GREMLIN Database
YFLS - Putative malate transporter YflS
UniProt: O34726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (411)
Sequences: 8959 (6017)
Seq/√Len: 296.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_S83_D4.6711.00
126_K129_G4.4161.00
108_K321_D4.2181.00
352_S356_N4.1101.00
286_V307_G3.5881.00
83_D347_E3.1521.00
118_V122_K3.0961.00
265_K268_E2.7871.00
199_L209_A2.7741.00
447_G451_S2.7641.00
445_P448_K2.7411.00
138_D156_I2.7151.00
221_T224_S2.7141.00
282_V307_G2.7131.00
97_V332_L2.6881.00
51_T69_A2.6221.00
366_S369_V2.6181.00
118_V121_Q2.5361.00
277_L281_I2.5141.00
45_F350_M2.4601.00
318_T321_D2.4301.00
42_W46_A2.4201.00
184_L438_F2.4071.00
448_K451_S2.3831.00
101_F308_L2.3721.00
105_G311_L2.3701.00
280_V284_L2.3591.00
288_V292_F2.3381.00
128_L245_Y2.2941.00
53_I57_S2.2731.00
282_V310_V2.2661.00
285_L289_L2.2561.00
320_D324_K2.2421.00
379_Y457_S2.2261.00
353_W357_A2.2191.00
272_F276_E2.1931.00
102_I286_V2.1891.00
139_L233_G2.1471.00
227_I231_V2.1181.00
343_N347_E2.0781.00
378_Y395_M2.0481.00
372_I465_L1.9881.00
114_R118_V1.9841.00
160_I187_G1.9691.00
134_L160_I1.9651.00
272_F275_S1.9651.00
185_K189_Q1.9571.00
47_I72_V1.9241.00
226_A230_I1.9241.00
365_F369_V1.9201.00
274_K278_S1.9091.00
105_G279_M1.9021.00
223_T227_I1.8991.00
458_I462_I1.8671.00
50_A54_G1.8571.00
242_L246_K1.8351.00
197_M233_G1.8071.00
70_L85_L1.8051.00
193_I236_S1.8001.00
292_F296_F1.7571.00
98_I308_L1.7341.00
416_S468_G1.7331.00
236_S460_H1.7301.00
47_I69_A1.7291.00
357_A360_S1.7281.00
264_E268_E1.7131.00
138_D191_N1.6831.00
285_L310_V1.6651.00
278_S314_S1.6591.00
224_S227_I1.6581.00
140_I144_A1.6551.00
376_V461_I1.6501.00
375_I420_I1.6221.00
98_I304_A1.6201.00
54_G65_I1.6121.00
368_I469_G1.5951.00
246_K249_P1.5901.00
281_I285_L1.5831.00
47_I73_T1.5811.00
114_R276_E1.5761.00
54_G57_S1.5701.00
132_Y241_P1.5551.00
466_V470_L1.5401.00
242_L245_Y1.5281.00
73_T344_F1.5141.00
104_R107_I1.5031.00
282_V311_L1.5011.00
47_I76_T1.4931.00
320_D323_K1.4891.00
142_S194_T1.4781.00
135_L190_G1.4671.00
97_V101_F1.4571.00
239_I459_V1.4561.00
41_A350_M1.4561.00
356_N360_S1.4551.00
234_L238_I1.4491.00
450_W454_F1.4461.00
123_F133_S1.4391.00
60_L65_I1.4371.00
429_H439_F1.4361.00
72_V76_T1.4261.00
60_L64_A1.4081.00
88_F336_A1.4051.00
392_I421_S1.3981.00
43_H76_T1.3781.00
427_T457_S1.3761.00
273_K276_E1.3711.00
125_K129_G1.3681.00
188_F438_F1.3631.00
44_L344_F1.3591.00
83_D86_S1.3531.00
190_G194_T1.3511.00
71_A309_A1.3451.00
200_T222_W1.3431.00
243_V246_K1.3361.00
93_I332_L1.3341.00
375_I416_S1.3341.00
416_S420_I1.3201.00
467_I471_W1.3181.00
270_G276_E1.3121.00
