GREMLIN Database
YLBK - Uncharacterized NTE family protein YlbK
UniProt: O34731 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (245)
Sequences: 8887 (6803)
Seq/√Len: 434.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_D149_R3.8741.00
44_A134_S3.3511.00
26_S244_N3.2731.00
26_S240_E3.1601.00
48_S131_V3.1171.00
237_S241_E2.9621.00
246_M249_K2.7261.00
25_S60_K2.6791.00
25_S240_E2.6431.00
111_A122_F2.5161.00
29_K240_E2.5011.00
26_S29_K2.4831.00
145_R150_L2.4791.00
92_H128_S2.4551.00
88_R129_D2.4371.00
231_N234_E2.4301.00
17_G42_M2.3361.00
113_D120_I2.2481.00
10_L20_H2.2481.00
47_G107_L2.2481.00
120_I151_L2.1101.00
26_S243_T2.0931.00
19_A242_A2.0141.00
215_I219_P1.9951.00
38_A165_V1.9841.00
119_K158_D1.9551.00
23_V176_S1.8361.00
26_S30_H1.8261.00
126_S129_D1.8141.00
60_K64_K1.8071.00
160_I175_A1.7351.00
37_I47_G1.7321.00
25_S57_A1.7041.00
42_M63_A1.6911.00
28_H56_V1.6791.00
233_E237_S1.6681.00
12_S159_R1.6681.00
240_E244_N1.6641.00
228_S231_N1.6641.00
55_D58_T1.6601.00
152_V156_V1.6521.00
241_E245_R1.6461.00
64_K233_E1.6441.00
98_K102_E1.6241.00
115_Q149_R1.5951.00
158_D163_S1.5751.00
88_R132_R1.5621.00
7_G165_V1.5591.00
113_D116_T1.5551.00
224_Y235_M1.5381.00
30_H244_N1.5331.00
24_L50_Y1.5061.00
30_H247_I1.4851.00
99_P102_E1.4821.00
129_D144_Q1.4801.00
90_L94_Y1.4521.00
138_P156_V1.4481.00
238_A241_E1.4461.00
111_A151_L1.4221.00
7_G36_M1.4191.00
61_K65_A1.4001.00
214_D219_P1.3971.00
25_S29_K1.3861.00
145_R148_G1.3841.00
242_A245_R1.3711.00
122_F130_A1.3641.00
131_V134_S1.3511.00
177_D218_R1.3441.00
38_A108_G1.3441.00
40_S110_V1.3341.00
225_S228_S1.3301.00
23_V243_T1.3221.00
11_G160_I1.3171.00
110_V119_K1.3101.00
119_K157_V1.3051.00
103_L127_V1.3031.00
243_T247_I1.3021.00
112_C157_V1.3021.00
123_R168_M1.2921.00
84_G132_R1.2791.00
237_S240_E1.2781.00
5_K35_D1.2511.00
7_G170_A1.2291.00
114_L152_V1.2191.00
29_K244_N1.2061.00
58_T61_K1.2011.00
89_Q93_A1.1961.00
234_E238_A1.1941.00
48_S107_L1.1931.00
164_V167_D1.1921.00
56_V59_M1.1881.00
196_Q200_I1.1861.00
37_I51_A1.1681.00
108_G121_V1.1651.00
80_G142_I1.1601.00
108_G123_R1.1551.00
136_S144_Q1.1481.00
6_I172_I1.1471.00
197_S201_L1.1291.00
44_A135_I1.1281.00
26_S247_I1.1261.00
224_Y228_S1.1251.00
110_V121_V1.1201.00
115_Q150_L1.1151.00
106_P123_R1.1051.00
5_K171_D1.1021.00
51_A107_L1.0991.00
108_G168_M1.0981.00
88_R92_H1.0941.00
164_V168_M1.0911.00
41_S153_D1.0851.00
37_I105_I1.0761.00
108_G164_V1.0611.00
61_K64_K1.0561.00
166_K173_I1.0561.00
204_E207_R1.0461.00
133_A151_L1.0431.00
207_R210_T1.0381.00
121_V164_V1.0371.00
241_E244_N1.0271.00
146_L151_L1.0241.00
217_I242_A1.0231.00
224_Y227_S1.0211.00
