GREMLIN Database
HIS6 - Imidazole glycerol phosphate synthase subunit HisF
UniProt: O34727 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (232)
Sequences: 6036 (3096)
Seq/√Len: 203.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_M116_G3.2851.00
145_H149_K2.5941.00
114_T165_R2.5561.00
21_I180_E2.4701.00
163_V198_V2.4511.00
109_R115_E2.3991.00
85_Q88_D2.3821.00
129_I159_A2.3801.00
37_E72_K2.3401.00
161_E165_R2.3171.00
141_K150_K2.3081.00
127_L162_G2.3011.00
37_E41_R2.1961.00
108_L145_H2.1791.00
236_S239_E2.1381.00
90_K94_R2.1241.00
141_K154_E2.0941.00
38_V42_E2.0751.00
210_Q213_L2.0381.00
210_Q214_E1.9691.00
181_K234_E1.9561.00
116_G125_I1.9541.00
56_H148_R1.9211.00
40_D74_A1.8801.00
83_I92_I1.8781.00
16_R28_D1.8351.00
141_K152_D1.8341.00
89_M125_I1.8311.00
63_V91_T1.8201.00
172_L188_L1.7611.00
190_K194_E1.7531.00
90_K119_F1.7391.00
31_D34_E1.7391.00
107_V144_T1.7391.00
154_E157_A1.7171.00
163_V197_P1.7011.00
22_Q180_E1.6801.00
86_L116_G1.6441.00
213_L243_Y1.6321.00
47_L75_I1.6001.00
186_H214_E1.5871.00
31_D68_Q1.5641.00
226_A230_F1.5631.00
42_E238_K1.5621.00
62_M65_V1.5541.00
209_A235_T1.5271.00
208_N211_H1.5231.00
206_A215_A1.5231.00
153_W161_E1.5141.00
226_A229_I1.5021.00
99_K126_V1.4841.00
128_A171_L1.4651.00
160_K195_A1.4641.00
213_L217_T1.4621.00
111_E115_E1.4551.00
161_E164_K1.4541.00
102_V105_A1.4511.00
14_E53_S1.4511.00
229_I235_T1.4461.00
64_D67_E1.3941.00
7_I46_E1.3871.00
70_A77_F1.3821.00
209_A243_Y1.3731.00
68_Q71_A1.3721.00
105_A112_L1.3541.00
8_P44_A1.3461.00
87_S90_K1.3431.00
86_L119_F1.3421.00
235_T240_V1.3401.00
193_S200_V1.3291.00
46_E99_K1.3211.00
143_Y150_K1.3141.00
86_L115_E1.3021.00
211_H214_E1.2871.00
174_S185_D1.2821.00
114_T118_E1.2711.00
49_F69_V1.2661.00
212_M229_I1.2601.00
29_A35_L1.2401.00
106_A127_L1.2091.00
128_A173_T1.2031.00
212_M226_A1.2011.00
216_F224_A1.2001.00
172_L192_V1.1961.00
131_A172_L1.1961.00
89_M100_V1.1941.00
38_V41_R1.1921.00
13_K25_E1.1831.00
104_T108_L1.1801.00
159_A192_V1.1771.00
42_E236_S1.1701.00
66_V79_V1.1671.00
107_V153_W1.1471.00
156_T195_A1.1451.00
5_R46_E1.1451.00
191_L194_E1.1421.00
144_T149_K1.1391.00
67_E95_A1.1361.00
67_E71_A1.1311.00
117_A122_S1.1291.00
21_I24_L1.1231.00
238_K242_S1.1171.00
184_F206_A1.1121.00
134_D141_K1.1071.00
126_V171_L1.1061.00
168_G199_P1.1041.00
170_I198_V1.0871.00
134_D143_Y1.0801.00
131_A188_L1.0781.00
171_L225_L1.0701.00
160_K164_K1.0691.00
16_R30_G1.0641.00
192_V200_V1.0581.00
215_A224_A1.0551.00
42_E237_I1.0541.00
133_Y176_D1.0541.00