197_M230_I1.3101.00
345_L350_M1.3041.00
139_L237_L1.3011.00
104_R327_G1.2981.00
267_K270_G1.2861.00
41_A353_W1.2851.00
346_N352_S1.2771.00
135_L186_T1.2671.00
413_A417_L1.2601.00
231_V467_I1.2571.00
345_L351_V1.2471.00
239_I463_V1.2461.00
289_L303_T1.2441.00
51_T65_I1.2401.00
46_A50_A1.2381.00
266_L272_F1.2321.00
400_L404_V1.2291.00
464_W468_G1.2251.00
289_L294_G1.2231.00
383_Y388_A1.2231.00
43_H78_T1.2221.00
63_G330_D1.2131.00
266_L269_M1.2111.00
384_F457_S1.2101.00
194_T237_L1.1991.00
70_L337_A1.1991.00
401_A404_V1.1981.00
124_G129_G1.1911.00
417_L421_S1.1901.00
408_A413_A1.1851.00
343_N346_N1.1831.00
282_V314_S1.1741.00
447_G450_W1.1731.00
284_L288_V1.1691.00
243_V247_L1.1671.00
243_V459_V1.1651.00
74_A84_T1.1611.00
264_E267_K1.1511.00
61_P65_I1.1491.00
376_V465_L1.1471.00
157_F437_V1.1461.00
44_L73_T1.1421.00
134_L163_L1.1411.00
454_F458_I1.1351.00
230_I234_L1.1351.00
376_V380_Y1.1351.00
289_L306_I1.1231.00
86_S343_N1.1111.00
466_V469_G1.1101.00
461_I465_L1.1071.00
164_S183_L1.1071.00
50_A72_V1.1061.00
49_V53_I1.1051.00
292_F295_S1.1001.00
152_A191_N1.0941.00
356_N359_K1.0861.00
67_I333_T1.0821.00
91_K301_T1.0801.00
224_S411_L1.0791.00
47_I51_T1.0781.00
184_L444_I1.0771.00
45_F49_V1.0721.00
147_S150_A1.0611.00
235_V463_V1.0561.00
91_K299_D1.0561.00
353_W356_N1.0351.00
266_L270_G1.0251.00
323_K333_T1.0211.00
107_I326_Q1.0191.00
104_R326_Q1.0101.00
268_E272_F1.0091.00
278_S282_V1.0081.00
232_P463_V1.0081.00
98_I305_L1.0001.00
380_Y385_F0.9981.00
194_T201_A0.9971.00
299_D302_T0.9961.00
270_G274_K0.9951.00
162_S166_T0.9941.00
48_F345_L0.9851.00
113_A117_Y0.9811.00
248_Y452_I0.9801.00
135_L237_L0.9791.00
240_T244_I0.9761.00
51_T341_L0.9741.00
185_K452_I0.9701.00
289_L293_G0.9701.00
271_P275_S0.9701.00
269_M272_F0.9671.00
399_F417_L0.9661.00
114_R117_Y0.9641.00
371_F416_S0.9631.00
384_F431_G0.9601.00
66_A337_A0.9571.00
143_P197_M0.9561.00
429_H436_P0.9541.00
195_S202_M0.9491.00
413_A416_S0.9461.00
381_S391_H0.9451.00
401_A405_A0.9431.00
148_N195_S0.9421.00
135_L240_T0.9411.00
207_L396_Y0.9401.00
335_F389_T0.9371.00
84_T340_M0.9351.00
275_S278_S0.9341.00
96_I389_T0.9331.00
282_V290_W0.9331.00
384_F427_T0.9301.00
379_Y461_I0.9301.00
87_G340_M0.9301.00
355_S359_K0.9271.00
415_L419_F0.9261.00
396_Y414_A0.9261.00
387_S390_A0.9251.00
278_S281_I0.9211.00
388_A431_G0.9121.00
271_P276_E0.9111.00
260_K264_E0.9091.00
106_F111_L0.9081.00
113_A265_K0.9071.00
48_F51_T0.9071.00
266_L276_E0.9041.00
378_Y420_I0.8931.00
44_L78_T0.8921.00
462_I466_V0.8921.00
137_S156_I0.8921.00
268_E276_E0.8911.00
68_F71_A0.8901.00
369_V373_I0.8891.00
