GREMLIN Database
SUMT - Uroporphyrinogen-III C-methyltransferase
UniProt: O34744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (220)
Sequences: 12754 (8233)
Seq/√Len: 555.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D23_K3.8561.00
22_L26_E3.2981.00
5_Y24_A2.5931.00
189_G212_D2.5281.00
75_Y80_K2.5281.00
125_Y204_Q2.5271.00
209_C213_T2.5231.00
28_A83_V2.4761.00
3_K111_E2.4631.00
197_H205_K2.4131.00
3_K109_P2.3241.00
23_K27_K2.2041.00
38_N85_L2.2031.00
7_V83_V2.1721.00
77_Q106_N2.1091.00
19_I22_L2.0901.00
5_Y81_M2.0791.00
118_S169_Y2.0451.00
50_D75_Y2.0371.00
122_A199_G2.0271.00
196_I199_G1.9951.00
29_D81_M1.9881.00
210_T213_T1.9591.00
198_W203_K1.8591.00
7_V21_A1.8491.00
75_Y78_K1.8391.00
209_C217_T1.8371.00
73_V106_N1.8361.00
193_A214_L1.7981.00
102_C106_N1.7351.00
29_D80_K1.7111.00
8_G113_I1.7071.00
23_K26_E1.6821.00
30_V75_Y1.6721.00
155_K158_A1.6711.00
181_K184_E1.6451.00
3_K81_M1.6061.00
24_A113_I1.6011.00
102_C105_E1.5981.00
5_Y111_E1.5801.00
15_D20_K1.5691.00
196_I206_S1.5521.00
74_K78_K1.5501.00
39_K43_Q1.5391.00
192_P232_G1.5061.00
117_T120_I1.4481.00
209_C214_L1.4411.00
217_T221_E1.4361.00
179_E183_L1.4221.00
77_Q108_I1.4151.00
13_D20_K1.4101.00
125_Y206_S1.4011.00
71_F75_Y1.3991.00
73_V77_Q1.3911.00
126_A194_A1.3911.00
20_K111_E1.3881.00
213_T217_T1.3821.00
187_R191_T1.3751.00
119_G169_Y1.3671.00
176_Q219_I1.3671.00
71_F74_K1.3541.00
198_W201_T1.3451.00
31_I45_A1.3401.00
27_K81_M1.3351.00
190_S212_D1.3321.00
149_E181_K1.3211.00
17_L22_L1.3071.00
122_A196_I1.3071.00
70_R74_K1.2981.00
182_L211_V1.2941.00
180_R184_E1.2921.00
233_N236_N1.2771.00
216_E220_K1.2751.00
117_T169_Y1.2741.00
8_G89_D1.2671.00
76_A108_I1.2661.00
168_I231_I1.2571.00
91_F96_G1.2531.00
22_L44_Y1.2521.00
50_D80_K1.2321.00
179_E215_S1.2261.00
33_Y51_L1.2131.00
112_I124_A1.2031.00
4_V76_A1.2011.00
18_T116_I1.1991.00
69_N102_C1.1811.00
140_A163_I1.1801.00
4_V103_L1.1731.00
24_A83_V1.1711.00
195_F227_S1.1641.00
67_T70_R1.1631.00
217_T220_K1.1351.00
32_L82_V1.1341.00
157_K184_E1.1221.00
32_L72_L1.1211.00
207_V217_T1.1171.00
141_F169_Y1.1141.00
193_A211_V1.1091.00
17_L21_A1.0831.00
73_V102_C1.0711.00
176_Q180_R1.0671.00
167_V230_V1.0651.00
142_V155_K1.0641.00
140_A164_D1.0641.00
84_R99_E1.0531.00
182_L231_I1.0531.00
194_A208_F1.0481.00
30_V82_V1.0431.00
205_K221_E1.0371.00
6_I96_G1.0351.00
194_A206_S1.0281.00
