HIS6 - BACSU - GREMLIN Contacts

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HIS6 - Imidazole glycerol phosphate synthase subunit HisF

UniProt:	O34727	Sequences: MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGADELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSVNTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAKEGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTKGEADAALAASIFHYKETSIKEVKSYLKEYGVNVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	252 (232)
Sequences:	6036 (3096)
Seq/√Len:	203.3

ECOLI - HIS6 HIS4
BACSU - HIS6 HIS4
HALSA - HIS6 HIS4
SULSO - HIS6 HIS4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
89_M	116_G	3.285	1.00
145_H	149_K	2.594	1.00
114_T	165_R	2.556	1.00
21_I	180_E	2.470	1.00
163_V	198_V	2.451	1.00
109_R	115_E	2.399	1.00
85_Q	88_D	2.382	1.00
129_I	159_A	2.380	1.00
37_E	72_K	2.340	1.00
161_E	165_R	2.317	1.00
141_K	150_K	2.308	1.00
127_L	162_G	2.301	1.00
37_E	41_R	2.196	1.00
108_L	145_H	2.179	1.00
236_S	239_E	2.138	1.00
90_K	94_R	2.124	1.00
141_K	154_E	2.094	1.00
38_V	42_E	2.075	1.00
210_Q	213_L	2.038	1.00
210_Q	214_E	1.969	1.00
181_K	234_E	1.956	1.00
116_G	125_I	1.954	1.00
56_H	148_R	1.921	1.00
40_D	74_A	1.880	1.00
83_I	92_I	1.878	1.00
16_R	28_D	1.835	1.00
141_K	152_D	1.834	1.00
89_M	125_I	1.831	1.00
63_V	91_T	1.820	1.00
172_L	188_L	1.761	1.00
190_K	194_E	1.753	1.00
90_K	119_F	1.739	1.00
31_D	34_E	1.739	1.00
107_V	144_T	1.739	1.00
154_E	157_A	1.717	1.00
163_V	197_P	1.701	1.00
22_Q	180_E	1.680	1.00
86_L	116_G	1.644	1.00
213_L	243_Y	1.632	1.00
47_L	75_I	1.600	1.00
186_H	214_E	1.587	1.00
31_D	68_Q	1.564	1.00
226_A	230_F	1.563	1.00
42_E	238_K	1.562	1.00
62_M	65_V	1.554	1.00
209_A	235_T	1.527	1.00
208_N	211_H	1.523	1.00
206_A	215_A	1.523	1.00
153_W	161_E	1.514	1.00
226_A	229_I	1.502	1.00
99_K	126_V	1.484	1.00
128_A	171_L	1.465	1.00
160_K	195_A	1.464	1.00
213_L	217_T	1.462	1.00
111_E	115_E	1.455	1.00
161_E	164_K	1.454	1.00
102_V	105_A	1.451	1.00
14_E	53_S	1.451	1.00
229_I	235_T	1.446	1.00
64_D	67_E	1.394	1.00
7_I	46_E	1.387	1.00
70_A	77_F	1.382	1.00
209_A	243_Y	1.373	1.00
68_Q	71_A	1.372	1.00
105_A	112_L	1.354	1.00
8_P	44_A	1.346	1.00
87_S	90_K	1.343	1.00
86_L	119_F	1.342	1.00
235_T	240_V	1.340	1.00
193_S	200_V	1.329	1.00
46_E	99_K	1.321	1.00
143_Y	150_K	1.314	1.00
86_L	115_E	1.302	1.00
211_H	214_E	1.287	1.00
174_S	185_D	1.282	1.00
114_T	118_E	1.271	1.00
49_F	69_V	1.266	1.00
212_M	229_I	1.260	1.00
29_A	35_L	1.240	1.00
106_A	127_L	1.209	1.00
128_A	173_T	1.203	1.00
212_M	226_A	1.201	1.00
216_F	224_A	1.200	1.00
172_L	192_V	1.196	1.00
131_A	172_L	1.196	1.00
89_M	100_V	1.194	1.00
38_V	41_R	1.192	1.00
13_K	25_E	1.183	1.00
104_T	108_L	1.180	1.00
159_A	192_V	1.177	1.00
42_E	236_S	1.170	1.00
66_V	79_V	1.167	1.00
107_V	153_W	1.147	1.00
156_T	195_A	1.145	1.00
5_R	46_E	1.145	1.00
191_L	194_E	1.142	1.00
144_T	149_K	1.139	1.00
67_E	95_A	1.136	1.00
67_E	71_A	1.131	1.00
117_A	122_S	1.129	1.00
21_I	24_L	1.123	1.00
238_K	242_S	1.117	1.00
184_F	206_A	1.112	1.00