226_S229_F1.0091.00
60_K236_I1.0091.00
20_H46_V1.0001.00
8_L34_V0.9881.00
205_L209_Q0.9881.00
57_A60_K0.9841.00
232_I236_I0.9841.00
6_I34_V0.9831.00
122_F151_L0.9791.00
163_S167_D0.9761.00
9_A165_V0.9711.00
207_R211_I0.9661.00
122_F146_L0.9651.00
87_V135_I0.9531.00
21_L56_V0.9501.00
129_D146_L0.9491.00
220_S242_A0.9451.00
85_D89_Q0.9381.00
100_I103_L0.9371.00
36_M165_V0.9351.00
197_S202_Q0.9341.00
201_L204_E0.9181.00
238_A242_A0.9181.00
240_E243_T0.9171.00
205_L208_H0.9161.00
204_E208_H0.9151.00
111_A130_A0.9131.00
90_L93_A0.9131.00
36_M108_G0.9111.00
45_L91_V0.9101.00
28_H50_Y0.9081.00
64_K236_I0.9011.00
132_R136_S0.8971.00
116_T149_R0.8971.00
10_L47_G0.8851.00
198_M202_Q0.8791.00
8_L24_L0.8741.00
198_M201_L0.8721.00
202_Q205_L0.8721.00
70_L74_Y0.8541.00
128_S132_R0.8481.00
38_A164_V0.8461.00
7_G38_A0.8451.00
22_G239_G0.8431.00
36_M168_M0.8401.00
8_L37_I0.8381.00
214_D217_I0.8381.00
208_H211_I0.8341.00
52_A95_T0.8341.00
189_H192_D0.8321.00
239_G243_T0.8301.00
20_H176_S0.8291.00
133_A146_L0.8261.00
28_H53_G0.8201.00
49_F95_T0.8151.00
162_V175_A0.8121.00
30_H248_S0.8111.00
181_V218_R0.8091.00
45_L135_I0.8081.00
20_H178_V0.8081.00
213_A216_M0.8031.00
225_S229_F0.8021.00
111_A120_I0.7991.00
138_P154_G0.7931.00
92_H126_S0.7901.00
57_A61_K0.7881.00
91_V95_T0.7851.00
47_G51_A0.7821.00
12_S40_S0.7801.00
199_D202_Q0.7801.00
113_D151_L0.7771.00
71_Y75_T0.7771.00
224_Y229_F0.7761.00
27_L243_T0.7741.00
12_S155_A0.7741.00
65_A93_A0.7731.00
59_M63_A0.7681.00
29_K55_D0.7631.00
35_D106_P0.7621.00
234_E237_S0.7591.00
17_G20_H0.7591.00
24_L28_H0.7591.00
34_V174_I0.7581.00
9_A162_V0.7571.00
114_L143_P0.7561.00
21_L60_K0.7561.00
54_H58_T0.7531.00
97_G126_S0.7501.00
49_F59_M0.7461.00
165_V170_A0.7441.00
44_A131_V0.7441.00
89_Q92_H0.7421.00
192_D195_M0.7371.00
33_E105_I0.7361.00
175_A213_A0.7361.00
193_V197_S0.7351.00
216_M220_S0.7351.00
194_I197_S0.7341.00
172_I176_S0.7321.00
56_V60_K0.7311.00
25_S56_V0.7281.00
62_V66_F0.7251.00
120_I149_R0.7231.00
28_H33_E0.7231.00
101_E124_K0.7181.00
14_G137_I0.7171.00
143_P152_V0.7171.00
7_G173_I0.7171.00
36_M170_A0.7151.00
131_V135_I0.7141.00
143_P150_L0.7131.00
213_A217_I0.7061.00
194_I198_M0.7001.00
215_I218_R0.6951.00
44_A109_I0.6951.00
22_G240_E0.6941.00
16_R179_S0.6921.00
200_I203_N0.6891.00
155_A159_R0.6861.00
42_M178_V0.6831.00
11_G178_V0.6811.00
67_K70_L0.6801.00
51_A103_L0.6801.00
201_L205_L0.6801.00
88_R128_S0.6771.00
109_I122_F0.6761.00
189_H193_V0.6731.00
41_S137_I0.6731.00
22_G243_T0.6711.00
11_G177_D0.6691.00
21_L46_V0.6691.00
99_P103_L0.6621.00
217_I222_E0.6611.00
37_I50_Y0.6611.00
49_F94_Y0.6560.99
158_D164_V0.6530.99
