GREMLIN Database
SULP - Sulfate permease CysP
UniProt: O34734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (309)
Sequences: 3029 (1573)
Seq/√Len: 89.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K39_Y5.0201.00
14_M217_L4.4281.00
58_E256_G4.3511.00
43_L174_F2.8801.00
110_V124_L2.8051.00
123_N126_I2.7801.00
115_A306_Y2.7171.00
222_V225_T2.7071.00
129_S133_F2.6981.00
42_I46_V2.6741.00
77_I112_V2.6161.00
144_F148_L2.6121.00
84_A304_I2.6011.00
128_V132_V2.5501.00
5_A195_A2.5471.00
307_L311_L2.5391.00
149_F240_L2.4801.00
28_A173_G2.4291.00
34_I170_L2.3751.00
61_K65_S2.3021.00
16_I101_T2.2771.00
19_S92_A2.2351.00
50_A178_F2.2041.00
49_F209_A2.1671.00
10_L210_F2.1611.00
10_L206_Y2.1481.00
91_T95_L2.1131.00
92_A99_L2.0381.00
309_V313_L2.0321.00
41_L216_L2.0231.00
68_I113_G2.0051.00
168_V239_I1.9761.00
303_S307_L1.9271.00
103_E263_Q1.9121.00
93_N222_V1.8951.00
47_G174_F1.8931.00
139_F274_M1.8661.00
25_M29_Y1.8651.00
245_G265_T1.8461.00
150_R276_K1.8251.00
179_S249_V1.8241.00
133_F137_F1.8121.00
8_F79_C1.7891.00
48_V215_A1.7841.00
213_L217_L1.7711.00
165_L239_I1.7441.00
310_S313_L1.7421.00
19_S93_N1.7421.00
87_L91_T1.7371.00
44_C177_A1.7321.00
27_V242_S1.7051.00
93_N99_L1.6771.00
20_G23_A1.6711.00
145_V240_L1.6561.00
125_L128_V1.6531.00
89_L101_T1.6411.00
2_E199_D1.6381.00
226_N266_S1.6251.00
48_V180_A1.6221.00
252_S259_V1.6061.00
212_A215_A1.5901.00
80_I308_L1.5901.00
27_V265_T1.5851.00
226_N269_I1.5801.00
300_L304_I1.5801.00
253_S256_G1.5791.00
33_A242_S1.5381.00
24_S176_E1.5171.00
282_F287_V1.5101.00
19_S89_L1.4761.00
151_Y154_I1.4741.00
13_A210_F1.4731.00
175_F246_A1.4540.99
34_I242_S1.4360.99
3_L7_L1.4160.99
148_L152_F1.4120.99
184_N262_A1.4090.99
41_L45_A1.4060.99
44_C215_A1.4050.99
147_K151_Y1.4030.99
306_Y310_S1.4000.99
97_I293_V1.3850.99
193_V202_K1.3840.99
12_F85_A1.3830.99
307_L310_S1.3730.99
196_G200_V1.3570.99
288_Q292_K1.3570.99
15_N90_F1.3410.99
32_G228_K1.3350.99
106_V127_I1.3350.99
136_L140_G1.3340.99
182_M253_S1.3320.99
11_F90_F1.3310.99
51_G208_G1.3300.99
116_Y309_V1.3170.99
205_L209_A1.3050.99
19_S222_V1.2970.99
172_A243_G1.2920.99
259_V264_V1.2920.99
88_S297_S1.2910.99
301_S305_S1.2850.99
19_S101_T1.2780.99
305_S308_L1.2780.99
82_I246_A1.2730.99
7_L136_L1.2710.99
24_S238_G1.2460.98
19_S99_L1.2450.98
143_Y275_A1.2410.98
143_Y278_G1.2240.98
125_L129_S1.2240.98
224_E229_K1.2120.98
249_V264_V1.2090.98
149_F153_K1.2070.98
234_S276_K1.2050.98
176_E233_F1.2030.98
