GREMLIN Database
FLAV - Probable flavodoxin-1
UniProt: O34737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (140)
Sequences: 4250 (2874)
Seq/√Len: 242.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_N116_V3.9281.00
89_G102_V3.6421.00
103_N122_K3.3821.00
11_M66_Y2.7691.00
84_K115_A2.7361.00
110_Q116_V2.6801.00
108_M111_E2.4251.00
100_E104_L2.3891.00
108_M112_A2.2791.00
85_T106_N2.2141.00
23_K35_C2.1301.00
88_F123_I2.0591.00
85_T110_Q1.9511.00
4_A26_L1.9421.00
64_L101_A1.9251.00
41_M49_Y1.9211.00
26_L144_L1.8671.00
6_I23_K1.7771.00
7_T38_I1.7411.00
87_C102_V1.7321.00
51_Y84_K1.7191.00
16_E20_F1.6581.00
9_A68_A1.6471.00
118_Q142_G1.6381.00
106_N120_T1.6151.00
85_T116_V1.5971.00
38_I71_F1.5811.00
15_T55_G1.5371.00
106_N110_Q1.5321.00
85_T114_A1.4931.00
54_I105_F1.4611.00
60_G63_D1.4581.00
23_K33_I1.4551.00
23_K27_Q1.4421.00
56_T105_F1.4291.00
54_I109_L1.4191.00
7_T41_M1.4191.00
53_L143_F1.4121.00
18_I136_C1.4071.00
76_K108_M1.3891.00
9_A56_T1.3871.00
10_S67_E1.3761.00
3_K32_D1.3531.00
103_N120_T1.3331.00
72_F105_F1.3161.00
109_L114_A1.2781.00
72_F104_L1.2691.00
15_T90_S1.2591.00
53_L86_A1.2581.00
18_I90_S1.2511.00
71_F105_F1.2161.00
52_V83_L1.2081.00
99_C122_K1.1861.00
5_L36_V1.1611.00
86_A118_Q1.1281.00
22_I55_G1.1151.00
20_F35_C1.1001.00
88_F136_C1.0741.00
72_F108_M1.0661.00
25_T140_A1.0651.00
9_A67_E1.0621.00
116_V119_E1.0541.00
89_G99_C1.0471.00
107_V111_E1.0461.00
38_I68_A1.0431.00
22_I140_A1.0371.00
118_Q143_F1.0271.00
100_E103_N1.0251.00
88_F121_L1.0241.00
34_D49_Y1.0141.00
57_Y65_P1.0071.00
37_E67_E1.0061.00
123_I136_C1.0051.00
37_E40_D0.9731.00
86_A143_F0.9721.00
56_T68_A0.9681.00
56_T101_A0.9651.00
26_L33_I0.9571.00
64_L68_A0.9541.00
58_T99_C0.9421.00
72_F101_A0.9211.00
99_C102_V0.9201.00
7_T52_V0.9171.00
64_L72_F0.9141.00
61_D97_K0.9111.00
142_G145_A0.9091.00
138_A141_R0.9091.00
82_G115_A0.8951.00
8_Y16_E0.8931.00
25_T29_Y0.8810.99
138_A142_G0.8680.99
55_G88_F0.8680.99
25_T141_R0.8650.99
3_K34_D0.8610.99
74_E78_I0.8600.99
141_R145_A0.8540.99
49_Y52_V0.8420.99
56_T65_P0.8350.99
5_L49_Y0.8210.99
116_V120_T0.8200.99
86_A117_Y0.8200.99
11_M15_T0.8160.99
118_Q121_L0.8160.99
22_I53_L0.8120.99
118_Q146_W0.8090.99
4_A31_L0.8030.99
9_A65_P0.8000.99
12_S61_D0.7950.99
80_L114_A0.7900.99
24_D27_Q0.7890.99
5_L34_D0.7880.99
42_D45_C0.7870.99
66_Y69_E0.7850.99
36_V40_D0.7830.99
39_N67_E0.7760.99
41_M74_E0.7750.99
10_S15_T0.7720.99
17_D21_I0.7680.99
4_A51_Y0.7600.98
72_F76_K0.7590.98
21_I137_R0.7570.98
102_V120_T0.7570.98
18_I55_G0.7550.98
119_E142_G0.7520.98
3_K50_D0.7500.98
85_T109_L0.7350.98
31_L51_Y0.7330.98
16_E67_E0.7280.98
25_T137_R0.7250.98
73_E77_Q0.7210.98
9_A38_I0.7200.98
123_I127_P0.7120.98
12_S125_L0.7100.98
107_V110_Q0.7060.98
136_C140_A0.6980.97
5_L50_D0.6970.97
87_C106_N0.6880.97
76_K104_L0.6850.97
7_T36_V0.6750.97
91_G99_C0.6710.97
135_S138_A0.6520.96
43_A74_E0.6510.96
97_K100_E0.6490.96
58_T102_V0.6480.96
83_L109_L0.6470.96
24_D28_E0.6420.96
10_S17_D0.6420.96
64_L104_L0.6380.96
56_T102_V0.6370.96
27_Q33_I0.6340.95
8_Y35_C0.6290.95
15_T57_Y0.6270.95
62_G65_P0.6240.95
121_L135_S0.6230.95
7_T54_I0.6220.95
84_K117_Y0.6170.95
4_A53_L0.6170.95
59_W125_L0.6150.95
79_Q112_A0.6140.95
6_I19_A0.6010.94
46_L52_V0.5990.94
91_G95_Y0.5980.94
78_I112_A0.5950.94
93_Y126_A0.5940.94
60_G90_S0.5940.94
42_D77_Q0.5930.94
63_D104_L0.5910.93
137_R141_R0.5900.93
44_S78_I0.5860.93
92_D95_Y0.5850.93
25_T144_L0.5710.92
90_S125_L0.5700.92
88_F143_F0.5700.92
17_D20_F0.5690.92
45_C48_S0.5690.92
102_V122_K0.5680.92
51_Y147_A0.5670.92
93_Y124_E0.5610.92
136_C139_F0.5580.91
29_Y144_L0.5570.91
123_I135_S0.5510.91
64_L105_F0.5490.91
9_A101_A0.5450.90
39_N43_A0.5430.90
12_S59_W0.5430.90
48_S115_A0.5430.90
95_Y99_C0.5400.90
6_I35_C0.5370.90
19_A35_C0.5360.90
6_I26_L0.5350.90
8_Y55_G0.5320.89
24_D29_Y0.5290.89
8_Y37_E0.5250.89
9_A59_W0.5250.89
6_I50_D0.5250.89
48_S82_G0.5240.89
92_D126_A0.5220.88
36_V41_M0.5220.88
3_K49_Y0.5220.88
143_F147_A0.5180.88
104_L107_V0.5150.88
98_F120_T0.5100.87
75_V112_A0.5090.87
90_S139_F0.5060.87
79_Q82_G0.5050.87
9_A124_E0.5040.87
12_S126_A0.5030.87
54_I65_P0.5030.87
33_I36_V0.5010.86
22_I89_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.9747 100 0.165 Contact Map
2bpoA 1 0.9873 100 0.228 Contact Map
3qe2A 1 0.981 100 0.231 Contact Map
3hr4A 2 0.9747 100 0.294 Contact Map
1bvyF 1 0.9367 100 0.371 Contact Map
4h2dA 1 0.9684 100 0.388 Contact Map
1ykgA 1 0.9051 100 0.404 Contact Map
4oxxA 1 0.943 100 0.412 Contact Map
2m6rA 1 0.9177 100 0.424 Contact Map
2hnaA 1 0.9177 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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