90_K120_F1.0511.00
79_V92_I1.0481.00
108_L144_T1.0471.00
186_H190_K1.0461.00
38_V233_K1.0451.00
189_T193_S1.0451.00
191_L195_A1.0391.00
163_V196_V1.0361.00
187_T190_K1.0331.00
127_L167_A1.0301.00
111_E114_T1.0301.00
239_E242_S1.0271.00
46_E76_P1.0141.00
33_V65_V1.0141.00
131_A155_V1.0071.00
108_L149_K1.0021.00
117_A167_A0.9941.00
17_V35_L0.9921.00
155_V192_V0.9841.00
79_V97_A0.9831.00
159_A196_V0.9811.00
133_Y187_T0.9781.00
33_V68_Q0.9761.00
70_A97_A0.9751.00
110_P161_E0.9731.00
214_E217_T0.9711.00
209_A240_V0.9691.00
5_R45_D0.9510.99
46_E126_V0.9480.99
169_E199_P0.9470.99
190_K218_K0.9380.99
35_L38_V0.9340.99
19_K228_S0.9320.99
40_D73_L0.9310.99
64_D68_Q0.9280.99
126_V169_E0.9220.99
93_L120_F0.9200.99
193_S221_A0.9200.99
215_A221_A0.9190.99
155_V159_A0.9180.99
157_A161_E0.9120.99
87_S91_T0.9110.99
228_S232_Y0.9100.99
60_K91_T0.9080.99
144_T151_T0.9040.99
13_K26_L0.9040.99
55_S104_T0.9000.99
209_A239_E0.9000.99
156_T191_L0.8960.99
113_I127_L0.8940.99
70_A98_D0.8850.99
67_E91_T0.8850.99
78_T101_S0.8840.99
27_K30_G0.8780.99
89_M120_F0.8770.99
209_A213_L0.8710.99
45_D76_P0.8640.99
91_T95_A0.8610.99
132_K143_Y0.8600.99
112_L116_G0.8590.99
66_V97_A0.8560.99
102_V116_G0.8480.99
68_Q72_K0.8480.99
37_E40_D0.8430.99
113_I162_G0.8370.99
236_S240_V0.8340.99
215_A219_G0.8340.99
132_K176_D0.8290.98
6_I226_A0.8190.98
156_T160_K0.8190.98
50_L171_L0.8180.98
76_P98_D0.8130.98
193_S222_D0.8120.98
216_F244_L0.8110.98
60_K88_D0.8100.98
88_D91_T0.7970.98
73_L76_P0.7950.98
86_L120_F0.7890.98
187_T191_L0.7880.98
40_D75_I0.7860.98
206_A224_A0.7830.98
207_G211_H0.7810.98
89_M93_L0.7790.98
208_N212_M0.7780.98
212_M235_T0.7630.97
114_T161_E0.7590.97
143_Y175_M0.7580.97
169_E222_D0.7530.97
156_T159_A0.7530.97
6_I224_A0.7490.97
107_V158_W0.7480.97
86_L90_K0.7460.97
194_E219_G0.7450.97
208_N234_E0.7420.97
177_S182_K0.7410.97
13_K53_S0.7400.97
134_D191_L0.7350.97
5_R223_A0.7320.97
155_V188_L0.7290.97
189_T200_V0.7280.97
61_T66_V0.7270.96
157_A160_K0.7270.96
186_H218_K0.7260.96
177_S180_E0.7230.96
50_L173_T0.7230.96
63_V92_I0.7200.96
212_M240_V0.7180.96
134_D154_E0.7170.96
99_K168_G0.7160.96
63_V67_E0.7130.96
21_I228_S0.7120.96
53_S58_G0.7110.96
33_V72_K0.7100.96
214_E218_K0.6980.96
34_E38_V0.6980.96
67_E94_R0.6940.95
98_D123_Q0.6920.95
160_K163_V0.6920.95
54_A61_T0.6920.95
134_D150_K0.6920.95
7_I126_V0.6890.95
34_E37_E0.6870.95
44_A237_I0.6870.95
171_L201_I0.6870.95
121_G169_E0.6860.95
65_V69_V0.6840.95
105_A109_R0.6840.95
163_V170_I0.6830.95