230_I233_G0.8851.00
240_T456_L0.8831.00
448_K452_I0.8801.00
298_I303_T0.8631.00
202_M205_N0.8631.00
427_T450_W0.8621.00
80_S347_E0.8581.00
212_A414_A0.8571.00
151_R191_N0.8551.00
455_I458_I0.8531.00
196_A233_G0.8501.00
362_V373_I0.8491.00
68_F309_A0.8471.00
278_S316_V0.8461.00
321_D324_K0.8461.00
428_T431_G0.8441.00
244_I452_I0.8431.00
418_A421_S0.8431.00
158_P162_S0.8421.00
203_A389_T0.8401.00
147_S389_T0.8391.00
51_T55_F0.8351.00
271_P274_K0.8351.00
272_F277_L0.8331.00
120_V163_L0.8321.00
128_L241_P0.8311.00
95_L304_A0.8291.00
404_V410_P0.8291.00
204_A389_T0.8281.00
277_L280_V0.8281.00
290_W304_A0.8271.00
198_F201_A0.8271.00
268_E271_P0.8271.00
142_S148_N0.8261.00
239_I243_V0.8261.00
193_I240_T0.8241.00
70_L340_M0.8231.00
228_A467_I0.8221.00
383_Y425_G0.8211.00
377_V381_S0.8211.00
238_I242_L0.8181.00
389_T392_I0.8171.00
90_N210_K0.8161.00
78_T344_F0.8151.00
44_L348_L0.8151.00
149_T202_M0.8151.00
427_T454_F0.8151.00
131_S183_L0.8141.00
231_V235_V0.8141.00
79_L340_M0.8141.00
286_V290_W0.8141.00
188_F435_A0.8121.00
308_L312_L0.8111.00
197_M226_A0.8061.00
413_A420_I0.8051.00
199_L226_A0.8011.00
136_F140_I0.8011.00
184_L187_G0.8001.00
328_A331_T0.7991.00
453_G456_L0.7981.00
66_A70_L0.7971.00
74_A302_T0.7971.00
141_L151_R0.7950.99
425_G431_G0.7950.99
383_Y431_G0.7940.99
211_L396_Y0.7940.99
274_K277_L0.7920.99
160_I183_L0.7880.99
257_D260_K0.7880.99
73_T341_L0.7870.99
281_I284_L0.7870.99
195_S198_F0.7870.99
273_K277_L0.7850.99
142_S195_S0.7840.99
380_Y457_S0.7830.99
360_S363_S0.7830.99
279_M283_F0.7810.99
271_P277_L0.7780.99
419_F464_W0.7750.99
68_F72_V0.7750.99
199_L206_P0.7730.99
262_A265_K0.7730.99
282_V286_V0.7730.99
76_T79_L0.7730.99
457_S460_H0.7730.99
397_S400_L0.7710.99
282_V289_L0.7710.99
246_K250_P0.7700.99
389_T433_G0.7690.99
414_A421_S0.7680.99
54_G68_F0.7590.99
409_P412_L0.7590.99
412_L416_S0.7590.99
212_A219_D0.7570.99
208_I418_A0.7560.99
55_F66_A0.7560.99
204_A432_S0.7550.99
269_M273_K0.7540.99
265_K270_G0.7510.99
389_T432_S0.7510.99
62_M387_S0.7510.99
387_S425_G0.7500.99
291_I294_G0.7500.99
387_S391_H0.7470.99
186_T190_G0.7460.99
78_T348_L0.7450.99
367_W371_F0.7440.99
279_M282_V0.7430.99
82_E86_S0.7380.99
48_F341_L0.7360.99
331_T389_T0.7350.99
414_A417_L0.7350.99
87_G343_N0.7340.99
374_L417_L0.7340.99
102_I311_L0.7340.99
237_L241_P0.7300.99
425_G432_S0.7280.99
229_A419_F0.7250.99
400_L403_V0.7230.99
396_Y400_L0.7230.99
192_L426_S0.7230.99
57_S60_L0.7230.99
140_I143_P0.7200.99
370_A406_A0.7200.99
40_K43_H0.7190.99
41_A45_F0.7180.99
109_T279_M0.7170.99
270_G273_K0.7150.99
269_M276_E0.7130.99
244_I248_Y0.7120.99
