GREMLIN Database
OPCR - HTH-type transcriptional repressor OpcR
UniProt: O34709 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (154)
Sequences: 652 (446)
Seq/√Len: 36.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T58_M3.9631.00
48_T88_L3.8181.00
84_V88_L3.5361.00
34_G37_L3.4021.00
137_E140_E2.5791.00
45_K51_E2.5561.00
45_K81_E2.3911.00
46_P87_D2.2960.99
20_I37_L2.1990.99
59_S65_Q2.1750.99
81_E88_L2.1540.99
52_L63_M2.1180.99
140_E143_N2.1020.99
49_L63_M2.0410.99
36_V52_L2.0210.99
72_D142_V2.0010.98
58_M87_D1.9950.98
99_F156_Y1.9410.98
20_I34_G1.8560.97
157_D161_R1.8210.97
111_V161_R1.7470.96
49_L60_K1.7210.96
12_A117_L1.6280.94
139_E143_N1.5810.93
119_K150_K1.5750.93
136_P140_E1.5680.93
31_S35_R1.5420.93
110_V113_K1.5380.92
23_N96_Y1.4570.90
75_I98_T1.4370.90
30_P111_V1.4340.90
59_S82_K1.4000.88
45_K48_T1.3950.88
116_V119_K1.3880.88
140_E144_Q1.3760.87
50_S86_K1.3710.87
82_K99_F1.3690.87
39_I47_M1.3610.87
79_V88_L1.3600.87
29_M86_K1.3070.85
12_A83_G1.2930.84
103_F149_L1.2680.83
35_R84_V1.2620.82
135_T138_A1.2510.82
58_M99_F1.2470.82
97_Q101_S1.2460.82
136_P143_N1.2340.81
56_T70_M1.2310.81
32_T99_F1.2260.81
34_G38_G1.2200.80
79_V90_D1.2060.79
115_K119_K1.1870.78
95_Y99_F1.1870.78
38_G103_F1.1790.78
117_L121_L1.1770.78
61_T65_Q1.1710.77
15_H120_K1.1660.77
11_H124_E1.1580.77
40_I43_N1.1490.76
68_R78_K1.1310.75
40_I81_E1.1240.74
62_R65_Q1.0990.73
21_A31_S1.0950.72
102_L149_L1.0910.72
23_N49_L1.0880.72
111_V122_N1.0870.72
119_K123_R1.0780.71
94_D108_T1.0680.70
129_L136_P1.0640.70
49_L64_S1.0630.70
74_N112_S1.0550.70
156_Y160_S1.0530.69
21_A35_R1.0440.69
65_Q88_L1.0340.68
13_E55_A1.0270.67
13_E141_K1.0260.67
40_I76_A1.0170.67
68_R77_E0.9980.65
86_K148_E0.9940.65
49_L114_N0.9870.64
30_P56_T0.9850.64
16_L106_N0.9840.64
103_F159_L0.9810.64
16_L91_V0.9800.64
56_T66_V0.9750.63
126_S139_E0.9740.63
122_N137_E0.9680.63
36_V66_V0.9670.63
56_T81_E0.9660.63
19_K114_N0.9610.62
54_E140_E0.9570.62
140_E154_H0.9440.61
122_N154_H0.9410.61
102_L106_N0.9380.60
21_A84_V0.9360.60
140_E150_K0.9300.60
39_I56_T0.9250.59
81_E122_N0.9200.59
100_I103_F0.9170.59
35_R87_D0.9160.58
30_P35_R0.9020.57
29_M33_V0.9020.57
21_A27_F0.9000.57
127_D136_P0.8990.57
54_E157_D0.8990.57
124_E127_D0.8990.57
10_E136_P0.8960.57
137_E147_N0.8940.57
37_L66_V0.8910.56
19_K22_E0.8860.56
138_A143_N0.8850.56
48_T156_Y0.8740.55
29_M57_G0.8730.55
38_G91_V0.8670.54
53_S67_V0.8590.54
29_M41_Y0.8440.52
16_L29_M0.8390.52
23_N95_Y0.8350.51
58_M61_T0.8330.51
89_Y152_W0.8330.51
17_I45_K0.8300.51
47_M126_S0.8300.51
76_A139_E0.8300.51