109_R112_L0.6790.95
101_S171_L0.6790.95
129_I158_W0.6770.95
7_I201_I0.6750.95
69_V77_F0.6710.95
142_V158_W0.6700.94
60_K84_N0.6670.94
89_M102_V0.6650.94
91_T94_R0.6650.94
199_P222_D0.6640.94
201_I223_A0.6620.94
190_K219_G0.6610.94
36_A69_V0.6590.94
70_A95_A0.6580.94
184_F207_G0.6570.94
185_D188_L0.6570.94
39_Y231_H0.6560.94
13_K56_H0.6540.94
129_I142_V0.6480.93
127_L170_I0.6470.93
189_T215_A0.6460.93
118_E164_K0.6450.93
212_M224_A0.6370.93
57_E61_T0.6370.93
192_V196_V0.6350.93
84_N108_L0.6300.92
58_G62_M0.6300.92
115_E118_E0.6300.92
219_G222_D0.6260.92
16_R25_E0.6250.92
83_I89_M0.6230.92
117_A121_G0.6190.92
133_Y185_D0.6150.92
49_F77_F0.6150.92
237_I241_K0.6140.92
207_G234_E0.6120.91
159_A170_I0.6090.91
7_I78_T0.6060.91
30_G34_E0.6050.91
179_G205_G0.6000.91
105_A116_G0.6000.91
212_M230_F0.6000.91
53_S62_M0.5950.90
16_R27_K0.5940.90
160_K196_V0.5920.90
206_A226_A0.5900.90
83_I102_V0.5890.90
87_S94_R0.5870.90
230_F240_V0.5860.90
60_K92_I0.5800.89
144_T148_R0.5780.89
29_A232_Y0.5770.89
45_D241_K0.5750.89
99_K169_E0.5740.89
7_I99_K0.5730.88
19_K178_D0.5730.88
189_T202_A0.5720.88
60_K63_V0.5710.88
169_E201_I0.5670.88
79_V83_I0.5640.88
44_A240_V0.5630.88
212_M216_F0.5620.88
102_V113_I0.5610.87
21_I26_L0.5580.87
206_A235_T0.5580.87
189_T221_A0.5540.87
73_L77_F0.5490.86
122_S168_G0.5450.86
12_V49_F0.5440.86
65_V77_F0.5440.86
117_A127_L0.5440.86
20_G23_F0.5420.86
123_Q169_E0.5390.85
179_G183_G0.5350.85
153_W157_A0.5340.85
227_A231_H0.5340.85
18_V23_F0.5330.85
59_R88_D0.5310.84
20_G147_G0.5250.84
184_F211_H0.5250.84
19_K177_S0.5210.83
20_G26_L0.5200.83
183_G205_G0.5200.83
206_A212_M0.5190.83
116_G120_F0.5190.83
12_V65_V0.5170.83
114_T164_K0.5160.83
20_G103_N0.5160.83
27_K232_Y0.5140.82
50_L128_A0.5140.82
38_V238_K0.5130.82
184_F212_M0.5130.82
12_V69_V0.5130.82
173_T203_S0.5110.82
202_A215_A0.5110.82
128_A201_I0.5100.82
93_L126_V0.5100.82
236_S242_S0.5080.82
54_A60_K0.5070.82
35_L39_Y0.5070.82
87_S115_E0.5070.82
86_L112_L0.5050.81
193_S218_K0.5010.81
58_G84_N0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9603 100 0.263 Contact Map
2agkA 1 0.869 100 0.274 Contact Map
1qo2A 1 0.9246 100 0.461 Contact Map
1thfD 2 0.9881 100 0.466 Contact Map
4gj1A 1 0.881 100 0.469 Contact Map
4evzA 1 0.9881 100 0.476 Contact Map
1h5yA 1 0.9881 100 0.501 Contact Map
2y88A 1 0.9484 100 0.506 Contact Map
4u28A 1 0.9087 100 0.515 Contact Map
2w6rA 1 0.8651 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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