GREMLIN Database
YODF - Uncharacterized symporter YodF
UniProt: O34745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 496 (457)
Sequences: 11591 (7392)
Seq/√Len: 345.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
431_A461_A5.9401.00
363_S366_K4.1241.00
420_Q462_V3.9021.00
268_S271_A3.8951.00
359_H366_K3.7371.00
173_A379_I3.4161.00
431_A457_A3.3821.00
20_C24_L3.3701.00
354_Y362_V3.2381.00
463_V467_P3.1141.00
428_G462_V3.1121.00
461_A465_L3.0551.00
427_I465_L3.0391.00
421_T469_F2.9871.00
465_L469_F2.9791.00
435_V457_A2.9111.00
206_L295_I2.8301.00
365_S369_L2.7791.00
424_A466_N2.7661.00
216_P219_D2.7131.00
116_R125_A2.6771.00
423_E469_F2.6261.00
413_V462_V2.6061.00
204_V208_L2.6001.00
160_N163_F2.5361.00
369_L373_S2.5361.00
181_I265_T2.4621.00
45_F185_T2.4441.00
169_F383_L2.4131.00
373_S377_V2.3631.00
296_A309_A2.3311.00
13_I17_T2.2731.00
421_T424_A2.2621.00
427_I461_A2.2561.00
36_E43_R2.2481.00
69_S307_R2.1691.00
267_K271_A2.1221.00
114_Y414_S2.0941.00
410_A425_T2.0911.00
116_R122_K2.0791.00
362_V366_K2.0581.00
123_L426_V2.0341.00
14_I18_V2.0281.00
421_T466_N2.0221.00
219_D223_K2.0091.00
417_W420_Q2.0001.00
359_H362_V1.9981.00
198_I329_T1.9701.00
16_L20_C1.9651.00
61_A146_G1.9591.00
119_F420_Q1.9441.00
40_V43_R1.9301.00
380_G384_L1.9261.00
166_I170_I1.9181.00
423_E427_I1.9161.00
424_A465_L1.9091.00
37_E42_G1.8851.00
460_I464_I1.8791.00
120_N123_L1.8701.00
434_A438_I1.8641.00
271_A274_K1.8191.00
351_N355_R1.8081.00
424_A428_G1.8051.00
216_P220_T1.7871.00
179_S183_G1.7791.00
49_L189_I1.7731.00
172_V338_C1.7721.00
417_W463_V1.7651.00
200_L204_V1.7631.00
354_Y370_V1.7601.00
270_D274_K1.7591.00
270_D273_R1.7491.00
413_V459_M1.7301.00
21_I190_I1.7181.00
419_N470_V1.7161.00
324_G328_A1.7111.00
108_L117_E1.7021.00
369_L372_R1.6931.00
419_N467_P1.6791.00
47_G271_A1.6701.00
417_W467_P1.6621.00
349_F374_M1.6341.00
354_Y359_H1.6281.00
222_V226_P1.6271.00
427_I431_A1.5921.00
188_A262_G1.5881.00
366_K369_L1.5821.00
312_H316_T1.5781.00
355_R367_L1.5681.00
170_I174_L1.5661.00
456_A460_I1.5621.00
8_L12_A1.5531.00
349_F353_L1.5411.00
130_I353_L1.5311.00
211_F217_M1.5281.00
113_D352_N1.5251.00
219_D222_V1.5211.00
148_Q165_V1.4991.00
300_L316_T1.4891.00
342_A379_I1.4781.00
431_A435_V1.4661.00
50_V53_L1.4631.00
7_A321_V1.4501.00
120_N422_K1.4401.00
354_Y366_K1.4321.00
228_M231_I1.4311.00
95_F412_A1.4261.00
52_F189_I1.4251.00
