GREMLIN Database
OXDC - Oxalate decarboxylase OxdC
UniProt: O34714 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (370)
Sequences: 453 (276)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_D120_R5.7801.00
182_A322_E4.8231.00
265_E328_P4.5911.00
100_A133_Y4.2881.00
112_V227_T4.0811.00
111_R125_D3.7921.00
358_Q365_K3.6170.99
286_S330_V3.4460.99
168_L349_L3.3740.99
230_L246_A3.3620.99
177_K192_S3.2270.98
50_F55_T3.0390.98
110_A142_I2.9110.97
105_M149_A2.8830.97
304_N324_I2.7820.96
289_A329_L2.7780.96
106_I285_I2.6980.95
105_M110_A2.6950.95
291_M313_V2.6470.95
27_R54_D2.6150.94
282_Q311_G2.6040.94
288_K326_D2.5600.94
57_N65_A2.4700.92
156_D256_T2.4410.92
114_I222_V2.4280.92
172_L180_I2.3740.91
28_D53_S2.3710.91
88_P147_E2.3400.90
286_S327_E2.2850.89
124_D229_R2.2780.89
290_R304_N2.2740.89
363_L367_F2.2430.88
264_V329_L2.2240.88
58_R65_A2.1790.87
263_T328_P2.1420.86
248_S258_A2.0990.84
356_F360_H2.0850.84
50_F68_V2.0740.84
110_A149_A2.0660.83
55_T68_V2.0080.82
228_Y233_Q1.9940.81
24_N30_Q1.9750.80
114_I138_L1.9490.80
264_V331_F1.9480.79
91_I356_F1.9320.79
48_M293_V1.9110.78
171_W318_G1.8980.78
262_V331_F1.8980.78
24_N306_Q1.8970.78
87_K90_A1.8700.77
73_L301_R1.8580.76
288_K324_I1.8570.76
103_A131_L1.8560.76
105_M142_I1.8110.74
47_N303_F1.7770.73
79_L154_V1.7710.72
262_V333_E1.7640.72
174_H345_L1.7390.71
154_V334_I1.7320.71
133_Y255_K1.7190.70
65_A292_T1.6920.69
282_Q291_M1.6910.69
284_Y329_L1.6500.67
99_E164_S1.6370.66
24_N27_R1.6350.66
174_H300_A1.6230.66
346_N371_L1.5970.64
26_E30_Q1.5740.63
109_S127_G1.5700.63
293_V317_M1.5260.61
27_R30_Q1.4990.59
184_F191_I1.4980.59
23_R28_D1.4980.59
84_M151_F1.4830.58
355_T359_A1.4700.58
171_W272_L1.4690.58
290_R322_E1.4430.56
364_G367_F1.4420.56
133_Y136_S1.4330.56
279_H315_F1.4190.55
231_L244_Y1.4030.54
167_Q360_H1.3990.54
225_P252_K1.3860.53
8_P12_R1.3740.52
91_I204_N1.3710.52
354_E368_T1.3660.52
167_Q202_F1.3630.52
114_I122_F1.3590.52
162_E198_E1.3520.51
172_L194_L1.3370.50
189_E192_S1.3350.50
282_Q313_V1.3280.50
59_L370_V1.3260.50
10_P16_G1.3190.49
166_F295_A1.3150.49
18_T85_R1.3110.49
84_M162_E1.3110.49
21_I64_Y1.3060.49
8_P29_R1.3040.49
327_E330_V1.3020.48
142_I310_V1.2940.48
19_V28_D1.2940.48
127_G229_R1.2890.48
228_Y232_E1.2820.47
180_I191_I1.2740.47
78_N312_Y1.2690.47
248_S254_S1.2580.46
258_A338_D1.2580.46
112_V142_I1.2350.45
204_N221_E1.2140.44
124_D227_T1.2100.43
228_Y231_L1.2040.43
262_V268_A1.2010.43
65_A90_A1.2000.43
142_I324_I1.1940.43
229_R232_E1.1870.42
106_I340_Y1.1870.42
276_P345_L1.1790.42
235_P242_K1.1730.41
60_E65_A1.1720.41
98_K164_S1.1680.41
224_Y253_V1.1660.41
44_T299_H1.1640.41
88_P144_A1.1550.40
82_V162_E1.1540.40
175_T327_E1.1520.40
89_G276_P1.1510.40
122_F225_P1.1470.40
78_N336_K1.1440.40
237_E265_E1.1430.40
202_F360_H1.1380.40
253_V334_I1.1360.39
100_A257_I1.1340.39
149_A340_Y1.1300.39
117_E341_A1.1300.39
175_T272_L1.1270.39
354_E369_D1.1250.39
292_T299_H1.1160.38
