GREMLIN Database
STET - Serine/threonine exchanger SteT
UniProt: O34739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (415)
Sequences: 24653 (16147)
Seq/√Len: 792.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_C336_I4.2681.00
317_K330_I4.2451.00
372_I376_R3.2121.00
364_V397_I3.2111.00
55_G237_T3.0901.00
320_H330_I3.0361.00
223_K227_R2.8871.00
13_G219_K2.8281.00
322_H325_F2.7651.00
218_M224_L2.6631.00
173_G246_A2.5781.00
79_Y309_R2.5751.00
220_N223_K2.5511.00
95_G306_M2.5221.00
317_K320_H2.5051.00
322_H329_W2.5011.00
307_A319_S2.4881.00
171_V175_W2.4141.00
18_L231_G2.3961.00
134_I340_L2.3621.00
275_I279_L2.3281.00
14_L231_G2.3181.00
216_G308_E2.2331.00
67_E374_R2.2011.00
83_E91_G2.1531.00
217_E301_R2.1441.00
333_S337_A2.1351.00
412_T415_C2.1351.00
416_G420_L2.1021.00
304_F308_E2.0971.00
14_L224_L2.0891.00
17_A218_M2.0761.00
367_F396_A2.0731.00
416_G419_I2.0701.00
266_T269_T2.0641.00
142_V146_I2.0621.00
14_L18_L2.0371.00
138_L340_L2.0191.00
145_I329_W2.0081.00
141_C332_I2.0021.00
134_I343_M1.9941.00
227_R231_G1.9831.00
149_K153_F1.9831.00
255_E270_M1.9701.00
394_I398_A1.9661.00
83_E88_E1.9221.00
425_G428_V1.9171.00
133_G343_M1.9151.00
310_K316_E1.9141.00
160_I164_I1.9091.00
86_Y372_I1.8841.00
182_F185_V1.8791.00
64_T367_F1.8771.00
56_I60_A1.8741.00
99_I335_Q1.8701.00
86_Y368_F1.8591.00
13_G16_F1.8381.00
415_C418_S1.8381.00
8_L321_V1.8311.00
318_L334_F1.8111.00
37_V47_A1.8111.00
252_S255_E1.7951.00
138_L336_I1.7071.00
230_T234_L1.6951.00
220_N224_L1.6861.00
16_F156_T1.6851.00
82_L94_C1.6801.00
178_D181_I1.6771.00
412_T416_G1.6711.00
144_N293_N1.6621.00
368_F397_I1.6511.00
50_A197_A1.6501.00
391_F395_L1.6491.00
398_A402_F1.6441.00
426_L430_Y1.6311.00
94_C365_M1.6171.00
128_L131_V1.6151.00
21_V232_G1.5981.00
427_P431_G1.5941.00
164_I168_C1.5851.00
18_L235_I1.5791.00
425_G429_Y1.5791.00
189_I192_M1.5761.00
266_T270_M1.5711.00
145_I333_S1.5651.00
325_F329_W1.5481.00
127_G131_V1.5401.00
137_V339_A1.5401.00
96_W425_G1.5391.00
415_C419_I1.5391.00
372_I375_K1.5271.00
146_I325_F1.5111.00
12_I16_F1.5101.00
57_L399_G1.5101.00
111_G292_L1.5021.00
56_I395_L1.4911.00
87_G90_W1.4711.00
60_A395_L1.4611.00
234_L238_A1.4581.00
214_L297_L1.4571.00
330_I334_F1.4411.00
269_T277_G1.4411.00
413_M416_G1.4381.00
177_G249_H1.4351.00
165_P283_G1.4331.00
141_C333_S1.4291.00
137_V336_I1.4171.00
322_H327_T1.4121.00
303_S331_A1.4101.00
134_I138_L1.4081.00
299_F335_Q1.4031.00
316_E319_S1.4001.00
174_L246_A1.3991.00
62_G233_L1.3981.00
304_F321_V1.3981.00
188_S192_M1.3891.00
316_E320_H1.3851.00
8_L304_F1.3671.00
86_Y90_W1.3671.00
220_N227_R1.3591.00
