GREMLIN Database
YJMC - Uncharacterized oxidoreductase YjmC
UniProt: O34736 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (321)
Sequences: 2096 (1555)
Seq/√Len: 86.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
318_R322_N3.9811.00
127_V163_A3.6931.00
71_V85_D3.6761.00
294_Q310_E3.3521.00
84_G92_N3.3301.00
203_G217_V3.0341.00
65_N85_D2.9701.00
205_D209_E2.8801.00
105_K133_E2.7451.00
197_E212_T2.6851.00
152_G296_S2.6551.00
12_K34_D2.5381.00
98_D129_K2.4991.00
328_R332_E2.4951.00
113_T243_A2.4301.00
97_M130_A2.3941.00
213_D216_K2.3661.00
197_E214_P2.2661.00
78_V107_K2.2631.00
131_A165_G2.2431.00
19_L52_T2.2311.00
75_T103_M2.1961.00
20_D26_E2.1631.00
77_P107_K2.1501.00
272_N275_F2.1451.00
45_H319_N2.1411.00
301_G304_R2.1341.00
304_R314_L2.0941.00
317_E321_K2.0831.00
164_Y234_V2.0521.00
68_A85_D2.0421.00
102_D106_K2.0381.00
316_E320_K1.9911.00
168_A287_D1.9821.00
11_A49_V1.9661.00
40_D45_H1.9491.00
120_C123_L1.9481.00
319_N325_S1.9431.00
99_H102_D1.9331.00
41_L319_N1.9021.00
200_E212_T1.8941.00
16_W30_E1.8901.00
148_V219_S1.8561.00
16_W20_D1.8131.00
172_K317_E1.8071.00
176_L230_G1.7911.00
33_A37_V1.7591.00
13_E17_Q1.7591.00
93_C268_V1.7491.00
128_Q132_D1.7461.00
192_R215_D1.7191.00
183_V202_W1.7071.00
101_I133_E1.6591.00
100_A110_G1.6531.00
120_C139_A1.6511.00
134_K283_L1.6501.00
205_D216_K1.6391.00
100_A270_A1.6101.00
73_K83_D1.6031.00
130_A270_A1.5971.00
51_H186_G1.5961.00
8_A41_L1.5681.00
148_V204_V1.5431.00
204_V219_S1.5411.00
165_G175_I1.5371.00
83_D116_N1.5321.00
77_P103_M1.5301.00
105_K135_L1.5281.00
159_T180_T1.5241.00
300_V304_R1.5101.00
65_N68_A1.5051.00
137_G165_G1.4810.99
80_G110_G1.4760.99
80_G112_V1.4670.99
198_I202_W1.4630.99
135_L273_P1.4600.99
147_V181_S1.4490.99
32_V88_F1.4310.99
294_Q304_R1.4100.99
42_R316_E1.3970.99
16_W26_E1.3950.99
237_V286_M1.3870.99
184_A187_K1.3660.99
111_M269_C1.3500.99
97_M129_K1.3470.99
68_A87_G1.3390.99
198_I217_V1.3360.99
94_D129_K1.3260.99
154_T296_S1.3220.99
109_V269_C1.3090.99
162_I235_V1.3090.99
137_G270_A1.3020.99
100_A112_V1.3000.99
31_K94_D1.2990.99
245_A265_G1.2910.99
138_M269_C1.2900.99
86_D116_N1.2880.99
80_G99_H1.2840.98
279_W283_L1.2800.98
99_H103_M1.2760.98
18_K56_V1.2750.98
28_D91_V1.2740.98
97_M270_A1.2650.98
211_V217_V1.2590.98
191_A198_I1.2570.98
117_S266_H1.2500.98
72_F82_L1.2470.98
26_E30_E1.2440.98
246_A263_K1.2430.98
101_I135_L1.2400.98
110_G270_A1.2320.98
291_D295_Q1.2300.98
41_L320_K1.2220.98
47_H119_H1.2170.98
15_V52_T1.2160.98
76_G275_F1.2160.98
24_L88_F1.2130.98
72_F80_G1.2030.98