174_N177_Q1.0281.00
37_V40_E1.0261.00
16_L20_K1.0241.00
134_D164_D1.0091.00
103_L108_I1.0031.00
28_A81_M1.0031.00
183_L212_D0.9931.00
157_K161_T0.9881.00
38_N42_L0.9871.00
223_I227_S0.9861.00
68_I71_F0.9831.00
183_L189_G0.9791.00
65_Q98_E0.9751.00
89_D124_A0.9721.00
32_L75_Y0.9661.00
180_R215_S0.9531.00
15_D19_I0.9491.00
142_V156_W0.9471.00
197_H224_T0.9391.00
153_E181_K0.9341.00
5_Y113_I0.9331.00
168_I171_G0.9301.00
32_L52_I0.9281.00
176_Q215_S0.9251.00
61_H64_K0.9201.00
177_Q181_K0.9201.00
40_E43_Q0.9031.00
104_S208_F0.8981.00
38_N45_A0.8981.00
8_G90_P0.8971.00
65_Q69_N0.8961.00
21_A113_I0.8961.00
104_S127_G0.8941.00
100_A110_F0.8941.00
19_I23_K0.8911.00
158_A161_T0.8911.00
41_I44_Y0.8901.00
157_K181_K0.8901.00
121_A200_T0.8831.00
5_Y28_A0.8811.00
52_I71_F0.8771.00
179_E211_V0.8771.00
64_K67_T0.8741.00
112_I206_S0.8741.00
171_G174_N0.8691.00
17_L41_I0.8661.00
134_D139_V0.8651.00
30_V80_K0.8611.00
190_S210_T0.8591.00
167_V228_L0.8571.00
32_L71_F0.8561.00
128_I194_A0.8541.00
183_L215_S0.8441.00
147_K154_E0.8421.00
157_K160_A0.8411.00
11_P16_L0.8411.00
139_V164_D0.8391.00
91_F112_I0.8361.00
143_T155_K0.8271.00
139_V155_K0.8271.00
101_E105_E0.8241.00
7_V24_A0.8201.00
53_Y61_H0.8141.00
177_Q180_R0.8131.00
123_A130_V0.8111.00
183_L211_V0.8091.00
7_V113_I0.8071.00
219_I222_N0.8051.00
175_V214_L0.8011.00
97_G101_E0.8001.00
69_N73_V0.7981.00
158_A162_G0.7951.00
24_A27_K0.7951.00
92_V120_I0.7821.00
175_V229_I0.7801.00
24_A111_E0.7801.00
122_A230_V0.7801.00
192_P210_T0.7791.00
90_P94_G0.7701.00
42_L45_A0.7661.00
188_D191_T0.7641.00
195_F214_L0.7621.00
178_I229_I0.7611.00
30_V52_I0.7581.00
182_L187_R0.7581.00
66_E102_C0.7491.00
104_S110_F0.7471.00
24_A81_M0.7461.00
170_M174_N0.7431.00
70_R102_C0.7361.00
74_K77_Q0.7351.00
112_I125_Y0.7331.00
26_E44_Y0.7291.00
20_K23_K0.7261.00
97_G129_P0.7261.00
134_D162_G0.7211.00
146_Y153_E0.7181.00
194_A230_V0.7171.00
76_A82_V0.7171.00
52_I75_Y0.7171.00
132_H139_V0.7131.00
89_D112_I0.7121.00
70_R106_N0.7121.00
169_Y228_L0.7041.00
125_Y200_T0.7031.00
191_T233_N0.7011.00
14_P40_E0.6991.00
20_K113_I0.6981.00
163_I187_R0.6971.00
96_G100_A0.6971.00
31_I49_A0.6961.00
207_V223_I0.6961.00
46_K49_A0.6901.00
97_G132_H0.6891.00
197_H227_S0.6881.00
172_I227_S0.6881.00
8_G121_A0.6881.00
207_V214_L0.6871.00
39_K42_L0.6861.00
40_E44_Y0.6861.00
216_E219_I0.6851.00
67_T71_F0.6821.00