278_K282_V1.3551.00
82_L365_M1.3541.00
54_G201_T1.3491.00
414_S418_S1.3471.00
9_K326_R1.3431.00
428_V431_G1.3421.00
72_I84_E1.3381.00
300_P332_I1.3361.00
16_F152_G1.3331.00
177_G180_H1.3291.00
272_F276_G1.3281.00
417_L420_L1.3261.00
170_I242_F1.3131.00
163_L167_A1.3061.00
269_T274_S1.3041.00
184_A187_E1.3041.00
75_T216_G1.3021.00
378_K382_R1.2981.00
221_P226_P1.2921.00
320_H329_W1.2911.00
238_A242_F1.2841.00
368_F372_I1.2771.00
62_G229_M1.2711.00
74_K80_T1.2711.00
313_P317_K1.2711.00
140_L292_L1.2691.00
224_L227_R1.2641.00
107_I339_A1.2631.00
12_I152_G1.2611.00
412_T418_S1.2611.00
14_L227_R1.2381.00
420_L423_L1.2361.00
48_L245_F1.2321.00
99_I303_S1.2311.00
64_T393_P1.2301.00
130_K134_I1.2291.00
303_S312_L1.2151.00
80_T84_E1.2141.00
388_L392_M1.2131.00
118_M132_I1.2091.00
12_I17_A1.2061.00
15_L19_T1.2011.00
61_G367_F1.2011.00
173_G250_I1.1991.00
114_F285_I1.1901.00
371_F394_I1.1891.00
85_V369_A1.1871.00
418_S422_G1.1851.00
419_I423_L1.1791.00
364_V401_F1.1781.00
379_G382_R1.1721.00
25_I236_V1.1721.00
313_P316_E1.1671.00
74_K84_E1.1661.00
63_L230_T1.1661.00
412_T419_I1.1641.00
110_L113_Y1.1631.00
111_G137_V1.1631.00
169_I173_G1.1571.00
426_L429_Y1.1551.00
118_M122_F1.1551.00
65_I78_L1.1431.00
402_F406_S1.1421.00
422_G425_G1.1271.00
391_F394_I1.1271.00
219_K224_L1.1271.00
143_I154_V1.1201.00
185_V188_S1.1191.00
401_F405_G1.1111.00
114_F136_A1.1021.00
71_Q382_R1.0981.00
38_L47_A1.0941.00
131_V135_I1.0931.00
330_I333_S1.0921.00
380_E383_A1.0831.00
154_V158_T1.0801.00
11_E219_K1.0771.00
69_G81_Y1.0661.00
390_P394_I1.0611.00
17_A228_A1.0591.00
108_G111_G1.0581.00
32_M113_Y1.0571.00
408_L411_D1.0461.00
20_L214_L1.0451.00
321_V326_R1.0431.00
141_C145_I1.0391.00
167_A171_V1.0391.00
388_L391_F1.0371.00
135_I139_F1.0351.00
82_L90_W1.0341.00
92_F96_W1.0301.00
168_C172_F1.0291.00
21_V211_L1.0271.00
182_F186_N1.0251.00
308_E319_S1.0191.00
155_Q293_N1.0181.00
67_E70_T1.0161.00
120_N123_G1.0121.00
52_L241_I1.0121.00
22_I235_I1.0081.00
153_F157_L1.0071.00
364_V400_S1.0021.00
375_K390_P1.0001.00
252_S270_M0.9991.00
259_L266_T0.9981.00
79_Y305_A0.9981.00
424_A428_V0.9931.00
111_G115_G0.9921.00
188_S191_D0.9911.00
262_N266_T0.9901.00
22_I236_V0.9871.00
115_G132_I0.9871.00
422_G426_L0.9861.00
337_A341_I0.9861.00
110_L291_C0.9791.00
195_G402_F0.9771.00
320_H323_P0.9721.00
169_I268_A0.9711.00
145_I327_T0.9641.00
158_T290_G0.9621.00
370_V393_P0.9601.00
84_E377_A0.9591.00
423_L427_P0.9551.00
389_Y393_P0.9521.00
148_T297_L0.9511.00
19_T156_T0.9501.00
26_I29_G0.9491.00
170_I246_A0.9481.00
60_A392_M0.9461.00
138_L142_V0.9451.00
425_G430_Y0.9451.00
215_G225_L0.9421.00