132_W151_F1.1160.38
347_Q375_K1.1130.38
52_F276_P1.1130.38
243_V340_Y1.1080.38
9_Q19_V1.1040.38
48_M303_F1.1000.38
180_I194_L1.0880.37
91_I345_L1.0870.37
37_P56_H1.0840.37
217_G220_G1.0800.37
186_V367_F1.0740.36
94_L294_F1.0730.36
70_V159_S1.0700.36
167_Q198_E1.0680.36
284_Y289_A1.0640.36
256_T272_L1.0620.36
107_Y285_I1.0620.36
139_P148_G1.0600.36
177_K181_A1.0580.35
144_A200_Y1.0520.35
174_H276_P1.0510.35
318_G345_L1.0500.35
181_A213_D1.0490.35
166_F375_K1.0480.35
76_S242_K1.0460.35
107_Y147_E1.0340.34
181_A187_T1.0320.34
125_D145_L1.0300.34
18_T23_R1.0300.34
180_I307_A1.0300.34
51_S69_T1.0290.34
105_M126_V1.0250.34
358_Q368_T1.0240.34
156_D228_Y1.0240.34
100_A255_K1.0180.33
215_V220_G1.0160.33
76_S79_L1.0120.33
237_E242_K1.0070.33
266_P279_H1.0040.33
250_N340_Y1.0040.33
228_Y246_A1.0000.33
225_P228_Y0.9990.33
109_S125_D0.9970.32
18_T283_Y0.9910.32
98_K317_M0.9890.32
138_L305_Y0.9870.32
35_L76_S0.9830.32
190_E367_F0.9780.32
113_T141_S0.9770.31
288_K327_E0.9690.31
208_G212_D0.9670.31
90_A144_A0.9660.31
340_Y343_V0.9640.31
73_L362_D0.9620.31
28_D35_L0.9600.31
347_Q351_M0.9560.30
186_V373_K0.9560.30
268_A331_F0.9560.30
166_F296_S0.9500.30
298_G366_D0.9490.30
46_S283_Y0.9460.30
24_N62_G0.9410.30
50_F282_Q0.9370.30
249_T339_H0.9370.30
172_L272_L0.9270.29
50_F303_F0.9270.29
255_K338_D0.9260.29
11_I18_T0.9240.29
234_E364_G0.9230.29
146_E246_A0.9190.29
76_S340_Y0.9150.29
20_K85_R0.9110.28
67_E99_E0.9110.28
256_T318_G0.9100.28
173_A363_L0.9090.28
179_V269_M0.9060.28
133_Y226_F0.9030.28
321_V331_F0.9010.28
327_E364_G0.8980.28
118_K321_V0.8940.28
295_A317_M0.8840.27
51_S244_Y0.8790.27
256_T336_K0.8780.27
65_A167_Q0.8780.27
81_S242_K0.8760.27
161_S311_G0.8760.27
372_S376_H0.8650.26
85_R139_P0.8620.26
18_T307_A0.8610.26
268_A285_I0.8570.26
111_R145_L0.8550.26
8_P25_I0.8550.26
284_Y305_Y0.8540.26
30_Q258_A0.8540.26
213_D355_T0.8520.26
100_A136_S0.8480.26
204_N359_A0.8460.26
81_S207_P0.8440.26
67_E91_I0.8430.26
19_V26_E0.8410.25
171_W345_L0.8390.25
284_Y291_M0.8390.25
164_S269_M0.8390.25
19_V23_R0.8380.25
173_A289_A0.8380.25
333_E342_D0.8360.25
17_A87_K0.8320.25
110_A126_V0.8320.25
278_T316_A0.8300.25
220_G223_P0.8290.25
58_R200_Y0.8270.25
164_S252_K0.8270.25
162_E167_Q0.8250.25
113_T356_F0.8220.25
230_L233_Q0.8210.25
52_F283_Y0.8150.24
367_F371_L0.8120.24
242_K263_T0.8090.24
133_Y254_S0.8090.24
98_K166_F0.8070.24
178_E322_E0.8050.24
262_V350_A0.8030.24
264_V268_A0.8010.24
264_V321_V0.8010.24
289_A324_I0.7970.24
74_P292_T0.7960.24
75_I264_V0.7900.23
117_E138_L0.7900.23
245_I253_V0.7890.23
186_V192_S0.7880.23
313_V364_G0.7870.23
42_H298_G0.7850.23
89_G345_L0.7820.23
56_H198_E0.7770.23
272_L329_L0.7750.23
271_E344_S0.7750.23
48_M116_D0.7740.23
162_E360_H0.7700.23
75_I291_M0.7700.23
350_A371_L0.7660.22
176_P320_Y0.7640.22
167_Q201_I0.7630.22
110_A310_V0.7620.22
104_Y332_L0.7620.22
295_A298_G0.7600.22
215_V218_P0.7590.22
10_P19_V0.7590.22