134_D	141_K	1.107	1.00
126_V	171_L	1.106	1.00
168_G	199_P	1.104	1.00
170_I	198_V	1.087	1.00
134_D	143_Y	1.080	1.00
131_A	188_L	1.078	1.00
171_L	225_L	1.070	1.00
160_K	164_K	1.069	1.00
16_R	30_G	1.064	1.00
192_V	200_V	1.058	1.00
215_A	224_A	1.055	1.00
42_E	237_I	1.054	1.00
133_Y	176_D	1.054	1.00
90_K	120_F	1.051	1.00
79_V	92_I	1.048	1.00
108_L	144_T	1.047	1.00
186_H	190_K	1.046	1.00
38_V	233_K	1.045	1.00
189_T	193_S	1.045	1.00
191_L	195_A	1.039	1.00
163_V	196_V	1.036	1.00
187_T	190_K	1.033	1.00
127_L	167_A	1.030	1.00
111_E	114_T	1.030	1.00
239_E	242_S	1.027	1.00
46_E	76_P	1.014	1.00
33_V	65_V	1.014	1.00
131_A	155_V	1.007	1.00
108_L	149_K	1.002	1.00
117_A	167_A	0.994	1.00
17_V	35_L	0.992	1.00
155_V	192_V	0.984	1.00
79_V	97_A	0.983	1.00
159_A	196_V	0.981	1.00
133_Y	187_T	0.978	1.00
33_V	68_Q	0.976	1.00
70_A	97_A	0.975	1.00
110_P	161_E	0.973	1.00
214_E	217_T	0.971	1.00
209_A	240_V	0.969	1.00
5_R	45_D	0.951	0.99
46_E	126_V	0.948	0.99
169_E	199_P	0.947	0.99
190_K	218_K	0.938	0.99
35_L	38_V	0.934	0.99
19_K	228_S	0.932	0.99
40_D	73_L	0.931	0.99
64_D	68_Q	0.928	0.99
126_V	169_E	0.922	0.99
93_L	120_F	0.920	0.99
193_S	221_A	0.920	0.99
215_A	221_A	0.919	0.99
155_V	159_A	0.918	0.99
157_A	161_E	0.912	0.99
87_S	91_T	0.911	0.99
228_S	232_Y	0.910	0.99
60_K	91_T	0.908	0.99
144_T	151_T	0.904	0.99
13_K	26_L	0.904	0.99
55_S	104_T	0.900	0.99
209_A	239_E	0.900	0.99
156_T	191_L	0.896	0.99
113_I	127_L	0.894	0.99
70_A	98_D	0.885	0.99
67_E	91_T	0.885	0.99
78_T	101_S	0.884	0.99
27_K	30_G	0.878	0.99
89_M	120_F	0.877	0.99
209_A	213_L	0.871	0.99
45_D	76_P	0.864	0.99
91_T	95_A	0.861	0.99
132_K	143_Y	0.860	0.99
112_L	116_G	0.859	0.99
66_V	97_A	0.856	0.99
102_V	116_G	0.848	0.99
68_Q	72_K	0.848	0.99
37_E	40_D	0.843	0.99
113_I	162_G	0.837	0.99
236_S	240_V	0.834	0.99
215_A	219_G	0.834	0.99
132_K	176_D	0.829	0.98
6_I	226_A	0.819	0.98
156_T	160_K	0.819	0.98
50_L	171_L	0.818	0.98
76_P	98_D	0.813	0.98
193_S	222_D	0.812	0.98
216_F	244_L	0.811	0.98
60_K	88_D	0.810	0.98
88_D	91_T	0.797	0.98
73_L	76_P	0.795	0.98
86_L	120_F	0.789	0.98
187_T	191_L	0.788	0.98
40_D	75_I	0.786	0.98
206_A	224_A	0.783	0.98
207_G	211_H	0.781	0.98
89_M	93_L	0.779	0.98
208_N	212_M	0.778	0.98
212_M	235_T	0.763	0.97
114_T	161_E	0.759	0.97
143_Y	175_M	0.758	0.97
169_E	222_D	0.753	0.97
156_T	159_A	0.753	0.97
6_I	224_A	0.749	0.97
107_V	158_W	0.748	0.97
86_L	90_K	0.746	0.97
194_E	219_G	0.745	0.97
208_N	234_E	0.742	0.97
177_S	182_K	0.741	0.97
13_K	53_S	0.740	0.97
134_D	191_L	0.735	0.97
5_R	223_A	0.732	0.97
155_V	188_L	0.729	0.97
189_T	200_V	0.728	0.97
61_T	66_V	0.727	0.96
157_A	160_K	0.727	0.96
186_H	218_K	0.726	0.96
177_S	180_E	0.723	0.96
50_L	173_T	0.723	0.96
63_V	92_I	0.720	0.96
212_M	240_V	0.718	0.96
134_D	154_E	0.717	0.96
99_K	168_G	0.716	0.96
63_V	67_E	0.713	0.96
21_I	228_S	0.712	0.96
53_S	58_G	0.711	0.96
33_V	72_K	0.710	0.96
214_E	218_K	0.698	0.96
34_E	38_V	0.698	0.96
67_E	94_R	0.694	0.95
98_D	123_Q	0.692	0.95
160_K	163_V	0.692	0.95
54_A	61_T	0.692	0.95
134_D	150_K	0.692	0.95
7_I	126_V	0.689	0.95