397_I401_F0.9351.00
413_M417_L0.9331.00
209_I213_A0.9311.00
89_F93_L0.9261.00
196_A200_A0.9261.00
71_Q380_E0.9241.00
96_W312_L0.9241.00
296_V336_I0.9231.00
415_C420_L0.9201.00
115_G118_M0.9191.00
367_F397_I0.9131.00
364_V368_F0.9081.00
245_F249_H0.9071.00
206_D359_I0.9071.00
139_F289_F0.8961.00
329_W333_S0.8941.00
8_L217_E0.8911.00
414_S417_L0.8851.00
41_S44_S0.8841.00
163_L239_I0.8731.00
231_G235_I0.8701.00
16_F153_F0.8671.00
396_A400_S0.8631.00
83_E309_R0.8621.00
405_G409_I0.8601.00
76_G80_T0.8601.00
419_I422_G0.8591.00
413_M419_I0.8581.00
119_A123_G0.8581.00
250_I267_A0.8561.00
11_E149_K0.8561.00
170_I174_L0.8561.00
76_G79_Y0.8541.00
90_W365_M0.8501.00
393_P397_I0.8441.00
420_L424_A0.8431.00
48_L248_L0.8431.00
49_F194_F0.8391.00
55_G205_Y0.8391.00
237_T241_I0.8371.00
140_L293_N0.8351.00
8_L301_R0.8351.00
312_L318_L0.8281.00
123_G126_S0.8261.00
371_F393_P0.8251.00
59_L63_L0.8241.00
162_K287_S0.8241.00
354_I358_M0.8211.00
132_I135_I0.8171.00
423_L426_L0.8171.00
153_F156_T0.8161.00
184_A188_S0.8161.00
14_L228_A0.8131.00
52_L56_I0.8111.00
15_L156_T0.8111.00
336_I340_L0.8041.00
89_F426_L0.8011.00
382_R385_S0.8001.00
70_T383_A0.7971.00
370_V374_R0.7951.00
210_L298_S0.7921.00
400_S403_V0.7911.00
384_Y387_P0.7911.00
26_I31_F0.7901.00
142_V145_I0.7851.00
145_I322_H0.7811.00
377_A380_E0.7781.00
427_P430_Y0.7781.00
174_L242_F0.7771.00
119_A122_F0.7751.00
274_S278_K0.7741.00
140_L296_V0.7741.00
82_L369_A0.7711.00
26_I162_K0.7641.00
61_G400_S0.7621.00
318_L330_I0.7611.00
59_L230_T0.7611.00
44_S47_A0.7601.00
146_I150_Y0.7601.00
109_A112_L0.7571.00
37_V41_S0.7551.00
425_G431_G0.7551.00
402_F405_G0.7541.00
416_G422_G0.7521.00
68_I370_V0.7481.00
111_G114_F0.7471.00
381_K385_S0.7471.00
11_E148_T0.7471.00
404_L407_T0.7461.00
371_F390_P0.7451.00
144_N332_I0.7431.00
374_R378_K0.7411.00
183_T186_N0.7371.00
115_G129_S0.7371.00
375_K378_K0.7371.00
113_Y117_L0.7371.00
170_I243_I0.7341.00
369_A373_L0.7321.00
118_M285_I0.7321.00
109_A352_S0.7281.00
145_I325_F0.7271.00
115_G119_A0.7271.00
396_A399_G0.7271.00
206_D363_Y0.7251.00
416_G430_Y0.7231.00
273_G276_G0.7231.00
71_Q383_A0.7221.00
30_V243_I0.7221.00
43_D248_L0.7211.00
377_A382_R0.7201.00
195_G406_S0.7201.00
243_I264_T0.7201.00
183_T187_E0.7171.00
134_I344_L0.7151.00
109_A113_Y0.7141.00
412_T425_G0.7131.00
60_A64_T0.7131.00
18_L21_V0.7121.00
18_L228_A0.7111.00
15_L153_F0.7111.00
130_K343_M0.7101.00
68_I81_Y0.7091.00
190_S193_N0.7091.00
109_A203_F0.7091.00
413_M418_S0.7061.00
328_P331_A0.7041.00
423_L429_Y0.7041.00
193_N196_A0.7031.00
418_S423_L0.7021.00
275_I278_K0.7011.00
23_G159_T0.7001.00
371_F375_K0.6991.00