123_I142_I0.7510.22
170_D229_R0.7480.22
84_M141_S0.7480.22
133_Y253_V0.7470.22
47_N152_L0.7450.22
196_G307_A0.7440.22
30_Q321_V0.7440.22
88_P337_D0.7430.22
128_E360_H0.7420.22
58_R144_A0.7410.21
244_Y364_G0.7390.21
48_M114_I0.7390.21
149_A169_T0.7370.21
160_F342_D0.7360.21
77_E161_S0.7330.21
8_P23_R0.7310.21
55_T322_E0.7310.21
100_A256_T0.7310.21
26_E29_R0.7310.21
46_S256_T0.7290.21
67_E163_N0.7280.21
233_Q245_I0.7270.21
144_A147_E0.7260.21
120_R222_V0.7240.21
120_R220_G0.7220.21
131_L252_K0.7200.21
269_M331_F0.7180.21
278_T315_F0.7160.21
78_N279_H0.7160.21
170_D318_G0.7150.21
123_I161_S0.7110.20
65_A200_Y0.7090.20
24_N174_H0.7080.20
283_Y340_Y0.7070.20
82_V151_F0.7070.20
243_V331_F0.7060.20
338_D347_Q0.7040.20
20_K123_I0.7030.20
227_T253_V0.7030.20
120_R223_P0.7010.20
172_L349_L0.7010.20
73_L307_A0.6990.20
305_Y363_L0.6980.20
67_E362_D0.6970.20
178_E269_M0.6960.20
113_T123_I0.6960.20
111_R315_F0.6950.20
65_A161_S0.6940.20
65_A162_E0.6910.20
20_K107_Y0.6890.20
38_P260_A0.6880.20
145_L206_L0.6870.20
274_W280_E0.6860.20
261_L330_V0.6860.20
112_V344_S0.6850.19
123_I154_V0.6840.19
157_D336_K0.6820.19
222_V227_T0.6810.19
225_P253_V0.6810.19
171_W174_H0.6810.19
126_V316_A0.6800.19
267_G300_A0.6800.19
222_V226_F0.6780.19
49_K292_T0.6780.19
206_L369_D0.6780.19
293_V311_G0.6750.19
75_I331_F0.6740.19
184_F247_D0.6730.19
204_N235_P0.6730.19
157_D200_Y0.6730.19
118_K187_T0.6720.19
154_V303_F0.6720.19
210_L229_R0.6690.19
109_S154_V0.6680.19
128_E336_K0.6650.19
168_L253_V0.6630.19
180_I187_T0.6630.19
50_F160_F0.6600.19
103_A158_G0.6600.19
208_G213_D0.6600.19
28_D117_E0.6590.19
209_S212_D0.6590.19
48_M54_D0.6550.18
148_G361_L0.6540.18
337_D347_Q0.6530.18
137_G348_W0.6520.18
65_A194_L0.6500.18
246_A373_K0.6490.18
115_V222_V0.6490.18
193_N327_E0.6480.18
237_E372_S0.6470.18
349_L368_T0.6460.18
20_K26_E0.6440.18
98_K157_D0.6420.18
170_D272_L0.6400.18
156_D336_K0.6400.18
11_I17_A0.6390.18
324_I336_K0.6380.18
83_N150_E0.6370.18
210_L214_I0.6340.18
194_L352_L0.6340.18
190_E194_L0.6340.18
186_V191_I0.6330.18
228_Y244_Y0.6330.18
123_I181_A0.6320.18
243_V311_G0.6320.18
159_S164_S0.6310.18
13_G182_A0.6310.18
25_I177_K0.6300.18
283_Y291_M0.6300.18
89_G144_A0.6280.18
305_Y321_V0.6270.18
78_N278_T0.6260.18
85_R163_N0.6240.17
121_S218_P0.6240.17
326_D374_E0.6230.17
267_G310_V0.6210.17
288_K306_Q0.6200.17
104_Y297_D0.6200.17
51_S180_I0.6170.17
234_E237_E0.6170.17
21_I317_M0.6160.17
211_K234_E0.6150.17
337_D375_K0.6150.17
180_I252_K0.6150.17
90_A110_A0.6140.17
300_A345_L0.6100.17
150_E247_D0.6090.17
21_I286_S0.6070.17
151_F267_G0.6070.17
142_I149_A0.6060.17
45_V272_L0.6050.17
63_G66_R0.6050.17
154_V253_V0.6040.17
46_S83_N0.6040.17
47_N50_F0.6030.17
198_E321_V0.6020.17
143_Q349_L0.6020.17
200_Y342_D0.6010.17
296_S339_H0.6010.17
147_E329_L0.6010.17
90_A306_Q0.6010.17
258_A336_K0.6000.17
56_H64_Y0.5970.17
118_K193_N0.5970.17
289_A321_V0.5960.17
14_D321_V0.5950.17
106_I168_L0.5940.17