127_L426_V1.4001.00
47_G51_W1.3961.00
362_V367_L1.3951.00
50_V266_A1.3891.00
172_V335_L1.3831.00
149_D305_N1.3771.00
428_G432_G1.3691.00
421_T470_V1.3561.00
188_A339_S1.3371.00
17_T21_I1.3361.00
162_K387_M1.3331.00
169_F379_I1.3311.00
345_A378_V1.3291.00
165_V383_L1.3211.00
118_R414_S1.3151.00
131_V433_L1.3101.00
12_A16_L1.3041.00
113_D351_N1.3021.00
215_T219_D1.2961.00
122_K126_S1.2961.00
39_S371_T1.2911.00
125_A352_N1.2901.00
220_T223_K1.2781.00
368_T372_R1.2671.00
147_I168_S1.2521.00
187_T339_S1.2501.00
457_A461_A1.2501.00
18_V190_I1.2481.00
222_V225_A1.2391.00
191_K339_S1.2381.00
226_P230_T1.2341.00
281_L286_L1.2301.00
281_L285_V1.2281.00
57_D340_I1.2261.00
163_F167_I1.2251.00
110_T347_N1.2231.00
29_K37_E1.2151.00
283_N286_L1.2071.00
122_K356_D1.2061.00
279_L286_L1.2061.00
366_K370_V1.2041.00
421_T465_L1.2031.00
124_L425_T1.2001.00
114_Y118_R1.1961.00
9_L13_I1.1911.00
41_G45_F1.1841.00
257_A261_T1.1761.00
282_Y286_L1.1741.00
34_S37_E1.1731.00
124_L426_V1.1701.00
419_N471_K1.1601.00
358_I362_V1.1581.00
116_R356_D1.1551.00
214_W218_I1.1411.00
163_F166_I1.1401.00
435_V461_A1.1391.00
349_F354_Y1.1331.00
420_Q424_A1.1301.00
295_I299_V1.1281.00
220_T298_L1.1281.00
423_E465_L1.1261.00
159_I164_V1.1241.00
162_K166_I1.1231.00
279_L282_Y1.1221.00
193_I197_V1.1161.00
212_N216_P1.1101.00
41_G181_I1.1071.00
245_A248_V1.1051.00
303_D306_P1.1051.00
50_V54_V1.1041.00
406_Q458_N1.1031.00
130_I134_L1.1021.00
152_Q161_V1.1011.00
53_L340_I1.1011.00
24_L28_D1.1011.00
128_V429_L1.0951.00
419_N472_N1.0911.00
428_G458_N1.0881.00
144_L169_F1.0821.00
166_I387_M1.0791.00
71_A78_A1.0781.00
350_A371_T1.0771.00
374_M377_V1.0761.00
83_P87_L1.0761.00
48_L52_F1.0741.00
14_I335_L1.0731.00
17_T190_I1.0701.00
188_A340_I1.0671.00
279_L283_N1.0631.00
172_V339_S1.0601.00
17_T20_C1.0601.00
175_Y335_L1.0601.00
432_G436_T1.0591.00
280_P284_I1.0551.00
166_I383_L1.0551.00
252_A256_W1.0511.00
201_F205_S1.0471.00
123_L127_L1.0431.00
257_A344_G1.0431.00
140_I382_A1.0401.00
127_L429_L1.0361.00
51_W55_G1.0331.00
135_M403_G1.0291.00
459_M463_V1.0281.00
314_I326_A1.0271.00
133_V349_F1.0241.00
175_Y339_S1.0241.00
19_V22_G1.0201.00
461_A464_I1.0171.00
364_Q367_L1.0141.00
420_Q466_N1.0131.00
453_W456_A1.0121.00
371_T375_V1.0121.00
105_I269_A1.0121.00
422_K426_V1.0121.00
119_F462_V1.0071.00
57_D188_A1.0071.00
80_F84_Y1.0051.00
197_V201_F1.0041.00
141_C385_F0.9971.00
9_L12_A0.9961.00