59_L66_P1.1940.98
111_M267_Y1.1850.97
35_V90_H1.1830.97
17_Q20_D1.1780.97
104_A110_G1.1650.97
83_D115_V1.1510.97
64_I118_S1.1490.97
116_N263_K1.1440.97
239_S265_G1.1420.97
315_H319_N1.1410.97
22_A56_V1.1390.97
203_G211_V1.1360.97
104_A135_L1.1300.97
174_F233_I1.1230.96
15_V19_L1.1110.96
198_I203_G1.1090.96
306_Y312_E1.1040.96
314_L318_R1.1010.96
81_V115_V1.0930.96
46_S187_K1.0910.96
273_P278_D1.0870.96
57_N61_A1.0810.96
166_V234_V1.0790.96
327_A330_V1.0710.95
185_F218_V1.0680.95
12_K30_E1.0660.95
19_L32_V1.0630.95
306_Y311_I1.0610.95
80_G103_M1.0600.95
7_A10_E1.0590.95
80_G100_A1.0590.95
141_T266_H1.0550.95
143_T146_I1.0500.95
101_I105_K1.0470.95
101_I104_A1.0450.95
290_I294_Q1.0390.95
127_V139_A1.0370.94
191_A196_K1.0360.94
306_Y314_L1.0310.94
111_M271_I1.0270.94
79_T276_F1.0260.94
8_A37_V1.0230.94
73_K81_V1.0190.94
70_P85_D1.0170.94
169_K284_E1.0160.94
11_A324_I1.0140.94
28_D69_Q1.0120.94
105_K272_N1.0120.94
157_L232_S1.0090.94
192_R214_P1.0080.94
101_I130_A1.0050.93
15_V33_A1.0010.93
149_P296_S0.9980.93
127_V165_G0.9980.93
95_M98_D0.9960.93
25_N67_G0.9940.93
315_H318_R0.9850.93
178_M230_G0.9820.93
300_V303_E0.9810.93
162_I231_L0.9790.93
15_V49_V0.9760.92
139_A268_V0.9680.92
140_M235_V0.9670.92
188_I217_V0.9650.92
171_K291_D0.9640.92
97_M137_G0.9600.92
287_D291_D0.9590.92
76_G272_N0.9570.92
111_M276_F0.9520.91
326_I331_Y0.9480.91
311_I315_H0.9430.91
69_Q95_M0.9430.91
174_F290_I0.9420.91
169_K287_D0.9350.91
29_A33_A0.9350.91
150_F229_Y0.9250.90
72_F99_H0.9240.90
128_Q175_I0.9230.90
146_I185_F0.9220.90
124_S127_V0.9220.90
197_E213_D0.9210.90
188_I276_F0.9200.90
119_H186_G0.9190.90
11_A326_I0.9100.90
201_G221_S0.9100.90
72_F95_M0.9070.89
22_A60_L0.9040.89
156_I296_S0.9040.89
149_P229_Y0.8990.89
96_A112_V0.8980.89
98_D102_D0.8940.89
38_H316_E0.8930.89
84_G114_A0.8920.89
147_V180_T0.8900.88
317_E320_K0.8840.88
169_K283_L0.8800.88
30_E34_D0.8710.87
200_E210_A0.8710.87
49_V330_V0.8700.87
183_V187_K0.8630.87
8_A324_I0.8590.87
12_K16_W0.8580.87
8_A320_K0.8520.86
71_V83_D0.8510.86
168_A171_K0.8510.86
34_D125_Y0.8500.86
14_L18_K0.8490.86
233_I289_M0.8460.86
120_C266_H0.8410.86
211_V216_K0.8400.85
25_N28_D0.8370.85
325_S328_R0.8340.85
9_E13_E0.8330.85
290_I307_V0.8270.85
104_A270_A0.8270.85
114_A266_H0.8260.84
250_H292_E0.8240.84
273_P277_T0.8220.84
157_L233_I0.8200.84
193_E333_F0.8130.84
143_T158_G0.8120.83
130_A137_G0.8100.83
128_Q316_E0.8100.83
156_I292_E0.8090.83
278_D281_T0.8060.83
70_P82_L0.8030.83
153_R207_N0.8000.83
229_Y233_I0.7980.82
103_M110_G0.7970.82
98_D133_E0.7950.82