28_A43_L1.2010.98
185_V211_V1.1990.98
53_V205_L1.1800.98
82_I178_F1.1740.98
292_K296_V1.1730.98
79_C312_F1.1700.97
148_L151_Y1.1650.97
224_E228_K1.1640.97
230_I286_V1.1580.97
108_A112_V1.1460.97
178_F243_G1.1410.97
119_L124_L1.1350.97
241_L265_T1.1280.97
183_N249_V1.1220.97
14_M218_L1.1200.97
11_F15_N1.1190.97
69_P72_T1.1040.96
139_F267_S1.1030.96
18_A93_N1.0960.96
87_L308_L1.0950.96
270_I287_V1.0950.96
64_S102_S1.0810.96
112_V305_S1.0790.96
120_F123_N1.0740.96
225_T290_M1.0680.96
49_F212_A1.0660.96
128_V300_L1.0610.95
45_A212_A1.0550.95
196_G199_D1.0530.95
308_L312_F1.0530.95
11_F86_A1.0440.95
81_I109_V1.0400.95
39_Y42_I1.0330.95
242_S265_T1.0310.95
63_I190_G1.0270.95
46_V50_A1.0250.95
169_L242_S1.0240.95
21_A211_V1.0200.94
220_R224_E1.0150.94
84_A301_S1.0080.94
127_I130_F0.9930.94
167_I171_V0.9920.94
219_G222_V0.9900.93
23_A261_L0.9900.93
305_S309_V0.9890.93
114_V118_V0.9890.93
283_H286_V0.9850.93
223_L230_I0.9820.93
61_K64_S0.9810.93
302_L306_Y0.9680.93
50_A54_I0.9670.93
55_G182_M0.9610.92
89_L93_N0.9590.92
64_S197_V0.9550.92
76_T312_F0.9550.92
2_E195_A0.9520.92
75_L198_L0.9450.92
80_I84_A0.9440.92
168_V171_V0.9430.92
249_V253_S0.9410.92
43_L47_G0.9400.92
107_G301_S0.9390.92
225_T286_V0.9370.91
132_V295_I0.9250.91
169_L238_G0.9180.91
42_I151_Y0.9170.91
32_G287_V0.9160.91
23_A180_A0.9140.90
278_G281_V0.9110.90
8_F178_F0.9100.90
7_L11_F0.9040.90
189_V207_G0.9010.90
228_K232_R0.9010.90
52_A208_G0.9000.90
81_I105_T0.8990.90
234_S237_E0.8980.90
115_A310_S0.8960.90
130_F134_V0.8930.89
93_N221_R0.8860.89
231_T273_G0.8810.89
184_N261_L0.8790.89
80_I312_F0.8780.89
143_Y147_K0.8780.89
130_F182_M0.8740.88
4_A76_T0.8680.88
59_V256_G0.8670.88
23_A297_S0.8650.88
99_L222_V0.8640.88
244_T267_S0.8610.88
33_A166_G0.8610.88
172_A242_S0.8560.87
156_V161_K0.8540.87
32_G221_R0.8520.87
264_V268_S0.8520.87
114_V144_F0.8520.87
244_T248_L0.8510.87
54_I178_F0.8490.87
245_G268_S0.8470.87
110_V119_L0.8460.87
15_N188_A0.8410.86
164_I168_V0.8380.86
278_G283_H0.8370.86
14_M90_F0.8340.86
55_G176_E0.8320.86
55_G208_G0.8300.86
175_F247_G0.8250.85
201_G204_T0.8220.85
285_Q288_Q0.8190.85
198_L202_K0.8160.85
205_L213_L0.8150.85
182_M195_A0.8100.84
103_E180_A0.8100.84
26_G218_L0.8090.84
45_A177_A0.8080.84
132_V140_G0.8060.84
173_G176_E0.8040.84
144_F149_F0.8040.84
66_G78_V0.8020.84
84_A302_L0.8000.83
92_A101_T0.7990.83
104_V297_S0.7950.83
285_Q289_T0.7930.83
121_V125_L0.7920.83
237_E276_K0.7920.83