96_L100_W0.9881.00
384_L388_L0.9841.00
413_V420_Q0.9831.00
414_S425_T0.9811.00
456_A459_M0.9791.00
410_A429_L0.9781.00
72_F303_D0.9771.00
349_F378_V0.9711.00
213_G216_P0.9651.00
155_G159_I0.9641.00
115_A124_L0.9631.00
230_T233_S0.9601.00
282_Y285_V0.9561.00
144_L165_V0.9561.00
133_V345_A0.9521.00
350_A370_V0.9511.00
51_W278_F0.9491.00
123_L422_K0.9461.00
177_F376_F0.9461.00
343_I346_S0.9451.00
451_G455_L0.9431.00
432_G435_V0.9411.00
229_L233_S0.9391.00
362_V370_V0.9381.00
118_R417_W0.9331.00
191_K332_L0.9321.00
119_F414_S0.9301.00
228_M232_P0.9271.00
156_T160_N0.9261.00
48_L51_W0.9251.00
311_L314_I0.9251.00
39_S347_N0.9241.00
242_F245_A0.9241.00
115_A128_V0.9221.00
370_V374_M0.9161.00
226_P231_I0.9131.00
201_F322_A0.9111.00
218_I222_V0.9081.00
225_A228_M0.9061.00
354_Y358_I0.9051.00
239_I242_F0.9051.00
231_I234_E0.9041.00
89_Y93_Y0.9021.00
73_T306_P0.9021.00
305_N308_L0.9021.00
229_L232_P0.9011.00
430_L434_A0.9001.00
53_L56_A0.8991.00
53_L262_G0.8971.00
241_W245_A0.8951.00
81_A84_Y0.8881.00
296_A313_L0.8881.00
423_E468_L0.8871.00
51_W54_V0.8861.00
20_C23_F0.8851.00
49_L185_T0.8851.00
175_Y336_I0.8821.00
336_I339_S0.8821.00
247_I256_W0.8821.00
175_Y191_K0.8781.00
61_A334_S0.8781.00
292_L313_L0.8781.00
97_P269_A0.8751.00
203_V288_L0.8741.00
72_F302_E0.8721.00
249_S252_A0.8701.00
97_P273_R0.8691.00
56_A262_G0.8681.00
106_H117_E0.8661.00
346_S350_A0.8611.00
312_H315_Q0.8591.00
217_M295_I0.8591.00
19_V23_F0.8551.00
18_V22_G0.8551.00
247_I252_A0.8541.00
211_F216_P0.8501.00
36_E107_K0.8491.00
14_I332_L0.8461.00
396_L404_M0.8461.00
380_G383_L0.8461.00
279_L285_V0.8451.00
33_T37_E0.8451.00
417_W466_N0.8421.00
187_T191_K0.8421.00
199_M289_V0.8411.00
210_H299_V0.8401.00
354_Y360_P0.8381.00
60_T139_Y0.8371.00
215_T218_I0.8311.00
93_Y277_M0.8311.00
23_F27_R0.8301.00
191_K336_I0.8301.00
47_G278_F0.8251.00
439_V453_W0.8231.00
244_T248_V0.8211.00
424_A427_I0.8201.00
239_I243_I0.8181.00
131_V429_L0.8171.00
52_F192_D0.8131.00
53_L57_D0.8111.00
71_A294_F0.8101.00
152_Q156_T0.8091.00
127_L430_L0.8091.00
47_G274_K0.8071.00
175_Y183_G0.8041.00
217_M221_L0.8041.00
459_M462_V0.8001.00
191_K337_P0.7991.00
413_V463_V0.7981.00
227_Q230_T0.7961.00
314_I323_Q0.7941.00
55_G282_Y0.7931.00
226_P229_L0.7901.00
266_A272_V0.7891.00
90_F94_F0.7881.00
64_F326_A0.7881.00
409_P459_M0.7871.00
393_L397_Q0.7841.00
14_I22_G0.7821.00
11_T331_A0.7821.00