257_I336_K0.5940.17
131_L246_A0.5940.17
211_K324_I0.5930.17
323_N329_L0.5920.16
293_V313_V0.5920.16
249_T326_D0.5900.16
75_I78_N0.5890.16
248_S252_K0.5890.16
294_F345_L0.5880.16
183_N247_D0.5870.16
284_Y321_V0.5870.16
59_L154_V0.5850.16
24_N253_V0.5840.16
151_F162_E0.5820.16
44_T72_E0.5820.16
29_R52_F0.5810.16
91_I355_T0.5800.16
333_E344_S0.5780.16
300_A326_D0.5770.16
74_P161_S0.5770.16
67_E172_L0.5750.16
16_G303_F0.5730.16
173_A194_L0.5730.16
359_A367_F0.5720.16
179_V320_Y0.5710.16
55_T292_T0.5680.16
141_S292_T0.5680.16
93_E200_Y0.5670.16
45_V68_V0.5670.16
226_F304_N0.5650.16
86_L132_W0.5640.16
79_L115_V0.5630.16
224_Y252_K0.5630.16
238_S340_Y0.5630.16
54_D244_Y0.5610.16
286_S354_E0.5590.16
354_E371_L0.5580.15
89_G174_H0.5570.15
124_D219_N0.5570.15
69_T162_E0.5570.15
233_Q246_A0.5560.15
79_L216_E0.5560.15
79_L257_I0.5540.15
338_D372_S0.5540.15
260_A333_E0.5540.15
145_L238_S0.5540.15
52_F168_L0.5530.15
103_A356_F0.5530.15
340_Y360_H0.5530.15
27_R72_E0.5530.15
60_E162_E0.5520.15
233_Q261_L0.5510.15
243_V246_A0.5510.15
199_K202_F0.5510.15
46_S285_I0.5500.15
84_M161_S0.5500.15
84_M132_W0.5490.15
158_G245_I0.5470.15
346_N372_S0.5470.15
139_P361_L0.5460.15
72_E98_K0.5440.15
19_V306_Q0.5430.15
178_E363_L0.5420.15
312_Y325_G0.5420.15
179_V322_E0.5410.15
157_D252_K0.5410.15
189_E336_K0.5400.15
303_F308_G0.5400.15
222_V225_P0.5400.15
148_G264_V0.5390.15
175_T329_L0.5390.15
142_I263_T0.5390.15
79_L147_E0.5370.15
16_G50_F0.5370.15
79_L248_S0.5360.15
336_K341_A0.5360.15
94_L330_V0.5360.15
17_A85_R0.5330.15
22_P83_N0.5320.15
46_S191_I0.5300.15
118_K149_A0.5300.15
112_V366_D0.5290.15
136_S168_L0.5290.15
277_N294_F0.5280.15
228_Y371_L0.5280.15
226_F239_E0.5270.15
146_E368_T0.5270.15
128_E330_V0.5260.15
187_T191_I0.5260.15
80_A154_V0.5250.15
68_V346_N0.5250.15
224_Y369_D0.5240.15
231_L277_N0.5240.15
9_Q253_V0.5240.15
291_M321_V0.5240.15
42_H73_L0.5210.14
114_I342_D0.5200.14
152_L301_R0.5190.14
100_A105_M0.5190.14
46_S313_V0.5190.14
286_S305_Y0.5190.14
72_E199_K0.5190.14
115_V225_P0.5170.14
17_A306_Q0.5150.14
181_A189_E0.5130.14
54_D178_E0.5130.14
65_A82_V0.5110.14
9_Q28_D0.5110.14
157_D226_F0.5090.14
36_V54_D0.5090.14
324_I356_F0.5080.14
124_D363_L0.5070.14
351_M375_K0.5060.14
148_G202_F0.5060.14
257_I341_A0.5050.14
118_K227_T0.5030.14
16_G47_N0.5030.14
272_L318_G0.5020.14
230_L261_L0.5020.14
318_G368_T0.5010.14
42_H49_K0.5010.14
363_L368_T0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j58A 5 0.9662 100 0.589 Contact Map
2vqaA 3 0.9143 100 0.663 Contact Map
2ea7A 3 0.8857 100 0.694 Contact Map
4lejA 3 0.8286 100 0.694 Contact Map
2e9qA 6 0.839 100 0.695 Contact Map
3qacA 3 0.8442 100 0.698 Contact Map
3kscA 4 0.8416 100 0.699 Contact Map
1uijA 3 0.8649 100 0.703 Contact Map
3kglA 3 0.8675 100 0.703 Contact Map
2cavA 3 0.813 100 0.705 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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