220_N226_P0.6971.00
115_G133_G0.6961.00
380_E385_S0.6961.00
108_G339_A0.6951.00
137_V343_M0.6941.00
268_A276_G0.6921.00
226_P229_M0.6881.00
307_A318_L0.6881.00
405_G408_L0.6871.00
110_L121_L0.6871.00
25_I232_G0.6861.00
300_P331_A0.6851.00
337_A340_L0.6821.00
152_G156_T0.6781.00
71_Q378_K0.6781.00
79_Y83_E0.6771.00
235_I239_I0.6761.00
105_A355_S0.6741.00
144_N297_L0.6731.00
58_T208_W0.6721.00
182_F249_H0.6721.00
98_Q102_Y0.6621.00
11_E15_L0.6601.00
48_L52_L0.6591.00
85_V372_I0.6581.00
414_S420_L0.6571.00
67_E387_P0.6571.00
8_L11_E0.6561.00
358_M362_F0.6561.00
113_Y116_S0.6541.00
416_G423_L0.6541.00
419_I425_G0.6531.00
323_P329_W0.6531.00
130_K133_G0.6531.00
318_L331_A0.6501.00
138_L141_C0.6491.00
79_Y95_G0.6491.00
172_F176_K0.6491.00
296_V300_P0.6481.00
140_L289_F0.6481.00
53_L198_I0.6481.00
111_G120_N0.6481.00
114_F289_F0.6471.00
403_V407_T0.6461.00
136_A292_L0.6431.00
191_D194_F0.6431.00
34_P244_N0.6431.00
47_A244_N0.6421.00
65_I366_A0.6421.00
389_Y392_M0.6421.00
243_I247_L0.6411.00
75_T304_F0.6401.00
212_A229_M0.6401.00
116_S119_A0.6391.00
49_F53_L0.6371.00
49_F52_L0.6371.00
364_V404_L0.6371.00
216_G304_F0.6361.00
301_R304_F0.6361.00
62_G208_W0.6361.00
44_S194_F0.6341.00
103_G335_Q0.6321.00
424_A427_P0.6301.00
268_A273_G0.6301.00
373_L377_A0.6301.00
112_L116_S0.6291.00
317_K334_F0.6291.00
303_S334_F0.6281.00
85_V373_L0.6241.00
69_G225_L0.6211.00
86_Y369_A0.6211.00
51_W204_A0.6181.00
69_G212_A0.6141.00
400_S404_L0.6131.00
15_L18_L0.6131.00
242_F246_A0.6131.00
145_I332_I0.6121.00
177_G181_I0.6121.00
114_F288_I0.6081.00
420_L425_G0.6081.00
172_F273_G0.6081.00
416_G425_G0.6061.00
101_I359_I0.6061.00
225_L229_M0.6061.00
322_H326_R0.6051.00
213_A298_S0.6041.00
150_Y153_F0.6031.00
24_T294_G0.6021.00
21_V25_I0.6011.00
259_L263_A0.6001.00
60_A396_A0.5981.00
62_G66_A0.5981.00
262_N265_S0.5981.00
406_S410_T0.5971.00
66_A70_T0.5961.00
110_L116_S0.5951.00
417_L422_G0.5951.00
107_I110_L0.5951.00
317_K321_V0.5931.00
111_G116_S0.5921.00
107_I111_G0.5921.00
102_Y295_K0.5921.00
79_Y91_G0.5911.00
63_L392_M0.5911.00
137_V340_L0.5891.00
386_V392_M0.5881.00
48_L241_I0.5881.00
110_L114_F0.5881.00
231_G234_L0.5871.00
222_E383_A0.5871.00
255_E258_T0.5861.00
78_L209_I0.5851.00
217_E328_P0.5831.00
97_V362_F0.5831.00
323_P326_R0.5821.00
26_I239_I0.5821.00
246_A249_H0.5811.00
24_T210_L0.5791.00
94_C362_F0.5771.00
161_G165_P0.5761.00
33_K352_S0.5761.00
68_I85_V0.5761.00
148_T214_L0.5751.00
112_L351_L0.5731.00
24_T295_K0.5731.00
282_V286_V0.5721.00
206_D209_I0.5711.00
221_P224_L0.5711.00
420_L427_P0.5691.00
114_F118_M0.5691.00
193_N197_A0.5681.00
161_G283_G0.5661.00
