0921.00
126_I178_F1.0921.00
110_A117_Y1.0911.00
117_Y302_T1.0891.00
163_A166_V1.0861.00
261_T265_Y1.0851.00
116_M304_G1.0821.00
220_V307_A1.0801.00
180_L184_G1.0801.00
68_V133_H1.0781.00
216_S220_V1.0751.00
24_K30_D1.0671.00
218_V228_K1.0601.00
233_F259_S1.0581.00
77_L106_M1.0581.00
117_Y121_T1.0561.00
195_K220_V1.0551.00
181_G192_L1.0541.00
55_A137_V1.0501.00
75_M131_Y1.0461.00
216_S305_A1.0451.00
21_D29_S1.0451.00
163_A168_P1.0441.00
74_D77_L1.0411.00
41_E264_K1.0411.00
246_A250_R1.0321.00
33_I37_T1.0321.00
181_G184_G1.0301.00
119_V274_P1.0281.00
226_L307_A1.0251.00
60_K70_A1.0241.00
174_G278_V1.0201.00
249_E258_M1.0161.00
23_E30_D1.0161.00
21_D30_D1.0131.00
268_T271_A1.0101.00
117_Y198_T1.0081.00
163_A167_G1.0021.00
72_D133_H1.0001.00
228_K234_L0.9971.00
62_A135_L0.9881.00
100_A103_A0.9871.00
221_I228_K0.9831.00
119_V136_V0.9821.00
56_V98_L0.9751.00
252_E255_V0.9711.00
25_M28_T0.9701.00
231_V291_V0.9691.00
224_A307_A0.9661.00
108_I121_T0.9651.00
260_K263_H0.9621.00
22_L261_T0.9611.00
77_L134_V0.9541.00
22_L29_S0.9531.00
116_M306_I0.9521.00
115_F274_P0.9501.00
22_L25_M0.9481.00
264_K279_E0.9481.00
40_E263_H0.9461.00
133_H177_S0.9461.00
217_C251_L0.9421.00
220_V305_A0.9381.00
167_G268_T0.9371.00
235_I276_S0.9361.00
176_L277_L0.9291.00
120_V130_T0.9261.00
261_T279_E0.9201.00
283_A290_D0.9201.00
153_T157_F0.9171.00
40_E43_R0.9151.00
94_I137_V0.9151.00
217_C293_V0.9041.00
121_T125_F0.9041.00
272_S276_S0.9021.00
62_A175_I0.9011.00
75_M104_C0.8981.00
138_G274_P0.8931.00
65_Q188_Q0.8831.00
188_Q285_K0.8791.00
23_E28_T0.8771.00
77_L122_G0.8751.00
113_A301_L0.8731.00
206_F209_A0.8731.00
164_A168_P0.8701.00
166_V269_S0.8701.00
74_D132_K0.8701.00
172_D268_T0.8681.00
265_Y275_I0.8661.00
282_E285_K0.8641.00
261_T275_I0.8631.00
80_T83_P0.8601.00
25_M29_S0.8591.00
195_K224_A0.8551.00
32_W37_T0.8531.00
27_E30_D0.8481.00
287_K290_D0.8471.00
86_S89_T0.8451.00
231_V234_L0.8431.00
199_I216_S0.8431.00
162_G165_V0.8381.00
153_T165_V0.8351.00
199_I219_N0.8321.00
201_N204_E0.8261.00
63_L70_A0.8211.00
52_S90_V0.8171.00
196_R306_I0.8161.00
90_V139_V0.8151.00
164_A167_G0.8141.00
155_V162_G0.8121.00
294_M308_I0.8101.00
55_A139_V0.8061.00
187_G190_L0.8041.00
201_N208_F0.7991.00
133_H183_D0.7981.00
22_L26_V0.7981.00
275_I279_E0.7961.00
77_L121_T0.7921.00
21_D28_T0.7921.00
190_L281_L0.7901.00
189_H192_L0.7901.00
241_I245_E0.7891.00
199_I215_E0.7861.00
36_R60_K0.7831.00
101_K215_E0.7831.00
76_I95_Q0.7791.00
70_A73_L0.7751.00
59_A137_V0.7701.00
92_C105_A0.7681.00
79_A118_G0.7671.00
231_V307_A0.7661.00
126_I129_G0.7631.00
205_V209_A0.7621.00
281_L308_I0.7601.00
59_A62_A0.7591.00
21_D279_E0.7591.00
212_Q215_E0.7561.00
63_L135_L0.7551.00
22_L30_D0.7541.00
253_L256_E0.7451.00
52_S93_M0.7421.00
236_P258_M0.7411.00
195_K223_K0.7401.00
122_G178_F0.7371.00
226_L288_D0.7331.00
217_C292_V0.7311.00
197_H219_N0.7301.00
54_M141_K0.7271.00
281_L284_G0.7241.00
217_C295_V0.7241.00
81_V84_D0.7231.00
221_I224_A0.7201.00
78_V139_V0.7191.00
26_V29_S0.7191.00
88_P111_A0.7181.00
78_V91_S0.7171.00
127_E223_K0.7171.00
245_E248_R0.7131.00
193_N197_H0.7111.00
119_V306_I0.7071.00
77_L80_T0.7061.00
133_H136_V0.7031.00