205_N225_W0.7120.99
373_I377_V0.7110.99
300_A304_A0.7080.99
154_G437_V0.7060.99
357_A362_V0.7030.99
231_V234_L0.7000.99
62_M66_A0.6990.99
232_P236_S0.6990.99
97_V327_G0.6990.99
151_R156_I0.6970.99
104_R108_K0.6960.99
188_F434_A0.6920.99
138_D190_G0.6890.99
161_R165_E0.6890.99
132_Y136_F0.6870.99
266_L274_K0.6870.99
62_M65_I0.6860.99
93_I336_A0.6840.98
169_S183_L0.6830.98
310_V314_S0.6820.98
93_I335_F0.6810.98
200_T203_A0.6810.98
106_F279_M0.6770.98
269_M274_K0.6770.98
81_I302_T0.6760.98
304_A307_G0.6750.98
194_T198_F0.6740.98
186_T244_I0.6740.98
98_I301_T0.6740.98
132_Y238_I0.6720.98
222_W225_W0.6700.98
209_A219_D0.6690.98
208_I392_I0.6650.98
365_F373_I0.6650.98
207_L389_T0.6640.98
118_V266_L0.6620.98
148_N201_A0.6610.98
204_A392_I0.6610.98
70_L73_T0.6600.98
44_L48_F0.6590.98
222_W226_A0.6590.98
55_F65_I0.6570.98
152_A438_F0.6570.98
228_A472_W0.6560.98
339_V393_S0.6550.98
81_I85_L0.6550.98
116_S163_L0.6510.98
94_W336_A0.6500.98
407_G410_P0.6460.98
375_I464_W0.6460.98
157_F184_L0.6450.98
267_K273_K0.6430.98
133_S210_K0.6420.98
290_W294_G0.6420.98
142_S201_A0.6420.98
226_A231_V0.6410.98
204_A335_F0.6410.98
372_I461_I0.6410.98
380_Y454_F0.6410.98
92_T96_I0.6410.98
81_I84_T0.6390.98
372_I376_V0.6380.98
150_A225_W0.6380.98
99_A286_V0.6370.98
61_P64_A0.6320.97
43_H46_A0.6300.97
71_A306_I0.6300.97
188_F192_L0.6280.97
192_L432_S0.6270.97
258_A262_A0.6230.97
108_K326_Q0.6230.97
73_T78_T0.6230.97
264_E270_G0.6210.97
454_F457_S0.6200.97
149_T387_S0.6200.97
455_I459_V0.6180.97
432_S435_A0.6180.97
318_T322_I0.6170.97
80_S84_T0.6170.97
388_A425_G0.6170.97
375_I461_I0.6160.97
61_P330_D0.6150.97
138_D151_R0.6140.97
53_I59_P0.6140.97
67_I337_A0.6130.97
152_A434_A0.6120.97
157_F438_F0.6120.97
149_T195_S0.6110.97
208_I396_Y0.6110.97
209_A220_L0.6080.97
414_A418_A0.6070.97
185_K453_G0.6060.97
368_I372_I0.6040.97
86_S90_N0.6040.97
58_K439_F0.6040.97
258_A261_I0.6040.97
196_A424_F0.6020.97
383_Y387_S0.6000.97
416_S464_W0.6000.97
63_G70_L0.5990.96
415_L418_A0.5990.96
192_L434_A0.5970.96
202_M432_S0.5970.96
171_P443_Y0.5970.96
95_L147_S0.5960.96
99_A155_I0.5950.96
131_S182_F0.5950.96
378_Y417_L0.5940.96
170_S251_E0.5930.96
148_N202_M0.5930.96
114_R270_G0.5910.96
379_Y384_F0.5910.96
41_A44_L0.5900.96
403_V413_A0.5890.96
417_L420_I0.5890.96
370_A374_L0.5880.96
444_I448_K0.5880.96
384_F425_G0.5860.96
138_D187_G0.5860.96
336_A340_M0.5850.96
148_N203_A0.5850.96
96_I100_F0.5850.96
282_V293_G0.5840.96
73_T76_T0.5840.96
187_G190_G0.5830.96
131_S241_P0.5820.96
321_D326_Q0.5770.96
426_S435_A0.5760.96
333_T337_A0.5760.96
423_L426_S0.5760.96
358_M377_V0.5750.96