57_A64_K0.6530.99
9_A38_A0.6470.99
132_R144_Q0.6430.99
199_D203_N0.6420.99
91_V128_S0.6410.99
244_N248_S0.6400.99
69_R75_T0.6390.99
223_T238_A0.6390.99
15_A229_F0.6380.99
178_V181_V0.6370.99
28_H55_D0.6370.99
193_V196_Q0.6350.99
194_I201_L0.6340.99
201_L207_R0.6340.99
196_Q199_D0.6320.99
216_M219_P0.6310.99
243_T246_M0.6310.99
197_S204_E0.6300.99
65_A68_R0.6280.99
190_I197_S0.6250.99
100_I127_V0.6230.99
106_P168_M0.6230.99
110_V164_V0.6220.99
9_A160_I0.6210.99
111_A133_A0.6190.99
84_G88_R0.6180.99
18_L42_M0.6180.99
82_L140_I0.6140.99
218_R222_E0.6120.99
198_M205_L0.6110.99
134_S154_G0.6080.99
118_E149_R0.6070.99
36_M106_P0.6020.99
216_M221_L0.6000.99
47_G109_I0.5970.99
33_E53_G0.5960.99
51_A105_I0.5950.99
219_P222_E0.5930.99
188_V193_V0.5920.99
86_R89_Q0.5850.99
27_L34_V0.5840.99
214_D218_R0.5830.99
192_D196_Q0.5820.99
46_V63_A0.5820.99
163_S209_Q0.5820.99
194_I202_Q0.5810.99
6_I9_A0.5810.99
137_I140_I0.5810.99
215_I221_L0.5790.99
22_G26_S0.5770.99
197_S205_L0.5770.99
191_F195_M0.5730.99
84_G142_I0.5720.99
217_I243_T0.5720.99
5_K170_A0.5710.99
27_L174_I0.5700.99
213_A218_R0.5680.99
223_T229_F0.5680.99
193_V198_M0.5670.99
239_G242_A0.5660.99
245_R248_S0.5660.99
121_V158_D0.5630.98
69_R74_Y0.5620.98
92_H97_G0.5620.98
99_P126_S0.5600.98
10_L37_I0.5580.98
24_L27_L0.5540.98
137_I152_V0.5530.98
109_I124_K0.5530.98
73_D83_K0.5520.98
15_A67_K0.5510.98
206_V209_Q0.5500.98
242_A246_M0.5470.98
69_R72_A0.5470.98
48_S109_I0.5450.98
165_V173_I0.5430.98
217_I221_L0.5400.98
18_L63_A0.5390.98
217_I220_S0.5380.98
71_Y74_Y0.5350.98
66_F70_L0.5340.98
165_V168_M0.5330.98
39_G43_G0.5310.98
64_K67_K0.5300.98
190_I198_M0.5300.98
194_I203_N0.5280.98
221_L238_A0.5270.98
97_G128_S0.5260.98
201_L208_H0.5240.98
117_G196_Q0.5240.98
204_E209_Q0.5210.97
189_H194_I0.5200.97
191_F198_M0.5180.97
224_Y231_N0.5180.97
120_I147_D0.5150.97
245_R249_K0.5140.97
107_L131_V0.5140.97
188_V192_D0.5130.97
193_V200_I0.5130.97
112_C117_G0.5120.97
63_A66_F0.5080.97
11_G159_R0.5070.97
18_L22_G0.5070.97
233_E236_I0.5070.97
129_D132_R0.5060.97
85_D88_R0.5020.97
28_H57_A0.5020.97
169_G172_I0.5020.97
25_S28_H0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4akfA 2 0.9808 100 0.263 Contact Map
4qmkA 2 0.7615 100 0.268 Contact Map
3tu3B 1 0.8385 100 0.284 Contact Map
4pk9A 2 0.9923 100 0.308 Contact Map
1cjyA 1 0.8231 99.4 0.753 Contact Map
3k89A 1 0.9269 83.4 0.92 Contact Map
4c23A 1 0.2962 68.4 0.93 Contact Map
2itmA 2 0.3846 66.1 0.931 Contact Map
3tqeA 1 0.9154 66 0.931 Contact Map
2uytA 1 0.3423 65.7 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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