34_E	37_E	0.687	0.95
44_A	237_I	0.687	0.95
171_L	201_I	0.687	0.95
121_G	169_E	0.686	0.95
65_V	69_V	0.684	0.95
105_A	109_R	0.684	0.95
163_V	170_I	0.683	0.95
109_R	112_L	0.679	0.95
101_S	171_L	0.679	0.95
129_I	158_W	0.677	0.95
7_I	201_I	0.675	0.95
69_V	77_F	0.671	0.95
142_V	158_W	0.670	0.94
60_K	84_N	0.667	0.94
89_M	102_V	0.665	0.94
91_T	94_R	0.665	0.94
199_P	222_D	0.664	0.94
201_I	223_A	0.662	0.94
190_K	219_G	0.661	0.94
36_A	69_V	0.659	0.94
70_A	95_A	0.658	0.94
184_F	207_G	0.657	0.94
185_D	188_L	0.657	0.94
39_Y	231_H	0.656	0.94
13_K	56_H	0.654	0.94
129_I	142_V	0.648	0.93
127_L	170_I	0.647	0.93
189_T	215_A	0.646	0.93
118_E	164_K	0.645	0.93
212_M	224_A	0.637	0.93
57_E	61_T	0.637	0.93
192_V	196_V	0.635	0.93
84_N	108_L	0.630	0.92
58_G	62_M	0.630	0.92
115_E	118_E	0.630	0.92
219_G	222_D	0.626	0.92
16_R	25_E	0.625	0.92
83_I	89_M	0.623	0.92
117_A	121_G	0.619	0.92
133_Y	185_D	0.615	0.92
49_F	77_F	0.615	0.92
237_I	241_K	0.614	0.92
207_G	234_E	0.612	0.91
159_A	170_I	0.609	0.91
7_I	78_T	0.606	0.91
30_G	34_E	0.605	0.91
179_G	205_G	0.600	0.91
105_A	116_G	0.600	0.91
212_M	230_F	0.600	0.91
53_S	62_M	0.595	0.90
16_R	27_K	0.594	0.90
160_K	196_V	0.592	0.90
206_A	226_A	0.590	0.90
83_I	102_V	0.589	0.90
87_S	94_R	0.587	0.90
230_F	240_V	0.586	0.90
60_K	92_I	0.580	0.89
144_T	148_R	0.578	0.89
29_A	232_Y	0.577	0.89
45_D	241_K	0.575	0.89
99_K	169_E	0.574	0.89
7_I	99_K	0.573	0.88
19_K	178_D	0.573	0.88
189_T	202_A	0.572	0.88
60_K	63_V	0.571	0.88
169_E	201_I	0.567	0.88
79_V	83_I	0.564	0.88
44_A	240_V	0.563	0.88
212_M	216_F	0.562	0.88
102_V	113_I	0.561	0.87
21_I	26_L	0.558	0.87
206_A	235_T	0.558	0.87
189_T	221_A	0.554	0.87
73_L	77_F	0.549	0.86
122_S	168_G	0.545	0.86
12_V	49_F	0.544	0.86
65_V	77_F	0.544	0.86
117_A	127_L	0.544	0.86
20_G	23_F	0.542	0.86
123_Q	169_E	0.539	0.85
179_G	183_G	0.535	0.85
153_W	157_A	0.534	0.85
227_A	231_H	0.534	0.85
18_V	23_F	0.533	0.85
59_R	88_D	0.531	0.84
20_G	147_G	0.525	0.84
184_F	211_H	0.525	0.84
19_K	177_S	0.521	0.83
20_G	26_L	0.520	0.83
183_G	205_G	0.520	0.83
206_A	212_M	0.519	0.83
116_G	120_F	0.519	0.83
12_V	65_V	0.517	0.83
114_T	164_K	0.516	0.83
20_G	103_N	0.516	0.83
27_K	232_Y	0.514	0.82
50_L	128_A	0.514	0.82
38_V	238_K	0.513	0.82
184_F	212_M	0.513	0.82
12_V	69_V	0.513	0.82
173_T	203_S	0.511	0.82
202_A	215_A	0.511	0.82
128_A	201_I	0.510	0.82
93_L	126_V	0.510	0.82
236_S	242_S	0.508	0.82
54_A	60_K	0.507	0.82
35_L	39_Y	0.507	0.82
87_S	115_E	0.507	0.82
86_L	112_L	0.505	0.81
193_S	218_K	0.501	0.81
58_G	84_N	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jvnA	1	0.9603	100	0.263	Contact Map
2agkA	1	0.869	100	0.274	Contact Map
1qo2A	1	0.9246	100	0.461	Contact Map
1thfD	2	0.9881	100	0.466	Contact Map
4gj1A	1	0.881	100	0.469	Contact Map
4evzA	1	0.9881	100	0.476	Contact Map
1h5yA	1	0.9881	100	0.501	Contact Map
2y88A	1	0.9484	100	0.506	Contact Map
4u28A	1	0.9087	100	0.515	Contact Map
2w6rA	1	0.8651	100	0.517	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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