31_S109_K0.8240.51
11_H51_E0.8230.50
123_R130_Q0.7930.48
16_L25_H0.7870.47
31_S96_Y0.7850.47
26_T63_M0.7790.47
105_A108_T0.7780.47
34_G103_F0.7770.46
30_P73_A0.7770.46
12_A51_E0.7760.46
142_V157_D0.7630.45
89_Y98_T0.7620.45
18_E57_G0.7590.45
77_E96_Y0.7590.45
8_I120_K0.7580.45
22_E40_I0.7500.44
71_I89_Y0.7490.44
50_S53_S0.7480.44
20_I27_F0.7430.44
32_T42_M0.7340.43
8_I130_Q0.7330.43
74_N156_Y0.7320.43
25_H142_V0.7310.43
72_D81_E0.7230.42
58_M66_V0.7230.42
42_M148_E0.7210.42
20_I24_M0.7020.40
63_M114_N0.7010.40
8_I44_R0.6980.40
9_I150_K0.6960.40
30_P65_Q0.6960.40
9_I43_N0.6860.39
71_I76_A0.6840.39
27_F60_K0.6810.38
57_G78_K0.6740.38
32_T62_R0.6730.38
13_E145_L0.6700.37
71_I87_D0.6690.37
79_V87_D0.6660.37
13_E43_N0.6620.37
62_R114_N0.6620.37
126_S150_K0.6600.37
89_Y97_Q0.6580.36
23_N114_N0.6560.36
8_I76_A0.6520.36
49_L96_Y0.6490.36
46_P88_L0.6460.35
65_Q82_K0.6430.35
128_L131_R0.6360.35
42_M74_N0.6330.34
89_Y93_Q0.6320.34
115_K123_R0.6280.34
47_M117_L0.6270.34
109_K113_K0.6260.34
39_I98_T0.6220.34
89_Y148_E0.6210.34
50_S97_Q0.6200.33
62_R70_M0.6160.33
36_V75_I0.6130.33
58_M103_F0.6020.32
55_A118_Y0.6000.32
11_H116_V0.5980.32
16_L42_M0.5970.32
73_A105_A0.5970.32
147_N161_R0.5900.31
14_E57_G0.5880.31
60_K113_K0.5780.30
77_E87_D0.5760.30
147_N164_E0.5730.30
50_S156_Y0.5730.30
25_H110_V0.5680.30
81_E154_H0.5640.29
126_S157_D0.5620.29
26_T32_T0.5560.29
24_M102_L0.5550.29
135_T139_E0.5520.28
49_L107_W0.5520.28
39_I105_A0.5510.28
24_M158_W0.5500.28
62_R106_N0.5460.28
36_V48_T0.5450.28
33_V66_V0.5450.28
14_E137_E0.5410.28
143_N147_N0.5410.28
92_E158_W0.5390.27
20_I38_G0.5370.27
39_I113_K0.5350.27
27_F113_K0.5350.27
37_L102_L0.5350.27
51_E154_H0.5320.27
68_R97_Q0.5320.27
86_K141_K0.5280.27
102_L148_E0.5270.27
10_E93_Q0.5250.27
99_F149_L0.5250.27
129_L139_E0.5210.26
16_L24_M0.5200.26
81_E84_V0.5180.26
12_A93_Q0.5150.26
76_A91_V0.5140.26
50_S62_R0.5130.26
8_I140_E0.5120.26
52_L76_A0.5110.26
41_Y95_Y0.5090.25
22_E110_V0.5070.25
48_T58_M0.5040.25
42_M145_L0.5020.25
102_L131_R0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nb5A 4 0.8 99.5 0.734 Contact Map
1ku9A 2 0.8162 99.3 0.765 Contact Map
3qphA 2 0.8378 98.8 0.805 Contact Map
3kp7A 2 0.7243 98.7 0.81 Contact Map
3g3zA 2 0.7676 98.7 0.811 Contact Map
3deuA 2 0.7135 98.7 0.811 Contact Map
4l9nA 2 0.7459 98.7 0.811 Contact Map
1lj9A 2 0.7784 98.7 0.812 Contact Map
3fm5A 4 0.7514 98.7 0.813 Contact Map
2fbhA 2 0.7189 98.7 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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