165_V386_G0.7821.00
458_N462_V0.7801.00
56_A191_K0.7791.00
184_P187_T0.7781.00
244_T247_I0.7781.00
48_L53_L0.7771.00
318_Y322_A0.7771.00
429_L432_G0.7761.00
201_F204_V0.7721.00
60_T64_F0.7681.00
126_S357_L0.7671.00
159_I167_I0.7661.00
11_T15_V0.7651.00
421_T471_K0.7641.00
253_L256_W0.7611.00
410_A458_N0.7601.00
202_M206_L0.7531.00
23_F178_F0.7521.00
70_T74_G0.7521.00
358_I361_N0.7491.00
279_L284_I0.7471.00
308_L312_H0.7471.00
228_M233_S0.7471.00
417_W424_A0.7451.00
417_W421_T0.7421.00
355_R360_P0.7411.00
25_A29_K0.7381.00
393_L400_G0.7370.99
80_F83_P0.7370.99
24_L186_Y0.7370.99
397_Q401_V0.7370.99
207_P213_G0.7360.99
432_G458_N0.7350.99
247_I251_L0.7320.99
94_F97_P0.7320.99
96_L272_V0.7310.99
425_T432_G0.7310.99
463_V466_N0.7270.99
205_S210_H0.7270.99
426_V430_L0.7260.99
375_V379_I0.7260.99
184_P340_I0.7250.99
397_Q404_M0.7250.99
413_V417_W0.7240.99
64_F199_M0.7240.99
377_V381_L0.7240.99
24_L27_R0.7230.99
419_N422_K0.7230.99
181_I185_T0.7230.99
464_I468_L0.7220.99
41_G265_T0.7200.99
156_T159_I0.7190.99
245_A252_A0.7180.99
161_V165_V0.7170.99
250_A256_W0.7140.99
46_G271_A0.7130.99
428_G431_A0.7130.99
53_L185_T0.7130.99
22_G26_G0.7120.99
186_Y189_I0.7110.99
87_L91_I0.7090.99
431_A465_L0.7080.99
373_S376_F0.7040.99
383_L386_G0.7040.99
94_F98_K0.7030.99
196_W200_L0.7030.99
151_L164_V0.7030.99
435_V438_I0.7020.99
464_I467_P0.7010.99
441_I445_A0.7010.99
58_L401_V0.7010.99
435_V439_V0.7000.99
442_T445_A0.6980.99
441_I444_S0.6970.99
423_E470_V0.6970.99
7_A323_Q0.6960.99
15_V18_V0.6940.99
10_I324_G0.6930.99
346_S375_V0.6920.99
454_G458_N0.6920.99
76_S294_F0.6920.99
457_A460_I0.6890.99
207_P214_W0.6840.99
292_L310_L0.6830.99
143_Q337_P0.6820.99
342_A375_V0.6820.99
50_V55_G0.6800.99
452_F456_A0.6790.99
303_D312_H0.6790.99
25_A186_Y0.6780.99
82_I85_S0.6770.99
98_K416_F0.6770.99
113_D117_E0.6760.99
252_A255_M0.6760.99
48_L189_I0.6750.99
389_F392_A0.6750.99
202_M310_L0.6740.99
218_I221_L0.6720.99
176_T339_S0.6720.99
367_L371_T0.6720.99
321_V325_F0.6710.99
337_P341_M0.6700.99
421_T425_T0.6690.99
191_K335_L0.6680.99
393_L401_V0.6670.99
53_L188_A0.6640.99
143_Q338_C0.6640.99
19_V174_L0.6630.99
247_I255_M0.6630.99
423_E426_V0.6620.99
126_S129_A0.6590.99
280_P283_N0.6570.99
81_A85_S0.6570.99
313_L317_S0.6550.99
38_W375_V0.6550.99
82_I86_V0.6550.99
126_S353_L0.6540.99
443_Q446_H0.6540.99
26_G178_F0.6540.99
120_N124_L0.6530.99
99_L260_A0.6520.99