166_G221_R0.7840.82
128_V295_I0.7830.82
96_G221_R0.7770.82
147_K150_R0.7760.82
132_V243_G0.7740.81
87_L213_L0.7670.81
223_L242_S0.7620.80
153_K165_L0.7600.80
40_A273_G0.7600.80
89_L99_L0.7600.80
131_W135_P0.7540.80
144_F307_L0.7490.79
44_C48_V0.7430.79
206_Y210_F0.7430.79
262_A297_S0.7400.78
197_V202_K0.7390.78
233_F241_L0.7370.78
18_A92_A0.7370.78
21_A215_A0.7360.78
81_I85_A0.7340.78
18_A101_T0.7290.77
142_T268_S0.7230.77
96_G108_A0.7200.77
227_G230_I0.7180.76
87_L304_I0.7140.76
185_V207_G0.7130.76
230_I269_I0.7120.76
230_I233_F0.7110.76
2_E201_G0.7110.76
23_A48_V0.7080.75
237_E256_G0.7080.75
64_S194_A0.7070.75
58_E127_I0.7070.75
20_G262_A0.7060.75
110_V115_A0.7060.75
28_A33_A0.7050.75
173_G177_A0.7040.75
85_A110_V0.7040.75
53_V208_G0.7030.75
89_L92_A0.7030.75
169_L235_K0.7030.75
29_Y40_A0.7020.75
49_F53_V0.6990.74
298_P301_S0.6960.74
189_V192_L0.6940.74
64_S78_V0.6910.74
81_I108_A0.6900.73
47_G216_L0.6820.73
179_S183_N0.6820.73
240_L244_T0.6820.73
180_A184_N0.6790.72
32_G35_K0.6770.72
7_L285_Q0.6750.72
43_L195_A0.6680.71
4_A312_F0.6680.71
238_G261_L0.6680.71
121_V205_L0.6670.71
37_K42_I0.6650.71
66_G119_L0.6650.71
116_Y301_S0.6650.71
179_S253_S0.6640.71
5_A79_C0.6630.70
63_I106_V0.6630.70
22_A135_P0.6620.70
186_A189_V0.6600.70
171_V198_L0.6600.70
91_T304_I0.6570.70
54_I291_L0.6560.70
177_A190_G0.6560.70
113_G298_P0.6550.70
20_G297_S0.6540.69
236_G240_L0.6530.69
8_F301_S0.6520.69
67_I190_G0.6480.69
31_S48_V0.6470.69
291_L295_I0.6470.69
46_V213_L0.6460.68
4_A94_L0.6440.68
172_A239_I0.6430.68
158_S161_K0.6390.68
59_V62_T0.6380.68
200_V203_G0.6360.67
75_L195_A0.6360.67
31_S102_S0.6350.67
84_A108_A0.6340.67
83_G122_N0.6340.67
145_V243_G0.6340.67
58_E61_K0.6330.67
6_I10_L0.6320.67
54_I58_E0.6300.67
76_T80_I0.6300.67
263_Q309_V0.6290.66
2_E61_K0.6280.66
104_V188_A0.6270.66
43_L51_G0.6270.66
179_S264_V0.6260.66
7_L74_T0.6250.66
294_W297_S0.6230.66
241_L269_I0.6230.66
7_L292_K0.6210.65
174_F177_A0.6200.65
153_K156_V0.6180.65
196_G204_T0.6170.65
59_V121_V0.6150.65
261_L297_S0.6140.65
77_I174_F0.6100.64
176_E245_G0.6090.64
192_L207_G0.6070.64
60_V193_V0.6070.64
104_V115_A0.6070.64
15_N89_L0.6050.63
12_F101_T0.6050.63
253_S263_Q0.6040.63
218_L222_V0.6040.63
148_L158_S0.6030.63
199_D202_K0.6010.63
14_M287_V0.5980.63
266_S270_I0.5950.62
79_C143_Y0.5950.62
7_L312_F0.5930.62
172_A275_A0.5910.62
87_L95_L0.5910.62
188_A207_G0.5900.62
276_K281_V0.5880.61
186_A218_L0.5880.61
143_Y177_A0.5880.61