42_R128_Q0.7910.82
287_D290_I0.7890.82
236_D240_G0.7890.82
168_A290_I0.7890.82
92_N114_A0.7820.81
209_E300_V0.7800.81
93_C120_C0.7800.81
134_K279_W0.7710.80
70_P92_N0.7710.80
305_V310_E0.7690.80
82_L112_V0.7640.80
280_D284_E0.7640.80
79_T275_F0.7630.79
99_H112_V0.7630.79
100_A130_A0.7620.79
167_P173_P0.7620.79
84_G117_S0.7610.79
201_G212_T0.7600.79
113_T267_Y0.7600.79
178_M231_L0.7590.79
166_V282_F0.7580.79
147_V219_S0.7580.79
180_T223_F0.7560.79
86_D263_K0.7560.79
50_L189_L0.7530.79
170_H287_D0.7530.79
47_H186_G0.7500.78
140_M267_Y0.7500.78
147_V222_T0.7490.78
164_Y235_V0.7440.78
229_Y307_V0.7430.78
192_R218_V0.7420.78
82_L95_M0.7410.77
38_H125_Y0.7370.77
307_V310_E0.7360.77
171_K287_D0.7360.77
277_T285_Q0.7300.76
139_A266_H0.7300.76
182_K225_G0.7280.76
24_L32_V0.7250.76
314_L317_E0.7220.76
147_V232_S0.7210.76
82_L96_A0.7210.76
204_V221_S0.7200.75
152_G229_Y0.7160.75
42_R122_A0.7160.75
31_K91_V0.7090.74
55_Y121_G0.7070.74
97_M101_I0.7060.74
94_D98_D0.7060.74
10_E13_E0.7060.74
51_H119_H0.7030.74
180_T232_S0.7020.74
74_E106_K0.7000.73
22_A59_L0.7000.73
184_A191_A0.6980.73
6_I331_Y0.6960.73
82_L99_H0.6930.73
70_P95_M0.6920.73
190_Q194_E0.6910.72
8_A12_K0.6870.72
76_G107_K0.6870.72
138_M164_Y0.6860.72
157_L289_M0.6850.72
168_A173_P0.6850.72
81_V113_T0.6840.72
310_E314_L0.6840.72
199_P202_W0.6800.71
206_E216_K0.6770.71
43_N309_G0.6750.71
7_A324_I0.6750.71
310_E313_Q0.6730.70
206_E321_K0.6720.70
18_K52_T0.6690.70
132_D172_K0.6670.70
40_D319_N0.6650.70
51_H189_L0.6640.69
135_L270_A0.6610.69
49_V326_I0.6550.68
40_D49_V0.6530.68
62_G214_P0.6520.68
16_W33_A0.6510.68
136_I238_F0.6500.68
182_K202_W0.6490.68
164_Y238_F0.6490.68
34_D94_D0.6460.67
97_M100_A0.6440.67
46_S119_H0.6420.67
114_A268_V0.6410.67
9_E12_K0.6410.67
32_V91_V0.6410.67
27_R30_E0.6400.67
242_L271_I0.6390.66
39_A121_G0.6390.66
182_K221_S0.6360.66
294_Q307_V0.6350.66
127_V131_A0.6350.66
159_T201_G0.6340.66
17_Q21_G0.6320.66
188_I220_L0.6320.66
75_T107_K0.6300.65
223_F231_L0.6270.65
14_L17_Q0.6250.65
55_Y119_H0.6240.65
27_R69_Q0.6230.64
96_A114_A0.6230.64
249_P292_E0.6220.64
36_L52_T0.6200.64
284_E288_A0.6190.64
28_D67_G0.6190.64
142_H245_A0.6180.64
11_A37_V0.6180.64
35_V122_A0.6170.64
180_T229_Y0.6170.64
120_C312_E0.6170.64
330_V333_F0.6160.64
73_K115_V0.6160.64
12_K320_K0.6150.63
235_V264_L0.6140.63
247_F288_A0.6130.63
174_F308_P0.6040.62
53_E333_F0.6030.62
117_S120_C0.6030.62
32_V90_H0.6030.62
195_G215_D0.6020.62
103_M107_K0.6020.62
69_Q85_D0.6010.62
35_V125_Y0.6000.62
30_E209_E0.5990.61
14_L334_L0.5980.61