290_I294_F0.6520.99
223_K226_P0.6520.99
132_G348_L0.6520.99
184_P262_G0.6500.99
420_Q428_G0.6490.99
199_M288_L0.6490.99
245_A249_S0.6480.99
29_K368_T0.6470.99
149_D307_R0.6460.99
468_L471_K0.6460.99
396_L400_G0.6440.99
47_G50_V0.6440.99
147_I334_S0.6410.99
66_G139_Y0.6410.99
7_A324_G0.6390.99
217_M298_L0.6390.99
470_V473_A0.6390.99
23_F26_G0.6380.99
266_A271_A0.6380.99
341_M344_G0.6380.99
126_S130_I0.6370.99
88_A92_A0.6370.99
236_P239_I0.6350.99
188_A336_I0.6350.99
433_L437_F0.6340.98
394_V402_S0.6330.98
208_L214_W0.6320.98
166_I380_G0.6320.98
434_A437_F0.6310.98
213_G217_M0.6300.98
70_T78_A0.6280.98
422_K425_T0.6280.98
455_L458_N0.6260.98
112_A128_V0.6260.98
460_I463_V0.6250.98
350_A367_L0.6240.98
119_F413_V0.6240.98
248_V252_A0.6230.98
173_A376_F0.6220.98
128_V407_I0.6220.98
357_L360_P0.6220.98
236_P240_P0.6210.98
431_A434_A0.6180.98
211_F298_L0.6170.98
124_L422_K0.6170.98
262_G340_I0.6170.98
384_L387_M0.6170.98
110_T352_N0.6170.98
399_L437_F0.6160.98
10_I321_V0.6140.98
298_L301_P0.6120.98
399_L440_Y0.6120.98
47_G54_V0.6120.98
7_A10_I0.6110.98
241_W244_T0.6110.98
149_D152_Q0.6110.98
109_T113_D0.6110.98
38_W372_R0.6100.98
355_R364_Q0.6100.98
471_K474_G0.6100.98
297_F301_P0.6080.98
349_F370_V0.6060.98
432_G439_V0.6050.98
85_S283_N0.6000.98
308_L311_L0.6000.98
242_F249_S0.6000.98
145_S149_D0.5990.98
70_T394_V0.5990.98
333_A336_I0.5990.98
383_L387_M0.5980.98
251_L256_W0.5980.98
229_L234_E0.5970.98
244_T251_L0.5950.98
139_Y341_M0.5940.98
89_Y277_M0.5940.98
249_S254_F0.5930.98
120_N473_A0.5930.98
139_Y256_W0.5900.98
341_M407_I0.5900.98
216_P298_L0.5900.98
184_P343_I0.5890.98
165_V169_F0.5890.98
408_F412_A0.5890.98
169_F386_G0.5880.98
262_G336_I0.5870.98
465_L468_L0.5870.98
205_S208_L0.5860.97
224_E297_F0.5860.97
47_G55_G0.5860.97
14_I191_K0.5850.97
72_F309_A0.5820.97
202_M326_A0.5810.97
52_F55_G0.5800.97
297_F309_A0.5800.97
244_T252_A0.5800.97
420_Q425_T0.5790.97
57_D262_G0.5780.97
139_Y258_H0.5780.97
45_F50_V0.5780.97
248_V256_W0.5770.97
148_Q161_V0.5770.97
440_Y450_E0.5770.97
37_E182_K0.5750.97
220_T224_E0.5750.97
166_I169_F0.5740.97
36_E364_Q0.5740.97
210_H317_S0.5740.97
249_S253_L0.5730.97
435_V454_G0.5730.97
427_I430_L0.5730.97
56_A192_D0.5710.97
227_Q231_I0.5710.97
217_M220_T0.5700.97
191_K333_A0.5700.97
55_G286_L0.5680.97
35_V38_W0.5650.97
274_K278_F0.5630.97
90_F250_A0.5620.97
393_L396_L0.5610.97
238_G242_F0.5600.97