5_Y83_V0.6811.00
45_A49_A0.6791.00
121_A199_G0.6741.00
119_G167_V0.6741.00
166_L231_I0.6711.00
97_G131_T0.6641.00
24_A28_A0.6601.00
146_Y181_K0.6591.00
13_D16_L0.6561.00
91_F124_A0.6551.00
142_V168_I0.6511.00
92_V130_V0.6491.00
66_E70_R0.6491.00
86_K94_G0.6481.00
28_A31_I0.6461.00
20_K24_A0.6411.00
176_Q216_E0.6401.00
25_I83_V0.6401.00
25_I31_I0.6331.00
100_A104_S0.6321.00
135_A236_N0.6301.00
21_A83_V0.6251.00
13_D200_T0.6251.00
158_A163_I0.6231.00
63_M67_T0.6231.00
175_V179_E0.6221.00
157_K186_G0.6221.00
52_I68_I0.6221.00
21_A41_I0.6201.00
153_E184_E0.6201.00
73_V103_L0.6121.00
215_S219_I0.6111.00
17_L45_A0.6111.00
32_L54_C0.6081.00
8_G116_I0.6041.00
6_I100_A0.6031.00
35_R53_Y0.5981.00
213_T216_E0.5961.00
49_A52_I0.5941.00
19_I44_Y0.5911.00
207_V221_E0.5901.00
25_I45_A0.5861.00
123_A230_V0.5831.00
22_L45_A0.5821.00
38_N41_I0.5750.99
155_K159_L0.5730.99
66_E98_E0.5730.99
122_A228_L0.5730.99
41_I45_A0.5720.99
69_N72_L0.5710.99
103_L110_F0.5700.99
172_I223_I0.5690.99
175_V227_S0.5650.99
171_G178_I0.5630.99
73_V108_I0.5630.99
53_Y62_T0.5610.99
217_T223_I0.5600.99
63_M71_F0.5550.99
144_G174_N0.5550.99
66_E69_N0.5540.99
180_R219_I0.5530.99
121_A125_Y0.5510.99
140_A162_G0.5500.99
93_F135_A0.5500.99
196_I230_V0.5490.99
155_K161_T0.5470.99
153_E157_K0.5470.99
175_V178_I0.5460.99
154_E157_K0.5440.99
29_D46_K0.5440.99
193_A215_S0.5420.99
69_N98_E0.5390.99
130_V167_V0.5390.99
65_Q68_I0.5370.99
91_F100_A0.5360.99
135_A233_N0.5330.99
156_W178_I0.5300.99
132_H135_A0.5290.99
14_P44_Y0.5290.99
31_I42_L0.5280.99
144_G148_K0.5260.99
188_D212_D0.5240.99
232_G235_V0.5220.99
212_D215_S0.5210.99
198_W226_P0.5180.99
35_R225_N0.5170.99
101_E132_H0.5170.99
34_D38_N0.5140.99
72_L76_A0.5130.99
178_I181_K0.5130.99
162_G166_L0.5120.99
36_L41_I0.5110.99
116_I121_A0.5070.99
6_I110_F0.5020.99
119_G141_F0.5010.99
54_C65_Q0.5010.99
19_I26_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.9377 100 0.207 Contact Map
2yboA 2 0.9222 100 0.211 Contact Map
1s4dA 4 0.9689 100 0.213 Contact Map
4e16A 2 0.8872 100 0.241 Contact Map
1ve2A 2 0.8833 100 0.249 Contact Map
3kwpA 2 0.8755 100 0.262 Contact Map
1cbfA 2 0.8988 100 0.27 Contact Map
2zvbA 2 0.8521 100 0.275 Contact Map
1va0A 2 0.9066 100 0.279 Contact Map
1vhvA 2 0.9144 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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