198_I212_T0.5950.61
65_N87_G0.5930.61
166_V237_V0.5920.61
74_E103_M0.5900.60
189_L192_R0.5890.60
86_D262_R0.5890.60
28_D88_F0.5870.60
188_I198_I0.5850.60
81_V275_F0.5850.60
293_L305_V0.5850.60
160_N235_V0.5820.59
189_L193_E0.5810.59
294_Q305_V0.5800.59
45_H49_V0.5770.59
238_F267_Y0.5770.59
315_H325_S0.5770.59
42_R312_E0.5730.58
143_T159_T0.5720.58
51_H185_F0.5710.58
156_I293_L0.5670.57
75_T99_H0.5670.57
102_D133_E0.5660.57
38_H42_R0.5650.57
35_V39_A0.5640.57
234_V267_Y0.5640.57
329_S333_F0.5640.57
56_V60_L0.5630.57
123_L266_H0.5620.57
75_T79_T0.5600.56
237_V282_F0.5590.56
87_G90_H0.5580.56
95_M99_H0.5570.56
46_S141_T0.5570.56
185_F203_G0.5560.56
30_E67_G0.5560.56
170_H291_D0.5550.56
306_Y310_E0.5550.56
328_R331_Y0.5550.56
171_K294_Q0.5540.56
18_K22_A0.5520.55
84_G229_Y0.5520.55
35_V126_F0.5510.55
134_K169_K0.5500.55
147_V159_T0.5490.55
233_I293_L0.5480.55
45_H325_S0.5480.55
166_V174_F0.5470.55
75_T80_G0.5460.55
136_I271_I0.5460.55
127_V175_I0.5460.55
12_K37_V0.5460.55
286_M290_I0.5450.54
127_V137_G0.5450.54
73_K103_M0.5410.54
206_E211_V0.5400.54
274_S278_D0.5390.54
293_L307_V0.5390.54
50_L193_E0.5380.53
27_R95_M0.5370.53
17_Q321_K0.5370.53
150_F226_P0.5370.53
26_E69_Q0.5350.53
250_H288_A0.5340.53
145_S252_A0.5320.53
65_N86_D0.5300.52
195_G200_E0.5290.52
288_A291_D0.5280.52
308_P311_I0.5280.52
89_G126_F0.5280.52
6_I10_E0.5270.52
117_S142_H0.5270.52
23_G104_A0.5270.52
104_A108_G0.5250.52
147_V185_F0.5240.52
146_I182_K0.5240.52
295_Q314_L0.5220.51
207_N321_K0.5220.51
273_P279_W0.5220.51
58_R118_S0.5190.51
46_S190_Q0.5190.51
72_F103_M0.5180.51
241_L249_P0.5160.50
11_A282_F0.5160.50
8_A11_A0.5150.50
131_A287_D0.5150.50
43_N222_T0.5140.50
12_K33_A0.5140.50
271_I276_F0.5130.50
176_L234_V0.5110.50
140_M147_V0.5110.50
151_G306_Y0.5090.50
193_E330_V0.5090.50
93_C114_A0.5080.49
62_G324_I0.5070.49
78_V109_V0.5070.49
129_K133_E0.5060.49
144_D185_F0.5060.49
52_T162_I0.5050.49
41_L323_G0.5050.49
77_P106_K0.5040.49
47_H51_H0.5030.49
87_G92_N0.5020.49
122_A142_H0.5000.48
213_D320_K0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vbiA 2 0.9852 100 0.048 Contact Map
4h8aA 2 0.9911 100 0.054 Contact Map
3uoeA 2 0.9852 100 0.058 Contact Map
3i0pA 2 0.9911 100 0.059 Contact Map
1z2iA 2 0.9911 100 0.061 Contact Map
1v9nA 2 0.9525 100 0.064 Contact Map
1nxuA 2 0.9763 100 0.066 Contact Map
2x06A 2 0.9703 100 0.069 Contact Map
1wtjA 2 0.9763 100 0.071 Contact Map
2g8yA 2 0.9822 100 0.075 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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