424_A461_A0.5600.97
251_L255_M0.5600.97
455_L459_M0.5590.97
401_V404_M0.5580.97
46_G49_L0.5580.97
261_T344_G0.5580.97
381_L384_L0.5570.97
60_T143_Q0.5570.97
118_R418_K0.5570.97
227_Q233_S0.5560.97
46_G50_V0.5560.97
112_A132_G0.5550.97
182_K186_Y0.5550.97
469_F472_N0.5550.97
249_S256_W0.5550.97
28_D182_K0.5540.97
419_N423_E0.5530.96
55_G192_D0.5520.96
438_I443_Q0.5520.96
15_V19_V0.5510.96
122_K125_A0.5510.96
83_P86_V0.5510.96
139_Y143_Q0.5510.96
149_D153_V0.5500.96
164_V168_S0.5500.96
221_L294_F0.5500.96
232_P235_G0.5480.96
143_Q146_G0.5480.96
425_T428_G0.5470.96
9_L16_L0.5460.96
26_G29_K0.5460.96
13_I20_C0.5440.96
197_V200_L0.5430.96
435_V450_E0.5420.96
394_V401_V0.5420.96
445_A453_W0.5410.96
84_Y87_L0.5410.96
21_I25_A0.5400.96
238_G241_W0.5380.96
123_L126_S0.5370.96
263_V276_S0.5370.96
221_L225_A0.5370.96
173_A177_F0.5360.96
47_G53_L0.5360.96
35_V367_L0.5350.96
41_G44_R0.5350.96
100_W269_A0.5340.96
242_F247_I0.5330.96
115_A410_A0.5330.96
81_A87_L0.5320.96
450_E454_G0.5290.95
214_W217_M0.5290.95
243_I247_I0.5290.95
448_I452_F0.5280.95
57_D176_T0.5270.95
395_T399_L0.5260.95
239_I244_T0.5250.95
227_Q232_P0.5250.95
35_V39_S0.5250.95
60_T66_G0.5240.95
64_F69_S0.5240.95
350_A354_Y0.5230.95
126_S356_D0.5210.95
318_Y326_A0.5190.95
125_A129_A0.5190.95
119_F425_T0.5180.95
398_L402_S0.5170.95
7_A22_G0.5170.95
244_T256_W0.5160.95
439_V443_Q0.5150.95
238_G245_A0.5150.95
56_A188_A0.5150.95
335_L339_S0.5150.95
28_D33_T0.5150.95
165_V387_M0.5150.95
10_I328_A0.5130.95
144_L183_G0.5120.95
208_L213_G0.5110.95
240_P244_T0.5110.95
200_L203_V0.5100.94
467_P470_V0.5100.94
191_K262_G0.5090.94
244_T249_S0.5060.94
397_Q400_G0.5060.94
65_L146_G0.5050.94
175_Y179_S0.5050.94
159_I163_F0.5050.94
188_A191_K0.5050.94
221_L297_F0.5030.94
80_F87_L0.5020.94
22_G25_A0.5010.94
414_S418_K0.5010.94
346_S371_T0.5010.94
303_D308_L0.5010.94
49_L186_Y0.5000.94
140_I338_C0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9254 100 0.232 Contact Map
3dh4A 3 0.881 100 0.273 Contact Map
3giaA 1 0.8448 99.4 0.849 Contact Map
3l1lA 2 0.8125 99.4 0.85 Contact Map
4wgvA 2 0.7339 99 0.873 Contact Map
2jlnA 1 0.8448 99 0.874 Contact Map
4djkA 2 0.7984 98.9 0.878 Contact Map
4c7rA 3 0.877 98.3 0.9 Contact Map
2wswA 3 0.8044 97.6 0.916 Contact Map
4us3A 1 0.7802 94.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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