287_S290_G0.5661.00
152_G293_N0.5651.00
423_L431_G0.5651.00
22_I159_T0.5641.00
423_L430_Y0.5621.00
141_C296_V0.5611.00
78_L213_A0.5611.00
263_A268_A0.5601.00
172_F272_F0.5571.00
218_M225_L0.5571.00
418_S429_Y0.5561.00
348_P352_S0.5541.00
150_Y154_V0.5531.00
299_F303_S0.5531.00
418_S425_G0.5531.00
27_G31_F0.5521.00
17_A214_L0.5521.00
414_S419_I0.5511.00
394_I397_I0.5511.00
87_G91_G0.5481.00
349_D352_S0.5481.00
110_L288_I0.5471.00
147_G150_Y0.5471.00
105_A110_L0.5461.00
359_I362_F0.5461.00
156_T160_I0.5461.00
151_G297_L0.5451.00
407_T411_D0.5451.00
54_G202_L0.5451.00
164_I167_A0.5441.00
217_E321_V0.5421.00
251_L255_E0.5421.00
97_V361_I0.5421.00
379_G383_A0.5411.00
360_Y400_S0.5411.00
36_A349_D0.5411.00
235_I238_A0.5401.00
123_G127_G0.5391.00
138_L333_S0.5391.00
103_G338_L0.5391.00
222_E381_K0.5391.00
223_K226_P0.5381.00
159_T162_K0.5381.00
10_K219_K0.5371.00
165_P279_L0.5371.00
235_I242_F0.5371.00
129_S133_G0.5361.00
54_G205_Y0.5351.00
127_G132_I0.5351.00
121_L282_V0.5351.00
321_V325_F0.5351.00
64_T396_A0.5351.00
279_L283_G0.5341.00
31_F166_I0.5341.00
67_E384_Y0.5341.00
104_P354_I0.5321.00
64_T386_V0.5301.00
30_V166_I0.5301.00
301_R321_V0.5291.00
206_D355_S0.5281.00
250_I271_L0.5281.00
117_L284_I0.5281.00
139_F143_I0.5281.00
176_K271_L0.5281.00
423_L428_V0.5281.00
77_G212_A0.5261.00
82_L91_G0.5261.00
105_A109_A0.5261.00
28_S203_F0.5251.00
110_L292_L0.5251.00
357_F404_L0.5221.00
395_L398_A0.5221.00
399_G403_V0.5221.00
374_R389_Y0.5211.00
413_M420_L0.5211.00
209_I363_Y0.5211.00
155_Q290_G0.5201.00
108_G342_M0.5201.00
378_K381_K0.5201.00
382_R386_V0.5201.00
211_L225_L0.5201.00
334_F338_L0.5171.00
221_P225_L0.5171.00
111_G121_L0.5171.00
97_V101_I0.5161.00
136_A140_L0.5151.00
383_A387_P0.5131.00
36_A39_A0.5121.00
47_A50_A0.5121.00
389_Y394_I0.5111.00
13_G149_K0.5111.00
135_I138_L0.5081.00
67_E385_S0.5081.00
278_K281_S0.5081.00
415_C422_G0.5071.00
426_L431_G0.5071.00
108_G112_L0.5061.00
8_L75_T0.5061.00
333_S336_I0.5061.00
329_W332_I0.5041.00
301_R328_P0.5041.00
98_Q362_F0.5021.00
90_W93_L0.5021.00
204_A240_Y0.5011.00
403_V408_L0.5011.00
157_L160_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9292 100 0.26 Contact Map
3giaA 1 0.9566 100 0.302 Contact Map
4djkA 2 0.9224 100 0.325 Contact Map
2jlnA 1 0.9132 98.6 0.864 Contact Map
3dh4A 3 0.9178 98.6 0.865 Contact Map
2xq2A 2 0.9201 98.5 0.869 Contact Map
2a65A 2 0.9406 97.9 0.889 Contact Map
4wgvA 2 0.8219 97.5 0.898 Contact Map
4xp4A 1 0.9429 96.8 0.908 Contact Map
4us3A 1 0.879 96.5 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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