83_G87_L0.5880.61
172_A246_A0.5860.61
29_Y272_I0.5850.61
83_G308_L0.5850.61
2_E6_I0.5830.61
207_G210_F0.5830.61
107_G111_G0.5820.60
18_A89_L0.5810.60
8_F86_A0.5800.60
128_V159_S0.5780.60
146_S236_G0.5760.60
304_I308_L0.5760.60
218_L221_R0.5750.60
13_A101_T0.5740.59
238_G242_S0.5710.59
163_K167_I0.5700.59
265_T269_I0.5700.59
186_A193_V0.5700.59
43_L208_G0.5670.58
46_V311_L0.5660.58
108_A149_F0.5660.58
226_N230_I0.5640.58
24_S28_A0.5640.58
36_K220_R0.5630.58
69_P91_T0.5620.58
186_A262_A0.5610.58
138_A257_M0.5610.58
112_V234_S0.5610.58
301_S304_I0.5600.58
133_F310_S0.5590.57
268_S287_V0.5590.57
13_A188_A0.5590.57
184_N187_N0.5570.57
229_K232_R0.5560.57
159_S163_K0.5560.57
58_E66_G0.5560.57
51_G131_W0.5550.57
85_A135_P0.5550.57
112_V115_A0.5540.57
249_V259_V0.5520.56
179_S250_I0.5490.56
170_L249_V0.5490.56
4_A83_G0.5490.56
80_I184_N0.5470.56
175_F250_I0.5450.56
28_A115_A0.5440.55
40_A269_I0.5430.55
104_V263_Q0.5430.55
43_L170_L0.5420.55
28_A170_L0.5410.55
31_S114_V0.5410.55
174_F247_G0.5410.55
127_I301_S0.5390.55
66_G69_P0.5390.55
141_F313_L0.5390.55
20_G261_L0.5380.55
83_G209_A0.5360.54
48_V103_E0.5340.54
7_L254_V0.5320.54
31_S42_I0.5320.54
85_A101_T0.5320.54
162_Q283_H0.5310.54
161_K209_A0.5310.54
124_L254_V0.5310.54
28_A242_S0.5300.53
170_L208_G0.5300.53
2_E136_L0.5280.53
18_A218_L0.5270.53
117_K143_Y0.5260.53
239_I288_Q0.5240.53
177_A267_S0.5240.53
144_F311_L0.5240.53
103_E293_V0.5230.53
222_V229_K0.5220.52
162_Q236_G0.5210.52
124_L243_G0.5210.52
103_E297_S0.5210.52
121_V193_V0.5200.52
183_N253_S0.5200.52
54_I145_V0.5190.52
47_G50_A0.5180.52
32_G281_V0.5170.52
86_A206_Y0.5140.51
248_L269_I0.5140.51
9_S82_I0.5120.51
226_N274_M0.5120.51
19_S135_P0.5120.51
225_T230_I0.5100.51
303_S310_S0.5100.51
71_Q311_L0.5090.51
32_G163_K0.5090.51
217_L220_R0.5070.50
193_V201_G0.5070.50
50_A292_K0.5060.50
106_V258_P0.5060.50
144_F292_K0.5060.50
21_A131_W0.5040.50
7_L205_L0.5010.50
113_G204_T0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cz8A 2 0.7175 17.5 0.969 Contact Map
4czbA 2 0.7373 16.4 0.97 Contact Map
2nq2A 2 0.7429 12.4 0.971 Contact Map
4pypA 1 0.5169 10 0.972 Contact Map
4humA 1 0.9011 9.9 0.972 Contact Map
3w4tA 1 0.8729 8.9 0.973 Contact Map
3pjzA 2 0.2006 7.6 0.974 Contact Map
4nefA 4 0.4548 7.5 0.974 Contact Map
2kncA 1 0.1412 7.4 0.974 Contact Map
2qi9A 2 0.7514 6.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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