197_H220_V0.7001.00
197_H216_S0.7001.00
89_T299_G0.6991.00
124_Q223_K0.6991.00
176_L274_P0.6981.00
123_K223_K0.6951.00
177_S180_L0.6951.00
174_G271_A0.6941.00
89_T207_K0.6931.00
65_Q282_E0.6891.00
245_E255_V0.6881.00
22_L27_E0.6861.00
277_L289_G0.6861.00
91_S105_A0.6841.00
59_A175_I0.6831.00
155_V158_G0.6821.00
140_E270_A0.6811.00
55_A90_V0.6781.00
27_E288_D0.6771.00
77_L81_V0.6721.00
176_L278_V0.6721.00
65_Q281_L0.6711.00
119_V178_F0.6711.00
276_S280_E0.6711.00
72_D185_T0.6691.00
243_I247_A0.6671.00
232_D286_I0.6651.00
190_L282_E0.6641.00
113_A295_V0.6611.00
140_E269_S0.6591.00
76_I103_A0.6581.00
161_A165_V0.6551.00
162_G167_G0.6541.00
111_A299_G0.6541.00
286_I290_D0.6531.00
217_C221_I0.6511.00
105_A200_M0.6511.00
276_S294_M0.6451.00
74_D100_A0.6451.00
245_E249_E0.6441.00
193_N196_R0.6411.00
188_Q192_L0.6371.00
214_G252_E0.6371.00
153_T156_L0.6361.00
119_V176_L0.6351.00
160_G163_A0.6341.00
268_T272_S0.6331.00
161_A167_G0.6321.00
116_M296_G0.6321.00
53_H57_A0.6311.00
155_V165_V0.6301.00
95_Q200_M0.6281.00
284_G308_I0.6281.00
154_A157_F0.6261.00
100_A135_L0.6221.00
281_L285_K0.6221.00
232_D290_D0.6211.00
221_I307_A0.6201.00
285_K288_D0.6191.00
204_E207_K0.6181.00
116_M273_I0.6171.00
204_E208_F0.6171.00
80_T107_D0.6151.00
51_S90_V0.6091.00
233_F284_G0.6071.00
73_L133_H0.6061.00
63_L98_L0.6061.00
68_V72_D0.6051.00
238_Q260_K0.6021.00
229_E257_K0.6001.00
63_L73_L0.5991.00
184_G189_H0.5991.00
125_F128_S0.5951.00
55_A59_A0.5951.00
115_F138_G0.5931.00
202_G205_V0.5911.00
76_I100_A0.5891.00
93_M97_Q0.5891.00
279_E283_A0.5851.00
34_R37_T0.5841.00
83_P87_F0.5811.00
104_C131_Y0.5781.00
181_G189_H0.5781.00
237_H241_I0.5771.00
186_G189_H0.5771.00
77_L84_D0.5751.00
238_Q244_M0.5691.00
194_E226_L0.5661.00
77_L108_I0.5641.00
154_A164_A0.5641.00
162_G168_P0.5631.00
206_F210_V0.5621.00
252_E257_K0.5591.00
185_T192_L0.5581.00
42_R45_A0.5581.00
154_A158_G0.5571.00
177_S184_G0.5541.00
241_I260_K0.5521.00
278_V281_L0.5511.00
32_W35_T0.5491.00
232_D257_K0.5461.00
61_N278_V0.5451.00
54_M173_R0.5401.00
78_V94_I0.5401.00
122_G131_Y0.5391.00
56_V59_A0.5361.00
242_R246_A0.5361.00
229_E252_E0.5331.00
154_A165_V0.5311.00
106_M117_Y0.5281.00
259_S276_S0.5271.00
138_G271_A0.5241.00
51_S141_K0.5201.00
234_L293_V0.5201.00
185_T191_Y0.5201.00
114_G118_G0.5201.00
59_A63_L0.5181.00
244_M248_R0.5151.00
203_R210_V0.5151.00
52_S89_T0.5151.00
113_A302_T0.5141.00
139_V173_R0.5131.00
261_T276_S0.5121.00
156_L163_A0.5111.00
31_E35_T0.5101.00
77_L83_P0.5091.00
78_V90_V0.5091.00
81_V140_E0.5091.00
221_I293_V0.5091.00
291_V307_A0.5091.00
164_A269_S0.5031.00
44_I47_D0.5031.00
244_M247_A0.5031.00
76_I80_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s21A 2 0.9712 100 0.221 Contact Map
1zowA 2 0.9968 100 0.233 Contact Map
1hnjA 2 0.9904 100 0.235 Contact Map
3gwaA 2 0.9936 100 0.236 Contact Map
2ebdA 2 0.9904 100 0.238 Contact Map
3il3A 2 0.9872 100 0.24 Contact Map
4rybA 2 0.9808 100 0.245 Contact Map
4x9kA 2 0.9936 100 0.245 Contact Map
1mzjA 2 0.9968 100 0.246 Contact Map
1ub7A 2 0.9872 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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