365_F370_A0.5730.96
193_I237_L0.5720.95
279_M290_W0.5710.95
148_N200_T0.5700.95
101_F327_G0.5700.95
375_I379_Y0.5700.95
309_A313_L0.5690.95
468_G472_W0.5690.95
79_L347_E0.5680.95
243_V455_I0.5670.95
99_A304_A0.5670.95
264_E274_K0.5670.95
197_M201_A0.5660.95
378_Y421_S0.5650.95
386_A391_H0.5640.95
226_A229_A0.5630.95
366_S373_I0.5630.95
306_I309_A0.5610.95
165_E441_A0.5610.95
63_G323_K0.5600.95
235_V459_V0.5600.95
306_I310_V0.5600.95
71_A305_L0.5590.95
345_L394_A0.5580.95
107_I112_G0.5580.95
128_L132_Y0.5570.95
55_F338_L0.5560.95
344_F348_L0.5550.95
54_G60_L0.5550.95
249_P253_K0.5550.95
349_G352_S0.5500.94
208_I414_A0.5490.94
195_S423_L0.5490.94
64_A68_F0.5490.94
103_S147_S0.5490.94
225_W418_A0.5480.94
106_F109_T0.5480.94
384_F388_A0.5450.94
102_I307_G0.5450.94
115_I141_L0.5450.94
235_V467_I0.5440.94
69_A74_A0.5440.94
412_L469_G0.5420.94
266_L271_P0.5420.94
239_I242_L0.5410.94
189_Q240_T0.5410.94
414_A420_I0.5410.94
351_V386_A0.5400.94
148_N151_R0.5400.94
96_I433_G0.5400.94
117_Y166_T0.5380.94
145_I151_R0.5370.94
66_A93_I0.5360.94
458_I461_I0.5360.94
416_S421_S0.5360.94
148_N192_L0.5340.94
289_L310_V0.5320.93
461_I464_W0.5320.93
414_A419_F0.5310.93
368_I466_V0.5310.93
267_K274_K0.5300.93
277_L288_V0.5300.93
207_L393_S0.5290.93
128_L131_S0.5290.93
155_I339_V0.5280.93
345_L348_L0.5270.93
205_N209_A0.5270.93
413_A421_S0.5230.93
381_S385_F0.5220.93
148_N191_N0.5220.93
335_F425_G0.5210.93
69_A73_T0.5190.93
96_I335_F0.5180.92
372_I469_G0.5170.92
452_I455_I0.5170.92
168_G171_P0.5150.92
91_K210_K0.5150.92
204_A421_S0.5150.92
290_W293_G0.5140.92
350_M353_W0.5140.92
149_T433_G0.5140.92
416_S419_F0.5130.92
253_K256_P0.5130.92
95_L99_A0.5130.92
135_L241_P0.5120.92
93_I150_A0.5120.92
233_G238_I0.5110.92
261_I265_K0.5100.92
293_G299_D0.5090.92
195_S204_A0.5090.92
241_P245_Y0.5070.92
84_T87_G0.5070.92
467_I470_L0.5070.92
251_E254_E0.5060.92
77_G84_T0.5040.91
235_V238_I0.5040.91
223_T226_A0.5040.91
106_F145_I0.5040.91
93_I96_I0.5030.91
143_P198_F0.5020.91
147_S151_R0.5020.91
46_A49_V0.5020.91
268_E274_K0.5010.91
403_V406_A0.5000.91
279_M286_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8975 100 0.382 Contact Map
4r1iA 2 0.8933 100 0.66 Contact Map
4r0cA 3 0.8745 99.9 0.724 Contact Map
3w9iA 3 0.3347 28.7 0.964 Contact Map
2m20A 2 0.1255 27.8 0.964 Contact Map
3l1lA 2 0.4414 16.8 0.968 Contact Map
3giaA 1 0.4456 15.8 0.968 Contact Map
3tdsE 3 0.4979 14.4 0.969 Contact Map
3kcuA 3 0.4665 14.1 0.969 Contact Map
3ne5A 3 0.3326 14 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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